Manganese Zinc Ferrite Nanoparticles Research Articles

A novel numerical note on the enhanced thermal features of water-ethylene glycol mixture due to hybrid nanoparticles (MnZnFe2O4 – Ag) over a magnetized stretching surface

In this article, we presented a numerical solution of steady-state magnetohydrodynamic (MHD) flow of an incompressible, electrically conducting Casson hybrid nanofluid through a stretching surface under the incitement of viscous dissipation, heat generation and induced magnetism. A viscous mixture of water and ethylene glycol ( W : E G = 60 % : 40 % ) is considered as a base fluid. Enhanced thermal aspects of the working fluid due to suspended manganese zinc ferrite ( MnZnFe 2 O 4 ) and silver ( Ag ) nanoparticles are analyzed by successive over relaxation iterative method. A self-similar procedure is adopted to obtain dimensionless system of governing equations. Order reduction and finite differences discretization of nonlinear coupled differential equations lead to the approximate solution of proposed problem. Impacts of various dominant parameters on the hybridized Casson fluid are examined through the graphs sketched for the functions of velocity, temperature, and induced magnetism. Skin friction coefficient and thermal transfer characteristics at the stretching surface have been simultaneously observed via tabular data prepared for pure nanofluid ( Ag-WEG ) as well as for hybrid nanofluid ( MnZnFe 2 O 4 -Ag/WEG ). It is perceived that induced magnetic field tends to decline the Nusselt number while exhibits a significant growth in the surface drag. Moreover, a significant enhancement in temperature of working fluid has been observed due to Eckert number and heat generation parameter. This decisive role of enhanced thermal features will help to improve industrial growth, waste-water treatment, and automobiles engine efficiency.

Structural and Magnetic Properties of Manganese Zinc Ferrite Nanoparticles Exhibiting Superparamagnetism

This thesis report delves into the intriguing realm of nanoscale magnetic materials by investigating the superparamagnetic behavior of MnZn ferrite nanoparticles. These nanoparticles have garnered significant attention due to their unique magnetic properties, which stem from their small size and high surface-to-volume ratio. The study begins with a comprehensive review of the existing literature on superparamagnetism. The obtained results reveal the Superparamagnetic nature of the MnZn ferrite nanoparticles, focusing on their response to external magnetic fields and their potential applications in various fields. The findings suggest that the nanoparticles' magnetic behavior transitions from superparamagnetic to blocked as the temperature decreases, leading to potential applications in data storage, biomedical imaging, and targeted drug delivery. The implications of these findings extend beyond the realm of fundamental research, opening doors for technological advancements. By understanding and harnessing the superparamagnetic behavior of MnZn ferrite nanoparticles, researchers can design novel devices with enhanced functionalities. However, challenges related to size distribution, stability, and surface modification need to be addressed to fully exploit the potential of these nanoparticles.

Aqueous Dispersion of Manganese-Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent.

Mixed manganese-zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin-spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.

Electrically conducting mixed convective flow of a hybrid nanoliquid over a rotating sphere with nonlinear thermal radiation

Hybrid nanofluids have specific features that make them suitable for various industrial and engineering applications. The engineering and industrial applications of hybrid nanofluids are refrigeration, air conditioning, drug delivery, cancer therapy, electronic cooling, gearboxes, power plants, engines, bearings, air pollution control, solar thermal collectors, and water treatment. The existing model is presented for the theoretical examination of the hybrid nanofluid flow at the stagnant point of a gyrating sphere. With applications of the quadratic Rosseland thermal radiation, the variations in quadratic density temperature is scrutinized. In this analysis, two different nanoparticles such as silver Ag and manganese zinc ferrite MnZnFe2O4 nanoparticles have mixed with kerosene oil. The main equations of the existing problem are framed by using the concepts of boundary layer theory. On the basis of this theory, the nonlinear PDEs are used in the formulation of the existing problem. HAM technique is used for evaluation of current flow problem. Some significant findings of the current model are that the heat transmission intensifies for upsurge in radiation factor and nanoparticles volume fractions. Also, it is found that the velocity distribution decreases for rise in the positive constant. Further, it has discovered that thermal distribution is higher for growth in radiation factor and temperature ratio factor.

