Controlled Release Matrices Research Articles

Gelucire: A wonderful excipient for improving the physicochemical characteristics of drugs and controlled release matrices

The Gelucire family of vehicles is made from a combination of PEG esters of fatty acids and mono-, di-, and triglycerides. These come in a variety of qualities based on their melting point range (33–65 °C) and HLB. They can be used in a wide range of topical and oral preparations. Enhancement of solubility and bioavailability, sustained drug release, taste masking, and protection of active pharmaceutical ingredients (API) against oxygen, light, and humidity are some of the uses for oral formulation. Topical formulations can be used as thickeners, stabilize creams, lotions, and gels, and improve drug absorption via the skin. Fast-release formulations are often prepared using gelucire that contains solely PEG esters. Sustained release formulations are prepared using gelucire that contains either glycerides alone or a combination of glycerides and PEG esters. Their low density and great hydrophobicity make them suitable carriers for the construction of sustained release medication delivery systems.

Removal of Cr(VI) in groundwater by controlled release materials based on nano zero-valent iron and activated carbon

ABSTRACT The use of nano zero-valent iron (nZVI) materials for groundwater Cr(VI) removal encountered challenges of agglomeration and low removal efficiency. Controlled release materials (CRMs) gradually release reactive substances or reducing agents, prolonging the release time. Here, we report the development of novel CRMs containing nZVI and activated carbon (AC). During the removal of Cr(VI) in groundwater, the prepared AC/nZVI/CRMs slowly released nZVI, greatly reducing the agglomeration of nZVI. The adsorption capacity of AC-containing CRMs prolonged the residence time of Cr(VI) in water, improving the removal efficiency of the AC/nZVI/CRMs. We found that lower pH enhanced the removal of Cr(VI) by the AC/nZVI/CRMs from simulated groundwater. The removal efficiency of the AC/nZVI/CRMs was also affected by the simulated groundwater environment and decreased with the increasing flow rate of the groundwater. Our results suggested that these novel nZVI-containing CRMs minimized agglomeration during the removal of Cr(VI) by nZVI, exhibited enhanced efficiency under acidic conditions, and facilitated Cr(VI) removal from similar groundwater environments.

The remediation performance and mechanism for tetracycline from groundwater using controlled release materials containing mesoporous MnOx with different morphology

Aiming at the effective remediation of antibiotic contaminants in groundwater, in-situ chemical oxidation (ISCO), using controlled release materials (CRMs) as an oxidant deliverer, has emerged as a promising technique due to their long-term effective pollutant removal performance. This study used different microstructures of mesoporous manganese oxide (MnOx) and sodium persulfate as active components to fabricate CRMs. Following that, a comparative study of tetracycline (TC) degradation and the formation of reactive oxygen species (ROS) by mesoporous MnOx powder and CRMs were conducted. The ROS formed during peroxodisulfate (PDS) activation by powder catalysts and CRMs differed, but MnOx powder catalysts and CRMs both had good reaction stoichiometric efficiency (RSE) for PDS, thus completely mineralizing TC. In PDS activation by mesoporous MnOx powder, oxygen vacancies (OVs) caused by defects in the catalysts contributed to the generation of singlet oxygen (1O2). The 1O2 and free radicals (·SO4− and ·OH) both worked as major ROS participating in TC degradation. Concerning the release of CRMs in static groundwater, the immobilization of catalysts inside CRMs made it difficult to release 1O2 in the solution, thus slowing the degradation of TC by CRMs containing MnOx(1) in static groundwater. In the TC remediation in dynamic groundwater, the water flowing slowly passed through the CRM layer, and TC molecules were trapped. Therefore, 1O2 degraded the trapped TC in the CRM layer in dynamic groundwater. Compared to TC, the toxicity of most intermediates during the TC degradation by CRMs has decreased in static and dynamic groundwater.

