Major Transformation Research Articles

Transformation of sartan blood pressure regulators by ferrate(VI) and its activation systems: Kinetics and mechanisms

With the increasing number of patients diagnosed with hypertension, the annual consumption of sartan drugs has surged, resulting in their ubiquitous detection in aquatic environments. This increases concerns about their environmental persistence and unexpected toxicity. This study explores the applications of ferrate(VI) (Fe(VI)) in removing sartan blood pressure regulators (losartan (LOS), valsartan (VAL), and telmisartan (TEL)). Results demonstrate that sartans could be effectively removed by Fe(VI). Oxidation of LOS by Fe(VI) was pH-dependent at pH 7.0–9.0, with HFeO4– dominating the reaction. The second-order rate constants (kapp) of LOS with Fe(VI) decreased with increasing solution pH, and kapp was calculated to be 148.37 M−1 s−1 at pH 8.0. Furthermore, the Fe(VI)-Fe(III), Fe(VI)-S(IV), and Fe(VI)-S2O32– systems demonstrated the enhancement for the elimination of LOS, while the Fe(VI)–HCO3– system inhibited the reaction. Oxidizing product (OP) analysis suggested that the major transformation patterns of LOS, VAL, and TEL treated by Fe(VI) and its activation systems included oxidation, imidazole ring cleavage, cyclization, N-dealkylation, and bond cleavage. Multiple OPs were estimated to be more persistent and mobile than parent sartans, while their toxicity toward aquatic organisms might be several times lower than those of their parents. Overall, this study elucidates the oxidizing feasibility of Fe(VI) and related activation systems to eliminate sartans in water treatment.

Emissions and transport of urban biocides from facades to topsoil at the district-scale

Urban biocides used in facade paints and renders to prevent algae and fungal growth are released into the environment during rainfall, subsequently contaminating groundwater. However, quantitative data on the emission, transport and infiltration of urban biocides at the district scale are generally lacking. In this study, we quantified the fluxes of the urban biocide terbutryn and its major transformation product, terbutryn-sulfoxide, from building facades into stormwater, sediment, soil, and vegetation within a seven-year-old district employing sustainable stormwater management such as infiltration trenches and ponds. Combining four months of field observations with district scale modeling, we estimated initial concentrations of terbutryn in facade paint, quantified the emissions of terbutryn and terbutryn-sulfoxide from facades to soil, and evaluated terbutryn storage in soil under various painting scenarios. Terbutryn concentrations in sustainable stormwater management systems ranging from 2 to 67 ng L−1, frequently exceeding predicted no-effect concentrations. The constant release of terbutryn and its transformation products in runoff highlighted the chronic exposure of non-target organisms to urban biocides. Terbutryn concentrations in topsoil and pond sediment indicated accumulation, while concentrations exceeding 1 μg g−1 in the vegetation suggested plant uptake. Model results revealed that a substantial portion (27 to 73 %) of biocides infiltrated near facades through permeable surfaces like gravel, while a smaller portion (7 to 39 %) reached the stormwater management systems. Additionally, significant biocide leaching in the topsoil (30 cm below the surface) underscored the potential for biocide contamination in groundwater. Overall, this district-scale study and modeling approach provide a comprehensive framework for evaluating scenarios and measures for sustainable stormwater management to mitigate the infiltration of urban biocides into groundwater.

The Great Transformation of the Agri-Food Sector: A Transformation for Life and Well-Being

This analysis aims to explore the urgent need to drive a major transformation of the agri-food sector. With this, it is intended to contribute to defining strategies for the future of agri-food systems. In this sense, the dynamics and importance of the agri-food sector are examined. Scientific and technological developments in the sector are described below. Subsequently, the implications of the link between health and agri-food systems are discussed. Next, alternatives are proposed to recover, heal and improve agri-food systems and the planet. Finally, some strategies are formulated to begin the great transformation of the agri-food sector, a transformation for the life and well-being of all. With appropriate planning and management, the great transformation of the agri-food sector can be achieved and the demand for healthy, nutritious and safe foods can be met.

