This work describes the preparatory and initial measurements of diffusion flames under the influence of an electric field aboard the International Space Station (ISS), as part of the Advanced Combustion via Microgravity Experiments (ACME) project. Intended as the foundation publication for the experimental effort, the work comprehensively includes the space experiment methods, the capabilities of the ACME insert, experiment procedures, data, and limitations and constraints. The measurements presented include images and ion currents of small diffusion flames of methane (in air), subjected to a ramping electric field in microgravity. While there have been prior microgravity studies of Electric Field Effects on Laminar Diffusion Flames (E-FIELD Flames) using a drop tower, the current measurements represent the first mapping of the effects of an ion-driven wind on flame behavior under an electric field in the absence of the confounding influences of buoyancy. The paper describes the challenges of remote measurement and manipulation of flames on the ISS and presents preliminary results from the first set of coflow flames. The on-orbit tests began in March 2018 using the modular ACME hardware within the ISS’ Combustion Integrated Rack (CIR) and were completed in the same year November. The results show that the flame is most compact at saturation while the measured voltage-current characteristic (VCC) curve demonstrates parabolic behavior after saturation which differs from observations in 1 g on Earth.