Mansoa Alliacea Research Articles

Phytosynthesis of Silver Nanoparticles Using Mansoa alliacea (Lam.) A.H. Gentry (Bignoniaceae) Leaf Extract: Characterization and Their Biological Activities

Background. Mansoa alliacea is a native plant renowned for its medicinal properties in traditional healing in the Amazon Region. This plant is rich in polyphenols, flavonoids, anthocyanins, phenolic acids, tannins, ketones, triterpenes, as well as other bioactive compounds. Objectives. This study aims to develop an innovative, eco-friendly method for synthesizing silver nanoparticles using an aqueous extract of M. alliacea (Ma-AgNPs), enhancing the biological activities of AgNPs by leveraging the therapeutic potential of the plant’s bioactive compounds. Methods. Silver nanoparticles were synthesized using the aqueous extract of M. alliacea. The biological activities of Ma-AgNPs were assessed, including antibacterial, anti-inflammatory, antioxidant, antitumor, and anti-biofilm effects, along with evaluating their hemolytic activity. Results. Quantitative analysis revealed that Ma-AgNPs exhibit potent antibacterial activity against multidrug and non-multidrug-resistant bacteria, with MIC values ranging from 1.3 to 10.0 µg/mL. The Ma-AgNPs significantly reduced NO production by 86.9% at 4 µg/mL, indicating strong anti-inflammatory effects. They demonstrated robust antioxidant activity with an IC50 of 5.54 ± 1.48 µg/mL and minimal hemolytic activity, with no hemolysis observed up to 20 µg/mL and only 4.5% at 40 µg/mL. Their antitumor properties were notable, with IC50 values between 2.9 and 5.4 µg/mL across various cell lines, and they achieved over 50% biofilm inhibition at concentrations of 30–40 µg/mL. Conclusions. These findings underscore the potential of Ma-AgNPs for biomedical applications, particularly in developing new antimicrobial agents and bioactive coatings with reduced toxicity. This research highlights a sustainable approach that not only preserves but also amplifies the inherent biological activities of plant extracts, paving the way for innovative therapeutic solutions.

Adenocalymma alliaceum: An Overview

Adenocalymma alliaceum, commonly known as Garlic Vine or Lahsun bel, is an herbal shrub belonging to the family Bignoniaceae. It is native to northern Brazil and the Amazon rainforest, and certain species can also be found in the Chhattisgarh, Kerala states of India. This evergreen plant is highly valued for its ornamental qualities, with bright green leaves and tri-colored blooms that emit a distinct garlic-like fragrance. It grows up to 6-8 feet in height and is popular for landscaping purposes. The plant has various pharmacological activities that have been studied particularly in the management of diabetes mellitus. The bark, leaves, stems, and roots of Adenocalymma alliaceum contain a range of bioactive compounds that have been used to treat different diseases and disorders. Phytoconstituents such as diallyl disulfide and diallyl trisulfide are major chemical constituents of the plant, exhibiting antimicrobial, antihyperlipidemic, antifungal, and antimycotic activities. These properties make Adenocalymma alliaceum a promising source for the development of allopathic drugs. While the plant has traditional and cultural significance, it has also gained attention for its potential therapeutic properties. However, it is important to note that although it is used as a folk medicine in local communities, it is not extensively mentioned in published books or literature. In summary, Adenocalymma alliaceum is an intriguing natural resource with a rich cultural heritage and significant pharmacological potential. Further research and exploration of this plant may uncover additional therapeutic benefits and contribute to the development of novel drugs and treatments.

