Performance Of Model Research Articles

Multi-modal fusion and feature enhancement U-Net coupling with stem cell niches proximity estimation for voxel-wise GBM recurrence prediction.

We aim to develop a Multi-modal Fusion and Feature Enhancement U-Net (MFFE U-Net) coupling with stem cell niche (SCN) proximity estimation to improve voxel-wise GBM recurrence prediction.
Approach: 57 patients with pre- and post-surgery MR scans were retrospectively solicited from 4 databases. Post-surgery MR scans included two months before the clinical diagnosis of recurrence and the day of the radiologically confirmed recurrence. The recurrences were manually annotated on the T1ce. The high-risk recurrence (HRR) region was first determined. Then, a sparse multi-modal feature fusion U-Net was developed. The 50 patients from 3 databases were divided into 70% training, 10% validation, and 20% testing. 7 patients from the 4th institution were used as external testing with transfer learning. Model performance was evaluated by recall, precision, F1-score, and Hausdorff Distance at the 95% percentile (HD95). The proposed MFFE U-Net was compared to the support vector machine (SVM) model and two state-of-the-art neural networks. An ablation study was performed.
Main results: The MFFE U-Net achieved a precision of 0.79±0.08, a recall of 0.85±0.11, and an F1-score of 0.82±0.09. Statistically significant improvement was observed when comparing MFFE U-Net with proximity estimation couple SVM (SVMPE), mU-Net, and Deeplabv3. The HD95 was 2.75±0.44mm and 3.91±0.83mm for the 10 patients used in the model construction and 7 patients used for external testing, respectively. The ablation test showed that all five MR sequences contributed to the performance of the final model, with T1ce contributing the most. Convergence analysis, time efficiency analysis, and visualization of the intermediate results further discovered the characteristics of the proposed method.
Significance: We present an advanced multi-modal fusion and feature enhancement learning framework, MFFE U-Net, for effective voxel-wise GBM recurrence prediction. MFFE U-Net performs significantly better than the state-of-the-art networks and can potentially guide early RT intervention of the disease recurrence.

Performance of risk prediction models for diabetic foot ulcer: a meta-analysis.

The number of prediction models for diabetic foot ulcer (DFU) risk is increasing, but their methodological quality and clinical applicability are uncertain. We conducted a systematic review to assess their performance. We searched PubMed, Cochrane Library, and Embase databases up to 10 February 2024 and extracted relevant information from selected prediction models. The Prediction model Risk Of Bias ASsessment Tool (PROBAST) checklist was used to assess bias risk and applicability. All statistical analyses were conducted in Stata 14.0. Initially, 13,562 studies were retrieved, leading to the inclusion of five development and five validation models from eight studies. DFU incidence ranged from 6% to 16.8%, with age and hemoglobin A1C (HbA1c) commonly used as predictive factors. All included studies had a high risk of bias, mainly due to disparities in population characteristics and methodology. In the meta-analysis, we observed area under the curve (AUC) values of 0.78 (95% CI [0.69-0.89]) for development models and 0.84 (95% CI [0.79-0.90]) for validation models. DFU risk prediction models show good overall accuracy, but there is a risk of bias. Adherence to the PROBAST checklist is crucial for improving their clinical applicability.

Optimizing data acquisition: a Bayesian approach for efficient machine learning model training

Acquiring a substantial number of data points for training accurate machine learning (ML) models is a big challenge in scientific fields where data collection is resource-intensive. Here, we propose a novel approach for constructing a minimal yet highly informative database for training ML models in complex multi-dimensional parameter spaces. To achieve this, we mimic the underlying relation between the output and input parameters using Gaussian process regression (GPR). Using a set of known data, GPR provides predictive means and standard deviation for the unknown data. Given the predicted standard deviation by GPR, we select data points using Bayesian optimization to obtain an efficient database for training ML models. We compare the performance of ML models trained on databases obtained through this method, with databases obtained using traditional approaches. Our results demonstrate that the ML models trained on the database obtained using Bayesian optimization approach consistently outperform the other two databases, achieving high accuracy with a significantly smaller number of data points. Our work contributes to the resource-efficient collection of data in high-dimensional complex parameter spaces, to achieve high precision ML predictions.

