Maximum Signal Research Articles

Impact of pretransplant T2DM on left ventricular deformation and myocardial perfusion in heart transplanted recipients: a 3.0 T cardiac magnetic resonance study

BackgroundPretransplant type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular and all-cause mortality after heart transplant (HT), but the underlying causes of this association remain unclear. The purpose of this research was to examine the impact of T2DM on left ventricular (LV) myocardial deformation and myocardial perfusion following heart transplantation using cardiovascular magnetic resonance imaging.MethodsWe investigated thirty-one HT recipients with pretransplant T2DM [HT(DM+)], thirty-four HT recipients without pretransplant T2DM [HT(DM−)] and thirty-six controls. LV myocardial strains, including the global longitudinal, radial, and circumferential strain (GLS, GRS and GCS, respectively), were calculated and compared among groups, as were resting myocardial perfusion indices, which included time to peak myocardial signal intensity (TTM), maximum signal intensity (MaxSI), and Upslope. The relationships between LV strain parameters or perfusion indices and biochemical indicators were determined through Spearman’s analysis. The impact of T2DM on LV strains in HT recipients was assessed using multivariable linear regression analyses with backward stepwise selection.ResultsIn the HT(DM+) group, the LV GLS, GRS, and GCS exhibited significantly lower magnitudes than those in both the HT(DM−) and control groups. TTM was higher in the HT(DM+) group than in both the HT(DM−) and control groups, while no significant differences were observed among the groups regarding Upslope and MaxSI. There was a negative correlation between glycated hemoglobin and the magnitude of strains (longitudinal, r = − 0.399; radial, r = − 0.362; circumferential, r = − 0.389) (all P < 0.05), and a positive correlation with TTM (r = 0.485, P < 0.001). Regression analyses that included both pretransplant T2DM and perfusion indices revealed that pretransplant T2DM, rather than perfusion indices, was an independent determinant of LV strain (β = longitudinal, − 0.508; radial, − 0.370; circumferential, − 0.371) (all P < 0.05).ConclusionIn heart transplant recipients, pretransplant T2DM has a detrimental effect on subclinical left ventricular systolic function and could potentially impact myocardial microcirculation following HT.

A Computational Framework for the Administration of 5-Aminovulinic Acid Before Glioblastoma Surgery.

5-Aminolevulinic Acid (5-ALA) is the only fluorophore approved by the FDA as an intraoperative optical imaging agent for fluorescence-guided surgery in patients with glioblastoma. The dosing regimen is based on rodent tests where a maximum signal occurs around 6h after drug administration. Here, we construct a computational framework to simulate the transport of 5-ALA through the stomach, blood, and brain, and the subsequent conversion to the fluorescent agent protoporphyrin IX at the tumor site. The framework combines compartmental models with spatially-resolved partial differential equations, enabling one to address questions regarding quantity and timing of 5-ALA administration before surgery. Numerical tests in two spatial dimensions indicate that, for tumors exceeding the detection threshold, the time to peak fluorescent concentration is 2-7h, broadly consistent with the current surgical guidelines. Moreover, the framework enables one to examine the specific effects of tumor size and location on the required dose and timing of 5-ALA administration before glioblastoma surgery.

Ag/AgCl‐Like Photogating of a COF‐on‐MOF Heterojunction in Organic Photoelectrochemical Transistor

AbstractThe pursuit of high on‐to‐off ratio (IOn/IOff), as one of the important performances for organic electrochemical transistor (OECT) has been ongoing, but to date, limited solutions are available. The interaction between light and matter has been demonstrated as a rich source for advanced electronic applications. However, its potential in IOn/IOff modulation has not been fully explored. Herein, the challenge is addressed through the unique light‐material interplay, which is represented by organic photoelectrochemical transistor (OPECT) gated by photosensitive COF‐LZU1 on mixed‐ligand MOF (COF‐on‐MOF) upon appropriate exposure illumination. Notably, the interplay between light and COF‐on‐MOF can adjust the device physics, optimizing the IOn/IOff to its maximum and enhancing signal transduction. Toward bio‐application, via exonuclease‐assisted cyclic cleavage amplification and hybridization chain reaction, such a device is validated for highly sensitive detection capabilities for human T‐cell lymphotropic virus type II (HTLV‐II) DNA down to 0.003 fM. This study features the possibility of Ag/AgCl‐like photogating of organic transistors via light‐matter interplay.