Exploring phytochemical tyrosinase inhibitors against melanoma skin cancer

Tyrosinase enzyme is the vital enzyme for synthesis of melanin pigment in melanocytes, though its dysregulated activity may cause over production of the pigment causing a skin cancer melanoma. Every year the cases of Melanoma is increasing by 1%. To control the hyperpigmentation, tyrosinase activity is to be inhibited in these cells. An attempt was made to find phytochemicals acting as an inhibitor for tyrosunase activity, thus reducing the synthesis of melanin pigment. Four plants were randomly selected namely Tacoma stans, Murraya paniculata, Galphimia gracilis and Mansoa alliacea for the work and the ethanol leaf extract were used to determine their inhibitory influence on freshly extracted and purified mushroom tyrosinase enzyme. Enzyme activity and product L-DOPA formation was estimated through UV-Visible Spectrophotometer and found to be 3.85U/min/ml and 0.018 mg/ml respectively. Murraya paniculata leaf extract shows the highest tyrosinase inhibitory action of 80.61% followed by Tacoma stans, Galphimia gracilis and Mansoa alliacea with74.71%, 72.95% and 71.99% respectively. Thus, the work conclude that the phytochemicals have the efficiency to control melanoma risk in human.. KEYWORDS :Mushroom Tyrosinase, Tyrosinase Inhibition, Melanoma, phytochemicals, Enzyme Activity

Physicochemical, microbiological, and sensory characterization of fresh cheese made with the Amazonian plants Mansoa alliacea and Eryngium foetidum in Pastaza, Ecuador

Physicochemical, microbiological, and sensory characterization of fresh cheese made with the Amazonian plants Mansoa alliacea and Eryngium foetidum in Pastaza, Ecuador

Effects of plants with presumed cardiotonic properties on the decreased contractility of isolated guinea pig atria caused by acetylcholine: Implications for their clinical usefulness

Heart failure (HF) has been related to a chronic imbalance between autonomic sympathetic and parasympathetic activation. In the Republic of Suriname (South America), this condition is regularly treated with plant-derived preparations with presumed cardiotonic properties, mostly by traditional healers. In this study, aqueous extracts from Annona muricata (leaf), Mansoa alliacea (leaf), Momordica charantia (leaf and stem), Gossypium barbadensis (leaf), Artocarpus altilis (leaf), Chrysophyllum cainito (leaf), Solanum melongena (unripe fruit), and Stachytarpheta jamaicensis (leaf and stem) were evaluated at serial dilutions for their capability to reverse the decreased contractility and for their effects on the decreased beating frequency of isolated guinea pig atria caused by EC50 acetylcholine (10-7 M). The effects of the plant extracts alone were also investigated. Experiments were for 3 min with 2 x 2-min intervals in Ringer-Locke buffer, 100% O2, and 30 °C. Results (g/sec and beats/min, means ± SDs; n ≥ 3) were expressed relative to those found with acetylcholine alone or buffer alone, and compared for statistically significant differences using one-way ANOVA (p < 0.05). None of the extracts reversed the decreased contractility and beating frequency of the atria caused by acetylcholine, but those from M. alliacea (0.001 mg/mL) and S. melongena (0.001 and 0.01 mg/mL) lowered these activities by more than 50%. The latter extracts exerted similar effects on their own. Thus, the preparations did not display useful cardiotonic properties against parasympathetic abnormalities in HF, and those from M. alliacea and S. melongena might even be cardiotoxic, warranting care when they are medicinally used.

Mansoa alliacea extract improves the growth performance and innate immune response of Arapaima gigas challenged with Aeromonas hydrophila and handling stress

ABSTRACT This study investigated the effects of dietary supplementation with Mansoa alliacea hydroalcoholic extracts on growth, blood and immune parameters of Arapaima gigas. Fish were fed for 30 days with diets enriched with 0, 4, 8, and 12 g kg-1 of M. alliacea hydroalcoholic extract and subjected to infection with Aeromonas hydrophila and handling stress. Fish fed with 8 g kg-1 of extract showed significant increase in final weight, specific growth rate and feed efficiency when compared to the other groups. Glucose, triglycerides, total proteins, and globulins increased significantly in fish fed with 8 g kg-1 of extract, whereas albumin decreased. The number of thrombocytes increased significantly with the dietary supplementation of 8 and 12 g kg-1 of extract. After the challenge with A. hydrophila and handling stress, fish fed with 8 g kg-1 of extract had significantly higher levels of glucose, globulins, and albumins, and fish fed with 8 and 12 g kg-1 of extract showed an increment of respiratory burst. Triglyceride levels dropped significantly in fish fed with 4, 8, and 12 g kg-1 of extract, whereas the number of neutrophils increased, and total thrombocytes, leukocytes and lymphocytes were higher in fish fed with 12 g kg-1 of extract. Dietary supplementation with M. alliacea extract at 8 g kg-1 was efficient in improving the growth and innate immunity of A. gigas, being potentially useful in fish farming to control the development of A. hydrophila infections.

