Mean Fasting Blood Sugar Research Articles

A LIPID PROFILE STUDY AMONGST THE CASES OF TYPE 2 DIABETES MELLITUS - A CROSS SECTIONAL STUDY

Introduction: India leads the world with largest number of diabetic cases and is often referred to as the diabetes capital. Diabetic dyslipidemia in India is one of the main causes for Coronary Artery Disease (CAD) mortality of the world. Dyslipidemia are disorders of lipoprotein metabolism, including lipoprotein overproduction or deficiency. It is a preventable risk factor which is mostly observed in diabetes cases and that may precipitate the cardiovascular disorders. Our aim of the study is to determine the impact of type 2 diabetes mellitus (T2DM) on lipid profile of diabetic cases reporting at tertiary care hospital. Materials and methods: It was a cross sectional study conducted at Department of Biochemistry, Patna Science College, Patna, Bihar. Total 140 diabetic cases were randomly selected and they were examined for dyslipidemia. Fasting blood glucose concentration and Lipid Profile [Total Cholesterol (TC), High Density Lipoprotein (HDL), Very Low Density Lipoprotein (VLDL) and Triglycerides (TG)] were investigated by using commercially available reagent kits in Biochemistry analyzer. Collected data was analyzed by using appropriate software. Results: Out of total 140 diabetic cases examined, the mean age of cases was 48.93 ± 12.1 years. In present study we found the mean Fasting Blood Sugar (FBS) was 188.76 ± 54.63 mg/dl. The prevalence rates in our study for high Total Cholesterol (TC) and Triglycerides (TG) were 13.6% and 41.4% respectively. The prevalence rates for high LDL-C, very high LDL-C and low HDL-C in the diabetic subjects were 8.6%, 5.0% and 72.9% respectively. Conclusion: The diabetic cases had elevated serum total cholesterol, elevated triglyceride (triacylglycerol) and slightly elevated low density lipoprotein (LDL-C) and reduced levels of high density lipoprotein (HDL-C) indicating that diabetic cases were more prone to cardiovascular diseases. Type 2 Diabetes Mellitus, Dyslipidemia, Triglyceride, HDL-C, LDL-C, Total Cholesterol.

Potentiation of incretin hormones and modulation of metabolic enzymes as possible mechanisms behind the insulin sensitizing effects of cabbage-metformin treatment

In our study, we treated high fructose diet-induced insulin resistance in rats with any of metformin, cabbage (80%w/w) or combined metformin and cabbage (MetCabb), and observed the activities of glycolysis and gluconeogenesis regulatory enzymes, incretin hormones and other hormones affecting glucose homeostasis. Comparisons were made with normoglycemic noninsulin resistance rats (control) and insulin-resistant untreated rats (INres). Baseline analysis showing elevated fasting blood sugar (>250 mg/dl), insulin (>25 µIU/ml) and HOMA-IR (>10) satisfied the criteria for recruitment into the insulin-resistant groups. Treatment lasted for 12 weeks. HOMA-IR values significantly (P < 0.05) decreased from 24.7 to 5.5 and 10.6 respectively with MetCabb treatment. MetCabb normalized HOMA-IR values and mean β-cell responsiveness of the INres. Cabbage and metCabb normalized the leptin levels relative to control. The mean fasting blood sugar, insulin, and c-peptide levels with MetCabb treatment reverted to control levels. We found a strong positive linear correlation between the glucagon levels (r = 0.9145) and increasing HOMA-IR values while both incretin hormones; GLP-1 and GIP negatively regressed (r = -0.8084 and -0.8488). MetCab treatment produced comparable values of GLP-1 and GIP to the control. A strong positive correlation was found between the HOMA-IR values and the PEPCK (r = 0.9065), F-1,6-BPase (r = 0.7951), and G-6-Pase (r = 0.7893). The hexokinase (r = -0.807), PFK (r = -0.9151), and PK (r = -0.7448) levels regressed as HOMA-IR values increased. The glycolytic and gluconeogenic enzymes except PEPCK reverted to control levels with MetCabb treatment. Combination of metformin and cabbage was more effective than individual treatments.