Experimental investigation into grain size effect on failure behavior and nonlinear time-varying acoustic emission series of granite

This study aims to investigate the grain size effect on mechanical properties and failure mechanisms of hard rock. Thus, a series of uniaxial compression experiments were carried out on granites with various grain sizes, and acoustic emission (AE) signals were synchronously collected in the experimental process for further nonlinear analysis. The results show that the four characteristic stresses of granite (σcc, σci, σcd, and σc) significantly decrease with the increase of grain size. The ratio of σcd/σc basically remains a constant of 0.8; the ratio of σci/σc increases gradually from 0.6 to about 0.7; the ratio of σcc/σc also shows a rising trend overall. With the increase of grain size, the AE energy level rises; the proportion of high-frequency tensile signals is reduced; the multi-fractal parameters Δα (non-uniformity of signals) and Δf (frequency difference between minimum and maximum signals) decrease. During the loading process, the time-varying value of Δα changes between 0.0 and 0.35, and that of Δf changes within the range from −0.2 to 0.5, showing a ‘rise-fall-rise-fall’ mode. The grain size effect on the influence of crack evolution is further discussed based on the nonlinear time-varying AE analysis. All these results reflect the mechanisms of grain size effect on granite. Large grain size weakens grain boundaries, facilitating shear slip along weak planes between crystal particles. In addition, the enhanced local stress concentration and initial defects in rock with large grain size could activate the crack coalescences of intra-crystalline cracks and weak boundary planes more easily in a relatively low-stress state.

A reflective textile metasurface for indoor signal coverage enhancement

The design of a reflective metasurface solely based on flexible textile material is presented for indoor signal coverage enhancement in a specific scenario – reflecting and reallocating radio frequency energy that would have leaked through a large window area. The proposed reflective metasurface design, reflective metasurface is composed of layers of square conductive textile patches and dielectric textile substrates. For the unit cell design, a reflective phase difference of up to 90° can be achieved via varying the size of the conductive patches. Meanwhile, a phase difference of up to 180° can be achieved by the alignment of conductive patches on different textile substrate layers, which is an ideal design philosophy for textile material. The proposed metasurface, consisting of 12 × 12 unit cells, can achieve a main reflected beam pointing in the direction of ±35° and a secondary reflected beam at ±63°. Simulated results show that the reflected beams remain relatively stable under the crumpling conditions often seen for curtains. A prototype of the design was fabricated and tested in a real-world scenario. A maximum signal strength enhancement of 15 dB and an average enhancement of 5.97 dB in a wide range of directions can be achieved with the reflective metasurface applied.

Impact of Single-Melamine Tautomerization on the Excitation of Molecular Vibrations in Inelastic Electron Tunneling Spectroscopy.

Vibrational quanta of melamine and its tautomer are analyzed at the single-molecule level on Cu(100) with inelastic electron tunneling spectroscopy. The on-surface tautomerization gives rise to markedly different low-energy vibrational spectra of the isomers, as evidenced by a shift in mode energies and a variation in inelastic cross sections. Spatially resolved spectroscopy reveals the maximum signal strength on an orbital nodal plane, excluding resonant inelastic tunneling as the mechanism underlying the quantum excitations. Decreasing the probe-molecule separation down to the formation of a chemical bond between the melamine amino group and the Cu apex atom of the tip leads to a quenched vibrational spectrum with different excitation energies. Density functional and electron transport calculations reproduce the experimental findings and show that the shift in the quantum energies applies to internal molecular bending modes. The simulations moreover suggest that the bond formation represents an efficient manner of tautomerizing the molecule.

Iterative interference cancel in a channel and estimation of its parameters for the OFDM-systems

In mobile reception, the reliability of orthogonal frequency division multiplexing (OFDM) is limited due to time-varying channel characteristics. This causes inter-channel interference (ICI) and increases the errors in tracking data transmitted over the channel. In this work, ICIs are simulated based on the study of the amplitudes’ derivatives of the signals in the channel. This made it possible to design a relatively simple receiver circuit that iteratively canceles the ICI. The structure of the proposed device noise reduction is aimed at ensuring maximum signal/(noise+ICI) at the input of the detector. A new method for estimating channel parameters is also proposed and it is shown that it provides reliable mobile reception in important practical situations that occur during the organization of terrestrial digital broadcasting DVB-T2. A large number of model experiments for a receiver with one or two antennas show that a small number of successive iterations of ICI suppression and proposed channel parameter estimation provide reliable reception at vehicle speeds above 100 km/h.

