Micellar Fluids Research Articles

Innovative use of lipid mesophase dispersions for bisphenol A sequestration in water

HypothesisMesophase dispersions are promising colloids for removing micropollutants from water. We hypothesized that the complex internal nanostructure and tunable lipid/water interface amounts play a crucial role in absorbed quantities. Modifications in interfacial organization within the particles while trapping the micropollutant is assumed. ExperimentsWe formulated stable monolinolein-based dispersions with four types of mesophases (bicontinuous and micellar cubic, hexagonal, and fluid isotropic L2) by varying dodecane contents. The absorption of bisphenol A by these dispersions from water was monitored using molecular spectroscopy. At equilibrium, absorbed quantities by mesophase dispersions were compared to unstructured dodecane/water miniemulsions for two bisphenol concentrations. Structural changes during bisphenol incorporation were identified using small-angle X-ray scattering. FindingsLipid mesophase particles of submicron size showed greater bisphenol incorporation than dodecane/water miniemulsions, with cubosomes being most effective ones, absorbing twice as much as unstructured emulsions. Higher absorption levels are observed for more complex nanostructures with increased lipid/dodecane ratios. The incorporation of bisphenol affected the curvature of internal interfaces, potentially causing phase transitions and indicating that bisphenol settles at interfaces. Similar absorption levels in identical mesophases suggest a strong correlation between nano-structure and absorbed quantities.

Critical analysis of analytical techniques developed for statins in biological fluids, environmental and fermentation samples.

Statins are the most prescribed drug for regulating the high cholesterol level in the blood, which can lead to severe complications, such as cardiovascular diseases and other health complications. A wide range of analytical techniques have been employed for the quantification of statins from various origins, including fermentation derived (lovastatin, pravastatin, and compactin), semi-synthetic (simvastatin), and synthetic (atorvastatin, rosuvastatin, and fluvastatin) routes. The presence of more than one structural form and structural analogue generated in the biosynthesis pathway, as well as reaction intermediates and macromolecules in the clinical sample, complicates the quantification of statins. Furthermore, significant concentrations of statins in environmental samples pose serious health and ecology hazards, and estimating statins in those diluted samples is extremely difficult. On the other hand, the: cost, accurate estimation of the desired one from other structural forms, sample complexity, time, limits of detection and quantification, were major criteria distinguishing the usability of each technique. As a result, the current manuscript focuses on analytical techniques such as molecular spectroscopy (normal and derivatives UV-Visible spectrophotometer), chromatography (TLC, HP-TLC, HPLC, GC, swing column, micellar, and supercritical fluid), mass spectroscopy (HPLC-MS/MS and GC-MS/MS), sequential flow injection, capillary electrophoresis, and cyclic voltammetry, as well as their: optimal operating conditions, limits of detection and quantification, advancements, and limitations. Furthermore, various online and offline sample preparations (precipitation, solid phase extraction, liquid-liquid extraction, and micellar extraction) have been highlighted as an essential pretreatment technique to avoid the interference caused by structural analogues and other macromolecules. The greener and more sustainable concepts used in analytical approaches for the quantification statins are also highlighted with current advancements.

Tunable Memory and Activity of Quincke Particles in Micellar Fluid

Memory can remarkably modify the collective behavior of active particles. We show that, in a micellar fluid, Quincke particles driven by a square-wave electric field exhibit a frequency-dependent memory. Upon increasing the frequency, a memory of directions emerges, whereas the activity of particles decreases. As the activity is dominated by interaction, Quincke particles aggregate and form dense clusters, in which the memory of the direction is further enhanced due to the stronger electric interactions. The density-dependent memory and activity result in dynamic heterogeneity in flocking and offer a new opportunity for research of collective motions.