Policy Learning for Actively Labeled Sample Selection on Lumbar Semi-supervised Classification.

Large labeled data bring significant performance improvement, but acquiring labeled medical data is particularly challenging due to the laborious, time-consuming, and medically qualified annotation. Semi-supervised learning has been employed to leverage unlabeled data. However, the quality and quantity of annotated data have a great influence on the performance of the semi-supervised model. Selecting informative samples through active learning is crucial and could improve model performance. Therefore, we propose a unified semi-supervised active learning architecture (RL-based SSAL) that alternately trains a semi-supervised network and performs active sample selection. Semi-supervised model is first well trained for sample selection, and selected label-required samples are annotated and added to the previously labeled dataset for subsequent semi-supervised model training. To learn to select the most informative samples, we adopt a policy learning-based approach that treats sample selection as a decision-making process. A novel reward function based on the product of predictive confidence and uncertainty is designed, aiming to select samples with high confidence and uncertainty. Comparisons with a semi-supervised baseline on collected lumbar disc herniation dataset demonstrate the effectiveness of the proposed RL-based SSAL, achieving over 3% promotion across different amounts of labeled data. Comparisons with other active learning methods and ablation studies reveal the superiority of proposed policy learning based on active sample selection and reward function. Our model trained with only 200 labeled data achieves an accuracy of 89.32% which is comparable to the performance achieved with the entire labeled dataset, demonstrating its significant advantage.

Systematic Evaluation of Hematoma Expansion Models in Spontaneous Intracerebral Hemorrhage: A Meta-Analysis and Meta-Regression Approach.

Accurate prediction of hematoma expansion (HE) in spontaneous intracerebral hemorrhage (sICH) is crucial for tailoring patient-specific treatments and improving outcomes. Recent advancements have yielded numerous HE risk factors and predictive models. This study aims to evaluate the characteristics and efficacy of existing HE prediction models, offering insights for performance enhancement. A comprehensive search was conducted in PubMed for observational studies and randomized controlled trials focusing on HE prediction, written in English. The prediction models were categorized based on their incorporated features and modeling methodology. Rigorous quality and bias assessments were performed. A meta-analysis of studies reporting C-statistics was executed to assess and compare the performance of current HE prediction models. Meta-regression was utilized to explore heterogeneity sources. From 358 initial records, 22 studies were deemed eligible, encompassing traditional models, hematoma imaging feature models, and models based on artificial intelligence (AI) or radiomics. Meta-analysis of 11 studies, involving 12,087 sICH patients, revealed an aggregated C-statistic of 0.74 (95% CI: 0.69 - 0.78) across seven HE prediction models. Eight characteristics related to development cohorts were identified as key factors contributing to performance variability among these models. The findings indicate that the current predictive capacity for HE risk remains suboptimal. Enhanced accuracy in HE prediction is vital for effectively targeting patient populations most likely to benefit from tailored treatment strategies.

Calibrating Car-Following Models Using SUMO-in-the-Loop and Vehicle Trajectories From Roadside Radar

This paper presents an innovative calibration method for car-following (CF) models in the Simulation of Urban MObility (SUMO) using real-world trajectory data from a 1.5 km signalized urban corridor, captured by roadside radars. By applying a sophisticated track-level association and fusion methodology, the study extends trajectory analysis beyond individual radar fields of view. The enhanced data is then utilized to refine the Krauss, IDM, and W99 CF models within SUMO, addressing the literature gap by integrating SUMO into the calibration loop, thereby accommodating the simulator's integration scheme and any model adaptations. The research identifies that default SUMO models tend to exhibit shorter time headways compared to real-world data, with calibration effectively reducing this discrepancy. Moreover, the W99 model, despite its unrealistic acceleration profiles when calibrated without considering acceleration, most accurately captures the higher-end energy consumption distribution. Conversely, the IDM model, with its default parameters, provides the closest approximation to observed acceleration behaviors, highlighting the nuanced performance of CF models in traffic simulation and their implications for energy consumption estimation. Detailed results of optimized parameters for each CF model are provided in appendix in addition to distribution information that may be useful for other modelers to use directly or other datasets to be compared in the future (including expansion of the work to include vehicle classification).