Innovation of Tarragon Leaves, Curry Leaves and Garlic Vine into Local Herbs

This research focused on the innovation of Tarragon Leaves, Curry Leaves, and Garlic Vines for the purpose of utilizing some herbs that are mostly unnoticed in the Philippines but have culinary potentials. The process involved a careful selection of raw materials, drying, formulation, testing, packaging, and labeling. To come up with a fully organic and desirable flavor, formulations were tested and evaluated by 10 food experts to determine the product’s general acceptability in terms of its quality attributes. Paired T-test was used for data interpretation using SPSS. The results showed that the product yields 44 calories per 9 grams of serving with a very low moisture content of 6.24%, therefore proving that it is safe and not susceptible to microbial growth. The product can also last for a month at room temperature or longer under proper storage conditions. Sensory evaluation results revealed that based on general acceptability, TCG local herbs highly complements grilled chicken, beef, pork, and fish respectively with a mean rating of 8.0, 7.3, 7.2, and 6.2 wherein seasoned chicken was perceived as “like very much” and seasoned fish with “like slightly”. As careful steps were completed, this research made the innovation of organic and underutilized herbs possible.

In vivo and in vitro Hyperglycaemic Screening of Adenocalymma alliaceum Miers, A Promising Herb

Abstract: Background: Ajos sacha is a shrubby herb and has attracted scientists’ attention due to its antioxidative, antineoplastic, larvicidal, and antibacterial properties. Hence, Ajos sacha assessed in vitro and in vivo diabetes protective properties. Materials and Methods: The methodology started with the quantitative phytochemical estimation of ethanolic extract of Adenocalymma alliaceum (EEAA). Then, the extract was studied for cytotoxicity, glucose utilization, and GLUT-4 redistribution. In vivo study, comprising six groups of Wistar rats. Different parameters of diabetes, antioxidant properties, and lipid profile were performed. Results: Phytochemical screening demonstrated positive results in phenolic compounds, tannins, and flavonoids. The EEAA found a minimal level of toxicity, with no dosages tested causing 50% cell death. EEAA had shown GLUT-4 redistribution assay in a dose-dependent manner on cell line procedure. After NOAEL on acute toxicity, glucose level, metabolic symptoms, serum creatinine, serum urea, and lipid profile were normal under EEAA treatment, and bodyweight, high-density lipoprotein, and protein levels increased. The liver homogenate included more antioxidative enzymes such as glutathione, catalase, and superoxide dismutase. The histopathological analysis also reveals EEAA’s ability to protect pancreatic β-cell from damage. Conclusion: The current investigation found the blossoms of Ajos sacha to restore glucose abnormalities in the body. Keywords: β-cell, Alloxan monohydrate, Adenocalymma alliaceum, Glucose utilization, GLUT-4 redistribution, Diabetes Mellitus.

Antinociceptive effect of Mansoa alliacea polar extracts involves opioid receptors and nitric oxide in experimental nociception in mice.

