Correlation Of Moderate Strength Research Articles

Hubungan Religiusitas dengan Agresi Verbal Pemain Game Online

Currently, the rise of online games causes many cases of violence, both verbal and non-verbal. However, in everyday life, it is found that online games more often have an impact on verbal violence of players; therefore, this study aimed to determine whether there is a negative relation between religiosity and verbal aggression on online game players in Sumbawa Besar City. The method used in this study was quantitative method. The populations in this study were online game players in Sumbawa Besar City consisting of 70 people who were found based on initial screening. Then, the sampling technique used was saturated sample. The research data was obtained from the research instrument in the form of two scales, namely religiosity scale comprising of 20 items and verbal aggression scale which was adapted from the verbal aggression scale (VAS) consisting of 14 items. The statistical method used was Pearson's Correlation. Based on the results of data analysis, it is known that there is a relation between religiosity and verbal aggression. This can be seen from the research significance value of 0.000 < 0.05 and the correlation coefficient value of -0.436 was included in the category of moderate correlation strength, and showed that there is a negative relation between religiosity and verbal aggression on online game players in Sumbawa Besar City.

The importance of matrix metalloproteinases in the development of atrial fibrillation in obesity

One of the trends in modern cardiology is the study of the matrix metalloproteinase (MMP) system. Currently, an increase in plasma concentrations of some MMPs and their tissue inhibitors is considered as one of the earliest biochemical markers of myocardial fibrosis in various diseases of the cardiovascular system. Discusses the importance of MMP in the development of atrial fibrillation (AF). To study the effect of the MMP system on the development of AF in obese patients. The study included 105 patients with a body mass index of more than 30 kg/m2. Depending on the presence of AF, the patients were divided into 2 groups. The criterion for inclusion of patients in group 1 was the presence of documented AF paroxysm in 55 obese patients. The comparison group (group 2) consisted of 50 obese patients without heart rhythm disorders. When patients were included in the study, in order to assess the severity of visceral obesity, all patients underwent a general clinical examination, echocardiography. To determine the activity of the MMP system, venous blood was taken from patients. Significantly higher values of MMP-9 were detected in patients with obesity and paroxysmal AF 315.753.4 ng/ml than in patients with obesity without heart rhythm disorders 220.954.7 ng/ml (p=0.002); the values of tissue inhibitor of metalloproteinase 1 were 185.342.2 and 119.242.6 ng/ml, respectively (p=0.007). In patients with obesity and paroxysmal AF, a correlation of moderate strength between the level of MMP-9 and the volume of left atrium and a direct dependence of moderate strength between the ratio of waist volume to height and the plasma values of MMP-9 was revealed. The MMP-9 index (AUC 0.92) had a high diagnostic value for determining the probability of having a paroxysmal form of AF in obese patients. With an increase in the level of MMP-9 more than 295 ng/ml, it is possible to predict the presence of paroxysmal AF in obese patients with a sensitivity of 74.5% and a specificity of 94%. In patients with obesity and paroxysmal AF, a significant increase in the parameters of the MMP system (MMP-9 and tissue inhibitor of metalloproteinase 1) was revealed when compared with obese patients without heart rhythm disorders (p0.05). With an increase in MMP-9 of more than 285 ng/ml in obese patients, the appearance of AF with a sensitivity of 74.5% and a specificity of 94% can be predicted.

Hubungan Pengetahuan dan Sikap Dengan Perilaku Pencegahan Demam Tifoid Pada Penjamah Makanan

Typhoid fever is a disease that attacks the digestive tract, caused by the bacteria Salmonella typhi. This disease can occur due to low personal hygiene, slum environmental sanitation, and habit of snacking carelessly. Typhoid fever prevention behavior in food handlers is needed to reduce the incidence of typhoid fever, where this behavior is influenced by the knowledge and attitudes of the food handlers about the prevention of typhoid fever. The purpose of this research was to determine the correlation between knowledge and attitudes about typhoid fever prevention with typhoid fever prevention behavior in food handlers in Air Hitam Sub District Payung Sekaki District Pekanbaru City. The research method used an analytic survey with a cross sectional approach. The sampling technique used accidental sampling with a sample size of 30 respondents. The data analysis used the Spearman correlation test, because the data were not normally distributed. There was a relationship between knowledge about typhoid fever prevention and typhoid fever prevention behaviors among food handlers with moderate correlation strength and positive correlation direction (p-value = 0.000; r = 0.555). There was also a relationship between attitudes about typhoid fever prevention and typhoid fever prevention behaviors among food handlers with strong correlation strength and positive correlation direction (p-value = 0.000; r = 0.674). The conclusion of this research was knowledge and attitude about typhoid fever prevention correlate with typhoid fever prevention behaviors among food handlers in Air Hitam Sub District Payung Sekaki District Pekanbaru City.

