Major Substances Research Articles

Involvement of UDP-glycosyltransferase of Kalanchoe pinnata (Lam.) Pers in quercitrin biosynthesis and consequent antioxidant defense

Plants in the Crassulaceae family are rich in flavonoids, which may contribute to their high antioxidant activity and strong tolerance to abiotic stresses. Kalanchoe spp. are known to have high antioxidant activity, but the main components responsible for this activity and the mechanisms that control antioxidant accumulation in these plants are unknown. In this study, we identified the dominant flavonoid and investigated the mechanisms of its accumulation in Kalanchoe leaves. A wide metabolomics analysis showed that flavonoids were the most enriched metabolites in the leaves of Kalanchoe pinnata (Lam.) Pers, Kalanchoe delagoensis (Eckl. et Zeyh.) Druce, and Kalanchoe fedtschenkoi ‘Rosy Dawn’. Among these metabolites, levels of quercitrin were significantly higher in K. pinnata (Lam.) Pers than in the other two species. RNA-seq and targeted metabolomics analyses conducted on four different K. pinnata (Lam.) Pers tissues indicated that UDP-glycosyltransferase regulates the synthesis of quercitrin. Using in vitro enzyme assays and overexpression in tobacco we demonstrated that KpUGT74F catalyzes glycosylation of quercetin to produce quercitrin. This study identified the major antioxidant substances and their key regulatory mechanisms in Kalanchoe pinnata (Lam.) Pers to provide an important theoretical basis for understanding the high stress tolerance of these plants.

Integrative Analysis of Transcriptome and Metabolome Reveals the Regulatory Network Governing Aroma Formation in Grape

The aroma metabolites in grape berries have received attention in recent years, but a global analysis of gene-regulated metabolites is still lacking. In this study, three grape cultivars, “Kyoho”, “Adenauer Rose”, and “Mei Xiangbao”, were used to determine the differential accumulation of metabolites and identify candidate genes related to grape berry aroma. A total of 27,228 genes were detected from the transcriptome, and 128 differentially accumulated metabolites (DAMs) were identified. Terpenoids and ester were the major substances in these three cultivars. KEGG enrichment showed that 12, 8, and 5 compounds were significantly enriched during the maturation process of these three grape cultivars, with most being terpenoids. A combined transcriptome and metabolome analysis found that the associated genes and metabolites were enriched in the following pathways: “Glycine, serine, and threonine metabolism”, “Cysteine and methionine metabolism”, “Tyrosine metabolism”, “Phenylalanine metabolism”, and “Phenylalanine, tyrosine, and tryptophan biosynthesis”. Seven structural genes (VvOMR1, VvGLYK, VvLPD2, VvAK2, VvSHM7, VvASP3, and VvASP1) and four transcription factors (VvERF053, VvERF4, VvMYB46, and VvMYB340) related to grape berry aroma accumulation were discovered. Our findings provide new insights into grape aroma formation and regulatory mechanism research, and the results will be beneficial for grape aroma breeding in the future.

Research Progress on Bioactive Substances of Beets and Their Functions

As a globally cultivated and economic crop, beets are particularly important in the cane sugar and feed industries. Beet pigments are among the most important natural pigments, while various chemical components in beets display beneficial biological functions. Phenolic substances and betalains, as the main bioactive compounds, determine the functional characteristics of beets. This review categorizes the basic types of beets by the chemical composition of bioactive substances in their leaves, stems, and roots and emphatically summarizes the research progress made on the functions of two major substances in different types of beets: phenolic compounds and betalain pigments. This study provides useful insights for the comprehensive and effective application of beets in the health food and pharmaceutical industries.

Chemical profiling, bioactive compounds, antioxidant, and anti-inflammatory activities of Indonesian propolis extract produced by Tetragonulalaeviceps