E-BDL: Enhanced Band-Dependent Learning Framework for Augmented Radar Sensing

Radar sensors, leveraging the Doppler effect, enable the nonintrusive capture of kinetic and physiological motions while preserving privacy. Deep learning (DL) facilitates radar sensing for healthcare applications such as gait recognition and vital-sign measurement. However, band-dependent patterns, indicating variations in patterns and power scales associated with frequencies in time–frequency representation (TFR), challenge radar sensing applications using DL. Frequency-dependent characteristics and features with lower power scales may be overlooked during representation learning. This paper proposes an Enhanced Band-Dependent Learning framework (E-BDL) comprising an adaptive sub-band filtering module, a representation learning module, and a sub-view contrastive module to fully detect band-dependent features in sub-frequency bands and leverage them for classification. Experimental validation is conducted on two radar datasets, including gait abnormality recognition for Alzheimer’s disease (AD) and AD-related dementia (ADRD) risk evaluation and vital-sign monitoring for hemodynamics scenario classification. For hemodynamics scenario classification, E-BDL-ResNet achieves competitive performance in overall accuracy and class-wise evaluations compared to recent methods. For ADRD risk evaluation, the results demonstrate E-BDL-ResNet’s superior performance across all candidate models, highlighting its potential as a clinical tool. E-BDL effectively detects salient sub-bands in TFRs, enhancing representation learning and improving the performance and interpretability of DL-based models.

Thermal Performance of Cattaneo-Christov Heat Flux Model on 3D Micropolar Fluid with Motile Microbes Across a Permeable Surface

Thermal Performance of Cattaneo-Christov Heat Flux Model on 3D Micropolar Fluid with Motile Microbes Across a Permeable Surface

BagFormer: Better cross-modal retrieval via bag-wise interaction

In the field of cross-modal retrieval, single encoder models tend to perform better than dual encoder models, but they suffer from high latency and low throughput. In this paper, we propose a dual encoder model called BagFormer that utilizes bag-wise late interaction mechanism to improve re-rank performance without sacrificing latency and throughput. BagFormer achieves this by employing a bagging layer, which facilitates the transformation of text to an appropriate granularity. This not only mitigates the issue of modal granularity mismatch but also enables the integration of entity knowledge into the model. Our experiments have shown that BagFormerViT-B outperforms the traditional dual-encoder model CLIPViT-B by 7.97% in zero-shot settings. Under fine-tuned conditions, BagFormerViT-B demonstrates an even more significant improvement of 17.98% over CLIPViT-B. Moreover, BagFormer not only matches the performance of cutting-edge single-encoder models in cross-modal retrieval tasks but also provides efficient inference processes characterized by lower latency and higher throughput. Compared to single-encoder models, BagFormer can achieve a speedup ratio of 38.14 when re-ranking individual candidates. Code and models are available at github.com/howard-hou/BagFormer.

Optimising synthetic datasets for machine learning-based prediction of building damage due to tunnelling

