Synthesis and characterizations of magnetically inductive Mn–Zn spinel ferrite nanoparticles for hyperthermia applications

Abstract

Monodispersed Mn0.5Zn0.5Fe2O4 (~ 14 nm) nanoparticles were prepared by using a chemical co-precipitation technique. The direct mixing method has been used to prepare ferrofluid (base fluid-water) and to investigate their properties for the application of magnetic hyperthermia. Phase identification, crystal structure, and average crystallite size of the prepared samples were revealed in the XRD analysis. It confirms the Fd3m space group cubic spinel structure and average crystallite size ~ 14 nm. From TEM evaluation, the average particle size was found at ~ 16 nm. The 41.12 emu/g magnetization value of the Manganese Zinc Ferrite (MZF) nanoparticles (NPs) was found at room temperature. A negligible coercivity and remanence values confirm the superparamagnetic behavior of MZF nanoparticles at room temperature were confirmed by vibrating sample magnetometer (VSM) analysis. The induction heating analysis on water dispersed MZF Magnetic NPs at 4 kA/m AC magnetic field amplitude and 280 kHz frequency was conducted to use them in the application of hyperthermia. The result specifies that the heating potential of prepared ferrofluids can be reached within 65 s of hyperthermia temperature (42 °C) at lower 4 mg/mL content, indicating that the prepared material can be used as a heating agent for the treatment of magnetic hyperthermia. The specific absorption rate (SAR) was found to be 110.90 W/g. Thus, the obtained results suggest that the prepared MZF nanoparticles are a promising candidate for hyperthermia therapy due to their high heat-generating ability with less time at a lower concentration.