Constant Measurements Research Articles

In situ measurement of triaxial coil constants for optically pumped magnetometer based on higher-order parametric resonance

We demonstrated a method for in-situ measurement of triaxial magnetic field coil constants of optically pumped magnetometer (OPM) operating in the spin-exchanged relaxation-free (SERF) regime based on higher-order parametric resonances. The triaxial coil constants play a vital role in achieving optimal operation of the OPM and amplitude calibration of weak signals such as magnetoencephalography (MEG). The measurement of the triaxial magnetic field coil constants is therefore particularly critical. Compared to the previous methods, our method is convenient and universal for practical application and commercialization. It does not require a complicated fitting process for measurements, and is applicable to both single- and dual-beam configurations of OPMs which are prevalent in current applications. The feasibility of the method is verified by simulation and experiment, and the average measurement errors of the triaxial coil constants of the OPM in single- and dual-beam configurations are 0.75 % and 1.74 %, respectively. This method holds substantial implications for calibrating and optimizing arrayed OPM systems, with the potential to enhance the measurement sensitivity and the accuracy of magnetic source localization in triaxial OPM-MEG systems.

Measurement of Distribution Constants Between Air and Solid Substrates Using Gas Chromatography for Quantification of Hydrocarbons in Solid Substrates via Headspace-Solid Phase Microextraction

Measurement of Distribution Constants Between Air and Solid Substrates Using Gas Chromatography for Quantification of Hydrocarbons in Solid Substrates via Headspace-Solid Phase Microextraction

Synthesis and evaluation of novel trifunctional chelating agents for pretargeting approach using albumin binder to improve tumor accumulation

IntroductionThe pretargeting approach consists of in vivo ligation between pre-injected antibodies and low-molecular-weight radiolabeled effectors. The advantage of the pretargeting approach is to improve a tumor-to-background ratio, but the disadvantage is to compromise tumor accumulation. In this study, we applied albumin binder (ALB) to the pretargeting approach to overcome low tumor accumulation. MethodsWe synthesized two novel trifunctional effectors containing an ALB moiety, a chelator, and a different tetrazine and two corresponding effectors without an ALB moiety. Albumin-binding assays and stability assays were performed using 111In-labeled effectors. Measurements of reaction rate constant were conducted using 111In-labeled effectors and anti-HER2 antibody trastuzumab modified by trans-cyclooctene, which drives the click reaction with tetrazine. Biodistribution studies using HER2-expressing tumor-bearing mice were performed with or without the pretargeting approach. ResultsIn albumin-binding assays, ALB-containing effectors exhibited a marked binding to albumin. Two ALB-containing effectors showed the difference in the reactivity and the slight difference in the stability. In biodistribution studies without the pretargeting approach, two ALB-containing effectors showed different pharmacokinetics in blood retention. With the pretargeting approach, the tumor accumulation was improved by the introduction of ALB and the highest tumor accumulation was observed in using the ALB-containing effector with higher blood retention. ConclusionThese results suggest that the application of ALB to the pretargeting approach is effective to improve tumor accumulation, and the structure of tetrazine influences the utility of ALB-containing effectors.

Cosmography with supernova Refsdal through time-delay cluster lensing: Independent measurements of the Hubble constant and geometry of the Universe

We present new measurements of the values of the Hubble constant, matter density, dark energy density, and dark energy density equation-of-state (EoS) parameters. These results have been obtained from a full strong-lensing analysis of the observed positions of 89 multiple images and 4 measured time delays of the supernova (SN) Refsdal in the Hubble Frontier Fields galaxy cluster MACS J1149.5+2223. By strictly following the identical modelling methodology (as done in our previous work undertaken before time delays were available), our cosmographic measurements are essentially blind, based on the frozen procedure. Without using any priors from other cosmological experiments, in an open wCDM cosmological model and via our reference cluster mass model, we measure the following values: H0 = 65.1−3.4+3.5 km s−1 Mpc−1, ΩDE = 0.76−0.10+0.15, and w = −0.92−0.21+0.15 (at the 68.3% confidence level). No other single cosmological probe has been able to simultaneously measure all these parameters. Remarkably, our estimated values of the cosmological parameters, in particular that of H0, are very robust and do not significantly depend on the assumed cosmological model or the cluster mass modelling details. The latter aspect introduces systematic uncertainties on the values of H0 and w, which are found to be largely subdominant compared to the statistical errors. The results of this study demonstrate that the combination of time delays in lens galaxy clusters with extensive photometric and spectroscopic information offers a novel and competitive cosmological tool.