To evaluate the antinociceptive effect and the possible mechanism of action of two polar extracts of Mansoa alliacea, a medicinal plant used in Perú, Brazil, and Mexico to treat rheumatic pain, we used the formalin and hot-plate tests in mice. We found that ethanolic (MA-EtOH) and aqueous (MA-AQ) extracts of M. alliacea induced antinociceptive effects in both nociceptive tests. The antinociceptive efficacy of the highest dosage (300mg/kg) of both extracts were also compared by using intraperitoneal and oral administration in the formalin test. Results showed that intraperitoneal injection of the two extracts produced better antinociceptive effects than that obtained by their oral administration. The mechanism of action involved in their antinociceptive activity was determined in the formalin test. Results showed that the presence of A784168 (TRPV1 antagonist) did not alter the antinociceptive effect induced by any of the M. alliacea extracts, whereas naltrexone (opioid antagonist) partially prevented the antinociceptive effect only of MA-EtOH in both phases of the formalin test. Furthermore, the effects of the extracts were diminished by L-NAME (inhibitor of nitric oxide synthase), but not by ODQ (inhibitor of the soluble guanylyl cyclase) or glibenclamide (blocker of K+ATP channels) in the neurogenic phase. However, the effect of MA-AQ was diminished by all the inhibitors in the inflammatory phase. These results support the use of M. alliacea as a potential natural product with efficacy for pain relief depending on the form of preparation and the route of administration by involving opioid receptors and the production of nitric oxide.

INSECTICIDAL AND ANTIFEEDANT ACTIVITIES OF AQUEOUS LEAF EXTRACTS AGAINST Epilachna vigintioctopunctata (COCCINELLIDAE: COLEOPTERA) UNDER LABORATORY CONDITIONS

The aqueous leaf extracts of different plant such as Cryptostegia grandiflora, Mansoa alliacea, Allamanda cathartica, Allamanda blanchetti and Xanthium strumarium and leaves of tree species such as Kigelia pinnata, Bauhinia Purpurea, Drypetes roxburghi, Conocarpus lancifolius and Polyalthia longifolia were studied against the grubs of Epilachna vigintioctopunctata at various concentrations under laboratory conditions. Among the plant tested, the maximum insecticidal activity and leaf area protection was noticed in Xanthium strumarium 93.33% and 91.62% at 7% concentration with an estimated LC50 of 1.11% followed by D. roxburghii (80.00% & 85.55%) and C. lancifolius (73.33% and 82.90%) respectively. The minimum per cent mortality was noticed in the treatment, Mansoa alliacea 7% with 40.00% and its antifeedancy were 50.97%. Results revealed that both the antifeedancy and mortality was increased with increasing in concentration of the plant extracts.

Efficacies of botanicals in the management of stem end rot disease of mango fruits

The phytopathogenic fungus Botryodiplodia theobromae Pat., causes stem end rot disease of mango fruits. Extracts from twenty angiospermic taxa were evaluated for their antifungal activity. The extracts were prepared in water, acetone, ethyl alcohol, petroleum ether, ethyl acetate and methanol. Among the selected plants, essential oil (EO) of Adenocalymma alliaceum was found to be effective in controlling the growth of Botryodiplodia theobromae. The minimum inhibitory concentration (MIC) of the EO was 100ppm. The oil was found to withstand a high inoculum density. Plant extracts of Allamanda cathartica, Lawsonia inermis, Prunus persica and Adenocalymma alliaceum in different solvents showed inhibitory effect on B. theobromae. However, Leaf extract of Adenocalymma alliaceum in all the solvents namely, water, acetone, ethyl alcohol, petroleum ether, ethyl acetate and methanol was found to have antifungal activity. An enhancement in the shelf life of mango fruits was recorded under in vivo trial after treatment with aqueous extract and essential oil of A. alliaceum. It is concluded that the aqueous extract and EO of A. alliaceum has a great potential in the management of B. theobromae damage to mango fruits.

Isolation, characterization, and biological evaluation of ethanolic extract of Ajos sacha in Streptozotocin-induced hyperglycemia in Wistar albino rats