Analysis of Kerosene oil conveying silver and Manganese zinc ferrite nanoparticles with hybrid Nanofluid: Effects of increasing the Lorentz Force, Suction, and volume fraction

The current study aims to explore the magnetic field on a spinning disk with the hybrid nanofluid flow and Cattaneo-Christov heat theory in the existence of nonlinear thermal radiation incorporating Ag and MnZnFe2O4 nanoparticles. Because silver may increase the thermal characteristics of the base material, it has a wide variety of industrial, pharmaceutical, power generation, and heating and cooling applications. The thermal properties of a hybrid nanofluid were to be found by exploring the aspect of nanomaterials on heat transfer and fluid flow. The principal partial differential equations are converted into ordinary differential equations using appropriate similarity treatments. With the aid of the shooting strategy, higher-order ordinary differential equations are converted to first-order ordinary differential equations. To present the numerical data and graphical results of the flow parameters, the built-in solver Bvp4c in the computational tool MATLAB is used. Several plots are also used to investigate the upshot of physical parameters on the graphically depicted profiles, such as the suction and injection parameter, magnetic parameter, Prandtl number, temperature ratio parameter, thermal radiation parameter, thermal relaxation parameter, and volume friction nanoparticles. For the magnetic parameter, both velocity profiles dropped, but the heat profile increased. When the temperature ratio and heat source-sink parameters were increased while the Prandtl number was decreased, the heat field increased.

Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications.

The aim of this project is to fabricate hydrogen-rich silicone doped with magnetic nanoparticles for use as a temperature change indicator in magnetic resonance imaging-guided (MRIg) thermal ablations. To avoid clustering, the particles of mixed MnZn ferrite were synthesized directly in a medical-grade silicone polymer solution. The particles were characterized by transmission electron microscopy, powder X-ray diffraction, soft X-ray absorption spectroscopy, vibrating sample magnetometry, temperature-dependent nuclear magnetic resonance relaxometry (20 °C to 60 °C, at 3.0 T), and magnetic resonance imaging (at 3.0 T). Synthesized nanoparticles were the size of 4.4 nm ± 2.1 nm and exhibited superparamagnetic behavior. Bulk silicone material showed a good shape stability within the study's temperature range. Embedded nanoparticles did not influence spin-lattice relaxation, but they shorten the longer component of spin-spin nuclear relaxation times of silicone's protons. However, these protons exhibited an extremely high r2* relaxivity (above 1200 L s-1 mmol-1) due to the presence of particles, with a moderate decrease in the magnetization with temperature. With an increased temperature decrease of r2*, this ferro-silicone can be potentially used as a temperature indicator in high-temperature MRIg ablations (40 °C to 60 °C).

Novel MR imaging nanoprobe for hepatocellular carcinoma detection based on manganese-zinc ferrite nanoparticles: in vitro and in vivo assessments.

Achieving new contrast enhancer agents that can produce high-resolution images in magnetic resonance imaging (MRI) with a minimum dose and side effects has always been important. Herein, the pegylated curcumin-coated manganese-zinc ferrite nanoparticles (MZF@CA-PEG-CUR NPs) have been reported as an MR imaging nanoprobe in hepatocellular carcinoma detection in the murine model for the first time.In vitrostudies were done on HEPA 1-6 cancer cells and L929 as normal cells, andin vivostudies were done on hepatocellular carcinoma (HCC) using xenograft models of HCC. The prepared NP had a diameter of 105nm with narrow size distribution and was superparamagnetic with a saturated magnetization (Ms) of 39emu/g. The NP was biocompatible without any significant hemolysis and cytotoxicity. Prussian blue staining showed more cellular uptake of HEPA 1-6 compared to L929 control cells after incubation (P < 0.05). The concentration of Fe in mice blood confirmed the plasma half-life of about 3h; it seems the PEGylation increased the circulation time. ICP-OES of Fe showed the highest tumor localization for MZF@CA-CUR-PEG NPs, due to passive accumulation, compared to the other mice studied organs. The r2 relaxivity of NPs was 134.89mM-1s-1, andin vitroMRI demonstrated better effects in HEPA 1-6 cells than in L929 (P < 0.05). Also,in vivoMR images showed signal enhancement efficacy in tumor-bearing mice. This study demonstrated that the MZF@CA-CUR-PEG nanoprobe could be a promising candidate as an MR imaging agent in hepatocellular carcinoma early detection.

