Serum Manganese Research Articles

Early primary biliary cholangitis is characterised by brain abnormalities on cerebral magnetic resonance imaging.

SummaryBackgroundBrain change can occur in primary biliary cholangitis (PBC), potentially as a result of cholestatic and/or inflammatory processes. This change is linked to systemic symptoms of fatigue and cognitive impairment.AimTo identify whether brain change occurs early in PBC. If the change develops early and is progressive, it may explain the difficulty in treating these symptoms.MethodsEarly disease brain change was explored in 13 patients with newly diagnosed biopsy‐proven precirrhotic PBC using magnetisation transfer, diffusion‐weighted imaging and 1H magnetic resonance spectroscopy. Results were compared to 17 healthy volunteers.ResultsCerebral magnetisation transfer ratios were reduced in early PBC, compared to healthy volunteers, in the thalamus, putamen and head of caudate with no greater reduction in patients with greater symptom severity. Mean apparent diffusion coefficients were increased in the thalamus only. No 1H magnetic resonance spectroscopy abnormalities were seen. Serum manganese levels were elevated in all PBC patients, but no relationship was seen with imaging or symptom parameters. There were no correlations between neuroimaging data, laboratory data, symptom severity scores or age.ConclusionsThis is the first study to be performed in this precirrhotic patient population, and we have highlighted that neuroimaging changes are present at a much earlier stage than previously demonstrated. The neuroimaging abnormalities suggest that the brain changes seen in PBC occur early in the pathological process, even before significant liver damage has occurred. If such changes are linked to symptom pathogenesis, this could have important implications for the timing of second‐line‐therapy use.

PS 08-32 THE PROTECTIVE EFFECT ON HYPERTENSION IN PATIENT WITH CHRONIC KIDNEY DISEASE

Objective: Manganese (Mn) is one of the essential trace minerals and known to have anti-oxidative functions which could be related to regulate blood pressure. The purpose of our study was to evaluate the association between serum manganese levels and the blood pressure in patients with chronic kidney disease. Design and Method: This study was a cross-sectional study based on the hospitalized patients with kidney problem. Total 200 patients were enrolled, and they were divided into two groups according to the level of manganese. Cut-off value was 8 ug/L, which was the highest normal range of the protocol of the our center policy. Results: High manganese group significantly showed lower systolic blood pressure (127.1 ± 19.1 vs. 138.2 ± 30.1;p = 0.002) and higher eGFR level (60.2 ± 74.0 vs. 21.9 ± 28.8; p = 0.000). Also we analyzed the association between systolic blood pressure and 3 tertile groups of manganese level which showed significant difference (138.0 ± 30.3, 126.8 ± 19.5, 127.6 ± 18.9, respectively; p = 0.010). But there was no significant correlation between blood manganese level and diastolic blood pressure. Conclusions: These results suggest the protective effect of manganese in systolic blood pressure and chronic kidney disease.

Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis.

Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269–0.798), 0.639 (0.383–1.065), and 0.614 (0.365–1.031) among men and 1.000, 0.773 (0.498–1.200), 0.602 (0.382–0.947), and 0.603 (0.381–0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes.

Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats.

This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose γ-radiation (LDR; 0.25 Gy, twice the total dose of 0.5 Gy at the 1st and 3rd day, respectively) was evaluated against TAA (300 mg/kg, intraperitoneal × 3) induced liver damage and HE in rats. Serum aspartate transaminase, alanine transaminase, γ-glutamyltransferase, total bilirubin, ammonia, and manganese were estimated to evaluate liver function. In addition, malondialdehyde (MDA) as well as reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) were determined to assess antioxidant capacity in liver tissue. Moreover, hepatic apoptotic markers (cysteine-dependent aspartate-directed proteases 3, 8 (caspase-3, 8) and cytochrome C) were estimated to indicate hepatic apoptosis. HE was evaluated through the determination of whole brain ammonia, manganese, MDA, GSH, GPX, SOD, CAT, and caspase-3. The cognitive and locomotor deficits were assessed via step through passive avoidance test, activity cage (actophotometer), γ-aminobutyric acid, and N-methyl-d-aspartate/adenosine triphosphate-neuronal nitric oxide synthase/nitric oxide-cyclic guanosine monophosphate axis in rats' cerebella and hippocampi. The involvement of hypoxia inducible factor-1α, aquaporine-4, and matrix metalloproteinase 9 in association with the brain water content (%) in the whole brain as an index for brain edema was also evaluated. The obtained results showed a marked amelioration of the aforementioned biochemical parameters and behavioral tasks which is supported by histopathological and immunohistochemical examination. It could be concluded that Daflon and LDR afforded hepatoprotection and neuroprotection against TAA-induced acute liver damage and HE.

