Correlation Of Moderate Strength Research Articles

Asprosin in nonalcoholic fatty liver disease and hypothyroidism: a case-control study

ABSTRACT Purpose The present study aimed to determine the serum level of asprosin, a novel glucogenic and orexigenic hormone, in NAFLD and hypothyroidism patients. Methods This is a case–control study that included three groups of age and sex-matched subjects: hypothyroid patients with NAFLD (n = 26), hypothyroid patients without NAFLD (n = 25) and normal control subjects (n = 27). A detailed clinical history was obtained, and an examination was performed. Laboratory tests included fasting plasma glucose and insulin, lipid profile, TSH, free T4, AST, ALT, albumin, and asprosin. The homeostatic model assessment of insulin resistance (HOMA-IR) score was calculated. Abdominal ultrasonography was performed to calculate the hepatorenal index and define participants with NAFLD. The data were statistically analyzed. Results There was a statistically significant difference between the three groups regarding serum asprosin concentration (p < 0.01). Serum asprosin levels were significantly higher in the patients with hypothyroidism and NAFLD compared to both other groups [2.70 ng/mL (2.17–4.10), 1.26 ng/mL (0.96–2.50), and 1.72 ng/mL (1.41–2.12), respectively]. There was no significant difference between the other two groups. There was a significant positive correlation of moderate strength between asprosin and HOMA-IR, BMI, and waist circumference. Asprosin and HOMA-IR were significantly higher in patients with NAFLD compared to subjects with normal liver (p < 0.001). Conclusion The coexistence of NAFLD and hypothyroidism is more strongly associated with increased asprosin than is the presence of hypothyroidism alone. This could be due to increased insulin resistance as a possible link.

Importance of L-carnitine as Biochemical Marker for Semen Quality Preservation after Cryopreservation in Stallions

Background: The aim of this work is to study the significance of carnitine fractions and NO metabolites for the assessment of spermatozoa resistance to cryopreservation, for which purpose these parameters were investigated in seminal plasma of animals divided according to the indices of spermatozoa of stallions subjected to cryopreservation. Methods: There were 18 breeding stallions with an average age of 11.28±5.46 years, all 18 were of Arabian breed. Using cluster analysis of indicators of semen quality, animals were identified into two groups: with high and low sperm resistance to cryopreservation-thawing. We assessed standard quality parameters in fresh and cryopreserved sperm, as well as carnitine and its fractions and NO metabolites in stallions’ seminal plasma, steroid hormones level and carnitine fractions in blood serum. Data were analyzed using JASP. Differences at p less than 0.05 were considered statistically significant. Result: Seminal plasma obtained from animals from the cluster with low motility after cryopreservation-thawing was characterized by a lower concentration of nitric oxide metabolites in 1,79 time (p=0.0415) and free carnitine in 1,64 time (p=0.0349). Positive moderate strength correlation were established between the level of seminal plasma free carnitine and the percentage of live spermatozoa after sperm cryopreservation-thawing.

ГИСТАМИН КАК МАРКЕР КАРДИОРЕНАЛЬНОГО СИНДРОМА

Currently, the combination of chronic heart failure (CHF) and chronic kidney disease (CKD) is considered within the framework of the cardiorenal syndrome, which is associated with a high risk of adverse outcomes. The purpose of this work is to is determine the concentration of one of the most important biologically active substances – histamine and assess histamine level in patients with cardiovascular and renal pathology. The study included 498 patients: 315 patients of the main group suffering from cardiovascular diseases, some of them also having CKD; comparison group – 83 healthy patients. The levels of histamine in the blood plasma of patients were assessed by high-performance liquid chromatography combined with mass spectrometry (HPLC-MS). Based on the results of the analysis, the following data were obtained: plasma levels of histamine in patients with cardiovascular diseases were lower than in healthy patients. The lowest concentration was observed in the group of patients with CHF. Also it was found, that histamine levels are significantly associated with the presence of CKD, while a correlation analysis of histamine levels and laboratory parameters revealed a direct correlation of moderate strength between histamine levels and glomerular filtration rate (GFR) (r=0,421, p&lt;0,000001). The results indicate the role of histamine in the pathogenesis of the cardiorenal syndrome, which requires further research in this direction.