Modyfikacja właściwości filtracyjnych ośrodków porowatych z wykorzystaniem micelarnej cieczy zabiegowej Multizol

The need for the modification of filtration properties of rock media (most frequently porous rocks) appears frequently, e.g., in hydrocarbon exploitation. Exploitation of crude oil and natural gas is frequently accompanied by an excessive and uncontrolled inflow of reservoir water to the production well, which often results in a significant reduction of hydrocarbon production in the late period of reservoir exploitation. The control of water inflow, through modification treatments of rock filtration properties of the near wellbore zone, is the solution to this problem. The use of dedicated treatment fluids is the basis of such success, which, after the injection and change of original physicochemical properties, create local insulation barriers, enabling the control of the flow of fluids in the geological formation. This paper presents the results of the laboratory assessment of the technological effectiveness of Multizol micellar treatment fluid, which is used for selective blocking of the reservoir water inflow to gas wells. Tests performed, at a preliminary stage, comprised the development of a procedure, the obtaining of samples of the treatment fluid, and the performance of flow tests in test glass tubes, which allow for a swift determination of the technological range of the fluid's capability to form gel and emulsion. Flood tests were the main element of testing, related to the measurement of pressure drops of fluids flowing through the sample under the simulated reservoir conditions. The tests were carried out using two types of media, porous rocks (Szydłowiec sandstone) and sand packs. The determination of the modification degree of filtration properties, both in individual zones and in the entire sample/model, was based on the value of the FRR (Residual Resistance Factor) coefficient, being the measure of their permeability reduction. Two types of tests were performed to assess the effect of Multizol treatment fluid on the initial filtration properties of gas and water-bearing zones.

Supramolecular self-assembly of robust, ultra-stable, and high-temperature-resistant viscoelastic worm-like micelles

HypothesisWorm-like micelles are susceptible to heating owing to the fast dynamic exchange of molecules between micelles. Inhibition of such exchange could afford robust worm-like micelles, which is expected to largely improve rheology properties at high temperatures. ExperimentsA cationic surfactant docosyl(trimethyl)azanium chloride (DCTAC) and a strongly hydrophobic organic counterion 3-hydroxy naphthalene-2-carboxylate (SHNC) were used for the worm-like micelles fabrication. The microstructure was characterized using cryogenic transmission electron microscopy and small-angle neutron scattering, and the interactions between DCTAC and SHNC were characterized using nuclear magnetic resonance spectroscopy. Rheometer was employed to measure the rheological properties of the solution. FindingsSHNC/DCTAC at the molar ration of 1:2 forms ultra-stable worm-like micelles, whose viscosity remain stable at temperature up to 130 °C. SHNC is found to strongly adsorbs on DCTAC micelle with the orientation on the surface of micelle, keeping the naphthalene backbone entire penetration into the palisade layer while both carboxylic and hydroxyl groups protrude out of the micelle. With temperature increasing, this adsorption further strengthens, resulting in the growth contour length and accompanying the enhancement of rheological properties. One SHNC molecule and two DCTAC molecules are speculated to form a stable complex via multiple interactions including hydrophobic, cationic-π, and π-π interactions, which decreases the dynamic exchange of them between micelles. These findings are helpful to understand surfactant aggregates stability and assist the development of novel stable supramolecular nanostructures. Additionally, the excellent thermal stability of this worm-like micellar fluid makes it a potential high-temperature resistant clean fracturing fluid for deep oil reservoirs.

Saturated C22-tailed cationic surfactant in concentrated brine: Structural evolution of wormlike micelles and rheological properties

Saturated C22-tailed ultra-long-chain imparts cationic surfactant stable chemical structure and strong hydrophobic interaction that favors the generation of wormlike micelles in brine. Such viscoelastic wormlike micellar fluid is expected to exhibit excellent salt-resistance and temperature-resistance. In this work, the self-assembled microstructures and microscopic flow properties of docosyl(trimethyl)azanium chloride (DCTAC) NaCl solutions were systematically investigated by means of cryogenic transmission electron microscopy (cryo-TEM), rheo-small angle neutron scattering (rheo-SANS), steady-state and dynamic rheology. It is found that DCTAC forms long, linear or branched, flexible or stiff wormlike micelles depending on NaCl concentration. The increase in salt content simultaneously promotes the growth of worm length and the formation of branches. While the worm chain elongation plays a dominant role in mid-range of NaCl concentrations, the branching formation acts as a leading role in supper high NaCl concentrations, which results in rheological properties experiencing a significant increase followed by a certain decrease upon increasing NaCl content up to ∼ 20 wt%. Moreover, DCTAC shows much better thickening power than corresponding homologue surfactants bearing shorter hydrophobic tail in brine, and DCTAC solution also shows much better temperature-resistance than them. These findings are helpful to understand salt effect on cationic surfactant self-assemble behavior, and the relationship between microstructure and solution macroscopical properties.

