Main Research Hotspots Research Articles

THz plasmon-induced transparency metasurfaces based on metal-graphene hybrid structure for high-sensitive amino acid disease-marker biosensing

Terahertz metasurface sensors have attracted great interest in recent years due to their fast and non-destructive detection. One of the main research hotspots is to further improve sensing sensitivity, i.e., to achieve accurate discrimination with minimal amounts of marker targets for fast disease diagnosis. Graphene is a two-dimensional material with unique properties, for example, its electrical properties can be manipulated by the contact biomolecules, providing excellent sensing performance. In this paper, a metal-graphene hybrid metasurface is proposed and demonstrated for high-sensitive biosensing based on the plasmon-induced transparency (PIT) resonances. Experimental results show that 0.8 ng of the tyrosine enhances the PIT window to 4.8-fold, with the limit of detection down to 10 ng/mL. And with increasing amino acid quantities, three amino acids can be high-effectively distinguished to diagnose tyrosinemia, phenylketonuria, and hyperglycinemia. This metasurface sensor has the advantages of high sensitivity, fast detection speed, label-free and steady properties, which has potential applications in the fields of trace molecular sensing and disease diagnosis.

Bibliometric and visualization analysis of literature relating to diabetic erectile dysfunction.

Diabetic erectile dysfunction (DMED) refers to erectile dysfunction secondary to diabetes. Erectile dysfunction is characterized by a persistent inability to achieve and maintain an erection sufficient to permit satisfactory sexual activity. Based on the Web of Science core collection database, we firstly analyzed the quantity and quality of publications in the field of DMED, secondly profiled the publishing groups in terms of country, institution, author's publication and cooperation network, and finally sorted out and summarized the hot topics of research. From 2001 to 2022, a total of 1,403 articles relating to this topic were published in 359 journals. They represent the global research status, potential hotspots, and future research directions. The number of DMED-related publications and citations has steadily increased over the few past decades. Academic institutions from Europe and the United States have played a leading role in DMED research. The country, institution, journal, and author with the most publications were the United States (294), INHA University (39), the Journal of Sexual Medicine (156), and Ryu, Ji-Kan (29), respectively. The most common keywords were erectile dysfunction (796), men (256), diabetes (254), diabetes mellitus (239), prevalence (180), corpus cavernosum (171), dysfunction (155), mellitus (154), nitric-oxide synthase (153), and expression (140). The main keyword-based research topics and hotspots in the DMED field were oral sildenafil, smooth muscle relaxation, nitric oxide synthase, gene therapy, metabolic syndrome, cavernous nerve injury, stem cell, and penile prosthesis. The terms oral sildenafil, smooth muscle relaxation, nitric oxide synthase, gene therapy, metabolic syndrome, cavernous nerve injury, stem cell, and penile prosthesis will be at the forefront of DMED-related research.

Bibliometric analysis and visualization of literature on assisted reproduction technology.

Assisted reproductive technology (ART) is a method that uses various techniques to process sperm or ova. Assisted reproductive technology involves removing ova from a woman's ovaries, combining them with sperm in the laboratory, and returning them to the woman's body or donating them to another woman. Based on the web of science core collection database, we firstly analyzed the quantity and quality of publications in the field of ART, secondly profiled the publishing groups in terms of country, institution, author's publication and cooperation network, and finally sorted out and summarized the hot topics of research. In total, 6,288 articles on ART were published between 2001 and 2022 in 1,013 journals. Most of these published articles represent the global research status, potential hotspots and future research directions. Publications and citations of research on assisted reproductive technology have steadily increased over the past few decades. Academic institutions in Europe and the United States have been leading in assisted reproductive technology research. The countries, institutions, journals, and authors with the most published articles were the United States (1864), Harvard Univ (108), Fertility and Sterility (819), and Stern, Judy E. (64). The most commonly used keywords are Assisted reproductive technology (3303) and in-vitro Fertilization (2139), Ivf (1140), Pregnancy (1140), Women (769), Intracytoplasmic Sperm injection (644), In Fertilization (632), Risk (545), and Outcome (423). Frozen embryo transfer, intracytoplasmic sperm injection, and in vitro fertilization are the main research topics and hotspots in the field of assisted reproductive technology.