THE RELATIONSHIP BETWEEN THE LEVEL OF PARENTAL KNOWLEDGE AND THE INCIDENCE OF DIARRHEA IN CHILDREN UNDER FIVE YEARS OF AGE IN HOSPITAL INPATIENT ROOMS

Diarrheal diseases are still a concern, especially in children's health. The main cause of death in diarrhea is due to dehydration resulting in fluid and electrolyte loss. One of the factors that influence the incidence of diarrhea in children is parental knowledge. The purpose of this study was to determine the relationship between parental knowledge and the incidence of diarrhea in children under five years of age at Santo Antonio Baturaja Hospital, South Sumatra. This study used a cross sectional design, namely the level of parental knowledge (independent variable) to the incidence of diarrhea in toddlers (dependent variable). Sampling in this study using accidental sampling technique using the slovin formula as many as 52 respondents. This study was conducted in the inpatient room of Santo Antonio Baturaja Hospital, South Sumatra. Data collection used a questionnaire of parental knowledge about diarrhea that had been tested for validity and reliability. The results showed that most of the 24 respondents (46.2%) had a good level of knowledge of parents of children under five years of age and most of the 33 respondents (63.5%) had acute diarrhea. The results of statistical analysis using Spearman obtained a p value of 0.0001 and r = 0.455 which means that there is a relationship between parental knowledge and the incidence of diarrhea in children under five years of age at Santo Antonio Baturaja Hospital with moderate correlation strength. Researchers suggest that education for parents about diarrhea in toddlers should be provided so that they can better prevent and manage diarrhea cases.

Pengaruh Nursery Rhymes terhadap Kemampuan Kosakata Reseptif pada Anak Usia Prasekolah di TK Negeri Pembina Trenggalek

Abstract Background: Nursery Rhymes is a song that is specifically made for children, that range from simple but happy notes and consist of lyrics that have specific meaning. While some rhymes seem designed purely to amuse, others are didactic and educational. Educational experts believe that nursery rhymes can sharpen children’s language skills. Through nursery rhymes, children can learn and understand many new vocabulary. Objectives: This study aims to find out the effect of nursery rhymes on receptive vocabulary skills in preschool children at TK Negeri Pembina Trenggalek. Methods: This study is a quantitative study with cross-sectional design. The sampling technique used in this study was purposive sampling with 52 respondents. The instruments used in this study were a nursery rhymes usage questionnaire and a receptive vocabulary skills test (Receptive One-Word Picture Vocabulary Test). The statistical test used in this study was Kendall's Tau. Results: The result of Kendall's Tau test showed a ρ value of 0.001 (ρ &lt; 0.05) and a correlation strength of 0.428. This means that there is an effect of nursery rhymes on receptive vocabulary skills, with moderate correlation strength and positive correlation direction. That is, the more often children use nursery rhymes, the higher receptive vocabulary skills they have. Conclusion: There is an effect of nursery rhymes on receptive vocabulary skills in preschool children at TK Negeri Pembina Trenggalek. Keyword: nursery rhymes, receptive vocabulary skills, preschool children