Non-Darcian Displacement of Oil by a Micellar Solution in Fractal Porous Media

A Buckley–Leverett analysis with capillary pressure to model the oil displacement in fractal porous media is herein presented. The effective permeability for a non-Newtonian micellar fluid is calculated by a constitutive equation used to describe the rheological properties of a displacement fluid. The main assumption of this model involves a bundle of tortuous capillaries with a size distribution and tortuosity that follow fractal laws. The BMP model predicts two asymptotic (Newtonian) regions at low and high shear and a power-law region between the two Newtonian regions corresponding to a stress plateau. Both the stress at the wall and the fluidity are calculated using an imposed pressure gradient in order to determine the mobility of the solution. We analyze different mobility ratios to describe the behavior of the so-called self-destructive surfactants. Initially, the viscosity of the displacing fluid (micellar solution) is high; however, interactions with the porous media lead to a breakage process and degradation of the surfactant, producing low viscosity. This process is simulated by varying the applied pressure gradient. The resulting equation is of the reaction–diffusion type with various time scales; a shock profile develops in the convective time scale, as in the traditional Buckley-Leverett analysis, while at longer times diffusion effects begin to affect the profile. Predictions include shock profiles and compressive waves. These results may find application when selecting surfactants for enhanced oil recovery processes in oilfields.

Flow past a sphere: Numerical predictions of thixo-viscoelastoplastic wormlike micellar solutions

In this work, we present numerical solutions to the benchmark flow past a sphere problem considering the rheology of semi-diluted and concentrated wormlike micellar viscoelastic solutions using the most recent model-variant of the Bautista–Manero–Puig (BMP) family of fluids, i.e. the BMP+ _ τ p model (López-Aguilar et al., [1] ). This study is performed using our in-house finite volume/element algorithm, stabilised to attain highly-elastic non-linear solutions with two novel constitutive and boundary-condition implementations, i.e. the ABS- f (ABSolute f -functional) and the VGR (Velocity GRadient) corrections (López-Aguilar et al., [2] ). The structuring level of various wormlike micellar fluids with different solute concentrations (from semi-diluted to extremely concentrated solutions) and degrees of strain-hardening is studied with a dynamic dimensionless fluidity that connects the internal structure construction-destruction dynamics with viscoelasticity. In complex flow, a viscoelastic flow-regime unveils the prediction of a flow transition from a stable steady flow (related to a steady sphere settling) to an unsteady quasi-periodic flow regime, in which transient cycles of vortex formation-disappearance behind the sphere are present, resembling experimental findings on negative-wake instabilities and oscillations in the settling velocity for the descend of particles in wormlike micellar solutions. This instability is predicted here for semi-diluted to concentrated wormlike micellar solutions and it is located in flow-rate ranges corresponding to extensional Deborah numbers in the interval of around 26 . 7 ≤ D e e x t ≤ 40 . 3 , as reported experimentally. This behaviour is correlated with a chaotic flow-structure behind the obstacle, for which strong fluctuation in the fluid’s internal-structure is recorded. In the steady viscoelastic flow regime, correlation between the BMP+ _ τ p fluidity structure-variable and its normal-stress response around and downstream of the sphere (in the form of localised extrema) is detected, where interaction between the rheological response of the material and mixed shear-to-extensional deformation provide insights into the forces the fluid elements experiment in the sphere wake. Here, a monotonic decline in the drag-correction factor is observed, this being one of the main experimental manifestations of the steady sphere-settling phase in these materials. These findings may serve to further understand flow transitions and instabilities related to negative wakes in this kind of shear-thinning extensional-hardening fluids (Rothstein and Mohammadigoushki, [3] ). In a plastic regime, complex thixo-viscoelastoplastic BMP+ _ τ p features manifest through the prediction of fore-aft asymmetries promoted by the thixotropic structure construction-destruction and viscoelastic properties of the model under extremely low solute-concentrations. Predicted yield-fronts resemble those reported experimentally by Holenberg et al. [4] for carbopol solutions. • Negative-wake instability predictions in the De -range recorded experimentally. • Correlation between extensional viscosity and normal stresses in the sphere wake. • Localised N 1 and internal-structure f -functional in the sphere wake. • First normal-stress activity in the sphere wake follows extensional viscosity response. • Asymmetric yield-fronts under highly-concentrated gel-like wormlike micellar solutions.