Mesure du diamètre pupillaire chez les patients diabétiques et non diabétiques : étude cas-témoins

To study the effect of type 2diabetes on pupil diameter. We carried out a case-control study at the Douala Obstetrics, Gynecology and Pediatric Hospital over a 5-month period. The cases were type 2diabetic patients, and the controls were non-diabetic patients paired for age and gender. We studied the correlation between the duration of diabetes, fasting blood sugar and the horizontal pupil diameter. We included 35patients in each group. The mean age was 56.6±10.01years. Both groups included 17males and 18females. The mean duration of diabetes was 2.72±4.31years, and the mean fasting blood sugar was 2.02±0.69g/L. The mean pupil diameter was similar in the two groups. On the right side, it was 4.75±0.73mm for controls and 4.52±0.69mm for cases (P=0.179). On the left side, it was 4.70±0.68mm and 4.42±0.73mm respectively for each group (P=0.101). The duration of diabetes was correlated to pupil diameter in the right eye (r=-0.43; P=0.01) and left eye (r=-0.45; P<0.01). No additional risk was found to be associated with diabetes for right pupil diameters (OR=0.79; P=0.33), or for left ones (OR=0.76; P=0.24). Pupil diameter is similar in diabetic and non-diabetic patients. However, the duration of diabetes appears to affect pupil diameter.

Glucoherb versus metformin on glycemic markers and glycosylated hemoglobin in prediabetes patients; a clinical trial study

Introduction: There is a high risk of diabetes mellitus in pre-diabetic patients. Objectives: The aim of the study was to compare the effect of the extracts of these herbs in the formulation of Glucoherb supplementation versus metformin in pre-diabetes patients on glycemic markers and glycosylated hemoglobin. Patients and Methods: Pre-diabetic patients who had indication of drug treatment according to the criteria of the American Diabetes Association, were selected and randomly divided into two groups of Glucoherb and metformin. Body mass index (BMI), fasting blood sugar (FBS), 2 hours postprandial blood glucose (BS2PP) and glycosylated hemoglobin (HbA1c) were measured before and after the intervention. Results: The mean BMI, FBS, BS2PP and HbA1c levels were significantly decreased after intervention in both Glucoherb and metformin groups (P &lt; 0.05) without any significant difference between them (P &lt; 0.05). Conclusion: Glucoherb showed similar efficacy to metformin in reducing blood glucose, BMI and HbA1c in pre-diabetic patients.

Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients

Background and study aim: Chronically Hepatitis C virus (HCV)-infected patient, develops many complications, as liver cirrhosis, diabetes, and hepatocellular carcinoma (HCC). This study aimed at evaluation of direct acting anti-viral therapy effect on insulin resistance (IR) and glycemic status in CHC patients with type 2 diabetes mellitus, 3 months after the end of treatment. Patients and Methods: This prospective work included 72 (better patients) with CHC and type 2 diabetes. All were enrolled for anti-viral therapy at the center for treatment of viral hepatitis in Ismailia Governorate during the period from September 2015 to September 2016. Data from patients’ candidate for anti-viral therapy was collected at pretreatment and after 12 weeks of therapy. The data including, FBS, IR by Homa IR index and quantitative HCV-RNA. Results: There was a significant decrease in the mean fasting blood sugar (FBS) had occurred after treatment with anti-HCV therapy (p < 0.0001). Also, a significant decrease in the mean of HOMA-IR had occurred after treatment with anti-HCV therapy (p < 0.0001). Conclusion: A significant improvement in FBS as well as IR was declared after successful HCV treatment.

Thiamine Level in Type I and Type II Diabetes Mellitus Patients: A Comparative Study Focusing on Hematological and Biochemical Evaluations.