Multiple-organ dysfunction in children with central nervous system infections

BACKGROUND: Multiple-organ dysfunction syndrome is one of the most dangerous complications of critical illness in children, which helps determine the disease outcomes.&#x0D; AIM: This study aimed to examine the features of multiple-organ dysfunction syndrome in children with severe central nervous system (CNS) infection and identify factors that determine disease outcomes.&#x0D; MATERIALS AND METHODS: This single-center, retrospective, observational study enrolled 98 patients, which included 66 (67%) boys and 32 (33%) girls. The average age was 3.6 ± 2.5 years. The Glasgow coma scale (GCS) score was 8.8 ± 2.4 points. Shock was diagnosed in 43 (44%) patients. The average treatment duration in the intensive care unit (ICU) was 9.5 ± 6.2 days, the duration of mechanical ventilation was 6.0 ± 3.9 days, and the mortality rate was 9%. Depending on the outcome, the children were divided into groups I (recovery, n = 88) and II (death, n = 10). All indicators were recorded in the first 12 h from ICU admission.&#x0D; RESULTS: The most pronounced phenomena of cardiovascular dysfunction, such as decreased Teicholtz ejection fraction (62.3 L/min), were observed when the pSOFA scale score was 10 points, which was statistically significant when compared with the indicators in children with a pSOFA scale score of 8 points. In all patients, regardless of age, a negative correlation of moderate strength was found between the pSOFA scale score and the Teicholtz ejection fraction, and it was pronounced in children aged 7–17 years (R = –0.41; p = 0.008). A positive correlation was found between heart rate and pSOFA scale score in children aged 7–17 years (R = 0.72; p = 0.009). In the evaluation of the discriminatory ability of the pSOFA scale and Phoenix sepsis scores regarding the outcome on the first day of treatment in the ICU, the latter has greater prognostic significance (area under the curve, 0.866 vs 0.838; sensitivity, 76% vs 72%; specificity, 82% vs 79%).&#x0D; CONCLUSIONS: Low cardiac output syndrome and systemic hypoxia are key factors associated with fatal outcomes in children with severe CNS infections. The high clinical significance of the ejection fraction in predicting the outcomes of severe CNS infections in children, regardless of age, allows the use of this parameter for goal-oriented therapy.

Correlation between the sacral tilt measured with an inclinometer and the pelvic tilt as a tool for assessing the pelvic position.

[Purpose] The aim of this study was to examine whether the forward tilt of the sacrum, which can be measured using an inclinometer, correlates with pelvic tilt and is therefore suitable for therapeutic use as part of a postural assessment for treatment planning or for preventive screening. [Participants and Methods] In 121 athletes (22 females, 99 males), we measured the forward tilt of the sacrum in habitual stance using a digital inclinometer attached to the skin at the level of the posterior superior spinae. At the same time, the forward tilt of the pelvis was determined using videography. For this purpose, we determined the angle between two marker spheres placed on the posterior and anterior superior spinae and the horizontal using sagittal posture photographs. [Results] Taking age as a control variable, we found a significant correlation of moderate strength between pelvic tilt and sacral tilt in men. In women, there was a significant correlation with a strong effect. [Conclusion] The measurement of sacral tilt using an inclinometer positioned on the skin between the posterior superior spinae correlates statistically significantly with pelvic tilt and is therefore suitable as an easy-to-use diagnostic tool for therapeutic use in treatment planning and evaluation.

Hubungan Tingkat Pengetahuan Tentang Vaksinasi Terhadap Kesediaan Vaksinasi Booster COVID-19 Pada Radiografer di Wilayah Jember

Radiographers are at high risk of being infected with COVID-19 related to the most common transmission of COVID-19, so radiographers must be vaccinated. Antibody levels from primary vaccine can only last for 12 to 20 weeks, so booster vaccine is needed. Booster vaccination is one of health behaviors that divided into three domains: cognitive (knowledge), affective (attitudes), and psychomotor (actions). Based on the background above, the authors are interested in researching the relationship between knowledge level about vaccination and willingness to be vaccinated COVID-19 booster among radiographers at Jember. This type of research is a correlational analytic survey with a cross-sectional approach. Population in this research were all radiographers who are members of the Indonesian Radiographers Association (PARI) and active in Jember. The sampling method using total sampling (n=60). Data analysis in this research included editing, scoring, coding, tabulating, univariate analysis, normality test, and bivariate analysis (Rank Spearman Correlation Test) using IBM SPSS Statistics 25 software. Respondent's knowledge level about vaccination showed 46% good, 27% moderate, and 27% less. Respondent’s willingness to be vaccinated COVID-19 booster showed 47% good, 43% moderate, and 10% less. Rank Spearman Correlation Test (Spearman Rho) showed p value or Sig. (2- tailed) of 0.001 and correlation coefficient was 0.43 (+). There is a significant relationship between knowledge level and willingness to be vaccinated COVID-19 booster among radiographers at Jember with moderate correlation strength and unidirectional correlation.