Micellar entanglement and its relation to the elastic behavior of wormlike micelle fluids

HypothesisThe elastic contribution to the fluid dynamics of wormlike micellar solutions makes these fluids unique due to the distinctive self-assembled micellar network formed by tubular micelles. Measured mesoscopic scales of the micellar network related to the degree of entanglement can give guidelines for understanding the origin of elastic forces and their effect on rheological response. ExperimentsDifferent experiments were made as flow curves, rotating the internal or external cylinder in a Couette geometry, small and large oscillatory shear tests, and linear shear banding observations, all of them to determine how elastic forces modify the rheological behavior in systems made of different ratios of hexadecyltrimethylammonium bromide (CTAB)/sodium salicylate (NaSal) and different ratios of CTAB/NaNO3. Diffusive wave spectroscopy micro-rheology was also performed to measure the mean square displacements of microspheres embedded in the micellar fluids to obtain their high-frequency viscoelastic spectra. With this information, the entanglement index κ, the ratio of the total contour of the micelles to the entanglement length, was estimated and correlated with the rheological behavior. FindingsThe entanglement index is a valuable piece of information to understand the origin of the contribution of the elastic forces from a molecular point of view on the fluid dynamics of wormlike micelle solutions.

Activation energy, spatial confinement, and mean first passage and escape times of a tracer in a wormlike micellar fluid: an effective potential approach

Wormlike micelles are long semiflexible cylindrical polymer structures formed by amphiphiles. In solution, these linear micelles percolate in multiconected entangled networks, where cross-links can break and recombine dynamically. Technological applications of wormlike micellar fluids include tunable encapsulation/delivery of molecules or colloids in biomedicine, oil industry, and/or cleaning processes. In this work, we propose that the experimental activation energy, the spatial confinement, and the mean first passage and escape times of a spherical tracer immersed in wormlike micellar network, in which caging effects are observed, can be estimated from economic Brownian dynamics simulations of a single particle interacting with an effective one-dimensional cosine-like potential of amplitude U 0 and periodicity L. The proposed one-fitting parameter method has been used to characterize the long-time dynamics of wormlike micellar solutions formed by the self-assembly of a mixture of zwitterionic and anionic surfactants at several temperatures and different concentrations of surfactant and brine. The amplitude U 0 has displayed a good agreement regarding the corresponding experimental activation energy at different temperatures. The periodicity L has shown to be an upper bound of the mesh size ξ and of the same order of magnitude regarding the entanglement length l e, obtained from rheology and microrheology experiments. The escape time of the tracer in the effective potential τ escape and the time t*, at which a change of curvature in the mean square displacement occurs, are upper and lower limits, respectively, of the experimental relaxation time. Our method is simple and fast, and we foresee that it should be applicable to model the long-time behaviour of tracers in other polymer systems, in which caging effects are present.