Immobilization of multilayer sodium alginate/polysaccharide antibacterial material composite beads as glufosinate controlled release matrices

To find a new way to slow down the release of glufosinate (GA) pesticide and to solve the susceptibility to decomposition by soil microorganisms, a series of novel antibacterial polysaccharide-based sustained release beads (PSRB) were prepared. The PSRB was prepared by immobilization of GA loaded polysaccharide-based chitosan quaternary ammonium salt (PS-HACC) microcapsules in the core and layers of the multilayer sodium alginate beads. The PSRB was characterized by FI-IR spectroscopy, XRD, SEM, and BET to reveal their composition and surface morphology. The optimal conditions of the slow release beads were as follows, the concentration of Ca2+, pH, temperature and the coating layer number was 0.1 mol/L, 7, 25 °Cand 3, respectively. The kinetic study showed that the slow release of PSRB was in accordance with the Higuchi kinetic model, and the FI-IR and XRD analyses revealed that the PS-HACC and GA were successfully cross-linked to the PSRB. BET showed that PSRB were greater than PSRB3 at surface area, pore volume and pore size. Inhibition circles experiments demonstrated that WPSRB3 has good antibacterial activity. The weed control in soybean with PSRB3 application is perfect and the weed control cycle is long. Therefore, this technology can provide a potential way to control GA release, improve utilization efficiency, reduce pesticide use and environmental pollution, and at the same time, provide a potential way to achieve ecological agriculture.

Release behavior of antifouling materials based on intercalated layered double hydroxides

Improving the utilization rate of environmentally friendly antifouling agents is highly important for reducing the economic costs of ship operations and protecting the marine environment. In this work, a new method for preparing a multistage controlled release material of an environmentally friendly antifouling agent, which first incorporates 2-(p-chlorophenyl)-3-cyano-4-bromo-5-trifluoromethyl pyrrole (Econea) into carboxyl-modified β-cyclodextrin (Econea@CMCD) followed by intercalation into Mg2Al layered double hydroxides (Mg2Al-Econea@CMCD-LDH), was reported. Powder X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) confirmed the incorporation of Econea@CMCD into the galleries of Mg2Al-LDH. Release tests conducted in 3.5 % NaCl solution demonstrated an initial burst release, followed by a slower release rate of Econea (12.3 µg/cm2·d) compared to that of the pristine Econea coating, indicating favorable controlled release behavior. Adhesion experiments using diatoms and mussels showed that Mg2Al-Econea@CMCD-LDH effectively inhibited the adhesion of typical fouling organisms. Hence, this study presents a practical approach for constructing a controlled release system that involves intercalating neutral and insoluble antifouling agents into LDH interlayers, effectively reducing the waste of antifouling agents and extending the service life of antifouling coatings.

A novel xanthan-chitosan based peroxydisulfate controlled-release material for in-situ sustained degradation of tetracycline: Performance, mechanism and application

In situ chemical oxidation (ISCO) is a promising technology to remove the organic pollutants from groundwater on site. In order to ensure the sustainable and long-term treatment performance, the oxidant controlled-release materials (CRMs) are required. In this study, a novel environmentally friendly and low-cost peroxydisulfate CRM (XG/CS-PDS) was synthesized via the mixing and mold method with xanthan, polyvinyl alcohol and chitosan as the binders for the first time. The XG/CS-PDS possessed significantly stable controlled-release properties under different pH and co-anions. 80% PDS in the CRMs could continuously and slowly release within 50 days. The simulation of PDS controlled-release process indicated that the process was controlled by the non-Fickian diffusion. Then the as-prepared CRM was applied to remove tetracycline (TC) from synthesized groundwater with nanoscale zero-valent iron (nZVI) as the PDS activator. The XG/CS-PDS/nZVI system could achieve 100% removal efficiency at different initial TC concentrations (5‐40 mg/L) and had a good anti-interference ability to pH, inorganic co-anions and humic acid. The quenching experiments and electron spin resonance (ESR) revealed that SO4•-, •OH and 1O2 were the main reactive oxygen species (ROS) for the degradation of TC, while SO4•- played the more dominant role. The intermediates and possible degradation pathway of TC were proposed and the toxicity of TC and its intermediates were evaluated. This study provided a new conception for the design of controlled-release material and theoretical strategies for in-situ remediation of groundwater.