PM069 Serum Manganese Is Associated With Dyslipidemia in Mexican Population

PM069 Serum Manganese Is Associated With Dyslipidemia in Mexican Population

Levels of arsenic, mercury, cadmium, copper, lead, zinc and manganese in serum and whole blood of resident adults from mining and non-mining communities in Ghana.

Human beings working or living near an industrial site where toxic chemicals such as As, Hg, Cd, Cu, Mn, Pb, Zn and or their compounds are used or indiscriminately discharged into the environment, are constantly exposed to such chemicals via ingestion (drinking or eating), dermal contact or inhalation (breathing). However, in developing countries such as Ghana, limited data on levels of the aforementioned chemicals in whole blood and serum of human beings as a result of exposure to the aforementioned chemicals from mining communities and non-mining communities is preventing effective policy formulation to protect human health. Hence, this study was undertaken to measure the levels of the aforementioned toxic chemicals in whole blood and serum of 300 resident adults from mining (Tarkwa Nsuaem Municipality Assembly (TNMA) and Prestea Huni Valley District (PHVD)) and non-mining (Cape Coast Metropolis) communities in Ghana, using neutron activation analysis (NAA). Blood samples were taken from 200 resident adults (105 males and 95 females) from mining and 100 resident adults (60 males and 40 males) from non-mining communities in the study area following the completion of an informed consent and the issuance of ethical clearance by the Ghana Health Service Ethical Committee. The mean concentrations for As, Hg, Cd, Cu, Mn, Pb and Zn in whole blood of residents from mining communities were as follows: 38 ± 320μg/L, 63 ± 0.23μg/L, 303 ± 117μg/L, 3300 ± 953, 195 ± 90μg/L, 28 ± 14μg/L and 1405 ± 458μg/L, respectively; while the levels of measured toxic chemicals in the serum of resident adults from mining communities were as follows: 65 ± 14μg/L, 358 ± 22μg/l, 134 ± 12μg/L, 3590 ± 254μg/L, 401 ± 113μg/L, 58 ± 5.8μg/L and 49 ± 31μg/L, respectively, for As, Hg, Cd, Cu, Mn, Pb and Zn and were found to have exceeded the permissible WHO guideline values.

Levels of Serum Zinc and Manganese among Post-Menopausal Patients with Thyroid Dysfunction

The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism in Post-Menopausal Patients. The content of the trace elements Zinc and Manganese (Zn, and Mn) in the serum of patients was determined. Forty patients with hyperthyroidism and hypothyroidism were participated in this study. Serum zinc and manganese were determined using flame atomic absorption spectrophotometer technique. The study showed that serum zinc and manganese levels of hyperthyroidism patients were significantly lower (p&lt;0.05). While a significant increase in serum manganese level with decrease serum zinc levels in patients with hypothyroidism (p&lt;0.05). The present study confirmed a significant change in the levels of serum Zn, Mn in hyperthyroidism and hypothyroidism among Post-Menopausal patients and these changes may be related to pathophysiology of thyroid disease.

Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing.

We examined serum and erythrocyte lead and manganese levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), which contains over 1000 registrants including over 200 cases of Alzheimer's disease (AD) and 100 mildly cognitively impaired (MCI) individuals. After correcting for confounding effects of age, collection site and sex, we found a significant decrease in serum manganese levels in AD subjects compared to healthy controls. Analysis of smaller subset of erythrocytes revealed no difference in either lead or manganese levels in AD. Although lead and manganese have neurotoxic effects and may be involved in AD pathology, our results showed that neither metal in serum nor erythrocytes are suitable biomarkers in our cohort. However, prospective studies might reveal whether the burden of either metal modifies disease outcomes.