Factors determining the relationship between adherence to treatment and quality of life in the elderly with chronic heart failure associated with arterial hypertension and chronic kidney disease: correlation analysis

The purpose of the work. To identify the factors that determine the relationship between adherence to treatment and QoL in the elderly with CHF on the background of AH and CKD, and to assess the possibilities of using the obtained data in clinical practice.Material and methods. The study included 93 patients from 60 to 74 years old with CHF on the background of AH and CKD. Clinical and laboratory studies, a questionnaire regarding the presence of side effects, an assessment of the quality of life using the Minnesota questionnaire and adherence to treatment according to the Morisky-Green scale were used in all the patients.Results. Correlation analysis revealed the following relationships: for adherence to QoL - -0.57 (-0.69; -0.42); for systolic blood pressure with QoL - 0.46 (0.28; 0.61) and with adherence - -0.35 (-0.52; -0.16;); for the creatinine with QоL - 0.35 (0.16; 0.52) and with adherence - -0.3 (- 0.47; -0.1); for EPI GFR with QoL - -0.46 (-0.61; -0.28) and with adherence - 0.33 (0.14; 0.5); for the 6-minute walk test with QoL - -0.65 (-0.78; -0.52) and with adherence - 0.49 (0.32; 0.63). For all identified relationships p is <0.05.Conclusions. In the elderly with CHF on the background of AH and CKD, correlations of moderate strength were found between the clinical and laboratory parameters of these diseases, QoL, and adherence to treatment. Identified pathogenetic links can be used to explain to the patient the need to follow the doctor's recommendations. A change in QoL can serve as a marker showing that some revising is needed in a patients’ treatment.

Relationships between in vivo surface and ex vivo electrical impedance myography measurements in three different neuromuscular disorder mouse models.

Electrical impedance myography (EIM) using surface techniques has shown promise as a means of diagnosing and tracking disorders affecting muscle and assessing treatment efficacy. However, the relationship between such surface-obtained impedance values and pure muscle impedance values has not been established. Here we studied three groups of diseased and wild-type (WT) animals, including a Duchenne muscular dystrophy model (the D2-mdx mouse), an amyotrophic lateral sclerosis (ALS) model (the SOD1 G93A mouse), and a model of fat-related atrophy (the db/db diabetic obese mouse), performing hind limb measurements using a standard surface array and ex vivo measurements on freshly excised gastrocnemius muscle. A total of 101 animals (23 D2-mdx, 43 ALS mice, 12 db/db mice, and corresponding 30 WT mice) were studied with EIM across a frequency range of 8 kHz to 1 MHz. For both D2-mdx and ALS models, moderate strength correlations (Spearman rho values generally ranging from 0.3–0.7, depending on the impedance parameter (i.e., resistance, reactance and phase) were obtained. In these groups of animals, there was an offset in frequency with impedance values obtained at higher surface frequencies correlating more strongly to impedance values obtained at lower ex vivo frequencies. For the db/db model, correlations were comparatively weaker and strongest at very high and very low frequencies. When combining impedance data from all three disease models together, moderate correlations persisted (with maximal Spearman rho values of 0.45). These data support that surface EIM data reflect ex vivo muscle tissue EIM values to a moderate degree across several different diseases, with the highest correlations occurring in the 10–200 kHz frequency range. Understanding these relationships will prove useful for future applications of the technique of EIM in the assessment of neuromuscular disorders.

Сondition of urogenital tract microbiotes and pro- and antioxidant system in male azoospermia