A novel paraffin-based N/P controlled-release material for biostimulation of phenol biodegradation in groundwater

To address the problem of the weak natural restoration ability of oligotrophic groundwater environments, a novel N/P controlled-release material (CRM) for biostimulation, prepared by an improved method, was developed. CRMs can encapsulate N and P (N/P) salts for sustained release in aquifers. Paraffin-based CRMs can be used to control N/P release rates by adjusting the particle size of CRMs and the mass ratio of the paraffin. The developed CRMs had a more remarkable adaptability to groundwater than other materials. Specifically, 0.4-cm CRMs released N/P stably and efficiently over a wide temperature range (7–25 ℃), and the release properties of various CRMs were not affected by pH. The release of N/P followed Fickian diffusion, and a dissolution-diffusion model was established to elucidate the mechanism of the controlled release. In contrast to bare N/P, CRMs obviously enhanced the biodegradation rate of phenol and prolonged the effectiveness of supplying N/P. The degradation rate of phenol in the CRM system increased by 20.8 %. The different supply modes of N/P, CRMs and bare N/P, resulted in differences in salinity. Metagenomic analysis showed that this difference changed the proportion of various phenol-degrading genera and thus changed the abundance of genes associated with the phenol degradation pathway.

Whey Protein Isolate as a Substrate to Design Calendula officinalis Flower Extract Controlled-Release Materials.

The use of natural active substances and the development of new formulations are promising directions in the cosmetic and pharmacy industries. The primary purpose of this research was the production of microparticles based on whey protein isolate (WPI) and calcium alginate (ALG) containing Calendula officinalis flower extract and their incorporation into films composed of gelatin, WPI, and glycerol. Both swollen and dry microparticles were studied by optical microscopy and their sizes were measured. Water absorption by the microparticles, their loading capacity, and the release profile of flower extract were also characterized. The films were analyzed by mechanical tests (Young's modulus, tensile strength, elongation at break), swelling capacity, contact angle, and moisture content measurements. The presented data showed that the active ingredient was successfully enclosed in spherical microparticles and completely released after 75 min of incubation at 37 °C. The incorporation of the microparticles into polymer films caused a decrease in stiffness and tensile strength, simultaneously increasing the ductility of the samples. Moreover, the films containing microparticles displayed higher swelling ability and moisture content compared to those without them. Hence, the materials prepared in this study with Calendula officinalis flower extract encapsulated into polymeric microspheres can be a starting point for the development of new products intended for skin application; advantages include protection of the extract against external factors and a controlled release profile.

Comparative study of reactive oxygen species and tetracycline degradation pathways in catalytic peroxodisulfate activation by asymmetric mesoporous TiO2 and the corresponding controlled-release materials

The removal of trace amounts of antibiotics from water environments while simultaneously avoiding potential environmental hazards during the treatment is still a challenge. In this work, green, harmless, and novel asymmetric mesoporous TiO2 (A-mTiO2) was combined with peroxodisulfate (PDS) as active components in a controlled-release material (CRM) system for the degradation of tetracycline (TC) in the dark. The formation of reactive oxygen species (ROS) and the degradation pathways of TC during catalytic PDS activation by A-mTiO2 powder catalysts and the CRMs were thoroughly studied. Due to its asymmetric mesoporous structure, there were abundant Ti3+/Ti4+ couples and oxygen vacancies in A-mTiO2, resulting in excellent activity in the activation of PDS for TC degradation, with a mineralization rate of 78.6%. In CRMs, ROS could first form during PDS activation by A-mTiO2 and subsequently dissolve from the CRMs to degrade TC in groundwater. Due to the excellent performance and good stability of A-mTiO2, the resulting constructed CRMs could effectively degrade TC in simulated groundwater over a long period (more than 20 days). From electron paramagnetic resonance analysis and TC degradation experiments, it was interesting to find that the ROS formed during PDS activation by A-mTiO2 powder catalysts and CRMs were different, but the degradation pathways for TC were indeed similar in the two systems. In PDS activation by A-mTiO2, besides the free hydroxyl radical (·OH), singlet oxygen (1O2) worked as a major ROS participating in TC degradation. For CRMs, the immobilization of A-mTiO2 inside CRMs made it difficult to capture superoxide radicals (·O2−), and continuously generate 1O2. In addition, the formation of sulfate radicals (·SO4−), and ·OH during the release process of CRMs was consistent with PDS activation by the A-mTiO2 powder catalyst. The eco-friendly CRMs had a promising potential for practical application in the remediation of organic pollutants from groundwater.

Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In Vivo Results.