Infradian rhythm in hematology, cell mediated immunity and serum micronutrient concentration around peripartum periods in high yielding crossbred cows before and after micronutrient supplementation

Alteration in hematology and cell-mediated immunity around peripartum periods before and after micronutrient supplementation was studied in this investigation. Twelve (12) high-yielding cross-bred cows in advanced pregnancy were selected for the experiment and divided into two equal groups viz. supplemented (n = 6) and unsupplemented (n = 6). Supplemented animals were provided with a micronutrient mixture (@ 25 g per cow) as per the recommendation of NRC over the normal feeding. Unsupplemented group of cows were kept as control with standard farm feeding management. Blood samples (15 ml/cow) were collected from all the animals during days 30th, 15th, and 7th before calving, on the day of calving, and during days 7th, 15th, and 30th after calving and analyzed for hematology viz. hemoglobin (Hb), total erythrocyte counts (TEC), total leukocyte counts, and differential leukocyte counts. In vitro phagocytic index (PI) of neutrophils and lymphocyte proliferation response (LPR) were also evaluated. Copper (Cu), zinc (Zn), manganese, and selenium (Se) concentrations in serum were estimated by atomic absorption spectrophotometer. The Hb concentration was found to be significantly (p < 0.01) higher in supplemented group compared to the unsupplemented group of cows. There were no significant differences in Hb concentration during different days of peripartum in both the group of cows. There was a significantly (p < 0.001) higher TEC in supplemented group compared to unsupplemented group of cows, though it did not vary significantly between different days of peripartum in both the group of cows. There was a significantly (p < 0.001) higher PI in supplemented group compared to the unsupplemented group of cows. In both the groups, the PI of blood neutrophils was significantly (p < 0.001) lower during calving. The LPR did not differ significantly between the groups, but it differed significantly (p < 0.01) between different days of peripartum and was lowest on the day of calving in both the groups. The Cu, Zn, and SE concentration was found to be significantly (p < 0.01) higher in supplemented group compared to the unsupplemented group of cows, but remained unaltered throughout the peripartum period. The study indicated that there was a marked immune depression around peripartum (15 days precalving to 15 days postcalving) in terms of in vitro phagocytic activity of blood neutrophils and in vitro LPR. Supplementation of micronutrients improves the hematological status as well as immune status, so it was recommended to supplement these micronutrients for better productivity and disease resistance in high-yielding cross-bred cows around peripartum.

Modulation of serum trace mineral profiles in post-partum acyclic surti buffaloes with GnRH alone and in combination with vitamin A, D3, E and toldimphos sodium preparation therapy

The weekly serum profile of trace elements (Cu, Co, Zn, Fe and Mn) studied from 45 day to 120 day postpartum in 18 acyclic surti buffaloes with GnRH alone and GnRH along with vitamin A, D 3 , E and toldimphos sodium preparation treatment revealed that the levels of most elements varied non-significantly between treatments (T 1 and T 2 ) and control (T 3 ) groups during different weeks postpartum and even within the group between intervals postpartum. The overall mean serum copper, cobalt, zinc, iron and manganese values in T 1 , T 2 and control (T 3 ) groups were 1.41±0.03, 1.42±0.03 and 1.29±0.03 ppm; 0.61±0.02, 0.62±0.02 and 0.61±0.04 ppm; 1.66±0.13, 1.78±0.12 and 1.60±0.09 ppm; 3.21±0.06, 3.28±0.04 and 3.24±0.08 ppm; 0.146±0.007, 0.153±0.008 and 0.142±0.022 ppm, respectively. In the study, no differences found in serum trace minerals levels between treated and control groups at different time intervals except in mean copper concentration at 14 th and 21 st day with 0 day and 7 th day in the GnRH treated (T 1 and T 2 ) group. It was found that control group mean copper values were differ significantly from GnRH treated (T 1 and T 2 ) groups at 7 th , 14 th and 21 st day, respectively. However, the mean copper values were placed within the normal physiological range. Moreover, microelements cannot be synthesized in the body. Hence, at last it was concluded that trace elements should be daily supplied in the field and in organized farms as mineral mixture to suffice the requirement of the trace elements.