D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments.

Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study, water-soluble amphiphilic vitamin E (TPGS, d-alpha-tocopheryl poly(ethylene glycol 1000) succinate) formulated MZF nanoparticles were synthesized to serve as both a magnetic resonance imaging (MRI) contrast agent and a vehicle for creating magnetically induced hyperthermia against cancer. The MZF nanoparticles were synthesized from a metallic acetylacetonate in an organic phase and further modified with TPGS using an emulsion and solvent-evaporation method. The resulting TPGS-modified MZF nanoparticles exhibited a dual-contrast ability, with a longitudinal relaxivity (35.22 s−1 mM Fe−1) and transverse relaxivity (237.94 s−1 mM Fe−1) that were both higher than Resovist®. Furthermore, the TPGS-assisted MZF formulation can be used for hyperthermia treatment to successfully suppress cell viability and tumor growth after applying an alternating current (AC) electromagnetic field at lower amplitude. Thus, the TPGS-assisted MZF theranostics can not only be applied as a potential contrast agent for MRI but also has potential for use in hyperthermia treatments.

The Therapeutic Effects of DDP/CD44-shRNA Nanoliposomes in AMF on Ovarian Cancer.

BackgroundGlobally, ovarian cancer is one of the most common gynecological malignant tumors, and the overall curative effect has been unsatisfactory for years. Exploring and investigating novel therapeutic strategy for ovarian cancer are an imperative need.MethodsUsing manganese zinc ferrite nanoparticles (PEG-MZF-NPs) as gene transferring vector and drug delivery carrier, a new combinatorial regimen for the target treatment of ovarian cancer by integrating CD44-shRNA, DDP (cisplatin) and magnetic fluid hyperthermia (MFH) together was designed and investigated in vivo and in vitro in this study.ResultsPEG-MZF-NPs/DDP/CD44-shRNA nanoliposomes were successfully prepared, and TEM detection indicated that they were 15–20 nm in diameter, with good magnetothermal effect in AMF, similar to the previously prepared PEG-MZF-NPs. Under the action of AMF, PEG-MZF-NPs/shRNA/DDP nanoliposomes effectively inhibited ovarian tumors’ growth, restrained the cancer cells’ proliferation and invasion, and promoted cell apoptosis. VEGF, survivin, BCL-2, and BCL-xl proteins significantly decreased, while caspase-3 and caspase-9 proteins markedly increased both in vitro and in vivo, far better than any of the individual therapies did. Moreover, no significant effects were found on bone marrow hematopoiesis and liver and kidney function of nude mice intervened by the combinatorial therapeutic regimen.ConclusionIn the present study, we developed PEG-MZF-NPs/DDP/CD44-shRNA magnetic nanoliposomes and inaugurated an integrated therapy through the synergistic effect of MFH, gene therapy, and chemotherapy, and it shows a satisfactory therapeutic effect on ovarian cancer in vitro and in vivo, much better than any single treatment regimen did, with no significant side effects. This study provides a new promising method for ovarian cancer treatment.

Synthesis and characterizations of magnetically inductive Mn–Zn spinel ferrite nanoparticles for hyperthermia applications

Monodispersed Mn0.5Zn0.5Fe2O4 (~ 14 nm) nanoparticles were prepared by using a chemical co-precipitation technique. The direct mixing method has been used to prepare ferrofluid (base fluid-water) and to investigate their properties for the application of magnetic hyperthermia. Phase identification, crystal structure, and average crystallite size of the prepared samples were revealed in the XRD analysis. It confirms the Fd3m space group cubic spinel structure and average crystallite size ~ 14 nm. From TEM evaluation, the average particle size was found at ~ 16 nm. The 41.12 emu/g magnetization value of the Manganese Zinc Ferrite (MZF) nanoparticles (NPs) was found at room temperature. A negligible coercivity and remanence values confirm the superparamagnetic behavior of MZF nanoparticles at room temperature were confirmed by vibrating sample magnetometer (VSM) analysis. The induction heating analysis on water dispersed MZF Magnetic NPs at 4 kA/m AC magnetic field amplitude and 280 kHz frequency was conducted to use them in the application of hyperthermia. The result specifies that the heating potential of prepared ferrofluids can be reached within 65 s of hyperthermia temperature (42 °C) at lower 4 mg/mL content, indicating that the prepared material can be used as a heating agent for the treatment of magnetic hyperthermia. The specific absorption rate (SAR) was found to be 110.90 W/g. Thus, the obtained results suggest that the prepared MZF nanoparticles are a promising candidate for hyperthermia therapy due to their high heat-generating ability with less time at a lower concentration.

