The study of multiphase flow characteristics of hydrate slurry was crucial for controlling the risks associated with hydrate slurry transport in deep-water oil and gas operations. Currently, multiphase flow research on the hydrate slurry flow system focuses on two-phase (solid-liquid) flow studies in single short straight pipes or elbows. This paper established a geometric model based on an experimental loop of high-pressure natural gas hydrate slurry. The Euler model contained n momentum equations and continuity equations for each term, and the Euler model can couple the pressure term with the surface exchange coefficients. Therefore, Euler model was suitable to deal with complex fluid motion problems. Such as bubble flow problem, floating problem, particle suspension problem and fluidized bed problem. In this paper, the hydrate particles in the grout were set as regular round spheres and do not decompose, so the Euler model was suitable for the simulation of the gas-liquid-solid three-phase flow of hydrate grout in the loop. The Euler model was used to simulate the three-phase (gas-liquid-solid) expansion in the loop, focusing on the influence of hydrate slurry inlet flow rate, inlet hydrate volume fraction, liquid phase viscosity and pipe diameter on slurry flow characteristics. The results are as follows:1) Based on orthogonal experiments, pipe diameter has the most significant impact on the pressure drop of the entire pipe section, while liquid phase viscosity has the greatest impact on the average aggregation particle diameter of hydrate on the cross section.2) The distribution of hydrate phase is related to the direction of the loop. Under the influence of gravity, hydrates are primarily dispersed in the liquid phase, with a high concentration in the solid-liquid mixing zone, tend towards the gas phase zone. Hydrate particles are symmetrically distributed in the vertical cross-section, with smaller particle diameters in the solid-liquid mixing zone compared to the gas phase and liquid phase zone 3). In the elbow section, centrifugal force and density difference cause hydrate particles to aggregate towards the lower pipe wall on the outside of the elbow. This results in the disappearance of the liquid phase zone, higher hydrate concentration on the outside of the elbow, and smaller hydrate particle diameter in the solid-liquid mixing zone compared to the gas phase zone.4). Throughout entire loop, the viscosity of the slurry in the solid-liquid mixing zone was the highest, and the volume fraction of hydrate particles was symmetrical both vertically and horizontally. To validate the simulation results, high-pressure multiphase flow hydrate generation experiments were conducted in a 6 MPa hydrate slurry experimental loop. The stable flow pressure drop value of the slurry was compared to the simulation results. The relative error between the simulated and experimental pressure drops is less than 15%, falling within an acceptable range and matching the experimental results. This proved that the multiphase simulation technique of hydrate slurry gas-liquid-solid in the loop can effectively guide the safe transportation of hydrate slurry under actual working conditions.