Drag of circular cylinders in viscoelastic fluid flow

Drag forces on a circular cylinder placed in a rotating cylindrical annulus filled with a viscoelastic wormlike micellar fluid are measured using a load cell. The flow patterns are extracted from the PIV (particle image velocimetry) measurements of the flow fields around the circular cylinder. In viscoelastic fluids, shear waves can be propagated, and the viscoelastic Mach number M is defined as the ratio of the speed of an object in a fluid to the speed of shear waves in the fluid. In this study, the effect of viscoelastic Mach number on the drag characteristics of the circular cylinder is investigated. The results show that when the viscoelastic Mach number M > 1, an increase of drag over that expected from the growth rate at viscoelastic Mach numbers M < 1 is observed. From the results of PIV measurements, a dead water region is observed, which is formed symmetrically around the circular cylinder when M < 1 and behind the circular cylinder when M > 1. It plays an important role in the drag increase on a circular cylinder.

Two step micro-rheological behavior in a viscoelastic fluid.

We perform micro-rheological experiments with a colloidal bead driven through a viscoelastic worm-like micellar fluid and observe two distinctive shear thinning regimes, each of them displaying a Newtonian-like plateau. The shear thinning behavior at larger velocities is in qualitative agreement with macroscopic rheological experiments. The second process, observed at Weissenberg numbers as small as a few percent, appears to have no analog in macro-rheological findings. A simple model introduced earlier captured the observed behavior and implied that the two shear thinning processes correspond to two different length scales in the fluid. This model also reproduces oscillations, which have been observed in this system previously. While the system under macro-shear seems to be near equilibrium for shear rates in the regime of the intermediate Newtonian-like plateau, the one under micro-shear is thus still far from it. The analysis suggests the existence of a length scale of a few micrometres, the nature of which remains elusive.

A review of the second normal-stress difference; its importance in various flows, measurement techniques, results for various complex fluids and theoretical predictions

Shear flow is ubiquitous. Not only is it arguably the most widely-used deformation type to characterise complex fluids in rheological studies but also, in practice, the deformation most likely to occur in the great majority of flows, e.g. involving fluid transport through pipes or conduits. In steady simple shear flow the rheological properties of a complex fluid are completely characterised in just three material functions; the variation with shear rate of the shear viscosity and the so-called first and second normal-stress differences. Despite requiring only three material functions to be completely characterised, most shear-flow rheological characterisations are usually restricted simply to the shear viscosity and, at best, the variation of the first normal-stress difference N1 with shear rate. The second normal-stress difference N2 remains very much neglected. For dilute polymer solutions where this quantity may be negligibly small in comparison to the first normal-stress difference, such neglect is justified but for a whole range of complex fluids – indeed even polymer solutions outside of the dilute regime and especially melts – it is not clear that N2 may be safely disregarded. Indeed, in this review article we spotlight a number of flows where second normal-stress differences are of importance and potentially major consequence. Following this attention, we review the many experimental techniques which have been proposed for its measurement and survey the available literature for measurements of this quantity for various complex fluids including the aforementioned polymeric solutions, melts, liquid crystals, dense non-Brownian suspensions (both with Newtonian and complex fluid bases), semi-dilute wormlike micellar fluids and magnetorheological fluids. Theoretical predictions for N2 from various commonly-used continuum constitutive equations – primarily from the polymer literature – are also given and their asymptotic predictions at low and high shear rates compared. Finally, we end with a brief summary and outlook.

In Situ Nanostructural Analysis of Concentrated Wormlike Micellar Fluids Comprising Sodium Laureth Sulfate and Cocamidopropyl Betaine Using Small-Angle Neutron Scattering.

Concentrated wormlike micellar fluids form the basis for a vast array of formulated products, from liquid soaps and shampoos to drag reduction and drilling fluids. Typically, these systems are analyzed using bulk rheological measurements to determine their flow properties and cryo-microscopy to detect their nanostructure. Small-angle neutron scattering provides an opportunity to directly and nonperturbatively analyze nanostructure in situ but is complicated for concentrated systems by correlations from interparticle volume exclusion. Here, we use small-angle and ultra-small-angle neutron scattering to probe directly for the first time the nanostructure of concentrated wormlike micellar fluids composed of the widely used surfactant pair sodium laureth sulfate and cocamidopropyl betaine in aqueous electrolytes. Obtained data are analyzed using different approaches to determine scattering contributions from the wormlike particles themselves and interactions between them. It is found that approximating worms as locally rigid cylinders offers some insight into their aggregation dimensions at short length scales, and both volume exclusion and screened Coulombic interaction potentials describe interactions reasonably well. Using the semi-empirical polymer reference interaction site model (PRISM) gives excellent agreement with observed scattering, and physical insight obtained using this approach is discussed in detail. A drawback of this method is the significant complexity in coding the model in order to fit data, so to facilitate this for future researchers, we provide with this paper a fully operational, open-source code to utilize this model.