Using Smartphones to Innovate Laboratories in Introductory Physics Courses

The SmartPhysics project involved two higher education institutions, one in Italy and one in the US, with the aim of exploring the use of smartphones for laboratory experiments in introductory Physics courses. Here we present and discuss two experiments that were developed in the project: the pendulum experiment, consisting in the measurement of the gravitational constant using a proximity stopwatch, and the ‘bouncing ball’ experiment, aimed at measuring the energy lost inelastic collisions with a hard surface. Both experiments were tested with the students in the academic year 2021-22. Our results and didactical reflections contain suggestions for the use of smartphone-based experiments in university settings, in comparison with traditional experiments and considering the specificities of different contexts.

A new method for instrumental profile reconstruction of high-resolution spectrographs

Context. Knowledge of the spectrograph’s instrumental profile (IP) provides important information needed for wavelength calibration and for the use in scientific analyses. Aims. This work develops new methods for IP reconstruction in high-resolution spectrographs equipped with astronomical laser frequency comb (astrocomb) calibration systems and assesses the impact that assumptions on the IP shape have on achieving accurate spectroscopic measurements. Methods. Astrocombs produce ≈ 10 000 bright, unresolved emission lines with known wavelengths, making them excellent probes of the IP. New methods based on Gaussian process regression were developed to extract detailed information on the IP shape from these data. Applying them to HARPS, an extremely stable spectrograph installed on the ESO 3.6m telescope, we reconstructed its IP at 512 locations of the detector, covering 60% of the total detector area. Results. We found that the HARPS IP is asymmetric and that it varies smoothly across the detector. Empirical IP models provide a wavelength accuracy better than 10m s−1 (5m s−1) with a 92% (64%) probability. In comparison, reaching the same accuracy has a probability of only 29% (8%) when a Gaussian IP shape is assumed. Furthermore, the Gaussian assumption is associated with intra-order and inter-order distortions in the HARPS wavelength scale as large as 60 m s−1. The spatial distribution of these distortions suggests they may be related to spectrograph optics and therefore may generally appear in cross-dispersed echelle spectrographs when Gaussian IPs are used. Empirical IP models are provided as supplementary material in machine readable format. We also provide a method to correct the distortions in astrocomb calibrations made under the Gaussian IP assumption. Conclusions. Methods presented here can be applied to other instruments equipped with astrocombs, such as ESPRESSO, but also ANDES and G-CLEF in the future. The empirical IPs are crucial for obtaining objective and unbiased measurements of fundamental constants from high-resolution spectra, as well as measurements of the redshift drift, isotopic abundances, and other science cases.

Comparison of Different Hubble Constant Measurements Approach

Comparison of Different Hubble Constant Measurements Approach

Multidimensional Spectroscopy of Nuclear Spin Clusters in Diamond.

Optically active spin defects in solids offer promising platforms to investigate nuclear spin clusters with high sensitivity and atomic-site resolution. To leverage near-surface defects for molecular structure analysis in chemical and biological contexts using nuclear magnetic resonance (NMR), further advances in spectroscopic characterization of nuclear environments are essential. Here, we report Fourier spectroscopy techniques to improve localization and mapping of the test bed ^{13}C nuclear spin environment of individual, shallow nitrogen-vacancy centers at room temperature. We use multidimensional spectroscopy, well-known from classical NMR, in combination with weak measurements of single-nuclear-spin precession. We demonstrate two examples of multidimensional NMR: (i)improved nuclear spin localization by separate encoding of the two hyperfine components along spectral dimensions and (ii)spectral editing of nuclear-spin pairs, including measurement of internuclear coupling constants. Our work adds important tools for the spectroscopic analysis of molecular structures by single-spin probes.

Moment Analysis Method for Measurement of Reaction Equilibrium and Rate Constants by Using High-Performance Liquid Chromatography.

