Optical coherence elastography for evaluating Rayleigh wave propagation in soft matter-micellar fluids

Abstract

Wormlike micellar (WM) fluids exhibit a self-assembly property and viscoelastic behavior which make them a promising material for representing biological fluids, ultrasoft tissue phantoms and drug delivery carriers. Although WM biochemistry has been investigated, the mechanical properties have been rarely discussed because of the complexity of soft matter systems. Here, we demonstrate that optical coherence elastography (OCE) is capable of measuring Rayleigh wave of micellar fluids. Three solutions with concentrations of 100, 200, 300 and 400 mM, were considered in the study. Ultrasound excitation to produce Rayleigh waves was accomplished using 7.5 MHz burst excitation signals of length 4.0 ms repeated at a rate of 19 Hz. The optical coherence tomography (OCT) acquisition was set to 50 lateral positions and 4000 A-scans for each lateral position at a 76 kHz scan rate for total acquisition time of 52.6 ms. Ultrasound-based shear wave elastography, implemented on a Verasonics system, was used to obtain group and phase velocity of the shear wave in all micellar fluids as reference. Our research results demonstrated that Rayleigh wave in micellar fluids can be evaluated by OCE and mechanical properties like Young’s modulus can be assessed. A wide of concentration ranges of WM fluids would provide a more realistic model to mimic biological fluids and tissues.