Over the past 20 years, there has been a clear trend to increase in the number of infertile men in Ukraine, their percentage reaches 50% in infertile couples. There is a significant percentage of male infertility caused by azoospermia – the lack of sperm in the ejaculate. In male infertility, azoospermia is found in 10–15% of patients, among other forms of pathospermia. Given the ambiguity of ideas about the etiology, pathogenesis and treatment and diagnostic approaches for various types of infertility, it remains important to clarify the relationship of urogenital infections with the regulatory systems of cells, including the state of the pro- and antioxidant system and the search for additional markers. 119 patients with various forms of azoospermia were examined. All patients underwent the following studies: spermogram, infectious screening, inhibin B, lipid peroxidation, activity of enzymes of the glutathione antioxidant system in sperm plasma and blood serum. Infectious screening included analysis of urethral secretions, bacteriological examination of sperm or prostate secretion, assessment of the species and quantitative composition of the microflora of the male urogenital tract. According to the results of spermogram and other diagnostic methods, a non-obstructive form of azoospermia was detected in 69 patients. In obstructive azoospermia, ejaculate as such was absent. It is suggested that inhibin B may be an important medical diagnostic test for azoospermia. As a result of the conducted researches the importance of determining the concentration of inhibin B as a marker of azoospermia was demonstrated and a negative correlation of moderate strength between the content of inhibin B and testosterone level in the plasma of men with non-obstructive azoospermia was revealed. It was found that Ureaplasma pervum and Ureaplasma urealyticum infect the male genitourinary system to the greatest extent among a number of microorganisms, both in non-obstructive and obstructive forms of azoospermia. Enterococcus faecalis is more pronounced in the sperm fluid in the non-obstructive form of azoospermia and prostate secreton in the obstructive form of azoospermia. In the non-obstructive form of azoospermia in the seminal plasma and serum, the processes of lipid peroxidation intensify, the concentration of reduced glutathione decreases and the activities of the enzymes of the glutathione antioxidant system (glutathione peroxidase and glutathione transferase) decrease. It can be considered that an important diagnostic test for the nonobstructive form of azoospermia is the ratio of reduced glutathione to oxidized glutathione in sperm plasma.

The role of calcification biomarkers in the formation of aortic stenosis

Abstract Background The main mechanism of aortic valve (AV) calcification is not yet known. One of the possibility pathway responsible for AV calcification (AVC) includes osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL) – the parts of the RANKL-RANK-OPG system and fetuin-A: cysteine protease inhibitors. Aim Evaluation of OPG, sRANKL, fetuin-A in blood serum and tissues in patients with varying severity of aortic stenosis (AS) to establish potential methods of estimation AVC depending on the presence of congenital heart disease: bicuspid AV (BAV) or its absence. Materials and methods The study involved 285 patients with AS (59.06±6.95 years, m:f – 1.1:1): 163 with (BAV) and 122 with tricuspid AV (TAV). The control group 53 patients (48.31±9.04 years, m:f-1:1) without valvular pathology, connective tissue dysplasia and coronary heart disease. ECHO (Vivid 7, GE, USA) was performed in all patients. The expression of OPG, RANKL, fetuin-A in homogenates of aortic valve were determined by immunoblotting. Serum concentration of OPG, RANKL, fetuin were performed in all pts by enzyme-linked immunosorbent assay. Results In the control group the concentration of fetuin-A in the blood serum was significantly higher than in TAV and BAV subgroups (446.66 [293.63; 619.19] vs 319.9 [239.6; 400.2] vs 315.6 [245.6; 385.6] pmol/l, p=0.ehab724.1560001). In all groups of patients with AS an increased level of sRANKL in the blood serum was revealed compared to the control group (TAV=0.39 [0.25; 0.53] vs BAV=0.38 [0.21; 0.55] vs control group 0.31 [0.18; 0.44] pmol/l; p<0.005). OPG level in serum was increased in patients with TAV: 8.1 [4.3; 11.9] pmol/l compared to BAV: 6.8 [3.9; 9.7] pmol/l, p=0.003, as well as the control group: 6.15 [3.41; 8.89] pmol/L, p=0.001. RANKL expression in AV tissue was significantly lower in patients in the control group: 2119,06 [1990.94; 2554.11] as compared with AS pts: 4273.03 [2887.620; 4956], p=0.001, and in subgroups with TAV: 4273.08 [2887.620; 5285], p=0.002 or BAV: 4272.99 [2884.430; 4847], p<0.01. In addition, a positive correlation of moderate strength was found between the RANKL in the blood serum and the expression of RANKL in the AV tissue in patients with BAV (r=0.357, p=0.04). OPG expression in the AV tissue was higher in patients in the control group: 3949,953 [1931.88; 6447.67], while significant only in comparison with the BAV subgroup: 2599.28 [1066.38; 4132.18], p=0.02. A positive correlation of moderate strength was found between the OPG in the blood serum and the expression of OPG in the AV tissue in TAV subgroup (r=0.423, p=0.03). Conclusion Different pathogenic mechanisms of AV calcification are accompanied by an increase in various markers of the OPG / RANK / RANKL system: in patients with TAV calcification marker is OPG, in patients with BAV it is RANKL. Funding Acknowledgement Type of funding sources: None.

