From the perspective of cognitive behavior science, the study takes domestic enterprises as samples of empirical research, uses the method of neuroeconomics, and selects 50 healthy quality department heads as paid subjects to voluntarily participate in the experiment to explore the effect and mechanism of TQM (Total Quality Management) on innovation performance. In order to explore the direct and indirect effects between TQM and innovation performance, this study introduces knowledge absorptive capacity and environmental dynamics into the relationship between TQM and innovation performance. On the basis of maturity scale, 184 valid questionnaires are collected and a statistical analysis is carried out with Lisrel software to validate the hypothesis of this study. The results show that: (1) TQM has a direct and positive effect on innovation, and the longer and deeper the implementation of TQM is, the more significant the promotion of innovation is performance. However, the resource factors of TQM have no significant effect on innovation performance, which indicates that enterprises implementing TQM strategy do not need to worry about the effect of enterprise size and resources. (2) TQM has a significant effect on the knowledge absorptive capacity, which is the key to enterprise innovation. (3) In addition to its direct effect on innovation performance, TQM indirectly acts on innovation performance through the intermediary variable of knowledge absorptive capacity, and its mechanism can be divided into direct effect and indirect effect. (4) The environmental dynamics faced by enterprises are different, and the effects of TQM on innovation performance are also different. Under the high dynamic environment, TQM has no significant effect on innovation, and even has negative effect. Under the low dynamic environment, TQM has a very significant effect on innovation. (5) TQM and innovation can succeed in an enterprise at the same time, it’s not conflict for enterprises to pursue the quality performance and the enterprise innovation at the same time since two are the key factors to improve the enterprise performance finally.