In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression method, and their hardness, diameter, thickness, friability, weight variation, content uniformity, and in vitro dissolution tests were assessed to determine 24-h drug release rates. The matrices with Ethocel 10 FP at a 10:4 ratio exhibited pseudo-zero-order kinetics (n-value of 0.986), while the dissolution data of the test matrices and reference tablets did not match. The new test-optimized matrices were also tested in rabbits, and their pharmacokinetic parameters were investigated: half-life (11.78 ± 0.018 h), Tmax (2.105 ± 1.131 h), Cmax (205.98 ± 0.321 μg/mL), AUCo (5931.10 ± 1.232 μg·h/mL), AUCo-inf (7348.46 ± 0.234 μg·h/mL), MRTo-48h (17.34 ± 0.184 h), and Cl (0.002 ± 0.134 mL/min). A correlation value of 0.985 between the in vitro and in vivo results observed for the test-optimized matrices was observed, indicating a level-A correlation between the percentage of the drug released in vitro and the percentage of the drug absorbed in vivo. The matrices might improve patient compliance with once-a-day dosing and therapeutic outcomes.

Development and evaluation of ciprofloxacin local controlled release materials based on molecularly imprinted polymers

The aim of this study was the molecular imprinting polymers (MIPs) assessment as a controlled release system of ciprofloxacin. The MIPs synthesis was performed by three different methods: emulsion, bulk, and co-precipitation. Lactic acid (LA) and methacrylic acid (MA) were used as functional monomers and ethylene glycol dimethacrylate as crosslinker. Also, nonimprinted polymers (NIPs) were synthesized. MIPs and NIPs were characterized by scanning electron microscopy, Fourier Transform Infrared Reflection, specific surface area, pore size, and release kinetics. Their efficiency against Staphylococcus aureus and Escherichia coli, and their cytotoxicity in dermal fibroblast cells were proven. Results show that MIPs are mesoporous materials with a pore size between 10 and 20 nm. A higher adsorption with the co-precipitation MIP with MA as a monomer was found. The release kinetics proved that a non-Fickian process occurred and that the co-precipitation MIP with LA presented the highest release rate (90.51 mg/L) in 8 h. The minimum inhibitory concentration was found between 0.031 and 0.016 mg/L for Staphylococcus aureus and between 0.004 and 0.031 mg/L for the Escherichia coli. No cytotoxicity in cellular cultures was found; also, cellular growth was favored. This study demonstrated that MIPs present promising properties for drug administration and their application in clinical practice.

Clay‐Loaded Starch‐Grafted Chitosan as Environmentally Controlled Release Material for Atrazine

Herein, controlled‐release material for atrazine (ATZ) herbicide was formulated using different ratios of kaoline (Kao) clay‐loaded starch (ST)‐grafted chitosan (CHT). The materials were characterized by FTIR, SEM and EDX. The ATZ‐release kinetics were studied using the zero‐order, first‐order and Korsmeyer–Peppas models. The percentage release of the active ATZ in the ST‐g‐CHT/Kao/ATZ, Kao/ATZ and bare ATZ were 9, 57 and 99 within 96 h, respectively. The Korsmeyer–Peppas model better described the release of active ATZ from the ST‐g‐CHT/Kao/ATZ system (R2 = 0.999), which delineates a non‐Fickian diffusion mechanism that the release was controlled by diffusion and dissolution.

Controlled-Release Materials for Remediation of Trichloroethylene Contamination in Groundwater

Groundwater contamination by trichloroethylene (TCE) presents a pressing environmental challenge with far-reaching consequences. Traditional remediation methods have shown limitations in effectively addressing TCE contamination. This study reviews the limitations of conventional remediation techniques and investigates the application of oxidant-based controlled-release materials, including encapsulated, loaded, and gel-based potassium permanganate since the year 2000. Additionally, it examines reductant controlled-release materials and electron donor-release materials such as tetrabutyl orthosilicate (TBOS) and polyhydroxybutyrate (PHB). The findings suggest that controlled-release materials offer a promising avenue for enhancing TCE degradation and promoting groundwater restoration. This study concludes by highlighting the future research directions and the potential of controlled-release materials in addressing TCE contamination challenges.

