Mushroom cultivation in more developed countries has evolved from an art into huge agri- business by way of the most innovative production technology and biotechnology available. However, there are still less-developed areas of the world where access to these technological advances are either unavailable or too expensive to utilize. West Africa exemplifies this problem, and a low cost mushroom production program would have compounded benefits for the region. This process would allow the use of secondary crops to be produced in a short time frame from agricultural byproducts derived from the primary agriculture of the region, such as millet and sorghum straw, cassava peelings, or virtually any other cellulose source. These and other potential raw materials are currently being disposed of as waste. After the production of edible or medicinal mushroom crops are harvested from these agricultural wastes, the residual mushroom substrate represents a bioconversion from the non- nutritional cellulosic material to an edible fungal matrix of high protein content which can be utilized as nutritious cattle and goat fodder as well as feedstock for tilapia farming. This diversified approach results in three successive cash crops from any agricultural operation where previously there had been only the one primary crop. The oyster mushroom complex (Pleurotus ostreatus and other Pleurotus and Hypsizygus species) appear to be the best candidates for production in the West African climate. These mushrooms are primary cellulose decomposers, and can grow on almost any plant material substrate including banana waste, coffee residue, sugar cane baggasse, paper or cardboard waste, river grass, sawdust and nearly all other agricultural waste. The purpose of this paper is to present low-cost, low-technology methods applicable to small- scale village mushroom production. The process obtained from this research represents the least training and smallest capital and infrastructure investment to implement a mushroom farming operation, while suggesting the easiest system to grow locally acclimatized mushroom strains for a large and valued mushroom crop in the shortest possible time with minimal financial risk for the farmers.