ObjectiveDiabetes has been found to be associated with low levels of thiamine stores in the body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of thiamine has been found in both type I and type II diabetic patients. It has been shown that high-dose thiamine therapy may have a therapeutic effect on early-stage diabetic nephropathy. The aim of this study was to evaluate various biochemical parameters and serum thiamine levels in type I and type II diabetic patients and compare them with a healthy control group.MethodsA case-control study was carried out in the diabetic out-patient multi-centers in Karachi. A total of 90 participants were selected by using a non-probability convenient sampling technique and divided into three groups, each with 30 subjects. Group A included healthy non-diabetic subjects, while group B included subjects with type I diabetes mellitus (DM), and group C included subjects with type II DM. After receiving informed consent, blood samples were collected from all the participants for hematological and biochemical evaluation. The duration of the study was eight months.ResultsThe study results revealed that the patients with type II DM had significantly higher mean fasting blood sugar (FBS), random blood sugar (RBS), and hemoglobin A1c (HbA1c) levels than those with type I DM or the control group (p<0.001 for all). Furthermore, the patients with type I or II DM had significantly higher mean levels of triglyceride (p<0.001) and total cholesterol (0.013) while significantly lower mean levels of high-density lipoprotein (HDL) (p=0.014) than controls. The study results further revealed that the patients with type I or II DM had significantly lower serum thiamine levels than controls (14.89±4.82 and 7.35±1.90 vs. 69.56±12.75, p<0.001).ConclusionThe study results revealed that FBS, RBS, HbA1c, triglyceride, and total cholesterol levels were significantly higher in both type I and type II diabetes patients compared to controls. Furthermore, HDL and serum thiamine levels were found to be significantly lower in both type I and type II diabetic patients than in controls.

Changes in Blood Glucose Level After Steroid Injection for Musculoskeletal Pain in Patients With Diabetes.

ObjectiveTo investigate changes in blood glucose level after steroid injection in patients with type 2 diabetes mellitus (DM) and factors affecting those changes.MethodsWe retrospectively studied 51 patients with type 2 DM who underwent steroid injection for shoulder and back pain. Mean fasting blood sugar (FBS) levels for 7 days before steroid injection was used as the baseline blood glucose level, which was compared with FBS levels for 14 days after steroid injection. We compared the differences in blood glucose changes between HbA1c >7% and HbA1c ≤7% groups and those between insulin and non-insulin treated groups. Demographic data, injection site, and steroid dose were analyzed.ResultsCompared to baseline, blood glucose significantly (p=0.012) elevated 1 day after steroid injection but not 2 days after injection. In the HbA1c >7% and insulin groups, blood glucose was significantly increased 1 day after injection compared to that in the HbA1c ≤7% (p=0.011) and non-insulin (p=0.024) groups, respectively. Higher HbA1c level before injection was significantly (p=0.003) associated with the degree of blood glucose increase 1 day after injection. No significant differences were noted in the degree of blood glucose increase according to injection site or steroid dose.ConclusionHigher HbA1c level was associated with greater elevation in blood glucose 1 day after steroid injection. Careful monitoring of blood glucose is required on the first day after steroid injection in patients with poorly controlled DM.

Duration of diabetes as an important risk factor of microalbuminuria in type 2 diabetes

BACKGROUNDMicroalbuminuria is the earliest evidence of diabetic nephropathy and a major predictor of end stage renal disease (ESRD). The objective of the study was to determine the influence of several risk factors on the presence of microalbuminuria in type 2 diabetics.METHODSThis observational cross-sectional study was done on 73 patients with type 2 diabetes, who attended the Prolanis program in Primary Health Care from May to November 2018. Detailed medical histories including duration of diabetes and relevant clinical examinations including fasting blood sugar (FBS), post-prandial blood sugar (PPBS), HbA1c, serum creatinine, blood urea and urinary microalbumin were recorded for each patient. A multiple regression analysis was used to analyze the data. The analysis was assessed at 5% level of significance.RESULTSMean age of study population was 51.89 ± 6.78 years with female preponderance (51.1%). Mean FBS, PPBS, HbA1c, duration of diabetes, systolic blood pressure, microalbuminuria and serum creatinine was 182.51 ± 74.63 mg/dL, 186.25 ± 26.72 mg/dL, 8.8 ± 1.83%, 9.37 ± 5.96 years, 118.44 ± 4.13 mmHg, 30.32 ± 3.2 mg/day and 1.33 ± 0.64 mg/dL respectively. Duration of diabetes and HbA1c were positively correlated with microalbuminuria (â=0.052; Beta =0.367; p&lt;0.001 and â=0.058; Beta=0.363; p&lt;0.001) respectively.CONCLUSIONSDuration of diabetes was the most important risk factor of microalbuminuria in type 2 diabetes patients. Therefore microalbuminuria can predict diabetic nephropathy earlier, as a warning to prevent further worsening of diabetic complications.