Plasma and platelets amino acids in coronary artery disease and atrial fibrillation patients – are they linked?

Introduction. The impact of circulating amino acid levels and their combinations on the pathogenesis of ischemic heart disease and atrial fibrillation is a current issue, otherwise, the platelets amino acid spectrum is still under discussion, despite the known pathogenetic role of platelets in these disorders. Aim. To compare changes in the plasma and platelets amino acid spectrum in patients with coronary artery disease and atrial fibrillation as well as to find their connections. Materials &amp; Methods. 300 patients were divided into 3 groups: I group – 149 patients with coronary artery disease without arrhythmias, II group – 124 patients with coronary artery disease and atrial fibrillation paroxysm, and the control group – 27 patients without coronary artery disease and arrhythmias. Plasma and platelet amino acid levels were detected by means of ion exchange liquid column chromatography. Results &amp; Conclusions. In platelets amino acid spectrum, a significant rise in leucine (12.63%), isoleucine (10.73%), and Fishers’ ratio (6.37%); a decrease in threonine (23.05%), valine (30.83%) levels, glycine (32.21%), serine (5.06%), and glycine+serine sum (20.51%) in group 2 patients was found compared with group 1, p&lt;0.05. In the plasma amino acids spectrum, a significant increase in glutamate, branched-chain amino acids, and Fishers’ ratio and a decrease in glycine in group 2 patients was checked in comparison with group 1, p&lt;0.05. Only 10 moderate strength correlations were revealed between the plasma and platelets amino acid spectrum of investigated patient’s groups. These changes in platelets and plasma amino acids spectrum were not significantly congruent in patients with coronary artery disease and atrial fibrillation. Plasma and platelets amino acid spectrum should be analyzed separately in patients with coronary artery disease and atrial fibrillation for further studies and evaluation of new prognostic markers and pathogenetic clues to their development. Keywords: myocardial ischemia, heart rhythm violations, proteins, metabolomics.

CORRELATION BETWEEN AXIAL LENGTH AND THE OCCURRENCE OF REFRACTIVE ERRORS

Background: Refractive errors result in difficulty in focusing on an object clearly, leading to blurred vision. A recent study by the WHO has reported that refractive errors have become the leading cause of visual impairment. The development of refractive errors has been a significant concern over the last two decades due to its high prevalence worldwide. One possible condition that may occur in individuals with refractive errors is a change in axial length. Axial length is defined as a measurement from the corneal surface to the retinal surface. Aims: To analyze the correlation between axial length and the occurrence of refractive errors in myopia and hypermetropia patients at the Ophthalmology Department of Diponegoro National Hospital. Methods: This observational analytical study with a cross-sectional design was conducted on 36 eyes from 18 patients; each suffering from myopia and hypermetropia at the Ophthalmology Department of Diponegoro National Hospital. Patients provided informed consent and then the axial length was measured using ultrasound biometry. Data analysis was performed using univariate analysis and Spearman correlation bivariate analysis. Results: The results of the Spearman statistical test showed a significant correlation between the axial length and the occurrence of myopia (p=0.003) with a moderate correlation strength and the occurrence of hypermetropia (p=0.000001) with a strong correlation strength. Conclusion: The axial length has a significant correlation with the occurrence of refractive errors, especially in myopia and hypermetropia patients.

Evaluation of cardiac and vascular remodeling in patients with arterial hypertension in combination with atherosclerosis of the lower extremity arteries

