Metallic Dots Research Articles

From Traditional Nanoparticles to Cluster-Triggered Emission Polymers for the Generation of Smart Nanotheranostics in Cancer Treatment

Nanotheranostics integrates diagnostic and therapeutic functionalities using nanoscale materials, advancing personalized medicine by enhancing treatment precision and reducing adverse effects. Key materials for nanotheranostics include metallic nanoparticles, quantum dots, carbon dots, lipid nanoparticles and polymer-based nanocarriers, each offering unique benefits alongside specific challenges. Polymer-based nanocarriers, including hybrid and superparamagnetic nanoparticles, improve stability and functionality but are complex to manufacture. Polymeric nanoparticles with aggregation-induced emission (AIE) present promising theranostic potential for cancer detection and treatment. However, challenges such as translating the AIE concept to living systems, addressing toxicity concerns, overcoming deep-tissue imaging limitations, or ensuring biocompatibility remain to be resolved. Recently, cluster-triggered emission (CTE) polymers have emerged as innovative materials in nanotheranostics, offering enhanced fluorescence and biocompatibility. These polymers exhibit increased fluorescence intensity upon aggregation, making them highly sensitive for imaging and therapeutic applications. CTE nanoparticles, crafted from biodegradable polymers, represent a safer alternative to traditional nanotheranostics that rely on embedding conventional fluorophores or metal-based agents. This advancement significantly reduces potential toxicity while enhancing biocompatibility. The intrinsic fluorescence allows real-time monitoring of drug distribution and activity, optimizing therapeutic efficacy. Despite their potential, these systems face challenges such as maintaining stability under physiological conditions and addressing the need for comprehensive safety and efficacy studies to meet clinical and regulatory standards. Nevertheless, their unique properties position CTE nanoparticles as promising candidates for advancing theranostic strategies in personalized medicine, bridging diagnostic and therapeutic functionalities in innovative ways.

Innovative applications of advanced nanomaterials in cerebrovascular imaging

Cerebrovascular imaging is essential for the diagnosis, treatment, and prognosis of cerebrovascular disease, including stroke, aneurysms, and vascular malformations. Conventional imaging techniques such as MRI, CT, DSA and ultrasound have their own strengths and limitations, particularly in terms of resolution, contrast and safety. Recent advances in nanotechnology offer new opportunities for improved cerebrovascular imaging. Nanomaterials, including metallic nanoparticles, magnetic nanoparticles, quantum dots, carbon-based nanomaterials, and polymer nanoparticles, show great potential due to their unique physical, chemical, and biological properties. This review summarizes recent advances in advanced nanomaterials for cerebrovascular imaging and their applications in various imaging techniques, and discusses challenges and future research directions. The aim is to provide valuable insights for researchers to facilitate the development and clinical application of these innovative nanomaterials in cerebrovascular imaging.

Double Metal Dots Configuration for Suppression of Spurious Responses in Temperature Compensated Surface Acoustic Wave Resonators on SiO2/LiNbO3 Structure

Double Metal Dots Configuration for Suppression of Spurious Responses in Temperature Compensated Surface Acoustic Wave Resonators on SiO₂/LiNbO₃ Structure

Introduction about Global infectious disease and use of nanotechnology

Infectious diseases, including COVID-19, malaria, tuberculosis, and sexually transmitted diseases (STDs), pose significant threats to global health. Nanotechnology has emerged as a promising tool in the diagnosis, treatment, and prevention of these diseases. This review highlights the applications of nanotechnology in combating infectious diseases. Nanoparticles, such as metallic nanoparticles, liposomes, and quantum dots, have been employed in the detection and treatment of infectious diseases. Nanotechnology-based drug delivery systems have improved the efficacy and reduced the toxicity of antiviral and antibacterial drugs. Additionally, nanotechnology has enabled the development of point-of-care diagnostics and vaccines for infectious diseases. This review provides an overview of the current state of nanotechnology in infectious disease management and highlights its potential to revolutionize the field. By leveraging the unique properties of nanoparticles, nanotechnology can provide innovative solutions for the diagnosis, treatment, and prevention of infectious diseases, ultimately improving global health outcomes. Keywords: Nanotechnology, Infectious diseases, COVID-19, Malaria, Tuberculosis, HIV/AIDS

Nanoparticle-Based Approaches in the Diagnosis and Treatment of Brain Tumors.