Bibliometric and hot spot visualization analysis of pneumoconiosis and smoking

Objective: To analyze the distribution and keywords of Chinese and English literature on pneumoconiosis and smoking, and to explore its characteristics and evolutionary laws. Methods: In November 2020, using PubMed, Web of Science, SinoMed, and CNKI as search databases, literature search was performed using Chinese and English search terms related to pneumoconiosis and smoking. The document management software Note Express 3.5.0 and the bibliometric analysis software VOS viewer 1.6.10 were used to analyze the publication year, number of publications, countries, research institutions and keywords. Results: In the English literature, there were 938 articles about pneumoconiosis and smoking related research, and the literature was first published in 1962. Among them, the United States published the largest number of articles (450 articles), and China published 29 articles, ranking fourth. There were a total of 601 research articles on pneumoconiosis and smoking in Chinese literature. The literature was first published in 1976. The institution that published the most articles was China Medical University (23 articles), followed by Lanzhou University (15 articles). Keyword co-occurrence analysis showed that domestic and foreign literatures were the main research hotspots on occupational exposure, carcinogenicity, risk factors, lung function, and DNA damage of pneumoconiosis and smoking. Conclusion: The research on pneumoconiosis and smoking focuses on carcinogenicity, risk factors, lung function, DNA damage mechanism, etc., providing research hotspots for the prevention and clinical treatment of related diseases.

Advances in Fine Structure Optimizations of Layered Transition‐Metal Oxide Cathodes for Potassium‐Ion Batteries

AbstractPotassium‐ion batteries (PIBs) have attracted significant research interest in the context of driving the advancement of grid energy storage due to K's elemental abundance and high theoretical output voltage. The main challenge facing PIBs is to find suitable cathode materials with fast transport kinetics and stable framework structures to intercalate/de‐intercalate the large‐size K+. Among these candidates, transition‐metal layered oxides are have excellent potential and have been extensively exploited due to their stable skeleton structure, simple synthetic chemistry, and high working potential. Herein, the current research status and prospects of layered transition‐metal oxide cathodes are summarized, especially focussing on the fine structure optimization engineering and energy storage mechanism. In addition, a brief overview of the research on advanced characterization techniques for PIBs is introduced in detail. Finally, the main research directions and hot spots of new‐type transition‐metal layered oxide cathode are also predicted, in order to guide the future development of advanced PIBs.

Global research trends in non-muscle invasive bladder cancer: Bibliometric and visualized analysis.

Bladder cancer is one of the most common urological cancers. Non-muscle invasive bladder cancer (NMIBC) accounts for about 75-85% of all newly diagnosed bladder cancers. Globally, there are many NMIBC-related publications. However, a bibliometric analysis of these publications has not been performed. This study aims to systematically analyze and visualize NMIBC-related publications through bibliometrics, and to reveal identified topics, hotspots, and knowledge gaps in related fields. Based on the Web of Science core collection database, we firstly analyzed the quantity and quality of publications in the field of NMIBC, secondly profiled the publishing groups in terms of country, institution, author's publication and cooperation network, and finally sorted out and summarized the hot topics of research. This bibliometric analysis was conducted from 2001 to 2022. The analysis identified 2,185 articles and reviews, which were published in 402 journals. The number of publications and citations on NMIBC-related research has steadily increased over the last two decades. Furthermore, academic institutions in Europe and the United States play a leading role in NMIBC research. The country, institution, journal, and author with the most publications were the United States (559), Radboud University Nijmegen (88), Urologic oncology: Seminars and Original Investigations (141), and Witjes J (74), respectively. The most frequently used keywords were Bladder cancer (793), Recurrence (671), Urothelial carcinoma (593), Progression (523), Bacillus-calmette-guerin (411), Transitional-cell carcinoma (401), Carcinoma (366), Risk (297), Transurethral resection (286), and Non-muscle-invasive bladder cancer (280). More and more scholars are devoted to the research of related NMIBC. This bibliometric analysis revealed that the main research topics and hotspots in NMIBC included pathological staging, clinical diagnosis and treatment, and bladder perfusion.