Objective: to evaluate the features of cardiac and vascular remodeling in patients with arterial hypertension (AH) and atherosclerosis of the arteries of the lower extremities (LAA) of varying severity. Materials and methods: the study involved 120 patients with hypertension. Depending on the presence of AANC, all patients were divided into 3 groups: group 1 — 46 patients with hypertension and clinically manifested AANC, group 2 — 39 patients with hypertension and asymptomatic AANC, group 3 — 35 patients with hypertension without AANC. The characteristics of cardiac and vascular remodeling were assessed based on the results of 24-hour blood pressure monitoring (ABPM) using Vasotens technology, triplex ultrasound scanning (UTS) of the arteries of the lower extremities (LEA), and echocardiographic examination (EchoCG). Statistical data processing was carried out using Microsoft Office Excel 16 (2015, Microsoft, USA), Statistica 10.0 (StatSoft, USA) and IBM SPSS Statistica 26.0 (IBM, USA). Results: in the group of patients with severe circulatory disorders of the lower extremities, compared with patients with asymptomatic AANK, significantly lower values of the indicator — reflected wave propagation time (RWTT, ms) (p = 0.006) and significantly higher values of the indicator — augmentation index (AIX) were revealed) and augmentation index in the aorta (AIXao) (p&lt;0.05). A direct statistically significant correlation of moderate strength was revealed between the degree of stenosis (%) of the ANC and the values of the AIX and AIXao indicators (r = 0.345, p = 0.001). Higher values of the dimensions of the walls of the left ventricle (LV) were determined: the thickness of the interventricular septum (IVS) and the posterior wall of the left ventricle (PLW) in patients of the 1st and 2nd groups in comparison with the indicators in patients of the 3rd group (p&lt;0 .05). Patients of all three groups had thickening of the left ventricle and intraventricular septum (&gt;11 mm) and an increase in LVMI. In patients with hypertension and severe AANC, the maximum values of LVMI were determined, which were significantly higher than the corresponding values in patients of the 2nd (p = 0.004) and 3rd (p = 0.0001) groups. LV systolic function in all patients included in the study was assessed as intact. However, the highest ejection fraction (EF) values were recorded in patients with hypertension without AANC, and were significantly higher than those in patients with hypertension and concomitant asymptomatic AANC (p = 0.02), as well as in patients with hypertension and clinically manifested AANC (p =0.001). Conclusions: the progression of AANK was associated with an increase in the stiffness of both peripheral and main arteries, which was accompanied by an increase in the load on the myocardium, which in 97.8% of cases led to more pronounced myocardial remodeling of the concentric hypertrophy type.

The Relationship FoMO (Fear of Missing Out) and Nomophobia with Phubbing Behavior among Adolescent Instagram Users

Aims: FoMO is experienced by many adolescents who constantly update information. The majority of an adolescent have accessed information through Instagram on their mobile phones, so adolescents cannot separate from a mobile phone called nomophobia, which can affect social interaction as apathetic those around called phubbing behavior. This study aims to determine the relationship between FoMO and nomophobia with phubbing behavior among adolescent Instagram users. Methods: This cross-sectional study was conducted on 319 respondents in Depok who were selected through a purposive sampling technique based on inclusion and exclusion criteria. This study was conducted in June-August using valid and reliable questionnaires, namely FoMO adaptation scale (r: 0.720), the Nomophobia Questionnaire (NMP-Q) (r: 0.901), and the phubbing scale questionnaire (r: 0,920). Univariate analysis was performed for categorical data using the frequency distribution test and central tendency test for numerical data, while the bivariate test used Pearson Correlation. Results: The correlation analysis of FoMO with phubbing behavior showed moderate correlation strength and positive direction (p-value 0.001), r = 0.446, while the results of the correlation analysis of nomophobia with phubbing behavior showed weak correlation strength and positive direction (p-value 0.001), r = 0.395. Conclusion: FoMO and nomophobia have a relationship with phubbing behavior among adolescent Instagram users. Health promotion and early detection of FoMO, nomophobia, related to phubbing behavior is important to prevent disruption of adolescent development. Further research regarding the improvement of self-management skills when using mobile phones can be provided.