Features of saliva diagnostics and threshold gustometry in patients with non-alcoholic fatty liver disease

Objective — to determine the features of dental complaints and the threshold of taste sensitivity of the tongue receptors to glucose in patients with non‑alcoholic fatty liver disease (NAFLD) against the background of insulin resistance.
 Materials and methods. The study included 65 patients (29 (44.6 %) women and 36 (55.4 %) men) with NAFLD (the main group) and 24 somatically healthy subjects. The mean body mass index was 36.4 kg/m2 in the main group, and 22.8 kg/m2 in the controls. All patients had insulin resistance (НОМА index — 8.0). Dental examinations included questionnaires of patients with complaints’ detailing, clinical examination of the oral cavity, study of salivation rate, determination of the sensitivity of the taste receptors of the tongue to glucose by the method of gustometry.
 Results. It has been established that the mostly frequent complaints of patients in the main group were constant dry mouth, taste distortion and halitosis. They demonstrated a decrease in salivation rate up to 0.24 ± 0.13 ml per minute, changes in the taste sensitivity of the tongue to sweet, that was several times higher than the threshold of the physiological norm. The strong direct correlation has been proved between oral dryness and salivation rate. Correlations of moderate strength were confirmed between the secretion rate and glucose concentration according to gustometry, and between taste distortion and halitosis.
 Conclusions. Almost 90 % of patients with non‑alcoholic fatty liver disease have typical dental complaints. Questioning patients on the main dental complaints, studying the parameters of the oral fluid and threshold gustometry are the modern, non‑invasive methods, enabling the control of the disease course and assessment of the treatment efficacy.

Correlation of Peak Systolic Velocity Value with Wagner Score in Diabetic Foot Ulcer patients in RSUP Dr. M. Djamil Padang

Background: Diabetic foot ulcers are one of the chronic complications of diabetes mellitus (DM) in the form of wounds on the skin surface of the feet of DM patients accompanied by internal tissue damage or tissue death, either with or without infection, which is associated with the presence of neuropathy and or peripheral arterial disease in patients with DM. The World Health Organization (WHO) states that at least 422 million people suffer from DM A new alternative parameter for assessing the degree of peripheral ischemia is ankle peak systolic velocity (PSV). The rationale for PSV is based on the observation that in the ischemic limb, blood travels at a much slower rate in the distal leg arteries than in the nonischemic limb. PSV is a quick and easy test to assess the patient's vascular status and monitor the development of diabetic foot ulcers, and can assess the degree of ischemia and predict healing of diabetic foot ulcers. This study aims to determine the Correlation of Peak Systolic Velocity Value with Wagner Score in Diabetic Foot Ulcer patients in RSUP Dr. M. Djamil Padang.
 Methods: This research is analytic observational with cross sectional design, the research uses primary data. This research will be conducted at the RSUP Dr. M. Djamil Padang from July 2021 to October 2021. The population in this study were diabetic foot ulcer patients who came for treatment at Dr. M. Djamil Padang. A sample of 32 patients Diabetic foot ulcer met the inclusion criteria. Univariate analysis was conducted to describe each of the variables studied. Numerical data is normally distributed, then it is presented in the form of mean ± standard deviation (SD), whereas if the numerical data is not normally distributed then it is presented in the form of median, minimum and maximum. Categorical data is presented in the form of frequency and percentage of each category. Bivariate analysis was started by using the data normality test using the Shapiro Wilk test (n<50). In testing the correlation between Peak Systolic Velocity and Wagner Score in diabetic foot ulcer patients, the Pearson correlation test is used if the data is normally distributed. Data analysis using SPSS version 22.0.
 Results: more than half of the subjects (65.6%) are male. The mean age of the subjects was 60.46±10.06 years. More than half of the subjects (62.5%) had a normal body mass index. The average length of suffering from diabetes mellitus was 5.48 ± 2.26 years. Half had a history of smoking (59.4%), a small proportion of subjects had hypertension (21.9%), hypercholesterolemia (6.3%) and neuropathy (12.5%). More than half of the subjects (53.1%) had immunopathies. There is a correlation between the popliteal PSV value and the Wagner score in diabetic ulcer patients (p<0.05), with a moderate correlation strength (r=-0.463) and a negative direction. There is a correlation between the PSV dorsali pedis value and the Wagner score in diabetic ulcer patients (p<0.05), with a strong correlation strength (r=-0.720) and in a negative direction. Furthermore, there is a correlation between the posterior tibial PSV value and the Wagner score in diabetic ulcer patients (p<0.05), with a moderate correlation strength (r=-0.530) and a negative direction.
 Conclusion: There is a correlation between the popliteal, tibialis posterior, dorsalis pedis PSV value and the Wagner score in diabetic foot ulcer patient