Research on the Planning and Design of Med–Small-Sized Hospitals in China Based on Patient Perceived Value in the Context of Healthcare Model Transformation

China’s aging society has led to a major transformation of the healthcare model from traditional therapeutic medical care to life support healthcare. Med–small-sized hospitals (with 20–299 beds) are expected to play a major role in this transition compared to large hospitals. However, hospitals often take 3–5 years or more from design to construction. In order to guide architects in planning and designing for future needs, this study aims to identify the key points of planning and design that can enhance the value of med–small-sized hospitals in terms of functional configuration, spatial environment, etc. In this study, a questionnaire survey was conducted on the perceived value of 600 patients in Nanjing, China. The data were used to construct a structural equation model (SEM) of perceived value for med–small-sized hospitals in China. There are 24 observed variables in six dimensions, including cost value, functional value, social value, cognitive value, patient satisfaction, and patient loyalty. The final SEM indicates that optimizing functional configurations and spatial environment design can significantly increase the value of hospitals, while patients’ willingness to go to the inpatient department is quite low. Finally, based on the survey findings from Nanjing, we proposed four optimization strategies: (1) promoting diversified development and collaboration based on regional characteristics, (2) optimizing functional configurations, (3) maintaining an efficient and concise patient experience, and (4) optimizing the inpatient department.

Immigration and Its Impact on Europe's Societal Security: Examining the Rise of Far-Right Parties (2014-2024)

This study examines the relationship between immigration and the rise of far-right parties in Europe from 2014 to 2024, focusing on the implications for societal security. It explores how far-right parties have capitalized on immigration, framing it as a critical threat to national identity and social stability. Applying the Copenhagen School’s securitization theory, the research analyzes how these parties have redefined immigration as a national security issue, thereby legitimizing more stringent immigration policies and exclusionary practices. The findings indicate that far-right parties have effectively utilized public anxieties and uncertainties surrounding immigration to influence the political discourse across Europe. This shift has significant socio-political consequences, posing challenges to the European Union’s foundational principles of integration, democracy, and human rights. The study highlights concerns over democratic backsliding, the erosion of social policies, and threats to freedom of movement and human rights. Additionally, it examines the potential impacts on the EU’s cohesion policy, foreign policy, enlargement process, and environmental sustainability. The research underscores a major transformation in Europe’s political landscape with far-reaching implications for the stability of the European Union and its member states.

Study on hydrolytic, oxidative and photolytic degradation behaviour of anticancer drug sonidegib: Characterization of the products by UHPLC-Q-TOF-MS/MS, 2D NMR and in silico toxicity assessment

Sonidegib (SDG) is a USFDA-approved anticancer drug developed for treating basal cell carcinoma. The presented study is focused on forced degradation studies of SDG with special emphasis on oxidative and photolytic degradation. Stress testing was performed as per ICH guidelines in hydrolytic, oxidative, and photolytic stress, revealing the formation of 15 transformation products. The results demonstrated the sensitivity of SDG to photolytic exposure under UV-A light, as well as to oxidative stress conditions involving hydrogen peroxide and a radical initiator. The observed DPs are separated and identified using RP-LC-PDA using a linear gradient program equipped with C18 (4.6 ×250 mm, 5 µm) column. All the DPs with >0.1 % concentration are characterized using tandem mass spectrometry and DPs with complex, unstable and isomeric nature are enriched and studied using solution NMR. Enrichment studies unveiled the formation of DP-6, DP-11, DP-12 and DP-13 as major transformation products. Interpretation of characteristic fragments from MS/MS spectra, NMR chemical shifts, and NOEs are utilized to solve the structure of the DPs. Further elucidated structures are employed to propose the involved mechanisms in degradation pathway. In addition, the DPs are studied for toxicity in silico and the potential/plausible carcinogenic, genotoxic and mutagenic nature of the DPs are illustrated.

