Hydrogen fuel cells are an attractive technology to power zero-emissions heavy-duty vehicles, including road vehicles, such as trucks and buses, as well as marine, rail, and mining applications. Hydrogen fuel cell powertrains can offer several advantages over incumbent technologies, such as diesel engines, including higher efficiency, reduced emissions, higher torque, and no noise pollution. Additionally, they offer fast fueling and adequate fuel storage for applications demanding longer range. In comparison to light duty fuel cell vehicles, which have begun early commercialization, fuel cell systems for heavy duty applications have important differences in their requirements and typical operation. Heavy duty fuel cell systems must offer high durability and efficiency to provide a competitive total cost of ownership considering capital costs, fuel costs, and lifetime. Furthermore, load-hauling applications, such as trucks, rail locomotives, and mining vehicles, must provide higher average and peak power while meeting heat rejection and onboard packaging constraints.Efforts to develop effective fuel cell materials, components, stacks, and systems for heavy duty applications must be guided by new targets and testing protocols. Fuel cell system modeling is essential to determine how application requirements translate to specific demands for the fuel cell system and components.The Department of Energy has set system-level targets for long-haul class 8 fuel cell trucks at 25,000 hour lifetime, 68% peak efficiency, and $80/kWnet fuel cell system cost by 2030 and ultimate targets of 30,000 hour lifetime, 72% peak efficiency, and $60/kWnet fuel cell system cost.[1] This presentation will discuss the system-level targets as well as the development of new targets and testing protocols for heavy duty fuel cell components and materials. This includes specific performance tests for different operational requirements, accelerated stress tests, and targets combining durability, performance, efficiency, and cost. We will also discuss differing needs between heavy duty applications, each of which presents unique requirements for fuel cell systems. It is desirable to address these unique requirements with standardized, cross-platform fuel cell stacks and components to enable high volume, low cost manufacturing, which requires the development of suitable cross-platform targets. [1] U.S. Department of Energy. “Hydrogen Class 8 Long Haul Truck Targets”. DOE Hydrogen and Fuel Cell Technologies Program Record. December 12, 2019: https://www.hydrogen.energy.gov/pdfs/19006_hydrogen_class8_long_haul_truck_targets.pdf