Abstract Access to genomic cancer risk assessment (GCRA) is standard of care in most developed countries, but is not readily available in Latin America. Following needs assessment, a dissemination and implementation intervention, including clinical training and application of in expensive genomic tools, was used to develop a model for vertical integration of GCRA among underserved populations in Latin America. A roundtable forum with 15 Latin American physicians representing Brazil, Colombia, Mexico, Puerto Rico and Peru was conducted to assess the state of GCRA services and barriers to implementation in these countries. The roundtable was conducted in Spanish, moderated by bilingual cancer genetics clinicians, recorded, transcribed, translated and thematically analyzed. Roundtable findings indicated a need for a multi-level approach with GCRA training, cost-effective genomic testing, and an evidence-based foundation to support the development of policy, infrastructure and resources to implement and sustain GCRA services in Latin America. The City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice (CCGCoP), an NCI R25-E multi-modal training and practice support program, was piloted to address in part the need for clinicians with GCRA skills as part of infrastructure development. A common prospective registry protocol was implemented via the Cancer Genomics Community Research Network (CCGCRN), and disruptive technologies (next generation sequencing and other rapidly evolving genomic tools) enabled inexpensive BRCA testing tools to be introduced to support GCRA services. Site assessments and clinical proctoring demonstrated successful initiation of GCRA services and has revealed barriers to follow up care. Thus, innovative pairing of disruptive technologies and multimodal training tools have the potential to accelerate implementation of genomic cancer risk assessment and prevention for underserved populations. Citation Format: Jeffrey Weitzel. A global perspective on clinical cancer genomics. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr IA02.