Glioblastomas are highly invasive brain tumors among perilous diseases. They are characterized by their fast proliferation and delayed detection that render them a significant focal point for medical research endeavors within the realm of cancer. Among glioblastomas, Glioblastoma multiforme (GBM) is the most aggressive and prevalent malignant brain tumor. For this, nanomaterials such as metallic and lipid nanoparticles and quantum dots have been acknowledged as efficient carriers. These nano-materials traverse the blood-brain barrier (BBB) and integrate and reach the necessary regions for neuro-oncology imaging and treatment purposes. This paper provides a thorough analysis on nanoparticles used in the diagnosis and treatment of brain tumors, especially for GBM.

Overcoming challenges in single electron charge detection of nanoscale dipoles

Single-electron transistors (SETs) can serve as electrometers to sense single-electron charge switching in nanoscale objects. A sub-20 nm metal double-dot (DD) structure, separated by a tunnel barrier, essentially functions as a dipole, and SETs have been utilized to detect single-electron switching within these DDs. The sensing of single-electron charge switching within these nanoscale metal DDs mimics single-charge sensing in molecular regimes and charge qubit sensing. In this study, two SET electrometers were employed to sense a single DD structure. The sensing outcomes of both SETs confirmed the detection of electron switching within the DD as well as the detection of the other SETs across the DD. To increase the induced charge in the SET due to electron switching within the DD, the SET electrometer was placed in very close proximity to the DD in one of the designs. This design, however, led to the formation of a metal dot tunnel-coupled to the SET electrometer, effectively functioning as a Single Electron Box and potentially disrupting the charge sensing fidelity of SETs while detecting charge switching in the DD. The impact of a SET tunnel-coupled to a metal dot was further investigated in a separate design. It was also demonstrated how proper design of SETs can incorporate a tunnel-coupled metal dot while maintaining the ability to detect electron switching within DDs with high fidelity simultaneously.

Comparative Assessment between Glowing Family Elements of Metal and Graphene Quantum Dots Based on their Properties: A Theoretical and Experimental Study

The quantum dots (QDs) have wide range of applications in the field of biology and energy due to exceptionally photo-physical properties and highly active larger surface area. Both metal quantum dots (MQDs) and graphene quantum dots (GQDs) have created a new platform for quantum chemistry not only theoretical point of view but also open various real applications. The photo-physical properties arise due to tunable band gap and active functional groups adhere to the surface. Both MQDs and GQDs have very good properties such as solubility in wide range of solvent, good stability in photo-physical and chemical environment, less poisoning in animal body, small size and tunable photoluminescence is favourable for cell dynamics and imaging, up-conversion and down conversion photoluminescence nature, good electrochemical activity. The functionalization of QDs with micro and macromolecules in all direction are possible as results we find different shape of QDs due to very small size of QDs just like few atoms. Some theoretical studies have been observed to evaluate the origin of these properties. This review focused on the comparative studies including advantage and disadvantage between GQDs and MQDs based on their properties and also give significant imminent to motivate more encouraging development. Moreover, this review study offers significant insights for enhancing the characteristics of quantum dots.

Cutting edge technology for wastewater treatment using smart nanomaterials: recent trends and futuristic advancements.

Water is a vital component of our existence. Many human activities, such as improper waste disposal from households, industries, hospitals, and synthetic processes, are major contributors to the contamination of water streams. It is the responsibility of every individual to safeguard water resources and reduce pollution. Among the various available wastewater treatment (WWT) methods, smart nanomaterials stand out for their effectiveness in pollutant removal through absorption and adsorption. This paper examines the application of valuable smart nanomaterials in treating wastewater. Various nanomaterials, including cellulose nanocrystals (CNC), cellulose nanofibrils (CNF), nanoadsorbents, nanometals, nanofilters, nanocatalysts, carbon nanotubes (CNTs), nanosilver, nanotitanium dioxide, magnetic nanoparticles, nanozero-valent metallic nanoparticles, nanocomposites, nanofibers, and quantum dots, are identified as promising candidates for WWT. These smart nanomaterials efficiently eliminate toxic substances, microplastics, nanoplastics, and polythene particulates from wastewater. Additionally, the paper discusses comparative studies on the purification efficiency of nanoscience technology versus conventional methods.

