Purpose The purpose of this paper is to identify and prioritize the positive and negative impacts of tourism on the process of tourism growth at a national scale in Iran, by taking into account the reviews of previous studies, views of experts and structural analysis. Design/methodology/approach In this investigation, structural analysis technique has been used to identify the correlation between variables by using mix method data analysis. By using cross-impact analysis (N × N integer matrix) in the form of the Micmac method, the economic, sociocultural and environmental factors have been evaluated. Findings The results of the distribution of factors in the coordinate axes and the graphs between them indicate their features, and for reaching a sustainable system of tourism development, at first, priority should be given to the negative influential factors, especially the environmental fields, and then the focus should be on the decrease of the dual and risk variables as they cannot be anticipated. Originality/value For the rapid growth of tourism in many countries, governments ensure that policies have been heeded in designing and preparing general plans of the country to understand how the development trend is moving on. In this respect, arisen impacts of tourism system are one of the important issues during the development path and in the field of tourism future. Because of the complexity and broadness of tourism activities, these impacts have also many interconnected dimensions that should also be considered while studying tourism impacts.