The moment analysis method was developed for the determination of association equilibrium constant (KA) and association (ka) and dissociation (kd) rate constants of intermolecular interactions between solute and ligand molecules. They are accurately determined by using moment equations from elution peak profiles because they are measured by using high-performance liquid chromatography (HPLC) under preferable conditions that neither immobilization nor chemical modification (i.e., fluorescence labeling) of solute and ligand molecules is required. To demonstrate the effectiveness of the method, it was applied to the inclusion complex formation system between dibenzo-18-crown-6 (DB18C6) and alkaline earth metal cations, i.e., Mg2+, Ca2+, and Sr2+, as a concrete example. Because the diameter of the three metal cations is smaller than that of the inner cavity of DB18C6, the values of KA, ka, and kd were analytically determined by assuming the stoichiometry of 1:1 between DB18C6 and the metal cation. They reflected the influence of the difference in the size between the inner cavity of DB18C6 and the metal cations on the inclusion complex formation. It seems that the moment analysis method based on HPLC separation is effective for the multifaceted analysis of chemical reactions because some characteristics of the method are different from those of other conventional methods. It must contribute to the dissemination of an opportunity for the study of chemical reactions to many researchers because of the versatility of HPLC.

Standard siren measurement of the Hubble constant using GW170817 and the latest observations of the electromagnetic counterpart afterglow

Standard siren measurement of the Hubble constant using GW170817 and the latest observations of the electromagnetic counterpart afterglow

Acoustoelastic characterization of aluminum plates using zero group velocity Lamb modes

Acoustoelasticity, a characteristic of material anharmonicity, gives rise to a link between wave propagation velocity and the stress state in materials. Ultrasonic techniques to monitor this coupling, particularly with high sensitivity and in a noncontact manner, can have widespread application both in the quantification of applied and residual stress and in the characterization of nonlinear material behavior through measurement of higher order elastic constants. Here, we use a laser ultrasonic technique to excite and detect zero group velocity (ZGV) Lamb wave resonances in aluminum plates under uniaxial loading. A laser line source is used to excite these resonances at different orientations with respect to the applied load and the signals are detected using an interferometer. The effects of stress and source orientation on ZGV resonance frequencies are validated using the theory of acoustoelastic Lamb wave propagation. In addition, a model-based inversion technique is used to extract Murnaghan’s third-order elastic constants from measurements of the stress dependence of the first two ZGV modes generated parallel and perpendicular to the applied load. Laser generation and detection of ZGV resonances is shown to be an effective and powerful approach for the noncontact and nondestructive acoustoelastic characterization of elastic waveguides.

Effects of Type Ia Supernovae Absolute Magnitude Priors on the Hubble Constant Value

We systematically explore the influence of the prior of the peak absolute magnitude (M) of Type Ia supernovae (SNe Ia) on the measurement of the Hubble constant (H 0) from SNe Ia observations. We consider five different data-motivated M priors, representing varying levels of dispersion, and assume the spatially flat ΛCDM cosmological model. Different M priors lead to relative changes in the mean values of H 0 from 2% to 7%. Loose priors on M yield H 0 estimates consistent with both the Planck 2018 result and the SH0ES result at the 68% confidence level. We also examine the potential impact of peculiar velocity subtraction on the value of H 0 and show that it is insignificant for the SNe Ia observations with redshift z > 0.01 used in our analyses. We also repeat the analysis in the cosmography model and find very similar results. This suggests that our results are robust and model independent.

Measurement of the Optical Constants of Sand Samples Using Ellipsometry on Sand-Adhesive Composites.

In order to model the propagation of light through a sand cloud, it is critical to have accurate data for the optical constants of the sand particles that comprise it. The same holds true for modeling propagation through particles of any type suspended in a medium. Few methods exist, however, to measure these quantities with high accuracy. In this paper, a characterization method based on spectroscopic ellipsometry (SE) that can be applied to a particulate material is presented. In this method, a polished disc of an adhesive compound is prepared, and its optical constants are measured. Next, a mixture of the adhesive and a sand sample is prepared and processed into a polished disc, and SE is performed. By treating the mixture as a Bruggeman effective medium, the optical constants of the particulate material are extracted. For verification of the proposed method, it is first applied to pure silica powder, demonstrating good agreement between measured optical constants and literature values. It is then applied to Arizona road dust, a standard reference material, as well as real desert sand samples. The resulting optical constant data is input into a rigorous scattering model to predict extinction coefficients for various types of sand. Modeling results are compared to spectroscopic measurements on static sand samples, demonstrating good agreement between predicted and measured spectral properties including the presence of a Christiansen feature near a wavelength of 8 µm.