Heavy atom effect boosts the achievement of ultra-efficient long afterglow room temperature phosphorescent carbon point composites: An enhanced approach

In recent years, room temperature phosphorescent (RTP) materials have experienced rapid growth due to their enduring luminescence, high resolution, and other distinctive characteristics. Simultaneously, carbon dots (CDs) have gained popularity across various disciplines for their efficient luminescence, straightforward synthesis, and environmental friendliness. In this study, we successfully synthesized a range of high-performance carbon dot materials using a simple one-step hydrothermal method. Through detailed morphological and photophysical characterizations, we discovered that these materials exhibited a remarkable phosphorescence quantum yield of up to 53.15 %, an impressive feat for both metal and non-metal carbon dot materials. Furthermore, we explored the enhancing effect of the heavy atom on ultra-efficient long afterglow RTP carbon dot composites and experimentally validated its effectiveness. Finally, we applied these materials to information encryption technology, offering novel ideas and methods for RTP material applications. This research not only opens new avenues for the development of carbon dot materials but also provides a promising direction and outlook for their future use.

First passage times of charge transport and entropy change

All real physical processes, including of the first-passage time, occur with a change in entropy. This circumstance is not taken into account when studying the first-passage time, but is illustrated in this article using the example of electron transfer through a metallic double dot. The statistics of the first-passage time of a random process N(t) for electrons transferred through a metallic double dot is considered. The expressions for the average first-passage time are compared with and without taking into account the change in entropy during this time. External influences on the average value of the first-passage time are considered for the case of DC bias voltage.

Analogous electronic states in graphene and planer metallic quantum dots

Graphene nanostructures offer wide range of applications due to their distinguished and tunable electronic properties. Recently, atomic and molecular graphene were modeled following simple free-electron scattering by periodic muffin tin potential leading to remarkable agreement with density functional theory. Here we extend the analogy of the π\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\pi$$\\end{document}-electronic structures and quantum effects between atomic graphene quantum dots (QDs) and homogeneous planer metallic counterparts of similar size and shape. Specifically, we show that at high binding energies, below the M¯\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\overline{M}$$\\end{document}-point gap, graphene QDs enclose confined states and standing wave quasiparticle interference patterns analogous to those reported on coinage metal surfaces for nanoscale confining structures such as vacancy islands and quantum corrals. These confined and quantum corral-like states in graphene QDs can be resolved in tomography experiments using angle-resolved photoemission spectroscopy. Likewise, the shape of near-Fermi frontier orbitals in graphene quantum dots can be reproduced from electron confinement within homogeneous metal QDs of identical size and shape. Furthermore, confined states analogous to those found in metallic quantum stadiums can be realized in coupled QDs of graphene for reduced separation. The present study offer a simple fundamental understanding of graphene electronic structures and also open the way towards efficient modeling of novel graphene-based nanostructures.

Superluminal propagation of surface plasmon polaritons via hybrid chiral quantum dots system

We present a novel methodology for enhancing superluminal surface plasmon polaritons (SPPs) propagations within a hybrid nanostructure configuration consisting of gold (Au) metal and chiral quantum dots (CQDs) medium. The arrangement of CQDs and metal hybrid nanostructures enables the production of SPPs when exposed to incident light. The resonances of SPPs within a hybrid nanostructure are determined through analytical calculations using Maxwell’s equations under specified boundary conditions, while the dynamics of the CQDs system are calculated using the density matrix approach. It is demonstrated that the propagation of SPPs is significantly influenced by both right-circularly polarized (RCP) and left-circularly polarized (LCP) SPPs. Additionally, we investigate the enhancement of superluminal SPPs propagation by varying the electron tunneling strength and the intensity of the control field within the hybrid system. The characteristics of RCP and LCP SPPs have been investigated, indicating a large negative group index and advancement in time. The observation of a large negative group index and advancement in time provides strong evidence for enhanced superluminal SPPs propagation within the proposed hybrid nanostructure. The results have potential applications in the fields of optical information processing, temporal cloaking, quantum communication, and the advancement of computer chip speed.