Possibilities of using chatbots in the teaching of grammar in teacher training

Education and the process of teaching and learning is undergoing a major transformation today. 21st century skills increasingly emphasize the importance of collaboration, self-development and lifelong learning. In addition, new information and communication technologies are emerging and the potential for the use of artificial intelligence in education is growing. In teacher education, the teaching of semantics and grammar (vocabulary, morphology, syntax) in the Hungarian Language II course is combined with the development of algorithmic thinking in mathematics. This provides space for integration between the subjects and the theory of multiple intelligences. By rethinking traditional teaching, we gave the students the task of playing the role of a chatbot. This paper summarizes the description and results of this experimental research, as well as the complex support for students based on multiple intelligences.

465. INNOVATION TO STANDARDIZATION OF THORACOLAPAROSCOPIC ESOPHAGECTOMY: CULMINATION OF THREE DECADES OF EXPERIENCE

Abstract Minimally invasive esophagectomy has seen a great deal of evolution over the last three decades. As one of the earliest adopters of minimally invasive approach for esophagectomy, we present our experience and the lessons we have learnt in over 1300 cases. We adopted the prone position and later modified to mid prone position for the thoracic phase of esophagectomy. This position has several advantages of better exposure due to gravity aided retraction of the lungs, clear operating field as blood trickles away as well as feasibility of rapid conversion to open thoracotomy in emergencies. A major transformation in our surgery was the technical modifications and the extent of mediastinal lymphadenectomy. With refinements in technique and greater understanding of the lymphatic spread, we evolved from standard to extended and even total mediastinal lymphadenectomy improving the oncological outcomes without increasing the operative morbidity. The mean total lymph node yield is over 35. Recurrent laryngeal nerve injury was noted in 7% of cases. The technique of anastomosis was also extensively modified from hand sewn to circular stapler to semi mechanical and finally fully mechanical side to side anastomosis using triangulation technique. The triangulation technique has led to significant reduction in leak rates to less than 5% and stricture formation (<1%). Finally, our innovative railroading technique for specimen extraction through the neck is oncologically safe that avoids large incisions in the chest or abdomen. The 30 day mortality rate is less than 1%

N-TUTORR: Addressing Artificial Intelligence as one element of the transformation of Ireland’s technological higher education sector

A major transformation programme is underway across seven technological higher education institutions in Ireland. Investment of €40m #NextGenerationEU funding enables a programme to empower learners, to enhance staff capabilities, to improve the digital infrastructure, and to ensure long-lasting sustainable impact. Designed and implemented by significant collaboration of partner institutions, the programme explicitly adopts a holistic approach with inter-related work streams and work packages. The programme is underpinned by the six core themes of academic integrity, digital transformation, education for sustainability, employability, equality diversity & inclusion, universal design for learning. This comprehensive structure enables focus on key issues, emerging topics, and ensuring sustainable enhancement of learning, teaching and assessment across the technological sector. Multiple elements of the programme provided opportunities to reflect on the role of artificial intelligence, ranging from the perspective of challenges associated with academic integrity to the wider potential to be exploited to support and enhance learning and teaching. Students play an active role in considering these issues through focussed projects in partnership with staff and by acting as student champions to ensure that students‟ perspectives inform related discussions. Staff development opportunities have focussed on artificial intelligence and specific training is in place for senior institutional leaders. Active cooperation with the National Academic Integrity Network, which is facilitated by the national external quality agency, has led to complementary focussed activities. A national practitioners‟ network is being established to examine the impact of generative AI on higher education. Many of these structures could be replicated in other institutions or groups of institutions. While there are many examples of programme activities addressing important or topical issues, this paper particularly focuses on themes relating to the 2024 EDEN conference.