Assessment of tunnelling-induced building damage is a complex Soil-Structure Interaction (SSI) probelm, influenced by numerous geometric and material parameters of both the soil and structures, and is characterised by strong non-linear behaviour. Currently, there is a trend towards developing data-driven models using Machine Learning (ML) to capture this complex behaviour. Given the scarcity of real data, which typically comes from specific case studies, many researchers have turned to creating extensive synthetic datasets via sophisticated and validated numerical models like Finite Element Method (FEM). However, the development of these datasets and the training of advanced ML algorithms present significant challenges. poses significant challenges. Reliance solely on parameter domains and ranges derived from case studies can lead to imbalanced data distributions and subsequently poor performance of models in less populated regions. In this paper, we introduce a strategy for designing optimal high-confidence datasets through an iterative procedure. This process begins with a systematic literature review to determine the importance of parameters, their ranges, and dependencies as they pertain to building damage induced by SSI. Starting with several hundred FEM simulations, we generate an initial dataset and assess its quality and impact through Sensitivity Analysis (SA) studies, statistical modelling, and re-sampling in statistically significant regions. This evaluation allows us to refine the model’s input space, seeking scenarios that mitigate output distribution imbalances. The procedure is repeated until the datasets achieve a satisfactory balance for training metamodels, minimising bias effectively. Our findings highlight the success of this approach in identifying an optimal and feasible input space that significantly reduces imbalanced distributions of output features. This approach not only proves effective in our study but also offers a versatile methodology that could be adapted to other disciplines aiming to generate high-quality synthetic datasets.

Classification Model for Real-Time Monitoring of Machining Status of Turned Workpieces

The occurrence of tool chatter can have a detrimental impact on the quality of the workpiece. In order to improve surface quality, machining stability, and reduce tool wear cycles, it is essential to monitor the workpiece machining process in real time during the turning process. This paper presents a tool chatter state recognition model based on a denoising autoencoder (DAE) for feature dimensionality reduction and a bidirectional long short-term memory (BiLSTM) network. This study examines the feature dimensionality reduction method of the DAE, whereby the reduced-dimensional data are concatenated and input into the BiLSTM model for training. This approach reduces the learning difficulty of the network and enhances its anti-interference capability. Turning experiments were conducted on a SK50P lathe to collect the dataset for model performance validation. The experimental results and analysis indicate that the proposed DAE-BiLSTM model outperforms other models in terms of prediction and classification accuracy in distinguishing between stable machining, over-machining, and severe chatter stages in turning chatter state recognition. The overall classification accuracy reached 96.28%.

Balancing Performance and Interpretability in Medical Image Analysis: Case study of Osteopenia.

Multiple studies within the medical field have highlighted the remarkable effectiveness of using convolutional neural networks for predicting medical conditions, sometimes even surpassing that of medical professionals. Despite their great performance, convolutional neural networks operate as black boxes, potentially arriving at correct conclusions for incorrect reasons or areas of focus. Our work explores the possibility of mitigating this phenomenon by identifying and occluding confounding variables within images. Specifically, we focused on the prediction of osteopenia, a serious medical condition, using the publicly available GRAZPEDWRI-DX dataset. After detection of the confounding variables in the dataset, we generated masks that occlude regions of images associated with those variables. By doing so, models were forced to focus on different parts of the images for classification. Model evaluation using F1-score, precision, and recall showed that models trained on non-occluded images typically outperformed models trained on occluded images. However, a test where radiologists had to choose a model based on the focused regions extracted by the GRAD-CAM method showcased different outcomes. The radiologists' preference shifted towards models trained on the occluded images. These results suggest that while occluding confounding variables may degrade model performance, it enhances interpretability, providing more reliable insights into the reasoning behind predictions. The code to repeat our experiment is available on the following link: https://github.com/mikulicmateo/osteopenia .

Revolutionizing anemia detection: integrative machine learning models and advanced attention mechanisms

This study addresses the critical issue of anemia detection using machine learning (ML) techniques. Although a widespread blood disorder with significant health implications, anemia often remains undetected. This necessitates timely and efficient diagnostic methods, as traditional approaches that rely on manual assessment are time-consuming and subjective. The present study explored the application of ML – particularly classification models, such as logistic regression, decision trees, random forest, support vector machines, Naïve Bayes, and k-nearest neighbors – in conjunction with innovative models incorporating attention modules and spatial attention to detect anemia. The proposed models demonstrated promising results, achieving high accuracy, precision, recall, and F1 scores for both textual and image datasets. In addition, an integrated approach that combines textual and image data was found to outperform the individual modalities. Specifically, the proposed AlexNet Multiple Spatial Attention model achieved an exceptional accuracy of 99.58%, emphasizing its potential to revolutionize automated anemia detection. The results of ablation studies confirm the significance of key components – including the blue-green-red, multiple, and spatial attentions – in enhancing model performance. Overall, this study presents a comprehensive and innovative framework for noninvasive anemia detection, contributing valuable insights to the field.