Diabetes mellitus is a metabolic endocrine disorder due to insulin imbalances associated with microvascular and macrovascular complications. This research was aimed to explore the diabetes-healing effect of Adenocalymma alliaceum Miers phytochemicals. Before secondary screening on animals, phytochemical constituent estimation, thin-layer chromatography, high-performance liquid chromatography, column chromatographies, Gas chromatography-Mass Spectroscopy (GC-MS), and acute toxicity study were performed. Then, Streptozotocin-induced hyperglycemia in Wistar albino rats was carried out in five groups of animals such as Normal control (NC), diabetic control (DC), Standard group (Std), Low dose (EEAAF 100 mg/kg, b.w), Medium dose (EEAAF 250 mg/kg, b.w) and High dose (EEAAF 500 mg/kg, b.w) group. Each group consists of six animals. Upon regular observation for fasting blood glucose level, body weight, polyuria, polyphagia, polydipsia, serum protein, serum creatinine, serum urea, and lipid profile for four weeks, the animals were sacrificed using Ketamine hydrochloride. Organs were removed. Pancreases were used for observing cellular injury using Olympus binocular microscope at 45X. Isolated liver cells homogenate used for free radical scavenging activity such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). The results showed the presence of polyphenol and alkaloids, especially flavonoids. Current characteristics of A. alliaceum include many principal secondary metabolites on GC-MS. On isolation and spectroscopic determination, Flacitran was found. There was neither mortality nor morbidity observed in the acute toxicity study. Adenocalymma alliaceum Miers flowers extract (EEAAF) shows promising efficacy in reducing blood glucose level, metabolic symptoms, total cholesterol, low-density lipoprotein, serum urea, and success in elevating body weight, high-density lipoprotein, and serum protein. The histopathological report also showed significant results from the trio's doses of EEAAF against pancreatic damages compared to the DC group. The data recommend that Adenocalymma alliaceum Miers could be very effective as a accepted resource of antidiabetic agent to modulate pancreatic action.

GC-MS Analysis of Ethyl acetate extract of Mansoa alliacea (Lam.) A.H. Gentry leaves

The intention of the existing look at is to investigate the bioactive phytochemical ingredients present in the leaves of ethyl acetate extract of Mansoa alliacea (Lam.) A.H.Gentry by GC-MS. The look at which done the dried and coarsely powdered leaves have been extracted the usage of solvent ethyl acetate for five hours through soxhlet extraction method. By the usage of GC-MS, presence of diverse phytochemical constituent in ethyl extract of Mansoa alliacea to be analyzed. Totally five chemical ingredients have been recognized. Among those 5 compounds detected from ethyl acetate extract are Neophytadiene (1.89%), Phytol (29.30%), Phytol acetate (3.54%), Squalene (59.58%) and dl-alpha-Tocopherol (5.69%) and organosulphur compounds have been recognized as therapeutically lively components. The received phytochemical ingredients have been recognized as doubtlessly lively and may be used for the remedy of diverse diseases. Constituents assisting nutritive value have been additionally recognized.

Two new pyranonaphthoquinones from Mansoa alliacea

Mansoa alliacea,commonly known as garlic vine,is native to the tropical rain forests of South America and widely cultivated in South China. As a popular folk medicine with various biological activities,however,this plant remains to be fully elucidated in terms of its phytochemical constituents. In this study,two new pyranonaphthoquinones were isolated from the 95% ethanol extract of the leaves and twigs of M. alliacea by various chromatographic approaches including silica gel,octadecyl silica( ODS),Sephadex LH-20,and preparative high-performance liquid chromatography( PHPLC). Their structures were determined to be 8,9-dimethoxy-α-lapachone( 1) and 7-hydroxy-8,9-dimethoxy-α-lapachone( 2) by comprehensive spectroscopic analyses and therefore respectively named as mansonin A( 1) and mansonin B( 2).

Insecticidal efficacy of Adenocalymma alliaceum extracts against cowpea weevils callosobruchus maculatus (F) stored Vigna unguiculata (L.)