أثر إدارة سلاسل التوريد على كفاءة وتكاليف شركات النقل بالمملكة العربية السعودية

This study aims to explore the impact of supply chain management on the efficiency and costs of transportation companies in the Kingdom of Saudi Arabia. The study is of particular importance in light of the major economic transformations witnessed by the Kingdom within Vision 2030, which seeks to enhance economic diversification and improve the efficiency of various sectors, including the transportation sector. The descriptive analytical approach was used to achieve the objectives of the study. Data were collected through a questionnaire distributed to a random sample of 165 transportation companies in the Kingdom, where the sample included supply chain managers and senior management in various companies. The results showed that there is a positive and noticeable impact of effective supply chain management on improving operational efficiency and reducing costs in transportation companies. It was also shown that adopting modern technologies and developing relationships with suppliers and distributors contribute significantly to enhancing the overall performance of companies. Based on these results, the study recommends the need to invest in developing supply chain management systems and adopting modern technology to enhance efficiency and reduce costs, in addition to enhancing cooperation and communication between companies and suppliers to achieve better performance and increase competitiveness in the local and regional market.

Metagenomic analyses of aerobic bacterial enrichment cultures that degraded Tris(2-chloroethyl) phosphate (TCEP) and its transformation products

Tris(2-chloroethyl) phosphate (TCEP) is of growing public concern worldwide because of its ubiquitous contamination, toxicity, and persistence. In this study, we investigated bacterial communities in aerobic enrichment cultures with TCEP and its two major transformation products bis(2-chloroethyl) phosphate (BCEP) and 2-chloroethanol (2-CE) as the sole carbon source. Burkholderiales and Rhizobiales were likely two main bacterial guilds involved in the hydrolysis of TCEP, while Rhizobiales and Sphingomonadales may play an important role in the hydrolysis of BCEP, given the increase of Rhizobiales and Sphingomonadales-related phosphoesterase genes when the carbon source was switched from TCEP to BCEP. All Burkholderiales, Rhizobiales, Sphingomonadales were probably efficient in 2-CE metabolism, because their dehydrogenase genes and dehalogenase genes increased after 2-CE enrichment. The different substrate preference of different bacterial guilds highlighted the importance to understand the diversity and collaboration among functional bacteria. Meanwhile, two TCEP-degrading strains affiliated with Xanthobacter and Ancylobacter were isolated. Xanthobacter sp. strain T2-1 was able to degrade both TCEP and BCEP following the pseudo-first-order kinetics with reaction rates of 1.66 h−1 for TCEP and 1.02 h−1 for BCEP, respectively. Ancylobacter sp. strain T3-4 could degrade TCEP following the pseudo-first-order kinetics with a reaction rate of 2.54 h−1, but is unable to degrade BCEP. Additionally, strains that were phylogenetically closely related were found to have different degradation capabilities toward TCEP and/or BCEP, indicating the importance to investigate functional genes such as phosphoesterase genes.

Synthesis of Chromone‐3‐phosphonates via Arbuzov‐Type C−P Cross Coupling from o‐Hydroxyphenyl Enaminones and Phosphites

AbstractWith an in situ C−H iodination tactic, a method for the synthesis of chromone‐3‐phosphonates was developed with trialkyl/triaryl phosphites as the reaction partners of o‐hydroxyphenyl enaminones by palladium catalysis. The product formation consists of cascade C−H iodination, chromone annulation, and Arbuzov‐type C−P cross coupling as major transformations. In addition to providing an enaminone‐based synthetic method to chromone‐3‐phosphonates, the work shows the advantage of step economy by skipping the separate operation for preparing the iodo‐functionalized chromone intermediate.