Propolis produced by stingless bees contains various chemical compounds that contribute to its bioactivity. The availability of certain plants at the growth site and the propolis's geographic origin have a significant impact on its chemical composition. The objective of this study was to examine the chemical profile, yield, total flavonoid and phenolic content, and in vitro antioxidant and anti-inflammatory effects of propolis extract from 10 distinct locations in Indonesia. The yield of propolis extract investigated in this study lies in the range of 26.25 ± 1.76 to 43.25 ± 3.60 %. The total phenolic content of the propolis extract varies from 50.03 ± 3.40–98.03 ± 13.94 mg GAE/g whereas the total flavonoid content of the propolis extract varies from and 0.70 ± 0.08–57.76 ± 0.67 mg QE/g. The antioxidant activity of the propolis extract in terms of IC50 values lies in the range of 332.07 ± 6.12 to 831.48 ± 29.48 ppm whereas the anti-inflammatory activity of the propolis extract in terms of IC50 values lies in the range of 28.69 ± 4.95 to 44.12 ± 19.22 ppm. Both the total flavonoid and phenolic content of the propolis extract from various locations were correlated with the antioxidant activities and anti-inflammatory activities. The results indicate that there was a significant negative correlation between the total flavonoid and phenolic content of the propolis extract with the antioxidant activity. However, the anti-inflammatory activity was not strongly correlated with the total flavonoid and phenolic content of the propolis extract. There were 36 volatile compounds in the propolis extract as identified by the Gas Chromatography–Mass Spectrometry with triterpenoid as the major substances (28.66–44.86 %). The presence of anti-inflammatory compounds particularly α, β-Amyrin (2.2–6.52 %) and lupeol (2–4.72 %) in the propolis extract highlights the potential of propolis in health and medicine application.

Phytochemical Analysis and Assessment of Antioxidant and Enzyme Inhibitory Activity of Alchemilla pseudocartalinica Juz.

This study aimed to evaluate and compare the antioxidant capacity and enzyme inhibitory activity of extracts, sub-extracts, and fractions prepared from the aerial parts and roots of A. pseudocartalinica. The phytochemical content of the active extracts was also analyzed. According to the results, ellagic acid (38.42 mg/g) was the major compound in the aerial part methanol extract and catechin (185.30 mg/g) in the root methanol extract. The DPPH inhibition activity of all fractions was monitored, with the most active one (Fr B) reaching an IC50 value of (4.92±0.59 μg/mL). All the fractions prepared from the aerial parts' water sub-extract showed higher a-glucosidase inhibitory activity than the positive control acarbose. In the tyrosinase assay, Fr B (58.81±7.50 μg/mL) exhibited the highest inhibitory actions among all fractions. The structure of the major substances of the most active fraction were elucidated as quercetin 7-O-β-glucopyranosyl-3-O-β-glucuronopyranoside- (1), and α-[(2-formyl-5-hydroxymethyl)pyrrol-1-yl]aspartic acid (2).

Zakłady niesevesowskie – stwarzające zagrożenie wystąpienia poważnej awarii przemysłowej

Non-Seveso establishments – plants posing a risk of a major industrial accident Various definitions and approaches used by organizations and control and supervisory institutions are reflected in the list of establishments posing a risk of a major industrial accident, which are not upper- and lower-tier establishments. The article proposes a definition that includes both sub-threshold establishments with smaller quantities of non-hazardous substances than qualify an establishment as a lower tier establishment and establishments containing other chemical substances that could be the source of a major accident. The results of analyses of databases of chemical substances present in non-Seveso establishments, the correlation of the definition of a major accident and chemical substances, and the failure rate for non-Seveso establishments are presented. Keywords: non-Seveso establishments, dangerous substances, major accidents

Cousinia birandiana (Asteraceae): phytochemical composition, antioxidant and enzyme inhibition capacity

Cousinia birandiana is one of the widely spread species of the Asteraceae family. In this study, the total phenolic and flavonoid contents, the inhibitory effect on α-amylase, α-glucosidase, acetylcholinesterase and butyrylcholinesterase enzymes, the antioxidant capacity (by DPPH, ABTS, FRAP, CUPRAC tests) and the phytochemical content (by LC-HRMS) of the ethanol extract and fractions were studied. As a result, it was shown that ethanol extract has better enzyme inhibitory effects on α-amylase, AChE and BChE enzymes with 300.000, 380.605 and 133.567 µg/mL IC50 values. Besides that, the highest phenolic and flavonoid content was found in the ethyl acetate fraction (735.986 mgGAE/gextract and 952.317 mgCA/gextract, respectively). It is observed that the same fraction has better antioxidant activity in DPPH (IC50 =112.701 mg/mL), ABTS (9.494 µM Trolox/gextract) and CUPRAC (1120.454 mgGAE/gextract) tests and the n-hexane fraction has a higher FRAP (1351.199 mmol Fe2+/gextract) antioxidant effect. According to the phytochemical analyses quinic acid, chlorogenic acid and isoquercitrin were found as major compounds in the ethanol extract and fractions. In addition, the same assays were carried out with these major substances. So, this plant can be viewed as a promising bio-resource for pharmaceuticals and biomedical products.