The Correlation between Anxiety and Insomnia Levels to Families of Health Workers during COVID-19

There are 5,197 positive confirmed cases of COVID-19 in Banjarbaru. It is known that the COVID-19 pandemic causes essential problems related to basic needs such as economic, social, shelter and nutrition, as well as the physical effects of the disease. Not only health workers but also families of health workers experience psychological pressure. In a preliminary study, it was found that the family feel worried and anxious about their families members who work in a hospital to take care of patients. This research aims to investigate the correlation between anxiety levels and insomnia in family members of health workers at Idaman Hospital, Banjarbaru, during the COVID-19 pandemic. This research uses a Cross-Sectional approach using social media with the google form platform taking 125 correspondence as a sample. The research instrument used the DASS-21 and Insomnia Severity Index. The data were analyzed using the SPSS program, with the Spearman rank correlation test working by testing the associative hypothesis of two ordinal scale variables (ranking). A total of 70.4% of family members of health workers at Idaman Hospital Banjarbaru have a very severe level of anxiety. In addition, 46.4% of the families of health workers at Idaman Hospital Banjarbaru experienced severe insomnia. The correlation for state anxiety-insomnia is 0.846 with a p-value = 0.000 (p < 0.05). This indicates that the two variables have a significant relationship with moderate correlation strength. The direction of the positive correlation indicates that these two variables move in the same direction, meaning that the higher the anxiety, the higher insomnia is experienced. Due to the COVID-19 pandemic, the population was limited. It is necessary to conduct further and comprehensive research on the psychological impact on family members of health workers. It is very limited to find research that examines the psychological condition of the family of health workers because, as we know, that not only affects the health workers themselves, but the family also experiences psychological impacts.

Do Orthopaedic In-Training Examination Scores Predict the Likelihood of Passing the American Board of Orthopaedic Surgery Part I Examination? An Update With 2014 to 2018 Data.

Previous research shows a correlation in performance between the Orthopaedic In-Training Examination (OITE) and the American Board of Orthopaedic Surgery (ABOS) Certifying Examination Part I; however, these studies are not current, with the most recent data from 2009. The purpose of this study was to update the relationship between the OITE and ABOS Part I scores with the five most recent nationwide cohorts of Part I scores and their corresponding OITE scores. The American Academy of Orthopaedic Surgeons provided the results for each resident taking the OITE from 2013 to 2017. The ABOS provided the results for each resident taking the Part I examination from 2014 to 2018. These two datasets were matched at the individual level and analyzed. Between 2014 and 2018, 3,502 first-time test-takers were present for the ABOS Part I Examination. A 96.6% pass rate was noted (3,383 of 3,502). A statistically significant correlation between the OITE score and ABOS Part I score was observed at all levels of training: postgraduate year (PGY) 1 r = 0.380, PGY2 r = 0.463, PGY3 r = 0.498, PGY4 r = 0.504, and PGY5 r = 0.504 (P < 0.001 for all correlations). The OITE scores continue to correlate with the ABOS scores and the pass rate for the ABOS with moderate strength correlation. However, although a correlation of the examinations exists when evaluated as a group, the predictive value of the OITE for passing the Part I examination for any specific individual is far from perfect. Individuals with PGY5 OITE percentile scores less than 10 pass the Part I examination, and individuals with PGY5 OITE percentile scores greater than 90 fail the Part I examination.

Contribution of Arab countries to Behçet disease research: a PubMed-based bibliometric and altmetric analysis.