Prevalence of Metabolic Syndrome and its Determinants in Tirunelveli City Police

Introduction: Metabolic syndrome has been reported to be on the rise in general population, more so inpersonnel involved in occupational stress. Hence the present study is undertaken to find out the prevalenceof metabolic syndrome and to determine the factors associated with it among the police personnel inTirunelveli city.Method: This is a cross-sectional study in which 133 police personnel working in Tirunelveli city in theage group of 30-58 were included. After getting due permission from the Deputy Commissioner of PoliceTirunelveli city, Head of Department of Bio chemistry, Institutional Ethical Committee clearance and oralinformed consent from the volunteers, the study was started. The study was conducted during the period ofAugust, 2013. Analysis was done using Chi square test and t test using SPSS software version 16. Results:Among the 133 police personnel examined, 92 of them were identified with metabolic syndrome. Hence,prevalence was found to be 69.1%. Majority of them 26 (28.3%) fell in the age group of 41 to 45 years.History of Smoking, Hypertension and Diabetes were found to be higher among those with metabolicsyndrome (31.5%, 20.7% and 17.4%) as compared to those who were not affected (7.3%, 7.8% and 2.4%)and they were found to be statistically significant with P values of 0.003, 0.007 and 0.017 respectively. Themean values of Age, BMI, Waist circumference, Systolic BP, Diastolic BP, Mean Arterial BP, Fasting BloodSugar, Serum Triglycerides and VLDL were significantly higher among those who were having metabolicsyndrome as compared to other participants.

Correlation between insulin resistance and liver histology in patients with nonalcoholic steatohepatitis with and without obesity.

Insulin resistance (IR) plays a central role in pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to correlate histopathological grading and IR in overweight/obese patients with NASH as compared with lean NASH. Patients with NASH who underwent liver biopsy between January 2012 and December 2012 were included. Anthropometric, clinical, and biochemical features, necro-inflammatory grades, and fibrosis stage on liver biopsies were scored according to Brunt and non-alcoholic fatty liver disease (NAFLD) activity score (NAS). Of 42 patients, 33 (78.6%) had body mass index (BMI) ≥ 23kg/m2 (overweight/obese) while 9 had BMI < 23kg/m2 (lean). Mean fasting blood sugar (FBS) and HbA1c levels in overweight/obese patients with NASH were higher than in lean NASH (p < 0.05). The median homeostatic model assessment-estimated insulin resistance (HOMA-IR) among NASH patients with BMI ≥ 23kg/m2 was higher than among those with BMI < 23kg/m2 (3.02 [0.34-17.22] vs. 2 [0.52-5.26]; p = 0.045). However, fasting insulin levels were comparable among lean and overweight/obese patients with NASH. Metabolic syndrome could be predicted with 75% sensitivity and 85.3% specificity at a HOMA-IR cutoff value of 3.9. No significant difference was observed with regard to HOMA-IR levels with Brunt grades, Brunt staging, Brunt grades 1 and 2, Brunt scores < 2 and > 2, and NAS scores, and NAS scores < 4 and > 4. Although IR was significantly higher in overweight/obese patients with NASH as compared with that in lean patients with NASH, there was no difference in the correlation of HOMA-IR with histology between these groups.

Risk factors for obstructive sleep apnea among train drivers.

