Low Luminescence Research Articles

Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy

BackgroundPhotodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light. X-ray-mediated photodynamic therapy (PDT) has gained a major attention owing to the limitless penetration of X-rays. However, substantial outcomes have still not been achieved due to the low luminescence efficiency of scintillating nanoparticles and weak energy transfer to the photosensitizer. The present work describes the development of Y2.99Pr0.01Al5O12-based (YP) mesoporous silica coated nanoparticles, multifunctionalized with protoporphyrin IX (PpIX) and folic acid (YPMS@PpIX@FA) for potential application in targeted deep PDT.ResultsA YP nanophosphor core was synthesized using the sol–gel method to be used as X-ray energy transducer and was then covered with a mesoporous silica layer. The luminescence analysis indicated a good spectral overlap between the PpIX and nanoscintillator at the Soret as well as Q-band region. The comparison of the emission spectra with or without PpIX showed signs of energy transfer, a prerequisite for deep PDT. In vitro studies showed the preferential uptake of the nanocomposite in cancer cells expressing the folate receptorFolr1, validating the targeting efficiency. Direct activation of conjugated PpIX with UVA in vitro induced ROS production causing breast and prostate cancer cell death indicating that the PpIX retained its activity after conjugation to the nanocomposite. The in vivo toxicity analysis showed the good biocompatibility and non-immunogenic response of YPMS@PpIX@FA.ConclusionOur results indicate that YPMS@PpIX@FA nanocomposites are promising candidates for X-ray-mediated PDT of deep-seated tumors. The design of these nanoparticles allows the functionalization with exchangeable targeting ligands thus offering versatility, in order to target various cancer cells, expressing different molecular targets on their surface.

Rare‐Earth Complexes with the 5,5′‐Bitetrazolate Ligand – Synthesis, Structure, Luminescence Properties, and Combustion Catalysis

A complete series of complexes of the lanthanides and yttrium (except radioactive Pm) with the 5,5′‐bitetrazolate (BT2–) ligand were synthesized from sodium 5,5′‐bitetrazolate and available rare‐earth (RE) salts. Eight new complexes were structurally characterized by single‐crystal XRD. The [M(BT)(H2O)7]2[BT]·6H2O [M = Pr (1), Gd (2)] complexes are isomorphous and consist of [M(BT)(H2O)7]+ ions in which only one BT2– ligand acts as a chelate for each metal center. The complexes [M(H2O)8]2[BT]3·4H2O [M = Y (3), Dy (4), Ho (5), Tm (6), Yb (7), Lu (8)] are saltlike compounds that do not exhibit any significant metal–nitrogen contacts. Luminescence was very informative for the determination of the number of inner‐sphere coordinated water molecules in the solid samples. Despite its low luminescence intensity owing to its high hydrate composition, the deuterated europium complex exhibited an internal quantum yield of 44 %. The catalytic activities of the 5,5′‐bitetrazolate salts for the decomposition and combustion reactions of energetic materials were tested. Although no effect was found for nitramine (HMX) explosive, the impact of the salts on the thermolysis of ammonium perchlorate (AP) was established. The addition of 5 % [Dy(H2O)8]2[BT]3·4H2O decreases the temperature at the maximum reaction rate by 100 °C. The catalytic effect during combustion is apparently masked by the inhibitory influence of water; however, for [Pr(BT)(H2O)7]2[BT]·6H2O, a 20 % increase in the AP burning rate was observed.

Self-assembled hierarchical nanostructured perovskites enable highly efficient LEDs via an energy cascade

The unique mesoscopic perovskite film architecture of 2D microplatelets on top of 3D nanocrystals enable an energy cascade, yielding highly efficient light-emitting diodes.

Understanding the quenching nature of Mn4+ in wide band gap inorganic compounds: design principles for Mn4+ phosphors with higher efficiency.

Mn4+ doped phosphors, as an alternative to rare-earth element doped phosphors, have attracted immense attention owing to their ultrahigh quantum efficiency of red emission for potential applications in high rendering white LEDs (light-emitting diodes). Their performance can be largely affected by quenching phenomena such as thermal quenching, concentration quenching and the quenching induced by some intrinsic/extrinsic defects. However, the quenching mechanisms due to the defect levels and host band are still incompletely understood. In this work, we carry out a comprehensive first-principles study on the underlying quenching mechanisms due to the defect levels of Mn4+ and other extrinsic/intrinsic defects, using the prototype oxide Y3Al5O12 (YAG), fluorides K2TiF6 (KTF) and ZnTiF6·6H2O (ZTF) as examples. From the comparison of the defect levels of Mn4+ with the host bands, we find that it is the very small energy difference between the defect levels of Mn4+ and the valence bands maximum (VBM) of YAG that causes the lower luminescence thermal stability of YAG:Mn4+, which we name as the hole-type thermal quenching mechanism. For the concentration quenching, it is nearly impossible for the Mn4+-Mn4+ pairs, previously considered as the main quenching centers, to appear in phosphors. A new quenching nature has been discussed. For the impurity ionic effects, the hole-type defects can largely stabilize the Mn ions in +4 states, thereby enhancing the emission intensity. These proposed mechanisms can offer deeper insights into the luminescence behavior of Mn4+ and a better practical understanding of the high photoluminescence quantum yield red phosphors by adjusting their chemical components.