Discharge and ignition mechanism of high-entropy alloy induced by crack propagation under quasi-static compressive load

In order to reveal the discharge and ignition mechanism of high-entropy alloy under quasi-static compression load, the stress, potential and ignition evolution process of high-entropy alloy with prefabricated cracks were tested. The atomic structure and dislocation evolution of high-entropy alloy during crack propagation and compression were determined by molecular dynamics simulation, and the discharge mechanism of crack tip was analyzed at the micro level. Based on the calculation of Gibbs free energy, the products in the ignition reaction process were predicted. The results of mechanical/thermal/electrical characteristics induced by compressive load show that the discharge usually occurs near the ignition moment of specimen fracture, and the maximum potential signal can reach 34.2 V. The formation of crack group, crack propagation, local stress concentration, charge accumulation and release at the crack tip jointly induce the generation of discharge signals. With the propagation of cracks, a large number of stacking faults appear and a diamond-shaped failure zone is formed. The increase of disordered atoms leads to fracture. During the compression process, a large number of dislocations induce the separation of charges, which aggravates the discharge at the crack tip. In the Hf-Zr-Ti-Ta-Nb-Cu high-entropy alloy system, the reaction product Ta2O5 is preferentially generated, while in the Ti–Zr-Hf-Cu system, Ti2O3 is preferentially generated. The tip discharge and chemical bond fracture during crack propagation induce ignition, and the chemical bond recombines with energy release.

Relationship among EPR oxidative stability and spectrophotometric parameters connected to antioxidant activity in beer samples

A relationship between EPR and spectrophotometric parameters related to beer staling and antioxidant activity, was identified. AUC (area under the curve), intensity at 150 min (T150), radical scavenging activity (RSA), total phenolic compounds (TPC), hydroxyl radical scavenging capacity (HRSC) and one parameter linked to staling degree of beers (thiobarbituric index, TBI) were related. Temperature was modified to find the proper working conditions for EPR spin-trapping experiments and it was found that it affected the kinetic of PBN adduct evolution. For the samples reaching a maximum intensity signal, the higher the heating temperature, the shorter the time interval needed to reach it. No linear relationship was detected among parameters obtained with EPR spin trapping experiments and RSA, TPC, TPI, and HRSC when correlating one parameter with another. On the contrary, a good linear relationship was found among AUC or T150 and a combination of RSA, TPC, TPI, and HRSC (R2 = 0.9562 and 0.9694, respectively). The goodness of fit increased to R2 = 1 when a combination of AUC and T150 was related to a combination of RSA, TPC, and TPI, and HRSC.

Thermal stability of the electron spin resonance signal of modern continental barite

The electron spin resonance (ESR) method has been successfully applied to dating hydrothermal barite; however, there have been few studies of modern continental barite, such as that generated by fault movement or in sedimentary deposits. To better understand the geological processes involved in the formation of continental barite, its thermal characteristics and age firstly need to be defined. In this study, one fault barite sample and two sedimentary barite samples were obtained from continental sites in China for ESR signal thermal stability experiments. Microwave-power experiments indicate that 0.5 mW produces the maximum ESR signal intensity and the highest signal-to-noise ratio. Stepwise-heating results reveal that ESR signal intensities remain stable below 100 °C then show an increasing trend that peaks at ∼180 °C, following which they decrease rapidly between 180 and 320 °C and disappear at ∼380 °C. Isothermal heating results show that ESR signal intensities remain stable within a temperature range of 100–200 °C but show a decreasing trend for temperatures of 240–320 °C. These results indicate that the thermal decay of the ESR signal intensity for the three studied continental barites follows second-order decay kinetics. The thermal lifetimes calculated for the three samples are 6.3 × 108, 7.5 × 107, and 8.7 × 106 a, respectively. Thus, barite ESR dating can be used to date related geological events since early Pleistocene.

Sodium triple quantum MR signal extraction using a single-pulse sequence with single quantum time efficiency.