The screening of risk factors for sleep apnea among drivers with safety-sensitive jobs is considered as an issue of utmost importance in a safe transportation system. This study was conducted to assess the risk factors of sleep apnea among locomotive drivers. The present research is a cross-sectional study conducted in Baharloo Hospital, Tehran University of Medical Sciences, Iran. The study population included 281 locomotive drivers referred for their annual physical examination. Demographic characteristics, Epworth Sleepiness Scale (ESS), blood pressure, body mass index (BMI), neck circumference, and laboratory measurements including fasting blood sugar (FBS), cholesterol, high density lipoprotein, and low-density lipoprotein were recorded for each participant. Blood pressure ≥140/90 mmHg, history of drug use, BMI > 35 kg/m2, age >50 years, and neck circumference >40 cm were defined as risk factors for obstructive sleep apnea (OSA-RFs). All participants were male with a mean age of 43±10 years. The mean BMI was 26.9±3.9 kg/m2. Also, the mean FBS and Total cholesterol of participants was 96.9±24.9 and 181.7±41.8, respectively. Among participants, 166 (59.9%) drivers had two or more risk factors of obstructive sleep apnea (OSA-RFs)CONCLUSIONS:The findings of this study indicated a high prevalence of obstructive sleep apnea among locomotive drivers. Therefore, further research is warranted to re-evaluate the current screening regulations of diagnosing sleep apnea among locomotive drivers.

Pattern of diabetes mellitus-related complications and mortality rate: Implications for diabetes care in a low-resource setting

Background: Diabetes mellitus (DM)-related morbidity and mortality is gradually assuming an endemic proportion in Africa. In Nigeria, DM-related complications are responsible for 3%–15% medical admissions in most facilities. Despite this growing trend, there is a paucity of studies highlighting the morbidity and mortality due to DM in Nigeria. Objective: This retrospective study documented the pattern of DM-related complications and mortality rates in Warri Central Hospital, Warri, Delta State, Nigeria. Materials and Methods: This was a retrospective, descriptive, hospital-based study covering a 7-year period (2012–2018). Data on age, sex, fasting blood sugar (FBS), random blood sugar (RBS), comorbid conditions, and the number of deaths were extracted from the case files of DM patients in the records department of the hospital. The extracted data were analyzed using the IBM IBM SPSS software version 20.0 (IBM Corp., Chicago, USA). Results: A total of 78 patients were studied. The age range of cases was between 20 and 79 years, with a mean age of 54.9 ± 13.9 years. The overall prevalence of DM was 18.3%; overall mean FBS and RBS were 186.0 ± 49.1 mg/dl and 272.9 ± 59.2 mg/dl, respectively. The overall mortality rate was 28.2%. Major complications observed were hyperglycemic emergencies (20%), hypertension (18%), stroke (17%), and nephropathy (14%). Conclusion: The study highlighted that DM is associated with morbidity and mortality among the patients. Therefore, efforts must be intensified on promoting DM management practices by individuals, families, communities, health-care system, government, and its international partners to reverse this ugly trend.

Effects of probiotic, cinnamon, and synbiotic supplementation on glycemic control and antioxidant status in people with type 2 diabetes; a randomized, double-blind, placebo-controlled study.

The aim of this study was to investigate the effect of probiotic bacteria of Lactobacillus acidophilus, cinnamon powder and their combinations on the glycemic and antioxidant indices in patients with type 2 diabetes. A total of 136 patients randomized with type 2 diabetes entered the study and were randomly divided into four groups who were matched for age and gender. Thereafter, alongside their routine pharmacotherapy, each group followed one of the following diets: Group A: Lactobacillus acidophilus 108cfu and 0.5g of powdered cinnamon (synbiotic). Group B: Lactobacillus acidophilus (probiotic), Group C: powdered cinnamon. Group D: rice flour powder as placebo. At the beginning and end of the intervention, fasting blood sugar (FBS), HbA1c, advance glycation end products (AGE), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and antioxidant enzymes of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Following 3months of treatment, the mean FBS level was decreased significantly in probiotic, cinnamon, and synbiotic supplementation groups compared with control (P < 0.01). FBS levels in probiotic, cinnamon, and synbiotic groups were significantly decreased compared with the control group (P = 0.001, P = 0.063 and P =0.001, respectively). The mean HbA1C in probiotic, cinnamon, and synbiotic groups were also decreased (P =0.001, P = 0.001 and P = 0.04, respectively). The mean AGE in synbiotic group was significantly decreased (P = 0.037). Probiotic, cinnamon and synbiotic all could improve antioxidant enzyme activity modestly. However, the most significant effect was seen in probiotic group. According to the current results, the use of probiotic supplements (individually or in combination with cinnamon) leads to a reduction in blood glucose and an increase in antioxidant enzymes in people with type 2 diabetes.