Research Status, Hotspots, and Evolutionary Trends of Global Digital Education via Knowledge Graph Analysis

With the rapid development of emerging technologies such as big data, artificial intelligence, and blockchain and their wide application in education, digital education has received widespread attention in the international education field. The outbreak of COVID-19 in December 2019 further catalyzed the digitalization process in various industries, including education, and forced the education system to carry out digital reform and innovation. Digital education transformation has become a new hotspot of great interest in countries around the world and a major direction for education reform practices. Therefore, to better understand the status of global digital education research, this study uses CiteSpace (6.1.R2) visual analysis software to visualize and quantitatively analyze the literature on digital education research in the social science citation index (SSCI). First, the basic information of digital education was analyzed in terms of annual publication volume, authors, countries, and research institutions. Secondly, the main fields, basic contents, and research hotspots of digital education research were analyzed by keyword co-occurrence analysis mapping and keyword time zone mapping. Finally, the research frontiers and development trends of digital education between 2000 and 6 September 2022 were analyzed by cocitation clustering and citations. The results show that, based on the changes in annual publication volume, we can divide the development pulse of the digital education research field into three stages: the budding stage (2000–2006), the slow development stage (2007–2017), and the rapid development stage (6 September 2018–2022); there are 26 core authors in this field of research, among which Selwyn N has the highest number of publications; the USA, England, Spain, Australia, and Germany have the highest number of publications; Open Univ is the institution with the most publications; digital education’s research hotspots are mainly focused on interdisciplinary field practice research and adaptive education research based on big data support. The research frontiers are mainly related to five areas: interdisciplinary development, educational equity, digital education practice, digital education evaluation, and digital education governance. This paper systematically analyzes the latest developments in global digital education research, and objectively predicts that human–computer interdisciplinary teaching models and smart education may become a future development trend of digital education. The findings of this study are useful to readers for understanding the full picture of digital education research so that researchers can conduct more in-depth and targeted research to promote better development of digital education.

Bibliometric and visual analysis of coronary microvascular dysfunction.

Coronary microvascular dysfunction (CMD) may play an important role in various cardiovascular diseases, including HFpEF and both obstructive and non-obstructive coronary artery disease (CAD). To date, there has been no bibliometric analysis to summarize this field. Here, we aim to conduct a bibliometric analysis of CMD to determine the current status and frontiers in this field. Publications about CMD were taken from the Web of Science Core Collection database (WOSCC). WOSCC's literature analysis wire, the VOSviewer 1.6.16, and CiteSpace 5.1.3 were used to conduct the analysis. A total of 785 publications containing 206 reviews and 579 articles are included in the sample. The leading authors are Iacopo Olivotto, Paolo G. Camici, and Carl J. Pepine. The most productive institutions are the University of Florence, Cedars Sinai Medical Center, and Harvard University. The most productive countries are the USA, Italy, and England. There are a total of 237 journals that contribute to this field, and the leading journals in our study were the International Journal of Cardiology, the European Heart Journal and the JACC. From 2012 to 2021, the top three most-cited articles focused on the association between HFpEF and CMD. The important keywords are heart failure, hypertrophic cardiomyopathy, chest pain, women, coronary flow reserve (CFR), endothelial dysfunction and prognostic value. "Positron emission tomography" shows the strongest burst strength, followed by "blow flow" and "artery." The keywords that started to burst from 2015 are particularly emphasized, including "heart failure," "coronary flow reserve," and "management." Studies about CMD are relatively limited, and the largest contribution comes from the USA, Italy and England. More studies are needed, and publications from other countries should be enhanced. The main research hotspots in the CMD field include CMD in patients with HFpEF, sex differences, the new methods of diagnosis for CMD, and the effective treatment of CMD. Attention should be given to CMD in patients with HFpEF, and untangling the association between CMD and HFpEF could be helpful in the development of physiology-stratified treatment for patients with CMD and HFpEF.