The factors associated with the modified Fisher grade in patients with aneurysmal subarachnoid hemorrhage

BackgroundAneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening medical condition with a high fatality and morbidity rate. There was a substantial link between the modified Fisher grade of aSAH and the neurological function deficit. This study aimed to analyze the factors associated with the modified Fisher grade of aSAH using a machine learning approach.MethodsA multi-center observational study was conducted. The patients with aSAH were recruited from five tertiary hospitals in China. The volume of hemorrhage in aSAH was measured using the modified Fisher grade scale. The risk factors responsible for the modified Fisher grade of aSAH were analyzed, which include sociodemographic factors, clinical factors, blood index, and ruptured aneurysm characteristics. We built several tree-based machine learning models (XGBoost, CatBoost, LightGBM) for prediction and used grid search to optimize model parameters. To comprehensively evaluate the model, we used Accuracy, Precision, Area Under the Receiver Operating Characteristic Curve (AUROC), Area Under the Precision-Recall Curve (AUPRC), and Brier as evaluation indicators to assess the model performance and select the best model.ResultsA total of 888 patients with aSAH were recruited, of whom 305 with modified Fisher grade of 3 and 4. The results show that the XGBoost model has the highest AUROC of 0.772, and the indicators are better than CatBoost and LightGBM. The feature importance graph shows that the top feature variables include platelet, thrombin time, fibrinogen, preadmission systolic blood pressure, activated partial thromboplastin time, and the time interval between the onset of aSAH and the first-time CT examination.ConclusionThe factors responsible for the modified Fisher grade of aSAH were identified, which offered valuable insights for future research and clinical intervention. These risk factors should be controlled in the treatment of unruptured aneurysms, and appropriate treatment can be given if necessary to reduce the risk of severe hemorrhage after aneurysm rupture.

Laser-induced breakdown spectroscopy as a method for millimeter-scale inspection of surface flatness

A non-contact method for millimeter-scale inspection of material surface flatness via Laser-Induced Breakdown Spectroscopy (LIBS) is investigated experimentally. The experiment is performed using a planished surface of an alloy steel sample to simulate its various flatness, ranging from 0 to 4.4 mm, by adjusting the laser focal plane to the surface distance with a step length of 0.2 mm. It is found that LIBS measurements are successful in inspecting the flatness differences among these simulated cases, implying that the method investigated here is feasible. It is also found that, for achieving the inspection of surface flatness within such a wide range, when univariate analysis is applied, a piecewise calibration model must be constructed. This is due to the complex dependence of plasma formation conditions on the surface flatness, which inevitably complicates the inspection procedure. To solve the problem, a multivariate analysis with the help of Back-Propagation Neural Network (BPNN) algorithms is applied to further construct the calibration model. By detailed analysis of the model performance, we demonstrate that a unified calibration model can be well established based on BPNN algorithms for unambiguous millimeter-scale range inspection of surface flatness with a resolution of about 0.2 mm.

Multi-parameter MRI-Based Machine Learning Model to Evaluate the Efficacy of STA-MCA Bypass Surgery for Moyamoya Disease: A Pilot Study.

Superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery represents the primary treatment for Moyamoya disease (MMD), with its efficacy contingent upon collateral vessel development. This study aimed to develop and validate a machine learning (ML) model for the non-invasive assessment of STA-MCA bypass surgery efficacy in MMD. This study enrolled 118 MMD patients undergoing STA-MCA bypass surgery. Clinical features were screened to construct a clinical model. MRI features were extracted from the middle cerebral artery supply area using 3D Slicer and employed to build five ML models using logistic regression algorithm. The combined model was developed by integrating the radiomics score (Rad-score) with the clinical features. Model performance validation was conducted using ROC curves. Platelet count (PLT) was identified as a significant clinical feature for constructing the clinical model. A total of 3404 features (851 × 4) were extracted, and 15 optimal features were selected from each MRI sequence as predictive factors. Multivariable logistic regression identified PLT and Rad-score as independent parameters used for constructing the combined model. In the testing set, the AUC of the T1WI ML model [0.84 (95% CI, 0.70-0.97)] was higher than that of the clinical model [0.66 (95% CI, 0.46-0.86)] and the combined model [0.80 (95% CI, 0.66-0.95)]. The T1WI ML model can be used to assess the postoperative efficacy of STA-MCA bypass surgery for MMD.

Enhancing genomic prediction with Stacking Ensemble Learning in Arabica Coffee

Coffee Breeding programs have traditionally relied on observing plant characteristics over years, a slow and costly process. Genomic selection (GS) offers a DNA-based alternative for faster selection of superior cultivars. Stacking Ensemble Learning (SEL) combines multiple models for potentially even more accurate selection. This study explores SEL potential in coffee breeding, aiming to improve prediction accuracy for important traits [yield (YL), total number of the fruits (NF), leaf miner infestation (LM), and cercosporiosis incidence (Cer)] in Coffea Arabica. We analyzed data from 195 individuals genotyped for 21,211 single-nucleotide polymorphism (SNP) markers. To comprehensively assess model performance, we employed a cross-validation (CV) scheme. Genomic Best Linear Unbiased Prediction (GBLUP), multivariate adaptive regression splines (MARS), Quantile Random Forest (QRF), and Random Forest (RF) served as base learners. For the meta-learner within the SEL framework, various options were explored, including Ridge Regression, RF, GBLUP, and Single Average. The SEL method was able to predict the predictive ability (PA) of important traits in Coffea Arabica. SEL presented higher PA compared with those obtained for all base learner methods. The gains in PA in relation to GBLUP were 87.44% (the ratio between the PA obtained from best Stacking model and the GBLUP), 37.83%, 199.82%, and 14.59% for YL, NF, LM and Cer, respectively. Overall, SEL presents a promising approach for GS. By combining predictions from multiple models, SEL can potentially enhance the PA of GS for complex traits.

Employing an Artificial Neural Network Model to Predict Citrus Yield Based on Climate Factors

Agricultural sustainability is dependent on the ability to predict crop yield, which is vital for farmers, consumers, and researchers. Most of the works used the amount of rainfall, average monthly temperature, relative humidity, etc. as inputs. In this paper, an attempt was made to predict the yield of the citrus crop (Washington Navel orange, Valencia orange, Murcott mandarin, Fremont mandarin, and Bearss Seedless lime) using weather factors and the accumulated heat units. These variables were used as input parameters in an artificial neural network (ANN) model. The necessary information was gathered during the growing seasons between 2010/2011 and 2021/2022 under Egyptian conditions. Weather factors were daily precipitation, yearly average air temperature, and yearly average of air relative humidity. A base air temperature of 13.0 °C was used to determine the accumulated heat units. The heat use efficiency (HUE) for cultivars was determined. The Bearss Seedless lime had the lowest HUE of 9.5 kg/ha °C day, while the Washington Navel orange had the highest HUE of 20.2 kg/ha °C day. The predictive performance of the ANN model with a structure of 9-20-1 with the backpropagation was evaluated using standard statistical measures. The actual and estimated yields from the ANN model were compared using a testing dataset, resulting in a value of RMSE, MAE, and MAPE of 2.80 t/ha, 2.58 t/ha, and 5.41%, respectively. The performance of the ANN model in the training phase was compared to multiple linear regression (MLR) models using values of R2; for MLR models for all cultivars, R2 ranged between 0.151 and 0.844, while the R2 value for the ANN was 0.87. Moreover, the ANN model gave the best performance criteria for evaluation of citrus yield prediction with a high R2, low root mean squared error, and low mean absolute error compared to the performance criteria of data mining algorithms such as K-nearest neighbor (KNN), KStar, and support vector regression. These encouraging outcomes show how the current ANN model can be used to estimate fruit yields, including citrus fruits and other types of fruit. The novelty of the proposed ANN model lies in the combination of weather parameters and accumulated heat units for accurate citrus yield prediction, specifically tailored for Egyptian regional citrus crops. Furthermore, especially in low- to middle-income countries such as Egypt, the findings of this study can greatly enhance the reliance on statistics when making decisions regarding agriculture and climate change. The citrus industry can benefit greatly from these discoveries, which can help with optimization, harvest planning, and postharvest logistics. We recommended furthering proving the robustness and generalization ability of the results in this study by adding more data points.