Prevalence and pattern of dyslipidemia in patients with type 2 diabetes mellitus in Zaria, Northwestern Nigeria.

IntroductionDyslipidemia confers excess atherosclerotic cardiovascular risk in type 2 diabetes mellitus (DM) patients, and this requires prompt identification and management to reduce morbidity and mortality. This study assessed the prevalence and pattern of dyslipidemia in type 2 DM patients in Zaria, Northwestern Nigeria.MethodsThis was a cross-sectional study of newly diagnosed type 2 DM patients at Ahmadu Bello University Teaching Hospital (ABUTH), Zaria. Demographic, clinical and laboratory data were extracted from the case notes of eligible patients and analyzed using STATA version 14. Continuous variables were presented as mean ± standard deviation (SD), or median and interquartile range (IQR) while categorical variables were as frequencies and percentages. Student t and chi-square tests were used to test for association at p < 0.05.ResultsA total of 322 subjects (161 male, 161 female) with a mean age of 53.5 ± 10.8 years partook in the study. The prevalence of dyslipidemia was 69.3%. Mixed dyslipidemia of high triglyceride (TG) and high low-density lipoprotein cholesterol (LDL-C) was present in 41.0%; high TG and low high-density lipoprotein cholesterol (HDL-C) in 2.8%; and high LDL and low HDL in 2.5%. Atherogenic dyslipidemia, isolated hypercholesterolemia and isolated low HDL-cholesterol were present in 3.4%, 2.5% and 23.6% respectively. Dyslipidemia status was not associated with age, sex, duration of DM or hypertension, obesity, and mean fasting blood sugar (FBS) and 2-hour postprandial glucose.ConclusionThe prevalence of dyslipidemia is high in the newly diagnosed type 2 DM patients and therefore, initial management should incorporate measures to control dyslipidemia.

Correlation of Hemoglobin A1c with Red Cell Width Distribution and Other Parameters of Red Blood Cells in Type II Diabetes Mellitus.

ObjectiveTo determine the correlation of glycated hemoglobin (HbA1c) with red cell width (RDW) and other analytic parameters of red blood cells (RBCs) in type II diabetic patients.DesignCross-sectional analytical study.Place and duration of the studyAl-Tibri Medical College and Hospital Karachi; from July 2017 to January 2018.Patients and methodsThis cross-sectional study was conducted on diagnosed type II diabetic patients visiting the outpatient department of medicine at Al-Tibri Medical College Hospital from July 2017 to January 2018. Diabetes mellitus was diagnosed according to American Diabetes Association (ADA) guidelines. After taking consent and conducting a clinical assessment (include history and physical examination), laboratory tests, such as fasting blood glucose, random blood glucose, complete blood count (CBC), and HbA1c, were collected on proforma.ResultsA total of 119 patients were eligible for the study with a mean age of 48.63±12.462 (range 24-76) years; among those, males were 74 (62.2%) and females were 45 (37.8%). The mean duration of diabetes mellitus (DM) was 6.735±3.759 (range 1-20) years. The mean hemoglobin of patients was 11.59±1.315 gm/dl. The mean corpuscular volume (MCV) was 76.65±11.121 fl and the mean RDW was found to be 18.287±4.352, with the highest value of 30.20. The mean MCH was 30.223±23.873 pg, with the highest value of 38.4 pg. The mean cell hemoglobin concentration (MCHC) was 28.214±4.7498 mg/dl.The HbA1c of the study population was found to be moderately uncontrolled and the mean HbA1c was 8.278±5.015%, with the highest value of 16.2%. The mean fasting blood sugar was 158±39.50 mg/dl while the mean random blood sugar was 236±57.390 mg/dl.The correlation of HbA1c with RDW turned out to be significant statistically (p-0.035) while other RBCs and/or hematological parameters, such as MCV, hemoglobin, and platelets, revealed no significant correlation.ConclusionThe study highlighted that RDW has a significant correlation with HbA1c and is an inexpensive and freely available test so it may be used as a marker of glycemic status.

