The data collected by sensors in modern chemical process systems are always contaminated by industrial noise, so robust fault detection is an important technology to ensure process safety. However, the existing robust detection techniques have limitations in extracting dynamic and time series features of chemical process data. In this paper, a robust fault detection method based on dynamic low-rank matrix and optimized LSTM is proposed for dynamic chemical processes under noise background. First, a new low-rank matrix decomposition method, dynamic principal component pursuit (DPCP), is proposed for the dynamic characteristics of process data containing noise. The PCP is improved using the time delay excursion method, i.e., the DPCP is constructed by embedding an augmented dynamic matrix with a time lag factor on the PCP and solved using the alternating direction multiplier method. The purpose is to strip the useless noise from the useful detection information and extract the dynamic low-rank matrix. Second, an optimized LSTM (OPLSTM) is proposed for the time series features of dynamic low-rank matrix. vector factors for feature selection of memory cells in the LSTM are reweighted to balance the time series features of industrial processes and avoid heavy reliance on erroneous fault information. In addition, support vector data description (SVDD) is used to describe the hypersphere with clear boundary, and distance-based statistic is constructed to achieve fault detection with high fault detection rate and low false alarm rate. Finally, to assess the effectiveness of the proposed method, we performed extensive experiments on the Tennessee Eastman Process and the electrolytic aluminum process, and compared them with multiple methods. The experimental results show that the proposed method is effective and robust for chemical processes fault detection in the background of industrial noise.