Intracellular pyruvate as one of the major bioactive substances of lactic acid bacteria isolated from kimchi.

The present study aimed to identify the metabolites associated with the physiological activity of kimchi-derived lactic acid bacteria (LAB). A clear difference was observed between the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging rates when the pyruvate content was high (273.5 ng/µL; radical removal speed 6.50% per min) and the rates when the pyruvate content had decreased (131.9 ng/µL; radical removal speed 3.63% per min). Additionally, the characteristics of LAB antioxidant activity (increase in ABTS radical scavenging activity with reaction time, low level of 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity) were similar to those of pyruvate-derived activity. Hydrogen peroxide content (WiKim0124, 2.08 → 0.26; WiKim0121, 0.99 → 0.47; WiKim39, 1.93 → 0.24) and lactate dehydrogenase activity (WiKim0124, 1.53 → 0.00; WiKim0121, 0.73 → 0.01; WiKim39, 1.72 → 0.02) decreased more in heat-killed LAB than in non-heat-killed LAB. Accordingly, this resulted in increased pyruvate content and the inhibitory activity of lipid peroxide production increased by 2-3 times. Our findings indicate that pyruvate is one of the major metabolites regulating LAB physiological activity. PRACTICAL APPLICATION: The safety of utilizing live probiotics remains a topic of debate. To mitigate associated risks, there is a growing interest in non-viable microorganisms or microbial cell extracts for use as probiotics. Various methods can be employed for probiotic inactivation. Heat treatment typically emerges as the preferred choice for inactivating probiotic strains in many instances. The present study shows the distinctions between inactivating lactic acid bacteria (LAB) through heat treatment and non-heat treatment. It may serve as a valuable reference for selecting an appropriate inactivation method for LAB in industrial processes.

Comparison of toxic effects and underlying mechanisms of carbon quantum dots and CdSe quantum dots on Chromochloris zofingiensis from the chemical composition perspective

Quantum dots (QDs) are widely utilized semiconductor nanocrystal materials with both nanotoxicity and composition-related toxicity. To determine the toxicological impacts and underlying mechanisms of QDs with different compositions on microalgae, carbon QDs (CQDs) and CdSe QDs were used in the present study. Results showed that QDs composed of CdSe were more toxic than QDs composed of carbon, which inhibited cell growth, with reductions in chl b content, chlorophyll fluorescence parameters, and increases in lipids and starch (two major storage substances). In addition, CdSe QDs elevated reactive oxygen species (ROS), resulting in oxidative damage, while CQDs had little effect on antioxidants. Comparative transcriptome analysis showed that gene expression was accelerated by CdSe QDs, and there was a compensatory upregulation of porphyrin metabolism, potentially to support chlorophyll synthesis. In addition, an MYB transcription factor was predicted by weighted gene co-expression network analysis (WGCNA) to serve as regulator in nanoparticle toxicity, while glutathione peroxidase (GPX) and dual-specificity tyrosine phosphorylation regulated kinases 2/3/4 (DYRK2/3/4) may be key mediators of the composition-related toxicity of CdSe QDs. This study highlights the critical role of QDs’ composition in determining their impacts on aquatic microalgae, providing a theoretical reference for selecting appropriate QDs materials for various industrial applications.

UV light absorption at 370 nm by mineral dust, organic carbon, and elemental carbon in the Himalayas and Tibetan Plateau

The mass and light absorption contributions of organic carbon (OC), elemental carbon (EC), and mineral dust influence glacial melting and potentially contribute to climate change over the high Himalayas and Tibetan Plateau (HTP). Plateau-scale investigations of these components and their respective light absorption are limited due to the high altitude. In this study, we combined the analysis of major light-absorbing substances and their corresponding multiwavelength absorption to determine their specific contributions firstly. We investigated the spatial variations of total suspended particle (TSP) mass across the HTP, noting high contributions from dust, carbonaceous components, and secondary inorganic aerosols (SNA, including sulfate, nitrate, and ammonium). Enhanced levels of primary and secondary OC and SNA were observed in the marginal areas of the HTP, associated with high relative humidity (RH) and OX levels (O3+NO2). EC was the primary contributor to light absorption, accounting for approximately 68%, 46%, and 64% in Ngari, Qinghai Lake, and Beiluhe, respectively. We found higher light-absorbing contributions from carbonaceous aerosols in the marginal areas compared to the central HTP site, particularly during the heating seasons (∼90%). Fugitive dust significantly contributed to TSP mass but not to light absorption. The concurrent constraints on the mass and optical properties of OC, EC, and dust in this study can help reduce uncertainties in climate models specific to the HTP.