Effect of an Educational Intervention Program Based on Bandura's Self-efficacy Theory on Self-care, Self-efficacy, and Blood Sugar Levels in Mothers with Pre-diabetes during Pregnancy

Background: Sense of self-efficacy prepares an appropriate framework for self-care behaviors. Aim: This study aimed at investigating the effect of an educational intervention program based on Bandura’s Self-Efficacy Theory (SET) on self-care, self-efficacy, and blood sugar levels in mothers with pre-diabetes during pregnancy. Method: This randomized two-group clinical trial was conducted on 100 pregnant women with pre-diabetes in Shirvan, Iran, during 2018. The intervention group received educational training according to the constructs of Bandura’s SET. On the other hand, the control group was provided with routine care. The data were collected using Diabetes Self-Care Activities and the standardized and adjusted Diabetes Self-Efficacy Questionnaires, as well as an automatic biochemistry analyzer, and a blood glucose monitoring device. The data were analyzed in SPSS software (version 22) through paired sample t-test, Mann-Whitney U test, and Wilcoxon signed-rank test. Results: The mean ages of the participants in the intervention and control groups were 28.9±7.1 and 29.3±6.2 years, respectively. According to the Mann-Whitney U test results, the intervention group obtained higher scores regarding self-care behaviors and sense of self-efficacy (41.8±13.5, 99.3±16.2), compared to the control group (22.8±5.0, 99.3±16.2, P˂0.001). The mean fasting blood sugar level in the intervention group (75.8±6.7) was significantly lower than that in the control group (85.4±9.7, P˂0.001). Implications for Practice: The promotion of self-care behaviors and self-efficacy strategies in mothers with pre-diabetes during pregnancy could prevent gestational diabetes and reduce the severity of its complications.

Sialic acid: an early sensitive marker improves detection of nephropathy in type-2 diabetes mellitus patients

Sialic acid: an early sensitive marker improves detection of nephropathy in type-2 diabetes mellitus patients - IJCBR- Print ISSN No: - 2394-6369 Online ISSN No:- 2394-6377 Article DOI No:- 10.18231/j.ijcbr.2019.036, International Journal of Clinical Biochemistry and Research-Int J Clin Biochem Res

Relation between Periodontitis and Prediabetic Condition

Statement of the Problem:Prediabetic condition, which is characterized by impaired glucose tolerance, impaired fasting blood glucose, and hemoglobin A1c (HbA1c) higher than normal might be associated with periodontitis. Early diagnosis of this condition might decrease consequent tissue damage caused by periodontitis. Purpose: The present study aimed to evaluate the association between prediabetes and periodontitis. Materials and Method: This cross-sectional study was conducted on 108 prediabetic patients screened by primary fasting blood sugar (FBS) test (100-125 mg/dL). Three subsequent blood tests including FBS, HbA1C, and oral glucose tolerance test (GTT) were performed for ultimate diagnosis of these patients. The periodontal health was evaluated by employing bleeding on probing (BOP), clinical attachment loss (CAL), and plaque index (PI), Lِe-Silness gingival index (GI), and pocket depth (PD). Data were analyzed by SPSS version 16, using t-test, ANOVA, and chi-square tests. Results: The sample included 20 (19%) male and 88 (81%) female individuals with mean age of 49 years and mean BMI of 27.5. The mean FBS, GTT, and HbA1C were 107 MG/DL, 137MG/DL, and 5.9%, respectively. Clinical evaluation showed 33% of patients involved with periodontitis. The mean CAL, BOP, PI, PD, GI was 3.7, 0.62, 1.9, 2.1, 1.5, respectively (p< 0.05). A significant difference in periodontal index was found among patients with prediabetes. Moreover, in the patients with periodontitis, a statistically significant relationship between FBS and BMI, BOP and GTT, and finally between CAL and HbA1C was detected. Conclusion:Periodontitis is associated with prediabetic condition. While diabetes is an important risk factor for periodontitis, the risk of periodontitis would be greater if glycemic control is poor. Glycemic control in prediabetic patients can reduce the severity of periodontal disease. Early diagnosis and prevention is crucial to avoid the largely irreversible tissue damage that occurs in periodontitis.

