The major goal of this project is to use the Gas Chromatography–Mass Spectrometry (GC-MS) instrument to evaluate the fingerprints of illicit amphetamine. Samples of amphetamine were obtained from the Iraqi Narcotics Control Bureau. The fingerprints were examined before and after contamination with anesthetic powder. The results showed a clear difference between the spectrum of the pure fingerprint and the spectrum of the contaminated fingerprint with amphetamine. The highest peak of the drug sample was recorded at the time (6.80) minutes and Abundance 120000, and in contrast the appearance of the same peak in the fingerprint sample at the time (6.80) and Abundance 120000, and thus we find that the (GC-MS) device is sensitive for a small amount of drugs and can be used to detect it in the fingerprints.