Analytical Modelling and Performance Characterization of Hybrid SET-MOS

Gordon Moore's "Moore's Law" suggests chip functionality demand doubles every 1.5-2 years, with global semiconductor technology roadmap recommending sub-nanometer ranges for IC production in nano-electronics. The single electron transistor (SET) is a promising nano-scale device that can be co-integrated with CMOS technology to improve performance. The paper explores the tunnelling effect between nanoparticles in single electron transistors (SET), revealing coulomb blockade transactions and resistance increases with reduced bias. It focuses on single electron transistors and pre-terminal devices, discussing IV characteristics, coulomb diamond plots, and metallic quantum dots. This research also explores the hybrid SET-FET based model, focusing on developing a room temperature SET in CMOS comparable technology with a Field Effect Transistor (FET). Prediction models and exploratory studies guide the integration of SET-FET technology. SIMON is a comprehensive simulator designed for single-electron devices and circuits. The output current is not impacted by capacitances up to 1 pF, and FET size in the micron range are appropriate for SET signal amplification up to 4 µA. This research explores the modelling of SET-FET technology in highlighting its ability to mitigate drawbacks in low drive current when combined with a FET. It also explores device variability mitigation in nanoscale array configurations, finding that SET-FET significantly reduces variability in larger arrays, despite the impact of capacitance and resistance.

High-definition direct-print of metallic microdots with optical vortex induced forward transfer

We demonstrate high-definition, direct-printing of micron-scale metallic dots, comprised of close-packed gold nanoparticles, by utilizing the optical vortex laser-induced forward transfer technique. We observe that the spin angular momentum of the optical vortex, associated with circular polarization, assists in the close-packing of the gold nanoparticles within the printed dots. The printed dots exhibit excellent electrical conductivity without any additional sintering processes. This technique of applying optical vortex laser-induced forward transfer to metallic dots is an innovative approach to metal printing, which does not require additional sintering. It also serves to highlight new insights into light–matter interactions.

Metal and non-metal doped carbon dots: properties and applications

Metal and non-metal doped carbon dots: properties and applications

Enhanced cycloaddition between CO2 and epoxide over a bismuth-based metal organic framework due to a synergistic photocatalytic and photothermal effect

The cycloaddition reaction between CO2 and epoxide is an efficient way to convert CO2 into high value-added chemicals. Therefore, it is particularly important to develop efficient catalysts that can catalyze the reaction under mild conditions. In this work, a metal–organic framework (Bi-HHTP, consisting of bismuth (Bi) as metal dots and 2,3,6,7,10,11-hexahydroxy-triphenylene (HHTP) as organic linkers) with zigzagging corrugated topology was successfully synthesized, which shows excellent catalytic activity under visible light irradiation. Various characterizations suggest that the excellent activity is derived from the following reasons: (1) the abundant exposed Bi sites provide Lewis sites for adsorption of epoxides and CO2; (2) the free holes produced over Bi-HHTP under light irradiation which could oxidize epoxide, which consequently facilitateing the subsequent ring-opening reaction; and (3) the existence of synergistic photocatalytic and photothermal effect in Bi-HHTP. This study provides a new avenue of developing bismuth-based metal organic frameworks to promote the efficiency of cycloaddition of CO2 under mild conditions.

Nanomaterial-based fluorescent biosensors for the detection of antibiotics in foodstuffs: A review.

Antibiotics are widely used as bacteriostatic or bactericidal agents against various microbial infections in humans and animals. The excessive use of antibiotics has led to an accumulation of their residues in food products, which ultimately poses a threat to human health. In light of the shortcomings of conventional methods for antibiotic detection (primarily cost, proficiency, and time-consuming procedures), the development of robust, accurate, on-site, and sensitive technologies for antibiotic detection in foodstuffs is important. Nanomaterials with amazing optical properties are promising materials for developing the next generation of fluorescent sensors. In this article, advances in detecting antibiotics in food products are discussed with respect to their sensing applications, with a focus on fluorescent nanomaterials such as metallic nanoparticles, upconversion nanoparticles, quantum dots, carbon-based nanomaterials, and metal-organic frameworks. Furthermore, their performance is evaluated to promote the continuation of technical advances.