Behçet's disease (BD), a rare multisystemic disorder, has an unknown etiology. Interactions between genetic and environmental factors play a major role in this disorder. Human leukocyte antigen B51 allele is the strongest risk factor for the development of Behçet disease. The high prevalence of BD in the Arab world makes it necessary to undergo local research and publications, to target particular genetic, geographical, or even cultural risk factors. This study aims to assess the numerical contribution of the Arab world to research on Behçet disease. Using the PubMed platform, the number of BD-related publications from 2005 to 2019 was assessed for all 22 Arab countries, and countries having the highest prevalence of the disease. Number of publications on BD was normalized to the average population size and GDP for each Arab country. From 2005 to 2019, Arab countries published 198 articles related to BD. This accounts for 0.1% of the total number of BD-related articles published in this period (4170). A significant, positive correlation of moderate strength exists between the number of publications and the average population, while a non-significant, positive correlation of week strength exists between the number of publications and GDP. Concerning the top 15 countries according to Behçet disease prevalence, Turkey had the greatest number of articles, while the USA had the highest ratio of publications per prevalence. The high prevalence of BD in Arabic countries was faced by paradoxically low research activity in this field. Arab countries are lagging behind in the field of Behçet disease-related research, which highlights the need for improving research productivity.

Association of Urinary Interferon Gamma Protein-10 Levels and Low Levels of Cluster of Differentiation 4 Serum in Patients with Tuberculosis-Human Immunodeficiency Virus Coinfection

BACKGROUND: Tuberculosis (TB) infection caused by Mycobacterium tuberculosis was the most frequent opportunistic infection in human immunodeficiency virus (HIV) patients that lead to increasing of morbidity and mortality. Very low cluster of differentiation 4 (CD4) levels causing problem in TB/HIV diagnostic because unspecific clinical manifestation. Urine interferon gamma protein-10 (IP10) examination is a method that is relatively easier and safer to do, so it can be used as an alternative method in establishing the diagnosis TB/HIV. AIM: The aim of this study was to investigate the association between urinary IP-10 and level of CD4 serum in patients with TB/HIV coinfection. MATERIALS AND METHODS: This study was conducted at the Department of Internal Medicine, Faculty of Medicine, Dr. M. Djamil Hospital, Padang, Indonesia, involved 30 patients with active TB/HIV coinfection whose urine and blood serum were collected to evaluate IP-10 and CD4 level. RESULTS: There is a significant relationship between urine IP10 levels as a biomarker for the diagnosis of active pulmonary TB in HIV patients and serum CD4 levels in TB-HIV coinfected patients with moderate correlation strength. CONCLUSION: Further research is needed with a larger sample size to see the effect of low serum CD4 levels on the sensitivity of urine IP10 diagnosis.

Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia.

Quantification of variation in levels of spontaneously occurring cancer driver mutations (CDMs) was developed to assess clonal expansion and predict future risk of neoplasm development. Specifically, an error-corrected next-generation sequencing method, CarcSeq, and a mouse CarcSeq panel (analogous to human and rat panels) were developed and used to quantify low-frequency mutations in a panel of amplicons enriched in hotspot CDMs. Mutations in a subset of panel amplicons, Braf, Egfr, Kras, Stk11, and Tp53, were related to incidence of lung neoplasms at 2 years. This was achieved by correlating median absolute deviation (MAD) from the overall median mutant fraction (MF) measured in the lung DNA of 16-week-old male and female, B6C3F1 and CD-1 mice (10 mice/sex/strain) with percentages of spontaneous alveolar/bronchioloalveolar adenomas and carcinomas reported in bioassay control groups. A total of 1586 mouse lung mutants with MFs >1 × 10-4 were recovered. The ratio of nonsynonymous to synonymous mutations was used to assess the proportion of recovered mutations conferring a positive selective advantage. The greatest ratio was observed in what is considered the most lung tumor-sensitive model examined, male B6C3F1 mice. Of the recurrent, nonsynonymous mouse mutations recovered, 55.5% have been reported in human tumors, with many located in or around the mouse equivalent of human cancer hotspot codons. MAD for the same subset of amplicons measured in normal human lung DNA samples showed a correlation of moderate strength and borderline significance with age (a cancer risk factor), as well as age-related cumulative lung cancer risk, suggesting MAD may inform species extrapolation.

Association of dietary calcium intake, total and ionized serum calcium levels with preeclampsia in Ethiopia