Sodium triple quantum (TQ) signal has been shown to be a valuable biomarker for cell viability. Despite its clinical potential, application of Sodium TQ signal is hindered by complex pulse sequences with long scan times. This study proposes a method to approximate the TQ signal using a single excitation pulse without phase cycling. The proposed method is based on a single excitation pulse and a comparison of the free induction decay (FID) with the integral of the FID combined with a shifting reconstruction window. The TQ signal is calculated from this FID only. As a proof of concept, the method was also combined with a multi-echo UTE imaging sequence on a 9.4 T preclinical MRI scanner for the possibility of fast TQ MRI. The extracted Sodium TQ signals of single-pulse and spin echo FIDs were in close agreement with theory and TQ measurement by traditional three-pulse sequence (TQ time proportional phase increment [TQTPPI)]. For 2%, 4%, and 6% agar samples, the absolute deviations of the maximum TQ signals between SE and theoretical (time proportional phase increment TQTPPI) TQ signals were less than 1.2% (2.4%), and relative deviations were less than 4.6% (6.8%). The impact of multi-compartment systems and noise on the accuracy of the TQ signal was small for simulated data. The systematic error was <3.4% for a single quantum (SQ) SNR of 5 and at maximum <2.5% for a multi-compartment system. The method also showed the potential of fast in vivo SQ and TQ imaging. Simultaneous SQ and TQ MRI using only a single-pulse sequence and SQ time efficiency has been demonstrated. This may leverage the full potential of the Sodium TQ signal in clinical applications.

Broadband noise signal source positioning method using flat linear antenna in Fresnel zone near ‘water-air’ boundary

Ways of broadband noise signal reception using flat linear extended antenna in Fresnel zone near surface boundary enabling to determine direction, range to the source and depth of its immersion simultaneously with detection are considered. The effect emerging when signal source and receiver are located near «water-air» interface and two beams arrive from source to receiver (direct beam and beam reflected from the surface) is investigated. The supervisor of compensation of delays of signal arriving to M receivers of the antenna focuses receiving system in the point of the expected positioning of the source. In case of dual-beam signal it may result in emergence of two range focusing points in space. It is shown that focal spots may have high range spreading or practically merge depending on the relative positioning of the source and the receiver. Method of source submergence depth analysis at known ranges to two focal spots is offered for the first case. Method of consolidated signal processing which includes additional scanning of time delays in possible delays of signal between beams with uniform delay for all antenna elements is offered for the case when focal spots are not separated. It is demonstrated that when obtaining maximum signal power entered delay will be functionally connected with depth of immersion of the source that enables carrying out joint determining of direction, ranges and depths of submergence of the source in offered method. Moreover, it is demonstrated that method of consolidated processing enables to increase power of arriving signal up to 50 % in the point of maximum response as compared to conventional signal reception algorithm using flat linear antenna in Fresnel zone.

Role of magnetic resonance imaging (MRI) in liver iron quantification in thalassemic (thalassemia major) patients

BackgroundIron overload is a major problem in beta thalassemia patients due to repeated blood transfusions. The liver is the first organ to be loaded with iron. An accurate assessment of iron overload is necessary for managing iron chelation therapy in such patients. Iron quantification by MRI scores over liver biopsy due to its non-invasive nature.MethodsFifty-one patients with thalassemia major were subjected to 3.0-T MRI. Multiecho T2* sequence was used to cover the entire liver. Region of interest (ROI) was placed in three areas with maximum signal change, and an average T2* value was obtained. Similarly, a single ROI was placed at the mid-interventricular septum in the heart, and T2* value was obtained. T2* values so obtained were converted to iron concentration with the help of a T2* iron concentration calculator. The liver iron values were correlated with serum ferritin value.ResultsThere was a significant negative correlation between liver iron concentration (LIC) and T2* value of the liver (r = − 0.895, p < 0.01) and between cardiac iron concentration (CIC) and T2* value of the heart (r = − 0.959, p < 0.01). There was a slight positive correlation between LIC and serum ferritin (r = 0.642, p < 0.01) and no correlation between CIC and serum ferritin (r = − 0.137, p = 0.354).ConclusionsMRI is a useful tool to titrate the doses of chelating agents as it is accurate and non-invasive, does not involve radiation hazards and hence can be repeated as and when needed. Simultaneous assessment of cardiac iron overload is an added advantage of MRI.

Optimal position and dimensions of embedded normal piezoelectric transducers, higher order plate models and experimental approach

This study investigates the different optimal parameters of piezoelectric transducers polarized in the thickness direction. The studied parameters are regarding sensor and actuator embedding position in the thickness, sensor ratio and sensor dimensions. It involves a parametric study using MUL2 FE numerical tool, via coupled electro-mechanical two-dimensional models. The performance of the corresponding configuration was judged by the maximum output electric potential signal induced in the sensor due to the propagated Lamb Wave induced by the actuator. An experimental campaign was carried out on glass fiber/ polyester plates embedded with piezoelectric transducers to validate the different results.

