Abstract
Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269–0.798), 0.639 (0.383–1.065), and 0.614 (0.365–1.031) among men and 1.000, 0.773 (0.498–1.200), 0.602 (0.382–0.947), and 0.603 (0.381–0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes.
Highlights
Diabetes mellitus is a major public health problem [1] and a leading cause of morbidity and mortality, with an estimated 346 million adults being affected worldwide in 2011 [2]
Based on the World Health Organization criteria, we identified prediabetes among 14.1% of the participants (339/2402; men: 15.1% (146/964), women: 13.4% (193/1438)), and diabetes among 32.6%
This study examined the associations of serum Mn levels with prediabetes and diabetes among community-dwelling adults who were ≥60 years old
Summary
Diabetes mellitus is a major public health problem [1] and a leading cause of morbidity and mortality, with an estimated 346 million adults being affected worldwide in 2011 [2]. The prevalence of diabetes increases with age, and reaches 22.5% among adults who are ≥60 years old [3]. Trace elements, such as copper, zinc, iron, selenium, and manganese (Mn), are essential for human health and are involved in various metabolic and biological functions [5]. Some trace elements (e.g., Mn) can potentiate insulin’s action in reducing blood glucose levels [10]. It remains unclear whether Mn has effects in patients with diabetes
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