Effects of elasticity and flow ramp up on kinetics of shear banding flow formation in wormlike micellar fluids

We report experiments on spatiotemporal evolution of the velocity profiles in shear-banding wormlike micelles upon inception of the flow in a Taylor–Couette (TC) cell. Both moderately entangled and highly entangled solutions are considered over a broad range of fluid elasticity E. Fluid elasticity, E = Wi/Re, characterizes the relative importance of the elastic to inertial effects. For both moderately and highly entangled solutions, upon inception of the shear, and during the stress decay period, fluid moves in the opposite direction to that of the imposed motion in a subset of the gap beyond critical thresholds of elasticity and flow ramp up rate, which depend on the fluid entanglement density. Surprisingly, beyond a second critical threshold of the fluid elasticity, the transient backflow disappears in moderately entangled solutions, highlighting the importance of the micellar entanglement on transient evolution of the flow in shear banding systems. More interestingly, we report the formation of multibanded quasisteady velocity profiles under certain conditions of fluid elasticity and flow ramp up rate. The multibanded profiles are characterized by a low shear band near the inner cylinder, a high shear band in the middle of the TC gap, and another low shear band near the outer cylinder. Finally, we show that the apparent wall slip at the inner cylinder of the TC cell is more pronounced for highly entangled solutions and decreases as the fluid elasticity increases. Experimental observations are compared with the existing simulations of the Vasquez–Cook–McKinley model, and several suggestions are made for future simulations.

Microemulsion Rheological Analysis of Alkaline, Surfactant, and Polymer in Oil-Water Interface

Injection of alkaline (A), polymer (P), and surfactant (S) chemicals in enhanced oil recovery (cEOR) processes increases output by changing the properties of the injected fluid. In this work, micellar fluid interactions were studied via microemulsion rheological analysis. Crude oil and stimulated brine with ASP or SP was used for bottle testing. The results revealed that no microemulsion was produced when ASP (Alkaline, Surfactant, and Polymer) or SP (Surfactant and Polymer) was left out during the bottle testing phase. The addition of ASP and SP led to the formation of microemulsions—up to 29% for 50% water cut (WC) ASP, and 36% for 40% WC SP. This shows that the addition of ASP and SP can be applied to flooding applications. The results of the rheological analysis show that the microemulsions behaved as a shear-thinning micellar fluid by decreasing viscosity with increase in shear rate. As per the power-law equation, the ASP micellar fluid viscoelastic behavior shows better shear-thinning compared to SP, suggesting more efficiency in fluid mobility and sweep efficiency. Most of the microemulsions exhibited viscoelastic fluid behavior (G’ = G”) at angular frequency of 10 to 60 rad s−1, and stable elastic fluid behavior (G’ &gt; G’’) below 10 rad s−1 angular frequency. The viscosity of microemulsion fluids decreases as temperature increases; this indicates that the crude oil (i.e., alkanes) was solubilized in core micelles, leading to radial growth in the cylindrical part of the wormlike micelles, and resulting in a drop in end-cap energy and micelle length. No significant difference was found in the analysis of viscoelasticity evaluation and viscosity analysis for both ASP and SP microemulsions. The microemulsion tendency test and rheology test show that the addition of ASP and SP in the oil-water interface yields excellent viscoelastic properties.