The schizophrenia and gut microbiota: A bibliometric and visual analysis

Many studies have explored the link between the gut microbiota and schizophrenia. To date, there have been no bibliometric analyses to summarize the association between the gut microbiota and schizophrenia. We aimed to conduct a bibliometric study of this association to determine the current status and areas for advancement in this field. Publications related to the gut microbiota and schizophrenia were retrieved from the Web of Science Core Collection (WoSCC). The WoSCC literature analysis wire and VOSviewer 1.6.16 were used to conduct the analysis. In total, 162 publications were included in our study. The publications generally showed an upward trend from 2014. A total of 873 authors from 355 organizations and 40 countries/regions contributed to this field. The leading authors were Timothy Dinan, John F Cryan, and Emily Severance. The leading institutions were Johns Hopkins University, the University College Cork, and the University of Toronto. The most productive countries were the United States (US), China, and Canada. In total, 95 journals contributed to this field. Among them, the top three productive journals were Schizophrenia Research, Progress in Neuro Psychopharmacology Biological Psychiatry, and Frontiers in Psychiatry. The important keywords in the clusters were gut microbiome, bipolar disorder, schizophrenia, antipsychotics, weight gain, metabolic syndrome, gut-brain axis, autism, depression, inflammation, and brain. The main research hotspots involving the connection between schizophrenia and the gut microbiota were the characteristics of the microbiota composition in schizophrenia patients, the gut-brain axis, and microbial-based interventions for schizophrenia. The studies about the association between gut microbiota and schizophrenia are limited, and more studies are needed to provide new insights into the gut microbiota in the pathogenesis and treatment of schizophrenia.

Research hotspots and trends of cardiopulmonary exercise test: Visualization analysis based on citespace

The study aims to grasp the hot spots and trends of global cardiopulmonary exercise research.Web of Science (WoS) core collection and Derwent Innovation Index database were retrieved to collect literature from 2002 to 2022 with Cardiopulmonary Exercise Test (CPET) as the retrieval theme. CiteSpace was used to conduct bibliometrics and visual analysis of 6679 pieces of literature in the web of science core collection database and 251 patent data in the Derwent Innovation Index database. The results show that: (1) the number of CPET theme research papers is increasing year by year, and the main research fields are cardiology, respiratory system, sports science, etc.; (2) The main research hot spots of CPET include exercise prescription, exercise and heart failure, COVID-19 cardiopulmonary rehabilitation and evaluation, etc.; (3) The development trend of CPET technology is majorly in the direction of intelligence, portability, individualization and the integration of Virtual Reality (VR) technology and evidence-based research of CPET guiding clinical decision-making.

The application of tranexamic acid in joint arthroplasty: A 20-year bibliometric analysis.

With the arrival of the era of the aging population, the amount of joint arthroplasty surgery keeps rising, and the articles related to the application of tranexamic acid (TXA) in joint arthroplasty (we called the application of tranexamic acid in joint arthroplasty as TIA in this study) also show a blowout growth. Therefore, we conducted a bibliometric analysis of TIA-related publications to identify the main research trends and hot spots in this field in the last 20 years. In this study, publications in the field of TIA from January 1, 2002 to December 31, 2021 were searched in the Web of Science Core Collection (WoSCC). A total of 1,013 publications were evaluated for specific characteristics with Microsoft Excel software, CiteSpace, VOSviewer, and Online Analysis Platform of Literature Metrology (http://bibliometric.com/). A total of 1,013 TIA-related articles were included in this study, and the number of articles in this field has increased yearly over the past 20 years. The USA and China dominated in the field of TIA. The Sichuan University published the most TIA-related articles among all the institutions. Of all the authors, Professor Pei was the most productive author with 64 articles. The lack of international cooperation was a significant problem in this field during the past 20 years. Furthermore, the results of the co-citation analysis and citation bursts analysis revealed that the safety and effectiveness of TIA and the optimal use strategy were the main trends and hotspots for the current and future. This bibliometric study reviewed the evolution trend of TIA research, and identified the countries, institutions, authors and journals that have made significant contributions to this field in the past 20 years, as well as the limitations and deficiencies in this field. In addition, this study revealed that the effectiveness and safety of TIA and the optimal use strategy was the current or future research trend and hotspot in this field.