Insecticidal activities of dried leaf powder and extracts (aqueous and methanol) of Adenocalymma alliaceum Miers, were assessed against Callosobruchus maculatus with a traditional grain storage insecticide Actellic 2% dust. For each sample, 100 g of cowpea seeds were mixed with respective plant preparation and about 25 adults of Callosobruchus maculatus were placed out in a randomized design with three replicates. All three test samples include powder, aqueous and methanolic extracts with irrespective concentration, providing a significant (P<0.05) increase in mortality of adult insects. High concentration aqueous extract exhibited a high reduction of bruchid survival and showed a maximum mortality rate of 90.67% followed by leaf powder (85.33%), and methanol extract (78.67%). The aqueous extract was found to be more effective than the methanol extract and plant powder, though it was not as effective as Actellic 2% dust. Further the LC10, LC50 and LC95 values for the aqueous extract against C. Maculatus unveiled through Probit analysis was 0.101g/100g,1.23g/100g and 30.4g/100g respectively followed by plant powder (LC10=0.199g/100g, LC50= 5.37g/100g and LC95=48.97g/100g) and methanol extract (LC10=0.986g/100g, LC50=2.34g/100g and LC95=56.23g/100g). From the results it was evident that the aqueous extracts of A. alliaceum exhibit highly toxic effects on C. maculatus than that of plant leaf powder and methanol extracts of the A. alliaceum. Consequently, from the study it was obvious that all the tested materials (plant leaf powder, aqueous and methanol extract) of A. alliaceum evaluated were found to have potential insecticidal properties and are capable of protecting stored cowpea against C. maculatus. Thus, this medicinal plant can be used as an environment- friendly product for inhibition of bruchid pests during the storage of cowpeas.

Review on garlic creeper-Mansoa alliacea (Lam.) A.H. Gentry (Bignoniaceae)

Mansoa alliacea (Lam.) A. H. Gentry belonging to the family Bignoniaceae, commonly called as ‘Garlic vine’ and or ‘false garlic’. Is a native plant used by the Indigenous Indian tribes of the Amazon areas and has great ancestral value for the local communities and also part of the traditional medicine due to the presence of several constituents with important pharmacological properties. In folk medicine treatments M. alliacea is widely used for many diseases like cold, as an aid to fertility, commonly added to baths to treat feverish conditions, flu, body aches, cramps, fatigue, mosquito and snake repellent, epilepsy, uterine disorders, etc. Plant consist of includes diallyl disulphide, diallyl trisulphide, alliin, allicin, propyl allyl, divinyl sulfide, diallyl sulfide, dimethyl sulfide, daucosterol, beta-sitosterol, fucosterol, stigmasterol, iridoides and isothiocyanates, naphthoquinones, alkaloids, saponins, flavones. M. alliacea pharmacological activities are antioxidant, antibacterial, antifungal, anti-inflammatory, larvicidal, anti-plasmodial, etc. This review article compiled the ethnobotanical and phytopharmacological properties of M. alliacea.

Uredospore germination of Hemileia vastatrix and its inhibition by the effect of plant extracts in vitro

Coffee leaf rust, caused by Hemileia vastatrix, is the most important disease of coffee (Coffea arabica L.) in Mexico. It causes production losses of up to 40% and leads to the use of considerable volumes of synthetic fungicides. The main goals of this research were to identify the temperature, pH, incubation time, and luminosity required for in vitro germination of H. vastatrix uredospores and to evaluate the effect of plant extracts on their germination. Uredospores from coffee plants (var. Caturra) grown in the state of Oaxaca, Mexico, were collected and subjected to treatments consisting of combined levels of T°, pH, and incubation time. The treatments were evaluated in darkness and under low-intensity white light (15 W). Uredospore germination occurred in the absence and presence of light. The highest percentage of uredospore germination was 44.95%, which occurred at pH 5.7, between 18 and 24 °C, and with an incubation time of 24 h. The effect of 30 plant extracts was evaluated in terms of inhibition of uredospore germination. The acetone and ethanol extracts of Tribulus terrestris, Datura ferox, Mansoa alliacea, Ricinus communis, and Acacia farnesiana inhibited 100% of uredospore germination. Thus, plant extracts may contribute to the integrated disease management of coffee leaf rust.