Influence of the chemical composition of leachates on the results of ecotoxicity tests for different slag types

In this study, four ecotoxicological tests on Vibrio fischeri bacteria, Sinapis alba L. (white mustard), Daphnia magna S. (daphnia's) and earthworms were performed for three types of aqueous slag (ladle, blast furnace and converter) leachates with two-grain sizes (<4 mm, <10 mm). Concentrations of toxic elements and concentrations of Cr(VI), Ca, Na, Al, and other ions were determined. The raw slags were analyzed using X-ray fluorescence spectroscopy (XRFS), and major substances were determined by X-ray powder diffraction (XRD). The aqueous slag leachates passed ecotoxicological tests and met the required criteria, showing no toxicity to Vibrio fischeri and complying with white mustard test criteria. According to the results of the ecotoxicity tests with daphnia, the blast furnace slag samples were not ecotoxic, while two other slag samples were found to be entirely compliant. Characterization of the slags showed that the effect of element/ion leachability and slag grain size is essential. Biplot principal component analysis (PCA) showed that grain size does not significantly affect the separation of individuals on the plane. A positive correlation on toxicity was found with pH, conductivity, calcium content, dissolved content, salinity and fluoride concentration, whereas a negative correlation was found with magnesium concentration, dissolved organic carbon and potassium concentration. The effective concentration at 50% inhibition (EC50) value for Vibrio fischeri correlated with the first dimension of bivariate assessment. In summary, it was found that the investigated slags can be effectively reused as they comply with regulations and do not endanger the environment.

Exploring Oral Manifestations: Unveiling the Impact of Illicit Drug Abuse

Addiction to illicit drugs is a major global public health issue that has a profound impact on both individual and community well-being. Although the effects of illegal substances on the body have been thoroughly examined, little is known about how they affect dental health. This thorough analysis seeks to clarify the complex interactions between major illegal substances and oral health, including both direct and indirect impacts. The review also addresses the effects of substance usage on treatment results, patterns of dental care utilization, and quality of life related to oral health. It emphasizes how crucial it is for public health authorities, addiction experts, and dentists to work together collaboratively to address the oral health requirements of those with drug use disorders.

Insecticidal Activity of Some Major Essential Oil Components against Metopolophium dirhodum and Its Predators.

Essential oils (EOs) are plant metabolites with important insecticidal effects. Nevertheless, information on the efficacy of the major substances on aphids and their natural enemies is still missing. The objective of this paper is, therefore, to identify the efficacy of selected EO majority substances-β-citronellol, carvacrol, isoeugenol, and linalool, including their binary mixtures-on the mortality and fertility of the aphid Metopolophium dirhodum, an important cereal pest. The best efficacy was proven for the binary mixture of β-citronellol and linalool (1:1 ratio), for which the estimated LC50(90) is 0.56(1.58) mL L-1. This binary mixture applied in sublethal concentrations significantly reduced aphid fertility. It was found that the phenomenon can be attributed to β-citronellol, as the females treated with LC30 laid 45.9% fewer nymphs, on average, compared to the control. Although β-citronellol and linalool, including their 1:1 mixture, showed very good efficacy on aphid mortality, they were, on the other hand, very friendly to the larvae of Aphidoletes aphidimyza and Chrysoperla carnea, which are important aphid predators. Based on our results, the newly discovered synergically acting binary mixture β-citronellol/linalool can be recommended as an efficient substance suitable for the further development of botanical insecticides used against aphids.

Self-assembly mechanism study of Xiaoqu Baijiu in the distillation and condensation stage

ABSTRACT The presented work proposes that the self-assembly of amphiphilic compounds in Xiaoqu Baijiu occurs at the distillation and condensation stage of Chinese Baijiu production for the first time. Such phenomena have similitude with the self-assembly nano-particles conducted by evaporation and condensation approaches. Hydrogen-bonding interactions prompting the formation of molecular clusters in the system. Herein, we characterized the variation of dipole moment, hydrogen bond strength, and cluster morphology in Xiaoqu Baijiu, based on electrochemical impedance spectroscopy, Raman spectroscopy, atomic force microscopy, and molecular dynamics simulation. The effects of major aroma substances on the self-assembly of Xiaoqu Baijiu were fully investigated, it turns out ethyl lactate had the strongest effect on resulting in self-assembled clusters.

