The confinement of radioactive material in a nuclear power plant, including the discharge control and the release minimization, is a fundamental safety function to be ensured in a design basis accident (DBA).For plant licensing analysis, the containment is usually modeled with a lumped parameter approach. Inherent to the lumped parameter approach is the assumption that within each region the fluid is well mixed. However, the containment is a large building with a complex configuration and it is distributed in several compartments that avoid the well mixing of the fluid and could have three-dimensional effects that affect the thermal–hydraulic behavior. Therefore, the commonly used lumped parameter approach may not be enough to capture these effects.In order to study these assumptions, four generic PWR containment models have been developed for Mass and Energy (M&E) release analysis with GOTHIC 8.0 (QA) code, three of them being subdivided and the fourth one is a lumped parameter model. A Large Break LOCA is simulated in order to compare the thermal–hydraulic behavior of the different models. The results show a high dependence on the three-dimensional phenomena, especially the temperature and velocity distribution. In contrast, the pressure evolution is qualitatively similar in all models with small quantitative differences.