Unraveling the Potential of Decentralized Finance: A Comprehensive Analysis of Opportunities, Risks, and Future Trends

The financial sector is going through a major transformation and evolution with the emergence of Decentralized Finance (DeFi). It is a modern concept that is reshaping the traditional financial landscape and thus changing traditional financial structures. This research delves into the term “Decentralized Finance” by exploring its various advantages, associated challenges, and future patterns and trends. Leveraging blockchain technology, DeFi offers new financial services without intermediaries that in turn enhance financial inclusion, autonomy, and economic empowerment of individuals, though this also entails enormous risks and challenges, including vulnerability to smart contract vulnerabilities, regulatory uncertainty, and market volatility. This research also attempts, through a systematic literature review, to identify the most significant opportunities for DeFi, such as democratized access to financial services, lower transaction fees, and increased liquidity. Additionally, this research highlights the key challenges facing the development of DeFi, such as limitations on its ability to handle large transactions, concerns about user data protection, and the need to adhere to regulatory standards. The paper concludes with a view and insights into the future of DeFi, emphasizing the importance of regulatory clarity, technological innovation, and community governance in shaping the trajectory of DeFi. This analysis contributes to gaining a deeper understanding of the potential and capabilities of DeFi, and provides stakeholders with indispensable insights to navigate the dynamics of DeFi.

Analysis of Social Perspectives in Reconstructing the History of Urbanization in Medan City

Urbanization is considered to be an ingrained social phenomenon in various large Indonesian cities, characterized by rapid urban population growth and drastic changes in social, economic and environmental structures. Urbanization in Indonesia shows a rapid increasing trend over the last few decades. Medan City, as one of the main urban centers in North Sumatra, has not escaped the impact of significant urbanization. Along with rapid economic and demographic growth, the city has experienced a major transformation in various aspects of city life. This research aims to identify the history of urbanization in Medan City from a social perspective. The research method used is a qualitative descriptive method through literature study sourced from journals, scientific articles, books and other relevant sources. The results of this research show that urbanization in Medan City has been going on for a long time. Strategically located on the east coast of Sumatra and between the confluence of the Deli River and the Babura River, Medan has vital trade access to the Malacca Strait. Especially in the period 2012 to 2022, the increase in population in Medan City occurred in almost all sub-districts. Of the 21 sub-districts, 17 sub-districts experienced an increase in population of more than 10%. Only one sub-district experienced a decline in population, namely Medan Baru Sub-district by 7.89%. The high level of urbanization in the city of Medan is generally caused by several factors, such as strategic location, the presence of natural resources (SDA), and supporting natural conditions. Meanwhile, the impact on society's social life includes rapid population growth, changes in societal structure, and social and cultural dynamics.Keywords: History, Urbanization, Social, Medan City

Glacial to periglacial transition at the end of the last ice age in the subtropical semiarid Andes

Atmospheric warming and circulation reorganization at the end of the last ice age represent the most important climate change of the last 100,000 years and provide an opportunity to uncover how the southern subtropics cryosphere responded to strong changes in the global climate system. Extensive mapping and chronologic records on cryogenic landforms to better understand the association and interactions between glaciers and viscous creep of ice-rich permafrost landforms (rock glaciers) are widely missing in the region. In this paper, we reconstruct the geomorphic imprint of the Last Glacial Maximum (LGM) and the Termination I in the high Andes of the Río Limarí Basin (30–31°S) in the subtropical semiarid Andes of Chile. 74 new 10Be surface exposure dating ages constrain the timing of glaciation, deglaciation, and glacial to periglacial transition. Glacial advances occurred first by 41.2 ± 0.6 – 35.0 ± 0.5 ka during Marine Isotope Stage 3, but probably earlier also; then, a second advance occurred during the global LGM between 24.2 ± 0.4 and 18.6 ± 0.2 ka. Deglaciation by 17.6 ± 0.2 ka left extensive hummocky moraines on the main valleys. Characteristic patterns of furrows and ridges typical of rock glaciers and solifluction superimposed on the LGM hummocky moraine indicate ice-rich permafrost in glacial deposits likely between 15.5 ± 0.3 and 13.6 ± 0.3 ka. We propose that moraines deposited by LGM debris-covered glaciers served as a niche for strong seasonal frost and permafrost creep, which substantially modified the original landforms. Our results contribute to a better understanding of major transformations in an ice-rich high mountain area of the southern hemisphere where the interplay of temperature and precipitation changes drove glacial to periglacial transitions.