Hepatobiliary Quiz (Answers)—15 (2015)

Hepatobiliary Quiz (Answers)—15 (2015)

Effect of non-bioartificial liver support system on serum manganese levels in patients with hepatic encephalopathy

Effect of non-bioartificial liver support system on serum manganese levels in patients with hepatic encephalopathy

Higher Grades and Repeated Recurrence of Hepatic Encephalopathy May Be Related to High Serum Manganese Levels.

Hepatic encephalopathy is a serious complication of liver failure. Until now, the precise pathophysiologic mechanisms are not fully determined. It has been demonstrated that manganese plays an important role in the pathogenesis of hepatic encephalopathy. Therefore, we studied manganese levels in serum of cirrhotic patients with hepatic encephalopathy in relation to grading and recurrence of hepatic encephalopathy. One hundred persons were enrolled in the study, 80 cirrhotic patients with or without encephalopathy and 20 healthy controls. Hepatic encephalopathy was diagnosed clinically and by laboratory findings. Serum manganese levels were measured in all participants. The grading of hepatic encephalopathy was significantly correlated to the severity of liver dysfunction. The mean serum manganese level was significantly higher in cirrhotic patients than in controls and in cirrhotic patients with encephalopathy than in those without encephalopathy. It was also significantly higher in patients with advanced grading of hepatic encephalopathy. Serum manganese level was positively correlated to number of recurrences of encephalopathy during a 6-month follow-up period. Serum manganese levels were able to predict recurrence of hepatic encephalopathy within 6months following the episode. Serum manganese levels are positively correlated to the modified Child-Pugh score of cirrhosis as well as grading and number of recurrences of hepatic encephalopathy. Higher manganese levels seem to be related to worsening of the condition, and its measurement may be used as a predictor of repeated recurrences.

Serum Manganese, Serum Iron and Ferritin Concentrations among Welders of Shipyard of Arab Contractors in Ismailia City

Serum Manganese, Serum Iron and Ferritin Concentrations among Welders of Shipyard of Arab Contractors in Ismailia City

PTH-212 High serum manganese levels in patients receiving long term total parenteral nutrition

Introduction In patients receiving long term total parenteral nutrition (TPN), high manganese (Mn) levels have been associated with nervous system disorders including parkinsonism. T1-weighted magnetic resonance imaging in these patients demonstrates high intensity signals in the globus pallidus which regresses on discontinuation of the Mn supplementation. NICE guideline (CG32) recommends checking Mn levels in patients on long term TPN every 3–6 months. The aim of the study was to assess serum Mn levels in patients on long term TPN and to establish if withdrawing Mn supplementation results in normalisation of serum Mn levels. Method Serum Mn levels were measured in all patients receiving long term TPN in the North East of England and Cumbria during the study period from Nov 2013 to Jan 2015. Of those with a high serum Mn, supplementation was withdrawn and the levels were rechecked within 12 months of withdrawal. Results In the North East of England and Cumbria, 77 patients were receiving long term TPN during the study period. Of these, 48 were female and 29 were male. The age range of patients was from 19 to 84 years. The indication for TPN included; 23 ischaemia, 21 inflammatory bowel disease, 10 intra-abdominal malignancy, 9 post-surgical complication, 5 enteric dysmotility, 4 radiation enteritis, 3 visceral myopathy, 1 connective tissue disorder and 1 congenital abdominal defect. Of the 77 patients, 46 had high serum Mn levels at initial measurement (mean 288nmol/l; range 90–1620). Serum Mn levels were rechecked in these patients within 12 months of Mn withdrawal. When rechecked, 26 patients had normal serum Mn levels and 11 patients had a reduced Mn levels but above normal limits. 9 patients did not undergo a repeat Mn level due to either acute illness, discontinuation of TPN or death. No patients reported any neurological symptoms to suggest toxicity. Conclusion The study demonstrated that high levels of Mn are found in 60% of all patients receiving long term TPN. Withdrawing Mn supplementation in these patients results in a normalisation of Mn levels in 57% and a reduction in Mn level in 20% within 12 months. Although no patients in the study showed signs of Mn toxicity, studies have shown a potential risk resulting in neurological disorders. This study highlights the importance of checking Mn levels in keeping with NICE guidance every 3–6 months and adjusting Mn supplementation for those with high levels to avoid potential toxicity. Mn is supplemented in combination with other trace elements some of which may not be replaced individually including molybdenum, iodine and chromium. Further studies are required to determine the clinical significance of withdrawing these trace elements. Disclosure of interest None Declared.