Magnetic properties of larger ionic radii samarium and gadalonium doped manganese zinc ferrite nanoparticles prepared by solution combustion method

Nanoparticles of Mn0.5Zn0.5Fe2O4, Mn0.5Zn0.5Fe1.95Sm0.05O4 and Mn0.5Zn0.5Fe1.9Gd0.05Sm0.05O4 ferrites are prepared by solution combustion method and characterized to comprehend their structural, microstructural and magnetic properties. The single-phase formation and spinel cubic structure of the samples analyzed by XRD method. The average crystallite sizes were found in the range 10.26 to 16.68 nm. The lattice parameters were found in the range 8.4157 to 8.4508 Å. The particle size was studied by using TEM micrographs and found to be in nano range. The results are good agreements with XRD results. A strong correlation between the size of the particle with respect to the Sm3+ and Gd3+ content has been identified using TEM micrographs. The M-H loop of Mn0.5Zn0.5SmxGdyFe2-(x+y)O4 (where x = 0, y = 0; x = 0.05, y = 0; x = 0.05, y = 0.05) nanoparticles exhibit ferromagnetic nature with saturation magnetization and coercivity. The M-H loop of Mn0.5Zn0.5Fe2O4 nanoparticles exhibit a high saturation and remanent magnetization. The saturation magnetization and remanent magnetization found in the range 44.16 to 5.805 emu/g and 24.46 to 0.093 emu/g, respectively. The saturation and remanent magnetization decreases after Sm3+ and Gd3+ substitution on Fe- site in Mn0.5Zn0.5Fe2O4 is because of the distinction in the cation distribution at tetrahedral site and octahedral site. Meanwhile, experiments demonstrate that the solution combustion method has significant effect on structure and magneticbehavior of the preparedferritenanoparticles.

Role of Mn+2 ions in monitoring structural, optical, magnetic and electrical properties of manganese zinc ferrite nanoparticles

Role of Mn+2 ions in monitoring structural, optical, magnetic and electrical properties of manganese zinc ferrite nanoparticles

Effect of chromium ions on the structural, magnetic, and optical properties of manganese–zinc ferrite nanoparticles

The present work describes the synthesis of Mn0.5Zn0.5CrxFe2−xO4 (x = 0.1, 0.2, 0.3) ferrite nanoparticles by solution combustion method and their detailed structural, electrical, magnetic, and optical characterizations. X-ray pattern represents the creation of a single spinel structure. In addition to this, the distribution of cations is also approximated from X-ray study which is then authenticated by the magnetization technique also. The crystalline size (23–21 nm) and lattice parameter (8.39–8.30 A) are found to shrink with the rise in chromium ions. A decrease in saturation magnetization (0.80–0.64 emu/g) and remanent magnetization (0.05–0.03 emu/g) is found with the rise in chromium ions, while the coercivity is found to increase (83–123 Oe) through the adding of chromium ions. FTIR predicted the two absorption bands (ν1 and ν2) near 600 and 400 cm−1. Dielectric constant and loss tangent were observed to decrease with an increase in frequency, whereas AC conductivity attains a nearly constant value at a lower frequency and observed to increase at higher frequencies with the addition of dopant.