Advances in Forest Management Research in the Context of Carbon Neutrality: A Bibliometric Analysis

Climate change has become a threat to humanity, and achieving carbon neutrality is a worldwide objective. Forests are significant natural carbon sinks; forest ecosystems are one of the effective ways to mitigate climate change, and professional management may effectively contribute to achieving carbon neutrality goals. Using the bibliometrix R-package in R and CiteSpace for bibliometric analysis of research areas from general statistics and knowledge base perspectives, this study systematically reviewed the status, evolution, and research hotspots of forest management in the context of carbon neutrality based on 6112 papers published in this research area between 2002 and 2022. The results revealed: (1) The research on forest management in the context of carbon neutrality has rapidly developed with a high level of attention between 2002–2022. Furthermore, this field of research has become a well-established discipline. (2) Throughout the research history, there were five main research hotspots, which were the function of forest carbon sinks, scientific and rational forest management, forest ecosystem services, assessment of forest carbon sinks, and forest management models. (3) Potential future research avenues include the development of a new model of forest management in the context of carbon neutrality.

Quantitative Analysis of the Research Development Status and Trends of Tannery Wastewater Treatment Technology

In order to better grasp the development and trends of tannery wastewater (TWW) treatment research, this paper provides a review of the TWW treatment research dynamics based on the Web of Science (WoS) database and using CiteSpace software. The research dynamics, hot topics, evolutionary history and research trends in this field are revealed. The results showed that research related to TWW treatment has shown a high growth trend in the number of articles in recent years, and India was outstanding in terms of influence in this area. The keyword clustering analysis showed that the main research hotspots in the field of TWW treatment were biological treatment processes (phytoremediation, constructed wetlands, anaerobic treatment and biofilm reactors) and chemical treatment processes (coagulation and flocculation, and advanced oxidation processes). The analysis of new research frontiers showed that the bioremediation and the application of biofuel cells in TWW will become important research directions in the future.

Global trends in the research on benign paroxysmal positional vertigo: A 20-year bibliometric and visualization analysis

Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vestibular vertigo. Although BPPV is benign, its underlying mechanisms are complicated, and patients diagnosed with BPPV are significantly affected by it in their daily lives. Hence, this study's purpose was to investigate global trends and frontiers in the field of BPPV. We searched the research literature published from 2002 to 2021 on BPPV using two databases from the Web of Science Core Collection, and we conducted a bibliometric and visualization analysis. Bibliometric tools were used to perform co-authorship, co-citation, and co-occurrence analyses of countries or regions, institutions, authors, journals, keywords, and references. In all, 1,419 publications from 4,594 authors, 1,542 institutions, and 65 countries or regions with 71 subject categories were included in the study. The number of articles increased gradually from 2002 to 2021. Seoul National University, the University of Munich, and Osaka University were among the leading institutions with the most publications, while United States of America, South Korea, and China were the leading countries. JS Kim was the most prolific author, Otology & Neurotology was the most prolific journal, and Otorhinolaryngology was the most published subject category. The five most frequently occurring keywords were BPPV, vertigo, dizziness, nystagmus, and management and the top research hot spots were osteoporosis and vitamin D. This study systematically analyzed trends in global scientific research on BPPV. The academic understanding of BPPV has improved significantly over the last two decades, with osteoporosis and vitamin D the two main research hot spots in the field of BPPV in recent years. These findings provide direction for current research to grasp the trends and research frontiers of current research.