The viscoelastic-like response of a repulsive granular medium during projectile impact and penetration

We study experimentally the penetration of a projectile into a two-dimensional granular bed composed of magnetic repelling grains. The projectile can experience either repulsive, attractive or neutral interaction with the particles generating different dynamics: i) the repulsive intruder compresses the granular bed without contact and experiences rebounds before stopping; ii) the attractive intruder is first accelerated when it approaches the bed, then, some magnets attach to its surface increasing its effective diameter and the drag force acting on the intruder until it reaches the repose; and iii) the neutral projectile penetrates deeper into the granular bed than in the two previous cases because there is no magnetic interaction with the particles. In addition, we developed molecular dynamics simulations able to reproduce the experimental results and used to determine the effect of the magnetic strength and the role of friction between the particles and the container walls. The results show that the medium behaves similar to a viscoelastic micellar fluid on impact, and the projectile dynamics can be modelled by a spring-dashpot model. Our findings can be useful in the design of new magnetic granular dampers.

Thermal property and shear wave speed indicators of phase transitions in a micellar fluid.

High concentration (>100 mM) wormlike micellar (WM) fluids are non-Newtonian with micelle lengths in the tens of nanometers. The viscoelastic properties of the fluid are affected by the structure and entanglement of the micelles and thus structural phase transitions can be indirectly studied using mechanical shear waves. Although these structural phase transitions have been extensively studied as a function of concentration, comparably less work is available on the temperature dependence. In this study, shear wave speeds (SWS) were studied as a function of temperature in a cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal)-based wormlike micellar fluid as an indicator of micellar structural changes. The heat capacity and thermal conductivity were also measured as these can be expected to change with structural phase transitions. Discontinuities in SWS were observed between 12 °C and 14 °C indicating the existence of a possible structural phase transition at this temperature. Gradual variation of the thermal properties was observed during controlled heating and cooling, while during autonomous heating from crystallization to fluid, a dramatic increase in both thermal properties peaking near 13.5 °C was observed.

Acoustic radiation force optical coherence elastography for evaluating mechanical properties of soft condensed matters and its biological applications.

Evaluating mechanical properties of biological soft tissues and viscous mucus is challenging because of complicated dynamic behaviors. Soft condensed matter models have been successfully used to explain a number of dynamical behaviors. Here, we reported that optical coherence elastography (OCE) is capable of quantifying mechanical properties of soft condensed matters, micellar fluids. A 7.5 MHz focused transducer was utilized to generate acoustic radiation force exerted on the surface of soft condensed matters in order to produce Rayleigh waves. The waves were recorded by optical coherence tomography (OCT). The Kelvin-Voigt model was adopted to evaluate shear modulus and loss modulus of soft condensed matters. The results reported that various concentrations of micellar fluids can provide reasonable ranges of elasticity from 65.71 to 428.78 Pa and viscosity from 0.035 to 0.283 Pa·s, which are close to ranges for actual biological samples, like mucus. OCE might be a promising tool to differentiate pathologic mucus samples from healthy cases as advanced applications in the future.

Optical coherence elastography for evaluating Rayleigh wave propagation in soft matter-micellar fluids

Wormlike micellar (WM) fluids exhibit a self-assembly property and viscoelastic behavior which make them a promising material for representing biological fluids, ultrasoft tissue phantoms and drug delivery carriers. Although WM biochemistry has been investigated, the mechanical properties have been rarely discussed because of the complexity of soft matter systems. Here, we demonstrate that optical coherence elastography (OCE) is capable of measuring Rayleigh wave of micellar fluids. Three solutions with concentrations of 100, 200, 300 and 400 mM, were considered in the study. Ultrasound excitation to produce Rayleigh waves was accomplished using 7.5 MHz burst excitation signals of length 4.0 ms repeated at a rate of 19 Hz. The optical coherence tomography (OCT) acquisition was set to 50 lateral positions and 4000 A-scans for each lateral position at a 76 kHz scan rate for total acquisition time of 52.6 ms. Ultrasound-based shear wave elastography, implemented on a Verasonics system, was used to obtain group and phase velocity of the shear wave in all micellar fluids as reference. Our research results demonstrated that Rayleigh wave in micellar fluids can be evaluated by OCE and mechanical properties like Young’s modulus can be assessed. A wide of concentration ranges of WM fluids would provide a more realistic model to mimic biological fluids and tissues.