Aroma Substances Generation and Variation of Broth in Pork Braised Processing based on Multi-Instrumental and Multiplex Analysis

The aim was to investigate and reveal the patterns of production and changes of major aroma substances in broth during quantitative repeated cycles of cooking and the effects of meat and spices on the formation of unique aroma in broth. Aroma substances were systematically identified and quantified for three groups (MS, broth cooked with meat and spices; M, broth cooked with meat; and S, broth cooked with spices) by using GC-MS, E-nose and tri-step infrared spectroscopy. The PCA model of M group E-nose showed that the total content of aroma substances reached the maximum value in the broth samples cooked for the third time. Meanwhile, the GC-MS results showed that benzaldehyde in the spices completely disappeared in the 4th brining, esters such as linalyl propionate and isopropyl myristate disappeared after the 5th and 6th brining, ketones basically disappeared in the 6th brining, and the relative content of alcohols in M group was highest in the 4th brining. Successful validation of the generation and variation of aroma substances by E-nose and GC-MS through tri-step infrared spectroscopy technique with increasing resolution. Therefore, the quality of braised meat products can be improved by replenishing the meat and spices after the 3th brining.

Real-time diagnosis and monitoring of biofilm and corrosion layer formation on different water pipe materials using non-invasive imaging methods

Water distribution networks play a crucial role in ensuring a reliable water supply, yet they encounter challenges such as corrosion, scale formation, and biofilm growth due to interactions with environmental elements. Biofilms and corrosion layers are significant contaminants in water pipes, formed by complex interactions with pipe materials. As the structure of these contamination layers varies depending on the pipe material, it is essential to investigate the contamination layer for each material individually. Specifically, biofilm growth is typically investigated concerning organic sources, while the growth of humus layers is examined in relation to inorganic elements such as manganese (Mn), iron (Fe), and aluminum (Al), which are major elements and organic substances found in water pipes. Real-time imaging of recently contaminated layers can provide important insights to improve system performance by optimizing operations and cleaning processes. In this study, cast iron (7.10 ± 0.78 nm) exhibits greater surface roughness compared to PVC (5.60 ± 0.14 nm) and provides favorable conditions for biofilm formation due to its positive charge. Over a period of 425 h, the fouling layer on cast iron and PVC surfaces gradually increased in fouling thickness, porosity, roughness, and density, reaching maximum value of 29.72 ± 3.6 μm, 11.44 ± 1.1%, 41673 ± 1025.6 pixels, and 0.80 ± 0.3 fouling layer pixel/layer pixel for cast iron, and 8.15 ± 0.4 μm, 20.64 ± 0.9%, 35916.6 ± 755.7 pixels, and 0.58 ± 0.1 fouling layer pixel/layer pixel, respectively. Within the scope of the current research, CNN model demonstrates high correlation coefficients (0.98 and 0.91) in predicting biofilm thickness for cast iron and PVC. The model also presented high accuracy in predicting porosity for both materials (over 0.91 for cast iron and 0.96 for PVC). While the model accurately predicted biofilm roughness and density for cast iron (correlation coefficients 0.98 and 0.94, respectively), it had lower accuracy for PVC (correlation coefficients 0.92 for both parameters).

Comparison of the chemical constituents of Saposhnikoviae Radix associated with three different growth patterns and its therapeutic effect against atopic dermatitis

