The fuel economy of electric vehicles (EVs) is an important factor in determining the competitiveness of EVs. Since the fuel economy is affected by the efficiency of an e-powertrain composed of a motor and inverter, it is necessary to select a high-efficiency topology for the e-powertrain. In this paper, a novel topology of e-powertrains to improve the fuel economy of EVs is proposed. The proposed topology aims to improve the system efficiency by integrating open-end winding (OEW) and winding changeover (WC). The proposed OEW-PMSM with WC enables to drive a permanent magnet synchronous motor (PMSM) in four different modes. Each mode can increase inverter efficiency and motor efficiency by changing motor parameters and maximum modulation index. In this paper, the system efficiency of the proposed topology was evaluated using electromagnetic finite element analysis and a loss model of power semiconductors. In addition, the vehicle simulations were performed to evaluate the fuel economy of the proposed topology, thereby proving the superiority of the proposed topology compared with the conventional PMSM.