Corrigendum to “Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles”

Corrigendum to “Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles”

Template-free microwave-assisted hydrothermal synthesis of manganese zinc ferrite as a nanofertilizer for squash plant (Cucurbita pepo L)

Manganese, zinc, and iron are the most essential micronutrients required for plant growth and applied as foliar fertilizers. Herein, a simple template-free microwave-assisted hydrothermal green synthesis technique was adapted to produce manganese zinc ferrite nanoparticles (Mn0.5Zn0.5Fe2O4 NPs) at different temperatures (100, 120, 140, 160 and 180 °C). The prepared nanomaterials were employed at different concentrations (0, 10, 20, and 30 ppm) as foliar nanofertilizers during the squash (Cucurbita pepo L) planting process. X-ray diffraction patterns of the prepared nanomaterials confirmed successful production of the nanoferrite material. The prepared nanofertilizers showed type IV adsorption isotherm characteristic for mesoporous materials. FE-SEM and HR-TEM imaging showed that the nanoparticles were cubic shaped and increased in particle size with the increase in microwave temperature during production. The impact of application of the synthesized ferrite nanoparticles on vegetative growth, proximate analysis, minerals content and the yield of squash plant was investigated for two consecutive successful planting seasons. The nanoferrite synthesized at 160 °C and applied to the growing plants at a concentration of 10 ppm gave the highest increase in % yield (49.3 and 52.9%) compared to the untreated squash for the two consecutive seasons, whereas the maximum organic matter content (73.0 and 72.5%) and total energy (260 and 258.3 kcal/g) in squash leaves were obtained in plants treated with 30 ppm ferrite nanoparticles synthesized at 180 °C. On the other hand, the maximum organic matter content (76.6 and 76.3%) and total energy (253.6 and 250.3 kcal/g) in squash fruits were attained with plants supplied by 20 ppm ferrite nanoparticles synthesized at 160 °C. These results indicate that the simple template-free microwave-assisted hydrothermal green synthesis technique for the production of manganese zinc ferrite nanoparticles yields nanoparticles appropriate for use as fertilizer for Cucurbita pepo L.

Altering saturation magnetization of manganese zinc ferrite nanoparticles by doping with rare earth Nd+3 ions

Manganese Zinc Ferrite Mn0.6Zn0.4NdxFe2-xO4 (x = 0.04, 0.05, 0.06, 0.07 and 0.08) nanoparticles doped with rare-earth ions of Neodymium (Nd+3) were synthesized using combustion method. The single spinel phase formation without any impurity was characterized using X-ray diffraction (XRD) technique and Infra-Red (IR) spectroscopy. Lattice constants ‘a’ show variation with Nd+3 doping. Particle sizes using TEM were found in the range of 5 nm–25 nm. Systematic alteration of saturation magnetization (MS) can be achieved by changing Nd+3 concentrations in the samples. These variations can be attributed to the inclusion of rare earth metal ions replacing Fe+3 in the matrix. Nd+3-Fe+3 interactions possibly improving the alignment of moments on B-sites leading to a decrease in the canting angle which in turn increases MS Relative to undoped Manganese Zinc ferrite samples.

Influence of Magnetic Field on the Two-Photon Absorption and Hyper-Rayleigh Scattering of Manganese–Zinc Ferrite Nanoparticles

Magnetic nanoparticles based on manganese–zinc ferrite presenting spherical and cubic shapes, verified by small-angle X-rays scattering, were studied by means of the hyper-Rayleigh scattering, the Z-Scan technique in the open-aperture configuration, and a spectrally resolved femtosecond transient absorption setup. Hyper-Rayleigh scattering and Z-Scan experiments were performed with applied magnetic field parallel to the laser polarization state and in the perpendicular direction. The hyperpolarizability of spherical nanoparticles was greater than the cubic ones due to the higher volume of spherical nanoparticles and, therefore, the increased influence of the spin-disoriented layer at the surface on cubic nanoparticles, resulting in a smaller orientational average contribution to the hyperpolarizability. The two-photon absorption cross section was the same for both samples, since the basic constituents are the same and the light absorption is not influenced by the surface anisotropy present on magnetic nanoparticles. For both nanoparticles, the measured optical second harmonic and the nonlinear absorption increased during experiments performed in the presence of external field in the parallel configuration, while a decrease was verified for experiments in the perpendicular case, which demonstrates a crystalline anisotropy on the nonlinear optical properties. Transient absorption measurements revealed an ultrafast relaxation process containing at least two separated dynamical processes, the faster with characteristic time below 1 ps and a longer one, much higher than 100 ps.