Serum metabolic and minerals profile in norgestomet primed postpartum anestrous surti buffaloes.

Aim:The study was undertaken to find out the serum metabolic and minerals profile in postpartum anestrous surti buffaloes treated with norgestomet ear implants alone and in combination with pregnant mare serum gonadotropin (PMSG).Materials and Methods:The study was conducted on 18 postpartum anestrous Surti buffaloes divided into three groups of six animals each at random to conduct the experiment. The buffaloes in Group-I and Group-II were implanted with Crestar ear implant for 9 days together with 2 ml injection of Crestar solution given i/m on the day of the implant insertion. In Group-II, additionally 500 IU PMSG was given i/m on the day of implant removal, whereas the buffaloes in Group-III served as anestrous control group and received 5 ml Normal Saline i/m on day 0 and 9 as a placebo treatment.Results:The overall serum total protein values did not differ significantly (p > 0.05) between time (days) intervals in any of the groups. The mean serum total cholesterol levels at 10th day and on the day of estrus were found significantly lower (p < 0.05) in the control group as compared to treatment Groups I and II. However, there was no significant difference (p > 0.05) at 10th day and on the day of estrus between treatment groups (T1 and T2). The overall mean serum cobalt, zinc, iron, and manganese values did not differ significantly (p > 0.05) between different time intervals among any of the groups, except copper which was significantly lower (p < 0.05) at 10th day in control group as compared to treatment groups.Conclusion:Microelements cannot be synthesized in the body. Hence, it is concluded that the mineral mixture should be supplied daily in the animals ration to suffice the requirement of the trace elements. The mean serum metabolic and micro-minerals profiles in treatment and control groups revealed that overall mean serum total protein, cholesterol, copper, and zinc levels were apparently higher in treatment groups whereas, mean serum cobalt, iron, and manganese concentration had no consistent trend between treatment and control groups of Surti buffaloes.

Essential metals profile of the hair and nails of patients with laryngeal cancer

Trace elements have an impact on numerous physiological processes. The monitoring of their levels in the organism allows you to detect not only their deficiencies, but also several illnesses. The aim of this study was to compare the levels of essential elements (calcium, magnesium, zinc, copper, iron, manganese) in hair, nails and serum of both patients with laryngeal cancer and healthy people. The determination of six metals was performed by an inductively coupled plasma mass spectrometry (ICP-MS) and an inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration of essential elements in hair and nails of the control group was statistically significantly higher than in the group of patients with laryngeal cancer. In the case of serum, differences were found between the patients and controls in respect of the level of three metals. The results of principal component analysis (PCA) revealed the strong and similar clustering behavior of essential elements in hair and nails. The metals did not correlate between two alternative materials. The present study indicated that, using the level of essential elements in hair and nails as a basis, it is possible to distinguish cancer patients from healthy people. The alternative materials are independent of homeostasis and therefore seem to be more useful in the detection of diseases and mineral deficiencies in human than the classical biological materials, such as blood.