Manipulating the alkali metal charge compensation and tungsten oxide to continuously enhance the red fluorescence in (Li,Na,K)Ca(Mo,W)O4:Eu3+ solid solution compounds

When compared to other phosphors typically the blue and green phosphors, red phosphors, which can be used for white light-emitting diodes (wLEDs), always suffer from various problems such as higher cost, lower luminescence efficiency and bad thermal stability. And thus, great interests have been paid to how to enhance the red fluorescence intensity in the recent years. Here we report on a red-emitting solid solutions, (Li,Na,K)Ca(Mo,W)O4:Eu3+, which enable exhibiting continuous Eu3+ emission enhancement through manipulating the alkali metal ions and the relative content ratios between tungsten and molybdenum oxides. X-ray powder diffraction (XRD) has been employed to check the phase purity, and results show that all samples crystallize in a scheelite structure with space group of I41/a (No.88). A regular blue-shifting of XRD peaks, which indicates the increase of crystal plane spacing, appears as the alkali cationic radius increases from 0.92 Å (for Li), 1.18 Å (for Na) and to 1.38 Å (for K). Replacing Mo ion (0.41 Å) by W ion (0.42 Å) enables not only forming the solid solution compounds (Li,Na,K)Ca(Mo,W)O4:Eu3+, but also blue-shifting the XRD position. Similar to the XRD position shifting, our samples also exhibit the regular change in the photoluminescence (PL) spectra, in which the charge transfer (CT) band position as the alkali cationic radii increase from Li, Na and to K and further from Mo to W shows a continuous red-shifting behavior. As for the CT and Eu3+ intensity, our experimental results show that the alkali ion that corresponds to the maximum intensity is Li, and this intensity can be further enhanced by adding W. In coincidence with the change in the excitation spectral intensity, the continuous enhanced Eu3+ emission intensity can be observed up excitation at the CT band and Eu3+ lines. We have discussed the above CT band shifting and Eu3+ fluorescence enhancement and give a feasible mechanism profile that base on the energy transfer from CT band to Eu3+ dopant.

Determination of Suitable Indicators of AlGaN/GaN HEMT Wafer Quality Based on Wafer Test and Device Characteristics

This study investigates various tests on AlGaN/GaN high electron mobility transistor (HEMT) wafers, including photoluminescence spectroscopy, secondary ion mass spectroscopy, X‐ray diffraction (XRD), and Hall measurement. The AlGaN/GaN HEMT wafers are grown on low‐resistivity Si substrates with various growth conditions for the buffer and channel layers. Characteristics of AlGaN/GaN HEMTs including drain lag, dynamic RON, and current transients were measured and correlated with the results from the wafer level tests. Results indicate that epitaxial wafers with low yellow luminescence (YL) to band edge (BE) and blue luminescence (BL) to BE ratios as well as a low carbon concentration but a similar low full width at half maximum of XRD profiles can result in devices with significant suppression of current collapse and the same on‐state device characteristics. Therefore, both YL/BE and BL/BE values combined with the carbon concentration in wafer level tests are suitable indicators for estimating device performance.

Bright Tail States in Blue-Emitting Ultrasmall Perovskite Quantum Dots.

All-inorganic lead halide perovskite quantum dots (CsPbBr3 QDs) are attracting significant research interests because of their highly efficient light-emitting performance combined with tunable emission wavelength facilely realized by ion exchange. However, blue emission from perovskite QDs with strong quantum confinement is rarely reported and suffers from lower luminescence efficiency. Here we report blue-emitting ultrasmall (∼3 nm) CsPbBr3 QDs with photoluminescence (PL) quantum yield as high as 68%. Using time-resolved and steady-state PL spectroscopy, we elucidate the mechanism of the highly efficient PL as recombination of excitons localized in radiative band tail states. Through analyzing the spectral-dependent PL lifetime and the PL line shape, we obtain a large band tail width of ∼80 meV and a high density of state of ∼1020 cm-3. The relaxation of photocarriers into the radiative tail states suppresses the capture by nonradiative centers. Our results provide solid evidence for the positive role of band tail states in the optical properties of lead halide perovskites, which can be further tailored for high-performance optoelectronic devices.

Sub-10 nm Water-Dispersible β-NaGdF4:X% Eu3+ Nanoparticles with Enhanced Biocompatibility for in Vivo X-ray Luminescence Computed Tomography.

