Urine analysis represents a crucial diagnostic technique employed in clinical laboratories. Creatinine and uric acid in urine are essential biomarkers in the human body and are widely utilized in clinical analysis. Research has demonstrated a correlation between the normal physiological concentrations of creatinine and uric acid in urine and an increased risk of hypertension, cardiovascular diseases, and kidney disease. Furthermore, the pH of urine indicates the bodyâs metabolic processes and homeostatic balance. In this study, an integrated multiâchannel electrochemical sensing system was developed, combining electrochemical analysis techniques, microelectronic design, and nanomaterials. The architecture of an intelligent medical detection system and the production of an interactive interface for smartphones were accomplished. Initially, multiâchannel selective electrodes were designed for creatinine, uric acid, and pH detection. The detection range was 10 nM to 100 ÎŒM for creatinine, 100 ÎŒM to 500 ÎŒM for uric acid, and 4 to 9 for pH. Furthermore, interference experiments were also conducted to verify the specificity of the sensors. Subsequently, multiâchannel doubleâsided sensing electrodes and functionâintegrated hardware were designed, with the standard equations of target analytes stored in the systemâs readâonly memory. Moreover, a WeChat miniâprogram platform was developed for smartphone interaction, enabling offâbody detection and realâtime display of target analytes through smartphones. Finally, the aforementioned electrochemical detection electrodes were integrated with the smart sensing system and wirelessly interfaced with smartphones, allowing for intelligent realâtime detection in primary healthcare and individual household settings.