BackgroundPreeclampsia is a well-known cause of maternal mortality and morbidity in Ethiopia. The exact pathophysiology has not been fully understood. Calcium and magnesium deficiencies have been given emphasis to play roles in the pathophysiology. Although evidence is abundant, they are equivocal. The study aimed to see the association of dietary calcium intake, serum total calcium level and ionized calcium level with preeclampsia. It also evaluated the association between dietary calcium intake and serum calcium levels.Materials and methodsAn unmatched case–control study was conducted in Gandhi Memorial, Tikur Anbessa, and Zewditu Memorial Hospitals, all in Addis Ababa, between October to December, 2019. Cases were 42 women with preeclampsia and controls were 42 normotensive women. The medical and obstetric history was gathered using a structured questionnaire and the dietary calcium intake information using a 24-h dietary recall. The serum levels of total serum calcium and ionized (free) calcium were measured using an inductively coupled mass spectrophotometer. Bivariate and multivariate logistic regression and Pearson correlation test were utilized during data analysis.ResultsIn comparison with controls, women with preeclampsia had lower mean (± 1SD) levels of ionized calcium level (1.1 mmol/l ± 0.11), total serum calcium level (1.99 mmol/l ± 0.35) and lower median (IQR) dietary calcium intake (704 mg/24 h,458–1183). The odds of having preeclampsia was almost eight times greater in those participants with low serum ionized calcium level (OR 7.5, 95% CI 2.388–23.608) and three times higher in those with low total serum calcium level (OR 3.0, 95% CI 1.024–9.370). Low dietary calcium intake also showed statistically significant association with preeclampsia (OR 3.4, 95% CI 1.092 -10.723). Serum ionized calcium level and total serum calcium level showed positive correlation of moderate strength (p = 0.004, r = 0.307), but no correlation was found between dietary calcium intake with both forms of serum calcium levels.ConclusionThis study showed significant association between low dietary calcium intake and low serum calcium levels with preeclampsia, hence this can be used as a supportive local evidence for the current context-specific recommendation of calcium supplementation in societies with low-dietary calcium consumption in an attempt to prevent preeclampsia, therefore implementation study should be considered in Ethiopia to look for the feasibility of routine supplementation.

Relationship between modified Nutrition Risk in the Critically Ill (mNUTRIC) Score and nutrition intake with quadriceps femoris muscle thickness in critically ill patients

Abstract Muscle wasting in critical illness is seen from inadequate nutrition intake and stress catabolism. Modified Nutrition Risk in the Critically Ill (NUTRIC) Score is a screening tool that measures starvation, inflammation, disease severity, and organ dysfunction. Relationship between muscle strength and muscle thickness causes the evaluation of muscle thickness is quite relevant. This study aimed to analyze the relationship between modified NUTRIC score and nutrition with muscle wasting in critically ill patients. The study was conducted on 30 patients in the ICU Dr Soetomo Hospital Surabaya. Nutritional intake and thickness of the quadriceps femoris muscle were monitored for one week. There was a relationship between mNUTRIC score with quadriceps femoris muscle thickness on days 3rd, 5th, and 7th. In the comparison between the low risk group and the high-risk group, it was found that there was a significant difference in the change in the percentage of muscle thickness difference on the 3rd, 5th and 7th day observation. There is a relationship between protein debt with quadriceps femoris muscle thickness (p = 0.008) with a positive correlation with moderate correlation strength (r = 0.477) on day 7. In conclusion, the modified NUTRIC Score had a moderate relationship with quadriceps femoris muscle thickness in critical patients from day 3rd until day 7th. The calorie intake not had a relationship with quadriceps femoris muscle thickness. Protein intake had a moderate relationship with quadriceps femoris muscle thickness only on day 7th measurement in critical patients. Keywords : Modified NUTRIC Score, Nutrition, Quadriceps Femoris muscleCorrespondence : mdr.lopulalan@gmail.com

Correlation between N-Terminal-Pro-Brain Natriuretic Peptide and Heart Failure in Children with Acyanotic Congenital Heart Disease Left-to-Right Shunt

Background: Heart failure is a significant problem causing morbidity and mortality in children with acyanotic CHD left-to-right shunt. Congenital heart disease is often associated with ventricular dysfunction, volume or pressure overload, resulting in a high risk of heart failure. N-Terminal-pro-Brain Natriuretic Peptide (NT- pro-BNP) is a biochemical marker in the left ventricle, which is used as a diagnostic marker for adult heart failure since it has depicted a significant correlation between heart failure and elevated levels of NT-pro-BNP. This study aimed to analyze the relationship between NT-pro-BNP levels and heart failure in children with acyanotic CHD left-to-right shunt. Methods: An observational analytic examination with a cross-sectional study design was conducted on children aged 1 month to 18 years with acyanotic CHD left-to-right shunt with suspected heart failure at the Pediatric Cardiology Outpatient Clinic, Emergency Department, and Pediatric Ward of Dr. Soetomo General Hospital Surabaya from September 2020 to March 2021. Statistical analysis was carried out using Mann-Whitney test and contingency correlation test of Chi-Square with a significance value of p < 0.05. Results: There were 43 subjects fulfilling the inclusion criteria in which 53.5% of them were female with a mean age of 48 months. Furthermore, the most common type of acyanotic CHD left-to-right shunt with heart failure was VSD, followed by ASD and PDA. There was a significant relationship between increasing NT-pro-BNP levels with heart failure with p < 0.001 based on chi-square test with moderate correlation strength (r = 0.57) based on the contingency correlation test. Conclusion: There is a significant positive correlation between NT-pro-BNP and heart failure in children with acyanotic CHD left-to-right shunt.