Biventricular Impairment and Ventricular Interdependence in Patients With Alcoholic Cardiomyopathy: Insights Through Cardiac Magnetic Resonance Imaging.

Alcoholic cardiomyopathy (ACM) can lead to progressive cardiac dysfunction and heart failure, but little is known about biventricular impairment and ventricular interdependence (VI) in ACM patients. To use cardiac MRI to investigate biventricular impairment and VI in ACM patients. Retrospective. Forty-one male patients with ACM and 45 sex- and age-matched controls. 3.0 T/balanced steady-state free precession sequence, inversion recovery prepared echo-planar imaging sequence and phase-sensitive inversion recovery sequence. Biventricular structure, function, and global strain (encompassing peak strain [PS], peak systolic, and diastolic strain rate), PS of interventricular septal (IVS), microvascular perfusion (including upslope and time to maximum signal intensity [TTM]), late gadolinium enhancement (LGE), and baseline characteristics were compared between the controls and ACM patients. Student's t-test, Mann-Whitney U test, Pearson's correlation, and multivariable linear regression models with a stepwise selection procedure. A two-tailed P value <0.05 was deemed as statistically significant. Compared to control subjects, ACM patients showed significantly biventricular adverse remodeling, reduced left ventricle (LV) global upslope and prolonged global TTM, and the presence of LGE. ACM patients were characterized by a significant decline in all global strain within the LV, right ventricle (RV), and IVS compared with the controls. RV global PS was significantly associated with LV global PS and IVS PS in radial, circumferential, and longitudinal directions. Multivariable analyses demonstrated the longitudinal PS of IVS was significantly correlated with RV global radial PS (β = 0.614) and circumferential PS (β = 0.545). Additionally, RV global longitudinal PS (GLPS) was significantly associated with radial PS of IVS (β = -0.631) and LV GLPS (β = 1.096). ACM patients exhibited biventricular adverse structural alterations and impaired systolic and diastolic function. This cohort also showed reduced LV microvascular perfusion, the presence of LGE, and unfavorable VI. 3 TECHNICAL EFFICACY: Stage 3.

Real-Time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels.

The lymphatic vasculature, now often referred to as "the third circulation," is located in many vital organ systems. A principal mechanical function of the lymphatic vasculature is to return fluid from extracellular spaces back to the central venous ducts. Lymph transport is mediated by spontaneous rhythmic contractions of lymph vessels (LVs). LV contractions are largely regulated by the cyclic rise and fall of cytosolic, free calcium ([Ca2+]i). This paper presents a method to concurrently calculate changes in absolute concentrations of [Ca2+]i and vessel contractility/rhythmicity in real time in isolated, pressurized LVs. Using isolated rat mesenteric LVs, we studied changes in [Ca2+]i and contractility/rhythmicity in response to drug addition. Isolated LVs were loaded with the ratiometric Ca2+-sensing indicator Fura-2AM, and video microscopy coupled with edge-detection software was used to capture [Ca2+]iand diameter measurements continuously in real time. The Fura-2AM signal from each LV was calibrated to the minimum and maximum signal for each vessel and used to calculate absolute [Ca2+]i. Diameter measurements were used to calculate contractile parameters (amplitude, end diastolic diameter, end systolic diameter, calculated flow) and rhythmicity (frequency, contraction time, relaxation time) and correlated with absolute [Ca2+]i measurements.

Lipophilic Group-Modified Manganese(II)-Based Contrast Agents for Vascular and Hepatobiliary Magnetic Resonance Imaging.

Effective vascular and hepatic enhancement and better safety are the key drivers for exploring gadolinium-free hepatobiliary contrast agents. Herein, a facile strategy proposes that the high lipophilicity may be favorable to enhancing sequentially vascular and hepatobiliary signal intensity based on the structure-activity relationship that both hepatic uptake and interaction with serum albumins partly depend on lipophilicity. Therefore, 11 newly synthesized derivatives of manganese o-phenylenediamine-N,N,N',N'-tetraacetic acid (MnLs) were evaluated as vascular and hepatobiliary agents. The maximum signal intensities of the heart, liver, and kidneys were strongly correlated with log P, a key indicator of lipophilicity. The most lipophilic agent, MnL6, showed favorable relaxivity when binding with serum albumin, good vascular enhancement, rapid excretion, and reliable hepatobiliary phases comparable to a classic hepatobiliary agent, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for in vivo liver tumor imaging. Inhibition experiments confirmed the hepatic targeting of MnL6 is mediated by organic anion-transporting polypeptides.