Analysis of Blood Group Discrepancy at Dr. Wahidin Sudirohusodo Hospital's Blood Transfusion Unit Makassar

Discrepancy is a lack of compatibility of blood group tests between forward grouping and reverse grouping. Based on the cause, discrepancies are divided into four groups as follows: group I discrepancies, which occur due to weak or missing antibodies, group II discrepancies, which occur due to weak or missing antigens, group III discrepancies, which result in the formation of rouleaux, and group IV discrepancies, which are caused by other problems. A retrospective study was carried out by using ABO blood group data, which were analyzed by the automatic gel test method with the IH-1000 device. Data from January 2019 to December 2021 was collected at the Blood Transfusion Unit, Dr. Wahidin Sudirohusodo Hospital of Makassar, and the data were grouped using SPSS version 22. A total of 21.742 samples were tested. The number of detected ABO blood group discrepancies was 127 (0.58%). There were 68 (51.3%) males and 59 (46.5%) females with an age range divided into toddler (38.6%), child (2.4%), adolescent (13.4%), adult (8.7%), pre-elderly (17.3%), and elderly (6.3 %). Based on the disease, discrepancies were categorized into samples with infectious disease (33.9%), autoimmune disease (3.9%), malignancy (23.6%), chronic disease (11%), and others (27.6%). The discrepancies consisted of group I (70.9%), group II (0%), group III (0.8%), and group IV (28.3%). There was a significant correlation between age and blood group discrepancy with p &lt; 0.001 and moderate correlation strength (0.54). The prevalence of discrepancy in this study was 0.58%. Discrepancies must be resolved before they are reported to minimize transfusion reactions.

COMPARISON OF HSP90 EXPRESSION IN CONJUNCTIVAL INTRAEPITHELIAL NEOPLASIA AND CONJUNCTIVAL SQUAMOUS CELL CARCINOMA

Abstract&#x0D; Introduction &amp; Objectives : Heat shock protein 90 (HSP90) participates in stabilizing and activating client proteins involved in malignant transformation. This study aims to determine whether there are different values for the expression of HSP90 in Conjunctival Intraepithelial Neoplasia (CIN) and Conjunctival Squamous Cell Carcinoma (CSCC).&#x0D; Methods : A total of 24 OSSN samples, including 15 cases of CIN and 9 cases of CSCC were evaluated. The immunohistochemical expression of HSP90 was assessed using a scoring system based on the percentage of positive staining of nuclear and cytoplasmic cells, then the intensity of staining was evaluated using the German Immunoreactive Score.&#x0D; Results : In the study, the average cytoplasmic Immunoreactive Score in CIN was 9.87 and CSCC was 16.89 with a significant result (p=0.007), while the average nuclear Immunoreactive Score in CIN was 11.30 and CSCC was 14.50 with insignificant results (p=0.274). The results of the correlation test showed that the cytoplasmic expression groups with low categories were all in CIN as much as 6 (100%) so they had a ratio of 6:0. and the high category of HSP90 cytoplasmic expression group was only found in CSCC as many as 2 (100%) samples with a ratio of 0:2. The results of the correlation test using the Pearson test obtained a significant correlation value (p=0.006) with a moderate correlation strength (r=0.545).&#x0D; Conclusion : There are differences in the expression of cytoplasmic and nuclear HSP90 but only the cytoplasmic expression of HSP90 is significantly associated with CIN and CSCC.

The relationship between husband’s emotional support and anxiety of third trimester pregnant women at Lulu’s independent midwifery practice Surabaya

Anxiety during pregnancy arises due to physical and psychological changes in the mother. Anxiety makes emotional conditions unstable. If anxiety persists until the third trimester, it will cause prolonged labor, low birth weight, and premature birth and cause hypertension which leads to preeclampsia. Anxiety in pregnant women can be overcome with husband support. A husband plays a role in providing support to pregnant women. Husband support is one of the important factors obtained by pregnant women, because husbands are the closest people to pregnant women. During pregnancy, the mother has an unstable emotional condition so there is a need for emotional support from her husband. This emotional support includes expressions of empathy, care, and attention. The purpose of this study was to analyze the relationship between husband's emotional support and anxiety of third trimester pregnant women. This study is an observational analytic study using a cross sectional design. Data analysis using Spearman's Rho correlation test. The number of samples that met the inclusion criteria was 52 third trimester pregnant women at Lulu’s Independent Midwifery Practice, Surabaya. Mothers with good husband's emotional support 86,4% were not anxious, while 53,3% of mothers with poor husband's emotional support experienced mild-moderate anxiety. The results of the Spearman's rho correlation test obtained an rs value: 0.468 (p &lt;0.001) which means that there is a significant correlation between husband's emotional support and anxiety of third trimester pregnant women, with moderate correlation strength. Husband's emotional support has a moderate relationship with anxiety of third trimester pregnant women.

