Objective To explore the quality of life (QOL) of asthma inpatients and analyze its influencing factors. Methods From July 2016 to August 2017, 163 asthma inpatients of Department of Respiratory in China-Japan Union Hospital of Jilin University were selected by convenience sampling. All of the patients were investigated with the Asthma Quality of Life Questionnaire (AQLQ) , Medical Coping Modes Questionnaire (MCMQ) , Herth Hope Index (HHI) . Simple correlation and multivariate regression analysis was used to analyze patients' influencing factors of QOL. Results The total mean score of QOL of asthma inpatients was (3.41±0.46) . A total of 60.1% of patients mainly took confrontation coping mode. There was no patient with the low hope level, 33.1% of patients with the intermediate hope level and 66.9% with the high hope level. There was statistical difference in total score of QOL of patients with different ages, occupations, education, times of being admitted to hospital due to asthma, courses of disease, disease condition, types of drug using, hope level, coping modes (t=4.593, 3.315, 6.698, 4.826, 5.637, 2.686, 6.637, 19.752, 26.330; P<0.05) . Multivariate regression analysis showed that avoidance and confrontation coping mode, drug combination by various ways, whether with basic disease or not, marital status as well as overall hope level were main influencing factors of QOL of asthma inpatients. Conclusions The total QOL of asthma inpatients is below intermediate level. Most patients take confrontation medical coping mode. The overall hope level is high. The main influencing factors of QOL of asthma inpatients include types of drug combination, whether with basic disease or not, marital status, avoidance and confrontation coping mode as well as overall hope level. Key words: Asthma; Quality of life; Influencing factors