A preparation strategy for highly reversible conversion reaction Tin dioxide/ Carbon anode: Simple, ultrafast and scalable

Combining nanoscale engineering and physical confinement approach to prevent aggregation is a reliable strategy to achieve fully reversible conversion reaction SnO2-based anode. However, the synthesis of such nanostructures relies on complex self-sacrificing template preparation and time-consuming thermal treatment processes, which limit the practical application of high-performance SnO2 anodes for lithium-ion batteries. Herein, we present a simple strategy for the in situ preparation of SnO2 quantum dots embedded in carbon martix using an inherently advantageous MOF template and ultrafast microwave-assisted treatment in a few seconds. (denoted as SnO2 QDs@C). The dispersed SnO2 quantum dots with precise size control (≈5 nm) in the nanostructure shorten the lithium ion transport distance and enhance the reaction kinetics. Meanwhile, the carbon matrix promotes electron transport and suppresses Sn coarsening, thus achieving a highly reversible conversion reaction. Consequently, the SnO2 QDs@C anode achieves a reversible capacity of 1337 mAh g-1 after 200 cycles at 0.2 A g-1 with a capacity retention rate of more than 80%. This preparation method can be extended to prepare other metal oxide quantum dots/ Carbon composites and is expected to be applied in a wide range of fields.

WC-Ni cemented carbides prepared from Ni nano-dot coated powders

This study presents a novel approach for the synthesis of WC-Ni cemented carbides with enhanced mechanical properties. A low-cost solution-based route was used to coat WC powders with well-distributed metallic nickel dots measuring between 17 nm and 39 nm in diameter. Varying compositions with loadings of 2, 6, and 14 vol% Ni were consolidated using spark plasma sintering (SPS) at 1350 °C under 50 MPa of uniaxial pressure giving relative densities of 99 ± 1 %. The sintered WC-Ni cemented carbides had an even distribution of the Ni binder phase in all compositions, with retained ultrafine WC grain sizes of 0.5 ± 0.1 μm from the starting powder. The enhanced sinterability of the coated powders allowed for consolidation to near theoretical densities, with a binder content as low as 2 vol%. This is attributed to the uniform distribution of nickel and an extensive Ni-WC interface existing prior to sintering. The small size of the Ni dots likely also contributed to the solid-state sintering starting temperatures of as low as 800 °C. The mechanical performance of the resulting cemented carbides was evaluated by measuring the hardness at temperatures between 20 °C and 700 °C and estimating toughness at room temperature using Vickers indentations. These results showed that the mechanical properties of the WC-Ni cemented carbides synthesised by our method were comparable to conventionally prepared WC-Co cemented carbides with similar grain sizes and binder contents and superior to conventionally prepared WC-Ni cemented carbides. In particular, the 2 vol% Ni composition had excellent hardness at room temperature of up to 2210HV10, while still having an indentation fracture toughness of 7 MPa·m0.5. Therefore, WC-Ni cemented carbides processed by this novel approach are a promising alternative to conventional WC-Co cemented carbides for a wide range of applications.

Drug Delivery Application of Functional Nanomaterials Synthesized Using Natural Sources.

Nanomaterials (NMs) synthesized from natural sources have been attracting greater attention, due to their intrinsic advantages including biocompatibility, stimuli-responsive property, nontoxicity, cost-effectiveness, and non-immunogenic characteristics in the biological environment. Among various biomedical applications, a breakthrough has been achieved in the development of drug delivery systems (DDS). Biocompatibility is necessary for treating a disease safely without any adverse effects. Some components in DDS respond to the physiological environment, such as pH, temperature, and functional group at the target, which facilitates targeted drug release. NM-based DDS is being applied for treating cancer, arthritis, cardiovascular diseases, and dermal and ophthalmic diseases. Metal nanomaterials and carbon quantum dots are synthesized and stabilized using functional molecules extracted from natural sources. Polymers, mucilage and gums, exosomes, and molecules with biological activities are directly derived from natural sources. In DDS, these functional components have been used as drug carriers, imaging agents, targeting moieties, and super disintegrants. Plant extracts, biowaste, biomass, and microorganisms have been used as the natural source for obtaining these NMs. This review highlights the natural sources, synthesis, and application of metallic materials, polymeric materials, carbon dots, mucilage and gums, and exosomes in DDS. Aside from that, challenges and future perspectives on using natural resources for DDS are also discussed.