Manganese and selenium concentrations in umbilical cord serum and attention deficit hyperactivity disorder in childhood

Existing evidence on the effects of manganese and selenium during fetal life on neurodevelopmental disorders is inadequate. This study aims to investigate the hypothesized relationship between fetal exposure to manganese and selenium and attention deficit hyperactivity disorder (ADHD) diagnosis in childhood. Children born between 1978 and 2000 with ADHD (n=166) were identified at the Department of Child and Adolescent Psychiatry in Malmö, Sweden. Controls from the same region (n=166) were selected from the Medical Birth Register and were matched for year of birth and maternal country of birth. Manganese and selenium were measured in umbilical cord serum. The median cord serum concentrations of manganese were 4.3μg/L in the cases and 4.1μg/L in the controls. The corresponding concentrations of selenium were 47 and 48μg/L. When the exposures were analyzed as continuous variables no associations between cord manganese or selenium concentration and ADHD were observed. However, children with selenium concentrations above the 90th percentile had 2.5 times higher odds (95% confidence interval 1.3–5.1) of having ADHD compared to those with concentrations between the 10th and 90th percentiles. There was no significant interaction between manganese and selenium exposure (p=0.08). This study showed no association between manganese concentrations in umbilical cord serum and ADHD. The association between ADHD diagnoses in children with relatively high cord selenium was unexpected and should be interpreted with caution.

Antioxidant status in blood of obese children: the relation between trace elements, paraoxonase, and arylesterase values.

Obesity is known to lead to complications involving several systems. The basic mechanism in obesity-related complications is chronic inflammation and increased oxidative stress. Trace element levels in obese children may vary due to poor nutritional habits. The purpose of this study was to investigate the relation between serum paraoxonase (PON1) and arylesterase (ARE) levels, markers of the oxidant-antioxidant balance in the body, and serum zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se) concentrations in obese children. Fifty-seven overweight patients aged 6-17 and 48 age- and sex-matched healthy children were included in the study. Serum PON1 and ARE activity levels were measured, together with Cu, Zn, Mn, Se, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, glucose, aspartate amino transferase, and alanine amino transferase levels. PON1 and ARE activity levels were significantly lower in obese patients compared to those in healthy individuals (P < 0.05). Various changes were determined in Cu, Zn, Mn, and Se levels between the study and control groups (P < 0.05). In terms of the relation between trace elements and PON1 and ARE levels, a significant positive correlation was determined between serum Se and PON1 levels in the study group (P < 0.05, r = 0.31). No significant correlation was determined between other trace element levels and PON1 and ARE levels (P > 0.05). In conclusion, the detection in our study of a positive correlation between Se and PON1 levels in obese children may be significant in terms of showing a relation between Se and antioxidant systems in obese children.

English

Background and objective: Cigarette smoke is a leading preventable cause of many diseases and death, because it contains a complex mixture of chemical compounds. Few studies about the relation between cigarette smoking and glycoconjugate were found in literature, while no study was observed regarding passive smokers. Thus this relation is obscure till now. Therefore this work was designed to study the effect of cigarette smoking on serum glycoconjugates levels. Methods: One hundred twenty one completely healthy males from different areas of Duhok governorate were included in this study. Their age was ranged between 20 and 50 years. They were classified according to the number and duration of cigarette smoking into: heavy smokers (31), moderate smokers (26), passive smokers (30) and non-smokers (control). Fasting blood was withdrawn from all groups and used for determination of serum fucose and its related parameters. Results: The results showed that there was a significant decrease in serum total protein in heavy smoker groups when compared to non-smokers. The levels of serum total fucose and protein bound fucose significantly increased in smoker groups, while the results indicated that there was a significant increase in serum lipid associated fucose levels in heavy and passive smoker groups comparing to non-smoker group. A significant decrease in serum protein bound hexoses was observed in both heavy and moderate smokers. The result also showed that serum total calcium concentration, Ca/TP and Mg/TP ratios significantly decreased in all smoker groups.Regarding to serum Manganese (Mn) and Mn/TP ratio, their values increased significantly in case of passive smokers only. Conclusion: The results revealed that cigarette smoking had significant effects on glycoconjugates status (expressed in serum fucose and its related parameters).