In-Situ Raman Spectroscopy of Li+ and Na+ Storage in Anodic Nanotubes

Anodizing is a high-voltage electrochemical conversion process that forms barrier-type oxide layers or self-organized nanoporous/nanotubular structures. So far, the Al2O3-like nanopores and TiO2-like nanotubes could be successfully synthesized on many valve metals and alloys.Recently, it become possible to form nanotubular structures on iron and consequently control the ratio of hematite (Fe2O3) to magnetite (Fe3O4) by subsequent thermal treatment.1 Electrochemically active nanotubes, such as self-organized TiO2 are of high interest in the battery field due to a unique one-dimensional (1D) geometry offering high volume expansion tolerance and applications without binders and conductive additives. Herein, we report an in - situ Raman spectroscopy study under current control for a better fundamental understanding of Li+/Na+ storage in nanotubes and correlate the structural fingerprints with the electrochemical data on differential capacity plots of d(Q–Q 0) dE –1.2 Real-time measurements revealed that the nanotubes had undergone two major phase transformations with increasing lithium content, disclosing the sequential steps of a lithium intercalation type of storage. In contrast, sodium-ion insertion induced no significant crystal structure modification but instead a slight crystallinity rupture, signifying a dominant nondiffusion-limited capacitive type of storage. The insight into the charge storage in a 1D material in relation to other nanostructures such as nanoparticles3 will be discussed.1. L. Fadillah, D. Kowalski, M. Vincent, C. Zhu, S. Kitano, Y. Aoki and H. Habazaki, ACS Applied Materials & Interfaces , 2023, 15, 52563-52570.2. M. Vincent and D. Kowalski, ACS Applied Nano Materials , 2023, 6, 6528-6537.3. M. Vincent, S. S. Kumar and D. Kowalski, Electrochimica Acta , 2023, 469, 143161. Figure 1

Mapping Photogenerated Electron-Hole Behavior of Graphene Oxide: Insight into a New Mechanism of Photosensitive Pollutant Degradation.

The use of graphene oxide (GO) photogenerated electron-hole (e-h+) pairs to degrade pollutants is a novel green method for wastewater treatment. However, the interaction between photosensitive pollutants and a GO-light system remains unclear. In this work, the mechanism of degradation of photosensitive pollutant tetracycline (TC) promoted by GO photogenerated e-h+ pairs was studied. Our studies encompassed the determination of TC removal kinetics, analysis of active substances for TC degradation, identification of degradation products, and computational modeling. Clear evidence shows that a new reaction mechanism of enhanced adsorption and induced generation of reactive oxygen species (ROS) was involved. This mechanism was conducive to significantly enhanced TC removal. Kinetic studies showed a first-order behavior that can be well described by the Langmuir-Hinshelwood model. Radical scavenging experiments confirmed that 1O2, •O2-, and holes (h+) were the main active substances for TC degradation. Electron spin resonance analysis indicated that photoexcited TC molecules may transfer electrons to the conduction band of GO to induce the generation of additional ROS. A major transformation product (m/z 459) during TC degradation was identified with liquid chromatography-mass spectrometry. Density functional theory calculation indicated a stronger adsorption between TC and GO under photoirradiation. This mechanism of photo-enhanced adsorption and synergistic induced generation of ROS provides a new strategy for the removal of emerging pollutants in water. Overall, the new mechanism revealed in this work expands the knowledge of applying GO to wastewater treatment and is of great reference value for research in this field.