Visualization analysis of research on climate innovation on CiteSpace

Climate change has brought great challenges to global sustainability, but only few research achievements in innovation for climate change mitigation and adaptation have been reported. This study aims to identify the current research status and trends in climate innovation via CiteSpace visual analysis. We searched for published papers (up to 2021) in the core repository of Web of Science by using the theme of innovation for climate change mitigation and adaptation. Using the collected articles, we conducted co-authorship analysis, co-citation analysis, and keyword co-occurrence analysis and found that the main contributors are from America, England, and China. Moreover, climate innovation has an interdisciplinary knowledge source, and its main research frontier focuses on the design of policies for energy efficiency improvement and new energy technologies. These results point out some directions for further research on climate innovation and outline the knowledge structure in this field, thereby addressing the lack of studies on such topic. By analyzing the lineage of research developments, it is found that energy technology and energy efficiency would be the main research hotspots in climate innovation in the future, and relevant policies also need to strengthen incentives for research in this area. This study is particularly helpful for those researchers who are interested in climate innovation and can subsequently contribute to the long-term development of various research directions in this field, to the formulation of climate change mitigation and adaptation policies, and to the sustainable development of human society.

DPSIR-TOPSIS Model-Based Assessment of Green Development Performance in Beijing, Tianjin, and Hebei

Green development is an important way to achieve sustainable development. In recent years, it has become one of the main research hotspots. Based on the principle of the DPSIR model, this paper constructed a green development evaluation index system including 17 second-level indicators from five first-level indicators, namely the driving force indicator, pressure indicator, state indicator, impact indicator, and response indicator, and used TOPSIS model to evaluate the green development of Beijing-Tianjin-Hebei region from 2010 to 2020. The results show that :(1) the closeness index of the driving force and pressure indicator layer generally shows a fluctuating trend of first rising and then falling, the closeness index of the state layer shows a fluctuating downward trend, the influence indicator layer shows an overall upward trend, and the closeness index of the response indicator layer shows a trend of first declining and then rising. (2) Due to the existence of regional heterogeneity, the green development of Beijing is higher than that of Tianjin, and the green development of Tianjin is slightly higher than that of Hebei. The Beijing-Tianjin-Hebei region needs to form cohesion in green development governance. (3) It is found that the economic growth rate of the Beijing-Tianjin-Hebei region is very fast, but in terms of green development, there is still an extensive development trend with high input and high consumption.

DPSIR-TOPSIS Model-Based Assessment of Green Development Performance in Beijing, Tianjin, and Hebei

Green development is an important way to achieve sustainable development. In recent years, it has become one of the main research hotspots. Based on the principle of the DPSIR model, this paper constructed a green development evaluation index system including 17 second-level indicators from five first-level indicators, namely the driving force indicator, pressure indicator, state indicator, impact indicator, and response indicator, and used TOPSIS model to evaluate the green development of Beijing-Tianjin-Hebei region from 2010 to 2020. The results show that :(1) the closeness index of the driving force and pressure indicator layer generally shows a fluctuating trend of first rising and then falling, the closeness index of the state layer shows a fluctuating downward trend, the influence indicator layer shows an overall upward trend, and the closeness index of the response indicator layer shows a trend of first declining and then rising. (2) Due to the existence of regional heterogeneity, the green development of Beijing is higher than that of Tianjin, and the green development of Tianjin is slightly higher than that of Hebei. The Beijing-Tianjin-Hebei region needs to form cohesion in green development governance. (3) It is found that the economic growth rate of the Beijing-Tianjin-Hebei region is very fast, but in terms of green development, there is still an extensive development trend with high input and high consumption.

Towards a Systematic Description of Fault Tree Analysis Studies Using Informetric Mapping

Fault tree analysis (FTA) is one of the important analysis methods of safety system engineering commonly utilized in various industries to evaluate and improve the reliability and safety of complex systems. To grasp the current situation and development trend of FTA research and to further point out FTA’s future development directions, 1469 FTA-related articles from the literature were retrieved from the SCIE and SSCI databases. Informetric methods, including co-authorship analysis, co-citation analysis and co-occurrence analysis, were adopted for analyzing the cooperation relationship, research knowledge base, research hotspots and frontier in the FTA research field. The results show that China has the highest number of publications, and the Loughborough University of England has the highest number of publications of relevant institutions. Dynamic fault tree analysis, fuzzy fault tree analysis and FTA based on binary decision diagrams are recognized as the knowledge bases in FTA studies. “Reliability Engineering and System Safety”, “Safety Science” and “Fuzzy Sets and Systems” are the core journals in this field. Fuzzy fault tree analysis, dynamic fault tree analysis based on Bayesian networks and FTA combined with management factors may be both the main research hotspots and the frontiers. Then, by deriving the above results, this study can help scholars better master the current research status and frontiers of FTA to improve system reliability and safety.