Text sentiment analysis and classification based on bidirectional long and short term memory networks

In this study, we explored the method of text sentiment analysis and classification using bi-directional long and short-term memory networks, which brings new ideas to the field of sentiment classification. In the text pre-processing stage, we processed chat phrases, non-alphanumeric characters, deactivated words, numbers, special characters, blanks, and addresses to convert the raw text data into numerical data that can be processed by the model. Subsequently, word frequency statistics were conducted for texts of different mood types to analyse the frequency of occurrence of different words in texts of different mood types. By introducing a bi-directional long and short-term memory network model for training, we observed the accuracy and loss value performance on the training and validation sets. The accuracy of the training set increases from the initial 94.6% to 99.5%, and the accuracy of the validation set gradually grows to 99.4%; at the same time, the loss value of the training set decreases from the initial value of 0.2075 to 0.0194, and the loss value of the validation set gradually increases from the initial value of 0.0538 to 0.0372. This indicates that the bi-directional long short-term memory network achieves a significant and stable performance improvement. The confusion matrix results for the test set show that our model achieves more than 99% prediction accuracy on the test set. This implies that our proposed method can efficiently classify textual sentiment with high prediction accuracy. This research result helps to improve the effectiveness of the application of sentiment analysis techniques in the fields of social media opinion monitoring and product review analysis, and provides a useful reference for further deepening the research on text sentiment analysis. In conclusion, this study achieves the optimisation of the text sentiment classification task by means of a bidirectional long and short-term memory network model, and achieves satisfactory results. In the future, the model performance and generalisation ability can be further improved by combining more corpus and optimising the model structure, so as to be better applied in real-world scenarios.

The Combined Effects of Financial and Market Indicators on the Valuation of New Listings: Evidence from the Biopharmaceutical Sector

This study confirms that financial and market data have a significant impact on the valuation of newly listed companies, especially in the biopharmaceutical industry. Using multiple linear regression models, this paper found significant differences in the impact of EBITGR and EBITDAGR on price-to-earnings ratio (P/E Ratio) across years. Other indicators such as Total Asset Turnover, Return on Assets (ROA) and Debt to Equity Ratio (D/E Ratio) have weaker explanatory power and unstable influence. In addition, fluctuations in market valuations of listed companies are influenced by market sentiment and the macroeconomic policy environment. In high-growth, high-risk industries such as biopharmaceuticals, regulatory policies and listing structure reforms in the market can cause structural changes in model performance. At the same time, changes in market sentiment and regulation can also affect the explanatory power of financial indicators to some extent. Further analyses showed that market preferences for valuation changed over time during the study period, especially when the market moved significantly, driven by regulatory policy and the external environment. This makes the conclusions of the study's findings subject to uncertainty in different market environments. Overall, this study reveals a number of key factors affecting the market valuation of newly listed companies and highlights the importance of the interaction between market data and financial indicators. In future research, more attention should be paid to the role of different time periods, market conditions and industry characteristics to avoid potential valuation traps and provide more informative support to market investors and managers.