Ethnopharmacological relevanceSaposhnikoviae Radix (SR) was initially documented in Shennong Bencao Jing classics for its properties in dispelling wind, dissolving surface, relieving pain, and alleviating spasms. This herb is commonly used in traditional Chinese medicine to address conditions that affect the body's surface, by aiding in the expulsion of pathogens from the surface and alleviating pain associated with the immune response. Atopic dermatitis (AD) is a prevalent allergic skin disorder, and the therapeutic effects of SR in dispelling wind and relieving the body's surface are consistent with the clinical symptoms commonly observed in AD. Aim of the studyThe anti-AD effects of SR were examined under three different growth patterns to identify active pharmacodynamic compounds. The results provide insight into the clinical efficacy of wild and cultivated SR. Materials and methodsThe efficacy of wild, wild-simulated, and cultivated SR was assessed in a mouse model of AD. In addition, the effects of wild and varying doses of cultivated SR were evaluated in mice with short-term AD symptoms. GC-MS and UPLC-MS/MS were used to analyze the chemical components of the three SR treatments and molecular docking was used to identify active components. ResultsA mouse model of AD was used to assess the pharmacodynamic effects of SR prepared by three different cultivation methods. The study found that all three SR preparations improved phenotypic markers and histopathological features in the AD mouse model. The efficacy of wild SR and wild-simulated SR was similar, although there was a significant difference between wild and cultivated SR. Both wild SR and various doses of cultivated SR ameliorated skin injuries and reduced inflammation in serum and skin tissues. Furthermore, skin thickness, inflammatory cells, mast cell infiltration, and IL-33 expression improved following treatment. Notably, wild SR, double-cultivated SR, and triple-cultivated SR demonstrated significant therapeutic effects. An analysis using GC-MS revealed the presence of 55, 52, and 43 volatile oils in the three SR preparations, with more common components observed between wild and wild-simulated SR. Fewer common components were evident between cultivated and wild SR. UPLC-MS/MS analysis identified a total of 37 compounds, with larger relative peak areas observed for the chromogenic ketones. Molecular docking studies revealed that certain compounds, such as n-propyl 9,12-octadecadienoate, (E)-9-octadecenoic acid ethyl ester, and various chromogenic ketones, such as cimifugin, 5-O-methyIvisamminol, hamaudol, 3′-O-acetylhamaudol, 3′-O-angeloyhamandol, adenosine and farnesylaceton, may be the major substances that distinguish the activities of SR with three different growth patterns. ConclusionVariations in the anti-AD efficacy of SR with three growth patterns were identified, and their chemical composition differences were determined. These findings suggest that increasing the dosage of cultivated SR could potentially be a viable clinical alternative for atopic dermatitis treatment.

Creators’ Creation of the Universe: An Ecological Implication in Chait Mundhum

This article deals with the creators’ creation of the universe as an ecologically interconnected world in Bairagi Kainla’s Chait Mundhum. The whole ecosphere and its components—biotic and abiotic—are not good and beautiful until the earth and human being is created by Tagera Ningwaphu Mang and her successor, Porokmi Mang. In initial phase, Tagera Ningwaphu Mang perceives her creation not suitable. She creates five major abiotic substances: sky, sun, air, earth, and water to address this problem. The middle phase extends with the beautification of earth by Porokmi Mang creating several organisms and species such as forests, flowers, insects, animals and mammals. The creators also manage water to each biotic and abiotic factor. To sustain the created world, each organisms and species are afforded with food and shelter. The creators become satisfied only in their final creation of man. They evaluate their creation beautiful and perfect in complementary existence of other things. Everything is interconnected in the creation. Therefore, Chait Mundhum mentions these ecological features implicated in the creation of the universe. To back up this, Barry Commoner’s principle of ecology has been used as a theoretical model. Subsequent Mundhums associated with this theme has also been used to support the claim. The article will be useful to those researchers and critics who want to study other Mundhums from the ecological perspective.

Phytochemical profiles and concentrations of major antioxidative substances of selected medicinal plant leaves

Phytochemical profiles and concentrations of major antioxidative substances of selected medicinal plant leaves

APPLICATIONS OF NANOTECHNOLOGY IN ANIMAL NUTRITION: A REVIEW

Nanoparticles are commonly used in human medicine but their applications in agriculture, animal nutrition and veterinary medicine are quite new. To meet the increasing demands on the livestock industry, synthetic antibiotics are the major substances that are used as growth promoters. However, the use of antibiotics as feed additives is risky due to cross-resistance among bacterial strains and residues in tissues of the animals which could be deposited in man after consumption of animal tissues. Thus, the use of most synthetic antibiotics has been banned in many countries in the world, leading to a reduction in usage and the search for alternative growth promoters with minimal or no residual effect has been intense in recent times. Many reports have suggested that nanoparticles may be good substances for animal growth promotion and antimicrobials because some nanomaterials can remove toxins and pathogens. They can also be better absorbed by animals, improving their performance and the quality of products. Nanotechnology can potentially transform the livestock sector because of better bioavailability, small dose rate, and stable interaction of the nanomaterials with other components. Therefore, using nanoparticles is a good alternate approach that is safe and cost-effective for the control of pathogenic microbes and production improvement in livestock. In view of recent developments, this review was undertaken to discuss issues relating to the use of nanomaterials in animal feeds