Model-based predictive control (MPC) is an advanced control method that is used to achieve energy and cost savings in building energy management. However, there are various challenges to implementing MPC in actual buildings, such as additional engineering costs, physical damage to systems, and security concerns. This study proposes a non-intrusive implementation method for MPC based on a low-cost communication system. Firstly, a grey-box building model was developed along with the heating, ventilation, and air conditioning (HVAC) models based on the actual measurements of the test building. A simulation case study of MPC was performed, along with baseline feedback control, using these constructed models. The MPC outperformed the feedback control in terms of comfort, electricity consumption, and cost. It was implemented in an actual test zone to demonstrate the feasibility of a low-cost and non-intrusive implementation method that was realized using Arduino-based infrared signal communication and to evaluate the cost-saving potential of the MPC when compared with the baseline control. This experiment was conducted under a confined schedule for occupancy and set-point temperature for three days for the MPC and two days for the baseline feedback control in the cooling season. The cost savings of the MPC are as high as 5.8 %. Additional feedback cases were considered with a non-confined occupancy schedule and set-point temperature. The resulting energy consumption and cost savings are 25.2 % and 33.7 %, respectively. In this study, the applicability of the Arduino-based low-cost and non-intrusive implementation method for MPC was demonstrated, and the actual saving percentage of the MPC was compared with the conventional control method in a real building.