Access authentication via blockchain in space information network.

Space Information Network (SIN) has significant benefits of providing communication anywhere at any time. This feature offers an innovative way for conventional wireless customers to access enhanced internet services by using SIN. However, SIN's characteristics, such as naked links and maximum signal latency, make it difficult to design efficient security and routing protocols, etc. Similarly, existing SIN authentication techniques can't satisfy all of the essentials for secure communication, such as privacy leaks or rising authentication latency. The article aims to develop a novel blockchain-based access authentication mechanism for SIN. The proposed scheme uses a blockchain application, which has offered anonymity to mobile users while considering the satellites' limited processing capacity. The proposed scheme uses a blockchain application, which offers anonymity to mobile users while considering the satellites' limited processing capacity. The SIN gains the likelihood of far greater computational capacity devices as technology evolves. Since authenticating in SIN, the technique comprises three entities: low Earth orbit, mobile user, and network control centre. The proposed mutual authentication mechanism avoids the requirement of a ground station, resulting in less latency and overhead during mobile user authentication. Finally, the new blockchain-based authentication approach is being evaluated with AVISPA, a formal security tool. The simulation and performance study results illustrate that the proposed technique delivers efficient security characteristics such as low authentication latency, minimal signal overhead and less computational cost with group authentication.

Climate change signals of extreme precipitation return levels for Germany in a transient convection‐permitting simulation ensemble

AbstractThe increase in extreme precipitation with global warming (GW) and associated uncertainties are major challenges for climate adaptation. To project future extreme precipitation on different time and intensity scales (return periods [RPs] from 1 to 100 a and durations from 1 h to 3 days), we use a novel convection‐permitting (CP), multi‐global climate model ensemble of COSMO‐CLM regional simulations with a transient projection time (1971–2100) over Germany. We find an added value of the CP scale (2.8 km) with respect to the representation of hourly extreme precipitation intensities compared to the coarser scale with parametrized deep convection (7 km). In general, the return levels (RLs) calculated from the CP simulations are in better agreement with those of the conventional observation‐based risk products for the region for short event durations than for longer durations, where an overestimation by the simulation‐based results was found. A maximum climate change signal of 6–8.5% increase per degree of GW is projected within the CP ensemble, with the largest changes expected for short durations and long RPs. Analysis of the uncertainty in the climate change signal shows a substantial residual standard deviation of a linear approximation, highlighting the need for transient data sets instead of time‐slice experiments to increase confidence in the estimates. Furthermore, the ensemble spread is found to be smallest for intensities of short duration, where changes are expected to be based mainly on thermodynamic contributions. The ensemble spread is larger for long, multi‐day durations, where a stronger dependence on the dynamical component is ascribed. In addition, an increase in spatial variance of the RLs with GW implies a more variable future climate and points to an increasing importance of accounting for uncertainties.

Purines recognition and quantitative analysis by surface-enhanced Raman spectroscopy

The common quantification methods of purines, including high-performance liquid chromatography, micellar electrokinetic chromatography, reverse phase ion pair chromatography, and capillary zone electrophoresis, have been used for the analysis of purines. These conventional techniques are limited by long operation times, large sample volumes, requirements for pretreatment and separation processes, or sophisticated, bulky and expensive equipment. Here, we have developed a simple method to prepare a probe for the quantitative analysis of purines using the surface-enhanced Raman scattering (SERS) method. The SERS probe is a rough Ag wire obtained with simple electrochemical treatment, which is optimized to reach the maximum SERS signal enhancement. The Raman enhancement factor (EF) of Ag wire after roughening can reach ∼106. Under optimized conditions, the rough Ag wire is capable of recognizing four purine bases (namely, guanine, adenine, hypoxanthine, and xanthine) in the range of 10−5 to 10−1 mg/mL with a linear relationship between SERS intensity of signature peak and purine concentration. The recovery rate of each purine base is higher than 80% in the mixture of four purines. The overall method was successfully applied to the monitoring of the level of purines in marketplace beer beverages. The novel wire-based SERS sensor used with portable Raman spectroscopy is prospective in diet safety and personalized point-of-care medical detection.