Acoustoelastic characterization of plates using zero group velocity Lamb modes

Acoustoelasticity, a characteristic of material anharmonicity, gives rise to a link between wave propagation velocity and the stress state in materials. Ultrasonic techniques to monitor this coupling, particularly with high sensitivity and in a noncontact manner, can have widespread application both in the quantification of applied and residual stress and in the characterization of nonlinear material behavior through measurement of higher order elastic constants. Here, we use a laser ultrasonic technique to excite and detect zero group velocity (ZGV) Lamb wave resonances in aluminum plates under uniaxial loading. A laser line source is used to excite these resonances at different orientations with respect to the applied load, and the signals are detected using an interferometer. The effects of stress and source orientation on ZGV resonance frequencies are validated using the theory of acoustoelastic Lamb wave propagation. In addition, a model-based inversion technique is used to extract Murnaghan's third-order elastic constants from measurements of the stress dependence of the first two ZGV modes generated parallel and perpendicular to the applied load. Laser generation and detection of ZGV resonances is shown to be an effective and powerful approach for the noncontact and nondestructive acoustoelastic characterization of elastic waveguides.

UAV-mounted thermal camera and its analysis on urban surface textures

Temperature increase, especially global warming, can be observed depending on various factors which led to several severe environmental problems. Urban areas are the most effected places by this temperature increase. Urban heat concentration, the so-called heat island effect, is high in structural areas. This situation causes human life to be adversely affected. Therefore, constant measurement and analyses are required to assess outdoor thermal comfort and thermal stress in urban areas. Today, unmanned aerial vehicle (UAV) systems are used as a rapid data production technique in Earth observation activities. Thermal cameras integrated into UAV systems can monitor the temperature values in urban areas precisely and constantly. This study focuses on the potential application of a UAV-mounted thermal camera system at a local scale due to its rapid response to surface temperature variables. A thermal camera UAV system to measure the energy fluxes and temperatures from the earth’s surface, which are integral to understanding landscape processes and responses. Thus, UAV thermal sensors were used directly for different land cover types in and around the Faculty of Engineering building of Kocaeli University in Turkey. Derived UAV surface temperatures were compared with simultaneously acquired in situ temperature measurements. Simultaneous terrestrial temperature measurements were obtained by using TFA ScanTemp 410 model surface temperature meter. A high correlation between UAV surface temperatures and terrestrial measurements was utilized by Pearson correlation with a 0.94 coefficient. It was concluded that the UAV-mounted thermal camera system is a promising tool that has increased opportunities to understand surface temperature variability at high spatial and temporal resolution.

Convergence properties of fine structure constant measurements using quasar absorption systems

ABSTRACT Searches for space–time variations of fundamental constants have entered an era of unprecedented precision. New, high-quality quasar spectra require increasingly refined analytical methods. In this paper, a continuation in a series to establish robust and unbiased methodologies, we explore how convergence criteria in non-linear least-squares optimization impact on quasar absorption system measurements of the fine structure constant α. Given previous claims for high-precision constraints, we critically examine the veracity of a so-called blinding approach, in which α is fixed at the terrestrial value during the model building process, releasing it as a free parameter only after the ‘final’ absorption system kinematic structure has been obtained. We show that this approach results in such small consecutive parameter steps during minimization that convergence is unlikely to be reached, even after as many as 1000 iterations. The fix is straightforward: α must be treated as a free parameter from the earliest possible stages of absorption system model building. The implication of the results presented here is that all previous measurements that have used initially fixed α should be reworked.

The Hubble tension from the standpoint of quantum cosmology

The Hubble tension is analyzed in the framework of quantum cosmological approach. It is found that there arises a new summand in the expression for the total energy density stipulated by the quantum Bohm potential. This additional energy density acts similarly to a stiff matter component, modifying the expansion history of the early universe and decaying with scale factor a as a-6\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$a^{-6}$$\\end{document}, faster than radiation, in late universe. Taking account of this matter-energy component of quantum nature can, in principle, eliminate a discrepancy between the direct late time model-independent measurements of the Hubble constant and its indirect model dependent estimates. The considered model allows one to extend the standard cosmology to quantum sector.