Influencing factors and controlled release kinetics of H2O2 from PVP-coated calcium peroxide NPs for groundwater remediation

Calcium peroxide nanoparticles (nCP) as a versatile and safe solid source of hydrogen peroxide (H2O2) receive substantial attention from researchers as a potential groundwater remediation reagent. In this study, we synthesized polyvinylpyrrolidone-coated calcium peroxide nanoparticles (PVP@nCP-PVP) to control the release rate of H2O2 and modulate pH fluctuation simultaneously. The PVP@nCP-PVP is fully characterized and the H2O2 releasing kinetics and mechanisms are investigated. The H2O2 release longevity of nCP increased with the concentration of controlled release material (CRM) encapsulated shell, while the production of H2O2 decreased inversely. The acidic condition is favorable for increasing H2O2 production by promoting the complex decomposition of nCP. The low temperature prolonged the longevity of nCP and suppressed the competitive side reaction for producing O2. The release of H2O2 is consistent with zero-order reaction kinetics and the release of O2 is consistent with first-order reaction kinetics. At last, different nCP composites were employed to construct a Fenton-like system for the degradation of nitrobenzene (NB). The degradation rate was raised from 57.6% by Fe (II)/nCP to 70.0% and 93.7% by Fe (II)/nCP-PVP and Fe (II)/PVP@nCP-PVP systems, respectively. These findings demonstrate that PVP@nCP-PVP has significant advantages in repairing organically contaminated groundwater. Environmental implicationGroundwater contamination poses a great threat to human health and ecosystems. In-situ chemical oxidation (ISCO) is a widely used groundwater remediation technology. Calcium peroxide (CP) as solid hydrogen peroxide showed merits of low cost and high stability, but the further application was limited due to its violent chemical reaction and short longivity in groundwater . In this work, we prepared polyvinylpyrrolidone-coated controlled release nCP (PVP@nCP-PVP) for modulating the release of H2O2. The investigation of H2O2 release kinetics under various environmental conditions enhances the understanding of the inherent relationship between the H2O2 release performance of controlled-release materials and contamination remediation. The feasibility using macromolecules preparing controlled-release oxidizing agents was confirmed, providing a novel solution for groundwater contamination remediation.

Starch-Grafted Sodium Alginate-Modified Clay Composites as Environmentally Controlled-Release Materials for NPK Fertilizer

In an effort to mitigate the harm caused by the irregular use of agrochemicals, a safer release system using biopolymers is promising due to their availability, biodegradability, and eco-friendliness. Herein, controlled-release materials for NPK fertilizer were formulated using clay-based graft biopolymer composites. The clay soil sample was collected and classified through Skempton’s laboratory tests for soils and used as filler in starch-grafted sodium alginate (ST-g-SAG) with different percentages of clay. The clay-based graft biopolymer composites were synthesized via a microwave-assisted method. The biopolymer composites were characterized by FTIR, SEM, and EDS. The materials were loaded with NPK fertilizer, and a leaching test was conducted via a conductometric method to ascertain their release capacities. Biodegradation studies and the effect of humidity on the release of the NPK fertilizer were studied. Results of classification studies of the clay show Ca-montmorillonite (Ca-MMT) type. The average percent graft yield of starch-grafted sodium alginate/Ca-MMT (ST-g-SAG/Ca-MMT) was 83%. The results from FTIR and EDS showed that OH-, COO-, and CONH2 were responsible for the absorption of water. The release profile of the active NPK in the biocomposites ranged from 1% to 103%. Biodegradation results also showed a significant breakdown in biopolymer structure and mass loss. The release of active NPK from the material was humidity-responsive.

In-vitro-digestion of a controlled release material: composite aerated gel containing egg white protein

This study aimed to produce a healthy jelly-like product containing protein and bioactive ingredient. Egg white protein (EWP: 0, 3, 6% w/w) and sucrose (0 and 7.5% w/w) were mixed at fixed levels of konjac glucomannan, κ-carrageenan, and sodium bicarbonate in an aerated gel preparation. An interaction between EWP and sucrose significantly yielded lower gas hold-up capacity exhibiting less and small pores confirmed by SEM images. The 3% EWP with 7.5% sucrose gel was selected to further study in vitro digestion by incorporating rice bran hydrolysate (RBH) and determining phenolic compound bioaccessibility. Syneresis and gas hold-up capacity of the gel was improved due to aeration and RBH (P<0.05). Aeration also enhanced the bioaccessibility of phenolic compounds and antioxidants after digestion. Therefore, this study introduces a new food matrix which is an aerated gel containing egg white protein that exhibits high bioaccessibility following pancreatic digestion.