Correlation between the sacral tilt measured with an inclinometer and the pelvic tilt as a tool for assessing the pelvic position.

[Purpose] The aim of this study was to examine whether the forward tilt of the sacrum, which can be measured using an inclinometer, correlates with pelvic tilt and is therefore suitable for therapeutic use as part of a postural assessment for treatment planning or for preventive screening. [Participants and Methods] In 121 athletes (22 females, 99 males), we measured the forward tilt of the sacrum in habitual stance using a digital inclinometer attached to the skin at the level of the posterior superior spinae. At the same time, the forward tilt of the pelvis was determined using videography. For this purpose, we determined the angle between two marker spheres placed on the posterior and anterior superior spinae and the horizontal using sagittal posture photographs. [Results] Taking age as a control variable, we found a significant correlation of moderate strength between pelvic tilt and sacral tilt in men. In women, there was a significant correlation with a strong effect. [Conclusion] The measurement of sacral tilt using an inclinometer positioned on the skin between the posterior superior spinae correlates statistically significantly with pelvic tilt and is therefore suitable as an easy-to-use diagnostic tool for therapeutic use in treatment planning and evaluation.

HISTORY OF PRETERM INFANTS WITH HYPOXIC BRAIN DAMAGE

Relevance. According to the experts of World Health Organization, diseases linked to perinatal hypoxic brain damage account for 70-80% of cases of childhood disability.&#x0D; This study aims to explore the historical records of heart rate and respiratory characteristics in preterm infants with hypoxic brain damage.&#x0D; Subjects and Methods. A prospective cohort study was conducted involving 160 preterm infants categorized into three groups: group I comprised conditionally healthy children, group II included children with hypoxic-ischemic central nervous system lesions, and group III involved children with hypoxic-hemorrhagic central nervous system lesions.&#x0D; Results. The analysis of heart rate parameters according to the data of daily monitoring of electrocardiogram has revealed a positive dynamic of reduction of heterotopic activity and a significant (p&lt;0.05) improvement in the functional state of the conduction system of the heart in all preterm infants aged 20-30 months after a course of timely rehabilitation therapy of hypoxic brain damage. The presence of periodic breathing with respiratory pauses in preterm patients in the neonatal period was established, and a significantly longer duration of apnea was found in children with hypoxic-hemorrhagic central nervous system damage. There has been found an inverse correlation of moderate strength between gestational age and the amount of apnea during the day. Throughout the observation period, there was a gradual establishment of the sleep profile and its structural characteristics, indicating a physiological consolidation process marked by a regular alternation of stable rhythm phases. However, in newborns with hypoxic brain damage, autonomic dysregulation of heart rhythm persisted in the form of hypersympathicotonia. This suggests a high level of electrical instability of the myocardium, underscoring the necessity for ongoing clinical monitoring.

Hubungan antara Kesadaran Orang Tua Tentang Perkembangan Bahasa Dengan Kemampuan Bahasa Ekspresif Pada Anak Usia Prasekolah di KB-TK Aisyiyah Al-Amin Surakarta

Abstract Background: The development of language skills in children is divided into 2, one of which is expressive language skills. An expansive language ability is a person's ability to convey messages verbally or in writing. The development of children can be influenced due to the awareness of the closest people, especially parents. But in reality, there are still many parents who do not have awareness of their role in stimulating children's language from an early age. Awareness consists of 5 aspects including AWAREness namely, Attention, Wakefulness, Architecture, Recall of Knowledge and Emotive. Purpose: The purpose of this study was to determine the relationship between parents' awareness about language development and expressive language skills in preschool-age children in KB-TK Aisyiyah Al-Amin Surakarta. Methods: This research is a quantitative study using a Cross Sectional research design. The sample used was 30 respondents based on the general benchmark of "role of thumb". The sampling technique uses purposive sampling technique. The statistical test used is the Spearman Rank correlation test. Results: Parents' awareness of language development was in the good category of 15 parents (50.0%). Enough for 10 parents (33.3%), and less for 5 parents (16.7%). Expressive language skills in the above category averaged 12 respondents (40.0%), in the average category there were 13 respondents (43.3%) while the remaining 5 respondents (10.0%) were in the below average category. The results of the bivariate analysis obtained that the p value was 0.001 which indicated that the p value was 0.001 &lt;0.05 and the correlation coefficient (r) was 0.560. Conclusion: Parents' awareness of language development is related to expressive language skills in preschool-age children in Aisyiyah Al-Amin Surakarta Kindergarten with moderate correlation strength. Keywords: Parental awareness, expressive language skills, age preschool.