Transition toward Sustainability in the Moroccan Food System: Drivers, Outcomes, and Challenges

Nowadays, food systems are undergoing major transformations to achieve the 2030 Sustainable Development Goals (SDGs). However, there are a lack of comprehensive reviews on this topic in developing countries. This work highlights food systems’ transition towards sustainability, focusing on Morocco. It was carried out through searching, selecting, evaluating, and synthesizing existing relevant scholarly and gray literature. In Morocco, a meaningful transition towards sustainability is being guided and carried out on several levels, despite numerous challenges, e.g., inability to cope with the detrimental effects of climate change and escalating water scarcity constitute fundamental problems. However, there are conflicting views on the outcomes of food system transformation. Some studies showed that Morocco has increased its agri-food export and reduced poverty to less than 5% of the population over the past decade; the proportion of wasted and malnourished children has declined from 25 to 15% and 4 to 3%, respectively, and the 2023 Global Hunger Index (GHI) showed a score of 9.0. Other studies showed that North Africa has entered a food security crisis; specifically, food inflation has reached unprecedented levels in Morocco. This paper provides valuable insights for policymakers and planners to design evidence-based policies and strategies to boost sustainable development in Morocco.

Projected rapid response of stratospheric temperature to stringent climate mitigation

Deep, rapid and sustained reductions in greenhouse gas emissions are required to meet the 2015 Paris Agreement climate target. If the world strengthens efforts toward near-term decarbonisation and undertakes major societal transformation, this will be met with requests from policymakers and the public for evidence that our actions are working and there are demonstrable effects on the climate system. Global surface temperature exhibits large internal variability on interannual to decadal timescales, meaning a reduction in the magnitude of surface warming would not be robustly attributable to climate mitigation for some time. In contrast, global stratospheric temperature trends have much higher signal-to-noise ratios and could offer an early indication of the effects of climate mitigation. Here we examine projected near-term global temperature trends at the surface and in the stratosphere using large ensemble climate models following three future emission scenarios. Under rapid, deep emission cuts following SSP1–1.9, modelled middle and upper stratospheric cooling trends show a detectable weakening within 5 years compared to a scenario approximately representing current climate commitments (SSP2–4.5). Therefore, stratospheric temperature trends could serve as an early indicator to policymakers and the public that climate mitigation is taking effect.

Degradation and detoxification of 6PPD-quinone in water by ultraviolet-activated peroxymonosulfate: Mechanisms, byproducts, and impact on sediment microbial community

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-Q) has been identified to induce acute toxicity to multifarious aquatic organisms at exceptionally low concentrations. The ubiquity and harmful effects of 6PPD-Q emphasize the critical need for its degradation from water ecosystems. Herein, we explored the transformation of 6PPD-Q by an ultraviolet-activated peroxymonosulfate (UV/PMS) system, focusing on mechanism, products and toxicity variation. Results showed that complete degradation of 6PPD-Q was achieved when the initial ratio of PMS and 6PPD-Q was 60:1. The quenching experiments and EPR tests indicated that SO4•− and •OH radicals were primarily responsible for 6PPD-Q removal. Twenty-one degradation products were determined through high-resolution orbitrap mass spectrometry, and it was postulated that hydroxylation, oxidative cleavage, quinone decomposition, ring oxidation, as well as rearrangement and deamination were the major transformation pathways of 6PPD-Q. Toxicity prediction revealed that all identified products exhibited lower acute and chronic toxicities to fish, daphnid and green algae compared to 6PPD-Q. Exposure experiments also uncovered that 6PPD-Q considerably reduced the community diversity and altered the community assembly and functional traits of the sediment microbiome. However, we discovered that the toxicity of 6PPD-Q degradation solutions was effectively decreased, suggesting the superior detoxifying capability of the UV/PMS system for 6PPD-Q. These findings highlight the underlying detrimental impacts of 6PPD-Q on aquatic ecosystems and enrich our understanding of the photochemical oxidation behavior of 6PPD-Q.