Mapping knowledge structure and themes trends in unilateral biportal endoscopic spine surgery: A bibliometric analysis.

BackgroundThe numerous benefits of unilateral biportal endoscopic (UBE) spine surgery have attracted the attention of many researchers, and a considerable number of relevant clinical studies have been published. However, global research trends in the field of UBE have received little attention. The purpose of this study was to apply bibliometric method to analyze the UBE-related publications to obtain an overview of the research trends in the field of UBE, as well as research hotspots and trends.MethodsWeb of Science database was searched for articles published until January 31, 2022. CiteSpace was used to analyze the data, which provided graphical knowledge maps. The following factors were applied to all literature: number of publications, distribution, h-index, institutions, journals, authors, and keywords.ResultsSeventy-three articles were identified. Since 2019, there has been a significant increase in the number of UBE-related publications. The country with the largest number of articles was South Korea (72.6%), followed by China (9.6%), Japan (4.1%), and Egypt (4.1%). South Korea had the highest h-index (16), followed by China (2), Japan (1), and Egypt (1). Leon Wiltse Memorial Hospital was the organization that produced the most papers (12 publications). Heo DH was the most productive author (16 papers) and was the most cited author (35 times). World Neurosurgery published the most papers on UBE (23.3%). The main research hotspots were spinal diseases, decompression, complications, learning curve, and interbody fusion. In addition, the recent concerns were “learning curve,” “interbody fusion,” “management,” and “dural tear.”ConclusionsThe quantity of publications on UBE research will increase, and South Korea being the major contributor and most prominent country in this field. The findings of our study will provide researchers with practical information on the field of UBE, and identification of mainstream research directions and recent hotspots.

Bibliometric study of soluble guanylate cyclase stimulators in cardiovascular research based on web of science from 1992 to 2021.

Background: Several studies have shown that soluble guanylate cyclase (sGC) stimulators have cardiovascular (CV) benefits. However, few bibliometric analyses have examined this field systematically. Our study aimed to examine the publications to determine the trends and hotspots in CV research on sGC stimulators. Methods: Publications on sGC stimulators in CV research were retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace visualization software were used to analyze publication trends, countries (regions) and institutions, journals and cited journals, authors and cited references, as well as keywords. Results: A total of 1,212 literatures were obtained. From its first appearance in 1992–2021 (based on WOSCC record), the overall volume of publications has shown a gradual increasing trend. Nearly one-third were authored by American scholars, and most were published in Circulation, Circulation Research, and Proceedings of the National Academy of Sciences of the United States of America. Bayer Agency in Germany was the leading driving force, and has a high academic reputation in this field. Stasch JP has published the most related articles and been cited most frequently. Half of the top 10 co-cited references were published in the leading highly co-cited journal Circulation and New England Journal of Medicine. “NO,” “allosteric regulation” and “free radicals” were the focus of previous research, “chronic thromboembolic pulmonary hypertension,” “pulmonary hypertension” and “heart failure” were the main research hotspots. The key words “chronic thromboembolic pulmonary hypertension,” “Pulmonary hypertension,” “preserved ejection fraction” and “heart failure” appeared most recently as research frontiers. Conclusion: The research in the CV field of sGC stimulators was relatively comprehensive, and there was a close relationship among countries, research institutions and authors, but it is still in the exploratory stage in the treatment of CV disease. At present, most studies focus on the results of clinical trials. sGC stimulators in the treatment of heart failure, especially heart failure with preserved ejection fraction, may be the hotpots and Frontier at present and in the future, and should be closely monitored.