The hysteretic behavior of friction isolators is affected by the variability of the friction coefficient caused by heating phenomena at the sliding interface. The aim of this paper is to investigate such heating phenomena through a series of full-scale experimental tests on a double curved surface slider. The prototype isolator is equipped with eight thermocouples placed in different points of the isolator, which are embedded in the sliding plate. The probes of the thermocouples are in contact with the stainless steel sheet covering the sliding plate, in such a manner that their measurements are representative of the temperature rise occurring at the sliding interface. By investigating different axial loads and sliding velocities, we discuss the measured temperature rise and its implications on the hysteretic behavior of the prototype isolator. Friction variation is observed in the cyclic response of the isolator, which reduces the energy dissipated per cycle and, consequently, may lead to some underestimations of the displacements occurring during real seismic events if a constant friction coefficient is assumed. The proposed data can be helpful to calibrate sophisticated thermo-mechanical finite element models, which is the object of ongoing research.