Light‐Regulated Pro‐Angiogenic Engineered Living Materials

AbstractRegenerative medicine aims to restore damaged cells, tissues, and organs, for which growth factors are vital to stimulate regenerative cellular transformations. Major advances have been made in growth factor engineering and delivery like the development of robust peptidomimetics and controlled release matrices. However, their clinical applicability remains limited due to their poor stability in the body and need for careful regulation of their local concentration to avoid unwanted side‐effects. In this study, a strategy to overcome these limitations is explored using engineered living materials (ELMs), which contain live microorganisms that can be programmed with stimuli‐responsive functionalities. Specifically, the development of an ELM that releases a pro‐angiogenic protein in a light‐regulated manner is described. This is achieved by optogenetically engineering bacteria to synthesize and secrete a vascular endothelial growth factor peptidomimetic (QK) linked to a collagen‐binding domain. The bacteria are securely encapsulated in bilayer hydrogel constructs that support bacterial functionality but prevent their escape from the ELM. In situ control over the release profiles of the pro‐angiogenic protein using light is demonstrated. Finally, it is shown that the released protein is able to bind collagen and promote angiogenic network formation among vascular endothelial cells, indicating the regenerative potential of these ELMs.

Black Tea Extracts/Polyvinyl Alcohol Active Nanofibers Electrospun Mats with Sustained Release of Polyphenols for Food Packaging Applications

The efficiency in the capabilities to store and release antioxidants depends on the film morphology and its manufacturing process, as well as on the type and methodology used to obtain the polyphenol extracts. Here, hydroalcoholic extracts of black tea polyphenols (BT) were obtained and dropped onto different polyvinyl alcohol (PVA) aqueous solutions (water or BT aqueous extract with and without citric acid, CA) to obtain three unusual PVA electrospun mats containing polyphenol nanoparticles within their nanofibers. It was shown that the mat obtained through the nanoparticles precipitated in BT aqueous extract PVA solution presented the highest total polyphenol content and antioxidant activity, and that the addition of CA as an esterifier or PVA crosslinker interfered with the polyphenols. The release kinetics in different food simulants (hydrophilic, lipophilic and acidic) were fitted using Fick's diffusion law and Peppas' and Weibull's models, showing that polymer chain relaxation is the main mechanism in all food simulants except for the acidic, which presented an abrupt release by Fick's diffusion mechanism of about 60% before being controlled. This research provides a strategy for the development of promising controlled-release materials for active food packaging, mainly for hydrophilic and acidic food products.

Gelucire: A Flexible Formulation Excipients

The utility of lipid-based oral formulations has been familiar for many years. There are an enormous variety of polymeric materials used to modify the delivery platform along with enhancement of therapeutic efficacy. Gelucires are a family of lipid-based excipients comprising of glycerides and esters of polyethylene glycol, these two components conferring hydrophobic and hydrophilic properties to the vehicle. Gelucire is used to enhance the drug’s physicochemical properties, as well as controlled release matrices. This review intends to give a critical overview of the published literature on the properties, chemical nature, advantages over other polymers, methods of characterization of gelucire containing formulations, applications and patents containing various grades of gelucires.

An S2- responsive nanocontainer for inhibiting microbial corrosion caused by sulfate-reducing bacteria

Controlled-release materials were ideal for improving drug utilization and reducing environmental pollution. In this study, Metronidazole @ Zeolite imidazole backbone − 8 nanocontainers (MNZ@ZIF-8) with high drug loading (59.8 mg/g) and S2 - specific response were prepared by co-precipitation method. Material characterization showed that MNZ was successfully loaded into ZIF-8 and that MNZ@ZIF-8 showed excellent S2- responsiveness in drug release experiments. The MNZ release rate increased significantly when the S2- concentration was greater than 0.5 mM, and the cumulative release of MNZ was even as high as 90.8% at the S2- concentration of 5 mM. The release kinetics of MNZ@ZIF-8 was consistent with the non-Fickian diffusion mechanism of the Korsmeyer-Peppas model. The bactericidal effect of MNZ@ZIF-8 was evaluated in sulfate-reducing bacteria (SRB) medium. The nanocontainer showed 100% antibacterial effect of SRB at a concentration of 300 μg mL−1. With the increase of nanocontainer concentration, the depth of corrosion pits on the surface of Q235 test pieces gradually decreased until disappeared (300 μg mL−1). This novel drug release system had various functions such as the simple synthesis process, antibacterial, and S2- specific response, which provided an idea for the development of drug release system with S2- as the response condition.