Compostos Organossulfurados: Atividade Leishmanicida e Nematicida do Óleo Essencial das folhas de Mansoa alliacea em Leishmania amazonensis e Caenorhabditis elegans

Doencas parasitarias representam um serio problema global e afetam diretamente a saude e a qualidade de vida da populacao. Mansoa alliacea e uma bignoniaceae encontrada principalmente nas matas brasileiras, conhecida como “cipo-de-alho” devido ao forte odor de alho. E uma planta utilizada na medicina popular, com relatos de diversas atividades biologicas (anti-inflamatoria, antifungica, antimicrobiana e antioxidante). O objetivo deste trabalho e caracterizar o oleo essencial de M. alliacea e sua avaliacao inedita das atividades nematicida e leishmanicida contra Leishmania amazonensis e Caenorhabditis elegans. O oleo essencial foi obtido por hidrodestilacao, sua composicao quimica foi analisada por GC-MS e quantificada por GC-FID. A atividade leishmanicida foi realizada em amastigotas intracelulares de L. amazonensis usando macrofagos caninos DH82, a atividade foi medida usando Enzyme Linked Immuno Sorbent Assay (ELISA). A atividade nematicida foi avaliada em larvas do modelo nematoide C. elegans por meio da avaliacao da motilidade. A citotoxicidade do oleo foi avaliada por ensaio colorimetrico de sal de tetrazolio (MTT) em diferentes concentracoes. Os farmacos utilizados como controle positivo foram: antimonio tetravalente na atividade leishmanicida e ivermectina na atividade nematicida. A analise de GC-MS revelou o perfil organossulfurado do oleo, tendo como majoritarios: metil alil dissulfeto (2,4%), dialil tetrassulfeto (3,4%) dialil dissulfeto (36,6%), dialil trissulfeto (53,3%). O oleo apresentou excelente atividade leishmanicida, IC50 de 9,4 μg/mL, valor 5 vezes menor que o antimonio (III) (IC50 53 μg/mL). A dose citotoxica (CC50) do oleo foi 90,7 μg/mL, enquanto o antimonio foi CC50=1,7 μg/mL. O indice de seletividade (razao entre CC50/IC50) do oleo foi 10 e o antimonio (III) foi 0,03. O oleo tambem foi eficiente em paralisar as larvas de C. elegans (IC50=113 µg/mL), na ordem de 94,65% das larvas, superior ao farmaco de referencia, ivermectina (92,2 %), na mesma concentracao. Os resultados ineditos, aqui apresentados, demonstram o potencial de M. alliacea no desenvolvimento de novos farmacos para o tratamento de leishmanioses e nematoides.

Phytochemical and In-Vitro Evaluation of Anti-oxidant Activity of Mansoa alliacea Leaves

Phytochemical and In-Vitro Evaluation of Anti-oxidant Activity of Mansoa alliacea Leaves

Conocimiento y utilización de plantas medicinales en comunidades yuracares. TIPNIS, Cochabamba, Bolivia

Objetivos: el objetivo del presente estudio fue analizar las características socioculturales, el uso y conocimiento de plantas medicinales en las comunidades indígenas yuracares de San Benito, San Juan y San Andita. Métodos: se realizó un estudio de tipo descriptivo, pero desde un enfoque cualicuantitativo. El universo fueron los habitantes indígenas yuracares mayores de 18 años, pertenecientes a una de las tres comunidades San Benito, San Juan y San Andita. El muestreo fue de tipo intencional, dirigida o no probabilístico, por tratarse de poblaciones pequeñas, obteniéndose una muestra de 95 participantes. Resultados: la edad promedio es de 29 años con una desviación estándar de 11,9 años, 55% son las mujeres y 45% los varones, 73% tiene un estado civil de unión estable o concubinato. En cuanto a grado de instrucción o escolaridad encontramos un promedio de 4 años de estudio y cuando se agrupa por niveles vemos que más del 50% tiene una formación básica. El 95% de la población conoce de la existencia de plantas medicinales en su comunidad, utilizadas principalmente en afecciones gastroenterológicas. Conclusiones: las afecciones gastrointestinales son la principal causa por la que estas comunidades acuden al uso de plantas medicinales. Las especies Mansoa Alliacea y Petiveria Alliacea son las plantas más utilizada en las comunidades indígenas yuracares.