Raman spectra tell us so much more: Raman features and saturation magnetization for efficient analysis of manganese zinc ferrite nanoparticles

AbstractRaman spectroscopy (RS) measurements contribute to characterization of spinel phase ferrite nanoparticles. However, the capabilities of micro‐Raman analysis of such materials are presently not fully exploited. In order to expand the frontier of RS in nanomaterials research, we conducted an in‐depth study of spinel‐structured MnxZn1‐xFe2O4 nanoparticles (0.75 &lt; x &lt; 0.9) to prospect the linkage of their Raman features with their respective chemical or physical properties. We correlate for the first time Raman features of MnxZn1‐xFe2O4 spinel‐structured nanoparticles with their saturation magnetization (MS), most notably via the band around 713 cm−1, the area of which was found to be inversely related to MS. The insights presented here show that assessment of MS via Raman features does not require prior knowledge of neither crystalline phase nor size of particles and thus can be used for rapid assessment of newly synthetized MnxZn1‐xFe2O4 samples, boosting the efficiency of Raman technique applied to nanostructured materials research.

Synthesis, Structural, and Magnetic Properties of Mn0.5Zn0.5Fe2O4 Nanoparticles by Sol–Gel Route

AbstractIn this work, the cubic spinel manganese‐zinc ferrite nanoparticle is synthesized by the sol–gel auto combustion method. It is the simple chemical route and low‐cost method for the formation of manganese zinc ferrite nanoparticles. Structural and morphological studies of the synthesized manganese‐zinc ferrite nanoparticles are done by X‐ray diffraction, Fourier transform infrared spectroscopy (FTIR), and scanning electron microsccopy (SEM). The X‐ray diffraction results indicate that the ferrite sample has a cubic spinel type structure with Fd3m space group. The average crystallite size of the synthesized manganese zinc ferrite nanoparticles is found to be 34 nm as determined by Debye–Scherrer equation. Two well‐known absorption bands at 467 and 558 cm−1, in FTIR spectroscopy data also confirm the cubic spinel structure in the prepared samples. Morphological studies by SEM exposed formation of largely agglomerated and well‐defined nanoparticles of the sample. From the magnetization data, parameters like magnetization, coercivity, remanance magnetization, and squareness ratio are calculated.

Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles

This study was performed to investigate the biocompatibility (BC), magnetothermal effect, and DNA binding biological characteristics of manganese zinc ferrite nanoparticles (Mn0.6Zn0.4Fe2O4-NPs (MZF-NPs)) coated with pegylated manganese (PEG-MZF-NPs). Their functions as gene transfer carrier for gene therapy and magnetic medium for tumor hyperthermia were also explored. The manganese zinc ferrite nanoparticles were synthesized through high temperature cracking, and their characterizations were discovered. Hemolysis test and MTT assay were performed to evaluate biocompatibility, and their self-heating effects in the alternating magnetic field were investigated. PEG-MZF-NPs with different concentrations were measured by using 7.0 T Micro-MR scanner (MRI) to calculate the T2 value and r2 relaxation rate of each sample. The CD44-shRNA plasmids were constructed, and their ability to bind PEG-MZF-NPs were examined. The DNA release from PEG-MZF-NP/DNA complex and protection of DNA from nuclease digestion were also detected. After CD44-shRNA-EGFP were transfected into the ovarian cancer SK-OV-3 cells by using PEG-MZF-NPs as carriers, the transfection efficiency was detected by a flow cytometer and expression of CD44 mRNA and protein in cells was detected using RT-PCR and Western blot, respectively. We successfully prepared PEG-MZF-NPs with favorable dispersity, magnetic responsiveness, and BC. Typically, the excellent magnetothermal effect can be used for a tumor magnetothermal therapeutic study. In vitro MRI showed the application potential for being magnetic resonance T2 relaxation contrast agents and the possibility to achieve goal of integration of targeting diagnosis and treatment. The CD44-shRNA plasmids have been successfully constructed and concluded that PEG-MZF-NPs may serve as gene transfer carriers for gene therapy.