AbstractNorthwest China is much more sensitive to climate warming, and the climate has varied rapidly from warm and drought to warm and humid conditions. In addition, due to the complex terrain of Northwest China, the methods and parameterization schemes of different CMIP6 models, these models are mostly applied to arid areas in Northwest China or Central Asia, lacking climate data for plateau areas and eastern Lanzhou, specifically in filtering CMIP6 models and evaluating applicable models. In this paper, 34 CMIP6 climate models are used to evaluate and forecast future trends in Northwest China under the SSP126, SSP245 and SSP585 scenarios in the short, medium and long term. CMIP6 models of temperature and precipitation are identified by applying the interannual variability skill score (IVS) between CN05.1 datasets and historical CMIP6 models, which are suitable for Northwest China. Then, we assess the characteristics, warming and wetting deviations, and uncertainties in the prediction of climatic change according to CMIP6 models over Northwest China. The results show that CMIP6 models in precipitation and temperature applicable to Northwest China are AWI‐CM‐1‐1‐MR, BCC‐CSM2‐MR, FGOALS‐g3, INM‐CM4‐8, INM‐CM5‐0 and MRI‐ESM2‐0. The multi‐model ensemble mean (MMEM) has better capability than individual CMIP6 models in precipitation and temperature prediction. Spatiotemporal climatic change over Northwest China shows overall warming and wetting trends. The IVS provides the ability to estimate CMIP6 model simulation performance both temporally and spatially. The temperature simulation is quite good in the Tarim Basin and Hexi Corridor region, and the precipitation simulation is quite good in the plateau region, Altai Mountains, Tianshan Mountains and Hexi Corridor region. Cold and wet deviations occur in Northwest China due to the topography and few stations, which are common reasons. The main sources of uncertainties in temperature prediction during this century are model uncertainty (before the 2090s) and scenario variability (after the 2090s), and model uncertainty in precipitation for CMIP6 becomes the main source of uncertainty.