HUBUNGAN SELF EFFICACY DENGAN EMOTION FOCUSED COPING SAAT PEMBELAJARAN JARAK JAUH PADA MAHASISWA RANTAU UNIVERSITAS TEKNOLOGI SUMBAWA DI MASA NEW NORMAL COVID-19

This study aims to determine the relationship between Self Efficacy variable with Emotion Focused Coping during long-distance learning on overseas students at Sumbawa University of Technology during the COVID-19 New Normal Adaptation. This study uses a quantitative correlation technique. The sampling technique uses cluster sampling and the determination of the number of samples is assisted by using the Slovin formula, the critical value or the accuracy limit is of 10%. The research sample is 85 students of Sumbawa University of Technology. The research data are obtained by using research instruments in the form of two scales, namely the Self Efficacy scale and Emotion Focused Coping. Based on the results of the data analysis that has been conducted, there is a relation between self-efficacy and Emotion Focused Coping. This can be seen from the significance value of 0.000 &lt;0.05 with a correlation value of0.508. Both of these variables have a positive correlation, or a unidirectional relation, which means an increase in Self Efficacy followed by an increase in Emotion Focused Coping, and vice versa, a decrease in Self Efficacy is followed by a decrease in Emotion Focused Coping. The correlation coefficient value of 0.508 is included in the moderate correlation strength category with the Self Efficacy variable with Emotion Focused Coping during long-distance learning on overseas students at Sumbawa University of Technology during the COVID-19 New Normal Adaptation.

Comprehensive hygienic assessment of the dust factor in the asbestos cement manufacturing industry

Objective: to conduct comprehensive hygienic studies of the dust factor in the asbestos cement manufacturing industry and to determine the presence of a relationship between the content level of respirable fibres and the mass concentration of suspended particles in order to actualize the methodology of the assessment of the air of a working area containing mineral fibrous aerosols. Materials and methods. The mass concentrations of dust and the content level of respirable fibres in the air of the working area and the morphological characteristics of dust aerosol were analyzed. Results. The content of dust in the air of the working area in terms of the mass measurements of suspended particles does not exceed the hygienic standards and ranges from 0.20 ± 0.004 mg/m 3 to 1.47 ± 0.085 mg/m 3 , and the content level of respirable fibres is from 0.20 ± 0.044 f/cm 3 to 1.13 ± 0.204 f/cm 3 . The presence of a positive correlation of moderate strength between the content level of respirable fibres and the mass concentration of suspended particles has been found. Conclusion. The microscopy of the preparations of dust samples makes it possible to determine a morphological picture which is characteristic for various stages of the technological process. There is a positive correlation of moderate strength between the content level of respirable fibres in the air of the working area and the concentration of suspended particles. However, the obtained patterns of dependence are capable of accounting up to 49.3 % of the variations of respirable fibres on the basis of the mass concentration of suspended particles, which does not make it possible to use them for the conversion of the values.

Severity Estimation of Depression Using Convolutional Neural Network

In the present study, we attempt to estimate the severity of depression using a Convolutional Neural Network (CNN). The method is special because an auto- and cross-correlation structure has been crafted rather than using an actual image for the input of the network. The importance to investigate the possibility of this research is that depression has become one of the leading mental disorders in the world. With its appearance, it can significantly reduce an individual's quality of life even at an early stage, and in severe cases, it may threaten with suicide. It is therefore important that the disorder be recognized as early as possible. Furthermore, it is also important to determine the disorder severity of the individual, so that a treatment order can be established. During the examination, speech acoustic features were obtained from recordings. Among the features, MFCC coefficients and formant frequencies were used based on preliminary studies. From its subsets, correlation structure was created. We applied this quadratic structure to the input of a convolutional network. Two models were crafted: single and double input versions. Altogether, the lowest RMSE value (10.797) was achieved using the two features, which has a moderate strength correlation of 0.61 (between estimated and original).