Beneficial Impacts of Dietary Zinc Supplementation on Islet β-cells Regeneration and Glycemic Profile in Diabetic Rats (P24-015-19)

ObjectivesThis experimentally-controlled designed nutritional study, aimed to determine the effects of Zn-supplemented diet on glycemic profile, tolerance and control, body weight and pancreatic Islet β-cells in diabetic male rats. MethodsTwenty four male Wistar rats each weighing ≥200 g were randomly categorized into three experimental groups (n = 8, each): Normal control (NC) fed with standard rat feed; Diabetic control (DC) fed with control diet and Diabetic (DZ) on test (zinc-supplemented) diet. Diabetes was inducted with freshly prepared alloxan monohydrate solution (150 mg/dL, intraperitoneally). Rats were fed for a period of eight weeks according to the experimental design with water ad libitum while their weights were measured twice weekly and recorded. Fasting blood sugar (FBS) levels were measured twice weekly while oral glucose tolerance test (OGTT) was conducted to construct the glycemic response curves. Animals were sacrificed at the end of eight week to extract pancreas for immunocytochemical and histomorphometric analyses. Microsoft Excel and statistical program SPSS version 22.0 were used to analyse data while P values <0.05 were considered significant. ResultsAt the end of eight week study, Zn-supplemented diet caused significant (P < 0.05) reductions in mean body weight gain (28.5%) and FBS (31.5%) levels, stimulated islet β-cells regeneration and improved glycemic tolerance and profile in DZ rats compared with the diabetic control rats. ConclusionsIn conclusion, zinc-supplemented diet impacts beneficial antidiabetic effect in diabetic rats via stimulation of pancreatic islet β-cells regeneration, reduction of body weight gain and lowering of blood glucose level. Funding SourcesThis Study was self sponsored. Supporting Tables, Images and/or Graphs▪

Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats

Introduction: Diabetes being one of the commonest non-communicable diseases worldwide has no cure. The available hypoglycemic drugs are costly, and have associated long-term side effects. M. oleifera leaves are used in many countries in Africa and Asia to treat diabetes. The study compared the hyperglycemic control of M. oleifera leaves aqueous extract and Glibenclamide tablet in alloxan monohydrate induced diabetic rats.&#x0D; Methods: Twenty-four female Wistar albino rats, made diabetic using alloxan monohydrate, received either M. oleifera extract, glibenclamide or distilled water were delivered intragastric. The mean body weight and mean fasting blood sugar were measured over a period of 28 days. &#x0D; Results: Rats that received distilled water had a mean fasting blood sugar of 329.3+44.9 mg/dl at the beginning, which increased to 448.0+189.9 mg/dl on day 14; all the rats were dead by day 21. The rats that received M. oleifera had blood sugar 443.4+134.7 mg/dl at the beginning, dropped to 166.5+162.79 mg/dl by day 14, and to 88.7+41.0 mg/dl by day 28. Rats that received glibenclamide had blood sugar 517.6+139.3mg/dl at the beginning, dropped to 209.0+201.9 mg/dl on day 14, and to 89.7+42.85 mg/dl on day 28. The blood sugar of the M. oleifera and glibenclamide groups reached normal level by day 21 and remained within the normal range up to day 28. Conclusion: Moringa oleifera leaves aqueous extract has similar pattern to glibenclamide tablet in causing hypoglycemia to alloxan monohydrate induced diabetic rats.