Resistance Drift in Melt-Quenched Ge2Sb2Te5 Phase Change Memory Line Cells at Cryogenic Temperatures

We characterized resistance drift in phase change memory devices in the 80 K to 300 K temperature range by performing measurements on 20 nm thick, ∼70–100 nm wide lateral Ge2Sb2Te5 (GST) line cells. The cells were amorphized using 1.5–2.5 V pulses with ∼50–100 ns duration leading to ∼0.4–1.1 mA peak reset currents resulting in amorphized lengths between ∼50 and 700 nm. Resistance drift coefficients in the amorphized cells are calculated using constant voltage measurements starting as fast as within a second after amorphization and for 1 h duration. Drift coefficients range between ∼0.02 and 0.1 with significant device-to-device variability and variations during the measurement period. At lower temperatures (higher resistance states) some devices show a complex dynamic behavior, with the resistance repeatedly increasing and decreasing significantly over periods in the order of seconds. These results point to charge trapping and de-trapping events as the cause of resistance drift.

Measuring Hydroxyl Exchange Rates in Glycans Using a Synergistic Combination of Saturation Transfer and Relaxation Dispersion NMR.

Molecular recognition events mediated by glycans play pivotal roles in controlling the fate of diverse biological processes such as cellular communication and the immune response. The affinity of glycans for their target receptors is governed primarily by the hydrogen bonds formed by hydroxyl groups decorating the glycan surface. Hydroxyl exchange rate constants are therefore vital parameters that report on glycan structure and dynamics. Here we present a strategy for characterizing hydroxyl hydrogen/deuterium (H/D) exchange in glycans that employs a synergistic combination of 13C chemical exchange saturation transfer (CEST) and Carr-Purcell-Meiboom-Gill relaxation dispersion (CPMG) NMR methods. We show that the combination of CEST and CPMG experiments facilitates the sensitive detection of the small (∼0.1 ppm) two-bond deuterium isotope shift on a 13C nucleus when the attached hydroxyl group fluctuates between protonated and deuterated states. This shift is leveraged for measuring site-specific kinetic H/D exchange rate constants as well as thermodynamic free energies of isotope fractionation. The CEST and CPMG modules are integrated with a selective J-cross-polarization scheme that provides the flexibility for rapid characterization of H/D exchange at a specific hydroxyl site. Moreover, our approach enables the precise isothermal measurement of hydroxyl exchange rate constants without the need for cumbersome isotope labeling. The H/D exchange rate constants of three different glycans assessed using this method highlight its potential for detecting transient intra- and intermolecular hydrogen bonds. In addition, the trends in H/D exchange rate constants establish site-specific steric accessibility as a key determinant of solvent exchange dynamics in glycans.

Determination of application boundaries to Giulotto method to during measuring of longitudinal relaxation time in nuclear magnetic flowmeters-relaxometers

The method of nuclear magnetic resonance, which is currently the most common in research and control of parameters of condensed matter, and the nuclear magnetic flowmeters-relaxometers that implement this method are described. The features of determining the times of longitudinal and transverse relaxation in nuclear magnetic flowmeters-relaxometers under different flow regimes of the medium in the process of monitoring its parameters have been established. The advantages of using a modulation technique for recording nuclear magnetic signals in flowmeters-relaxometers in comparison with other registration methods are noted. Using various approximations by the Giulotto method from the Bloch equations, a relation was obtained to determine the longitudinal relaxation time from the results of two measurements of the amplitudes of the nuclear magnetic resonance signal or resonant frequencies at different modulation frequencies. It has been experimentally proven that this relationship has a number of restrictions on its application for flowing liquid. These limitations are associated both with the technique of recording nuclear magnetic resonance signals and with the ability to generate such signals at different modulation frequencies of a constant magnetic field, the amplitudes of which differ from each other beyond the measurement error. The reasons that led to this discrepancy in the ratio for determining the time of longitudinal relaxation have been established. The limits of applicability of the obtained relation are found and it is experimentally proven that within these limits this relation can be used for reliable measurements of relaxation constants. Using experimental data, the relationship for determining the longitudinal relaxation time was studied. It has been proven that in a number of cases it is impossible to determine the desired value using the indicated relationship, although nuclear magnetic resonance signals of the current medium are recorded, and the medium has relaxation times. The results obtained make it possible to eliminate errors when using the nuclear magnetic resonance method to study flowing media and solve a number of complex problems in the energy, oil, chemical and pharmaceutical industries.