Hubungan Antara Tingkat Pendidikan dan Pengetahuan Orangtua dengan Kualitas Hidup Anak Talasemia Mayor di RSUD Dr. M. Yunus Bengkulu Tahun 2017

One of the problem in thalassemia children is poor quality of life. It is assessed through 4 functions, namely physical, emotional, social, and school functions. Many factors affect the quality of life in thalassemia patients. This study is aimed to know the relationship between educational level and knowledge of parents, with the quality of life in thalassemia children. A cross-sectional study with 54 subjects with thalassemia and 54 pairs of parents. Subjects who met the inclusion criteria and did not meet the exclusion criteria were taken by the consecutive sampling method. Data collection technique was done by conducting interviews based on characteristic data questionnaires, parental knowledge questionnaires, and quality of life questionnaires using PedsQL 4.0 Core Scales. We analised the data by Spearman correlation test and Pearson correlation test. Maternal’s educational level has a significant correlation to the quality of life in children with thalassemia with moderate correlation strength on spearman test (r = 0,410; p = 0,002). Father’s educational level has a significant correlation to the quality of life in the children with thalassemia with a weak correlation strength (r = 0.359; p = 0.008) on the spearman test. Maternal’s level of knowledge have significant correlation to the quality of life in children with thalassemia with medium correlation strength (r = 0,404; p = 0,002) on spearman test. Father’s level of knowledge have significant correlation to quality of life in children with thalassemia with weak correlation strength (r = 0,335; p = 0,013) on the spearman test. Multivariate test found that most factors affecting the quality of life of children with thalassemia is the level of knowledge of mothers with p = 0.014 and OR = 1.179. There is a significant correlation between the level of education and knowledge of parents on the quality of life of major thalassemia children.

MATERNAL KNOWLEDGE REGARDING THE FIRST 1000 DAYS OF LIFE WITH THE INCIDENCE OF STUNTED CHILDREN UNDER THE AGE OF FIVE IN THE WORKING AREA OF SUKOMULYO COMMUNITY HEALTH CENTER

Background: Stunting is a global and national health problem. The World Health Organization (WHO) determines that if the prevalence of stunting is between 30-39%. Based on the reports of Riskesdas in 2010, it was reported that 35.6% of Indonesian children under five were stunted. Stunting is a condition that describes a linear growth disorder characterized by height that is below normal standards for age and sex that is commonly associated with malnutrition and chronic (non-endocrine) infections. The stunting intervention was focused on 1000 Hari Pertama Kehidupan (HPK) period, which is a golden period of a child and if not utilized appropriately, permanent damage could occur. Objective: To determine the correlation between maternal knowledge levels regarding 1000 HPK and the incidence of stunting in children under five. Methods: This study used an observational analytic method with a cross sectional design. Sampling was done with consecutive sampling technique. In this study, will be examined for body length using a stadiometer. After that, the mother will be interviewed to find out the correlation between mother's knowledge regarding 1000 HPK and the incidence of stunting in toddlers. Then the stunting and normal children will be grouped based on the standardized WHO growth chart. Results: Kendall's tau-b statistical test showed a significant relationship (p = 0.000) with positive moderate strength correlation (τ = 0.442). Conclusion: There is a significant relationship and a moderate strength positive correlation between the mother's level of knowledge regarding 1000 HPK and the incidence of stunting Keywords: Maternal knowledge of 1000 HPK, Stunted, Children under five