As a novel molecular and functional imaging modality, X-ray luminescence computed tomography (XLCT) has shown its potentials in biomedical and preclinic applications. However, there are still some limitations of X-ray-excited luminescent materials, such as low luminescence efficiency, poor biocompatibility, and cytotoxicity, making in vivo XLCT imaging quite challenging. In this study, for the very first time, we present on using sub-10 nm β-NaGdF4:X% Eu3+ nanoparticles with poly(acrylic acid) (PAA) surface modification, which demonstrate outstanding luminescence efficiency, uniform size distribution, water dispersity, and biosafety, as the luminescent probes for in vivo XLCT application. The pure hexagonal phase (β-) NaGdF4 has been successfully synthesized and characterized by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM), and then the results of X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray spectrometry (EDX), and elemental mapping further confirm Eu3+ ions doped into NaGdF4 host. Under X-ray excitation, the β-NaGdF4 nanoparticles with a doping level of 15% Eu3+ exhibited the most efficient luminescence intensity. Notably, the doping level of Eu3+ has no effect on the crystal phase and morphology of the NaGdF4-based host. Afterward, β-NaGdF4:15% Eu3+ nanoparticles were modified with PAA to enhance the water dispersity and biocompatibility. The compatibility of in vivo XLCT imaging using such nanoparticles was systematically studied via in vitro cytotoxicity, physical phantom, and in vivo imaging experiments. The ultralow cytotoxicity of PAA-modified nanoparticles, which is confirmed by over 80% cell viability of SH-SY5Y cells when treated by high nanoparticle concentration of 200 μg/mL, overcome the major obstacle for in vivo application. In addition, the high luminescence intensity of PAA-modified nanoparticles enables the location error of in vivo XLCT imaging less than 2 mm, which is comparable to that using commercially available bulk material Y2O3:15% Eu3+. The proposed nanoparticles promote XLCT research into an in vivo stage. Further modification of these nanoparticles with biofunctional molecules could enable the potential of targeting XLCT imaging.

Brightly and directionally luminescent single-walled carbon nanotubes in a wedge cavity

Single-walled carbon nanotubes suffer severely from their extremely low luminescence quantum yield and spectral purity. In this work, we produced brightly and directionally luminescent, as well as spectrally pure, carbon nanotubes by embedding them into a wedge-shaped planar cavity. By controlling the detuning between the cavity mode and exciton emission, the photoluminescence of carbon nanotubes could be enhanced up to 60 times. Coupling efficiency, i.e., percentage of nanotube luminescence emitted into a cavity mode, was found to be detuning dependent with a maximum efficiency of ∼54%. Moreover, emission from nanotubes inside the cavity becomes highly directional. The emission angle was measured to be less than 1.8°, demonstrating their great potential in device applications of future optoelectronics.

Femtosecond laser excited second harmonic and multiphoton absorption induced UV luminescence generation behaviour of ZnO nanofibers

Femtosecond (fs) laser excited second harmonic (SH) and multiphoton absorption (MPA) induced UV luminescence generation behaviour of Zinc oxide (ZnO) nanofibers is reported here. The used nanofibers are grown by seed assisted chemical bath deposition technology over glass substrates and are excited by a near-infrared (NIR) Ti: Sapphire laser emitting pulses of wavelength 812nm and duration 100fs. The peak wavelength of SH and MPA induced UV luminescence signals are found to be 406nm and 398nm respectively. Due to good optical quality, no defect level related MPA induced visible luminescence is observed in nanofibers. In comparison to this, ZnO nanostructures grown over plane substrate without seed layer shows very less SH and MPA induced UV luminescence. However in this case, the defect level related MPA induced visible luminescence was found to be very high. Applications like ultrafast pulse diagnostics, NIR induced photodynamic therapy etc. require high SH and MPA induced UV luminescence and low defect level related visible luminescence. So the ZnO nanofibers can be a potential candidate for these applications.

Dual-Activator Codoped Upconversion Nanoprobe with Core-Multishell Structure for in Vitro and in Vivo Detection of Hydroxyl Radical.

Monitoring the fluctuation of hydroxyl radical (·OH) in the body can serve as an effective tool for the prediction of relative diseases; however, it is highly challenging due to the radical's short lifetime, high reactivity, and extremely low concentration. Sandwich structured lanthanide-doped upconversion nanoparticles (UCNPs) exhibit unique luminescence properties and great prospects in bioimaging. Nonetheless, their rather low luminescence efficiency and intensity are serious limitations for their application. Herein, we report on dual-activator codoped UCNPs with a core-multishell structure that greatly improve the luminescence intensity and lifetime by 46-fold and 2.6-fold, respectively, compared to those of the monoactivator doped sandwich structured UCNPs. Moreover, emitting ions in the designed core-multishell (CMS)-UCNPs were confined in a homogeneous and thin shell layer (∼2 nm); thus, the luminescence resonance energy transfer (LRET)-based CMS-UCNPs@azo dye nanoprobe exhibited a largely shortened energy transfer distance and a pronounced luminescence quenching yield (97%), affording the nearly zero background signal and achieving an ultrahigh sensitivity for the detection of ·OH (with limit of quantitation (LOQ) of 0.10 fM). With good biocompatibility, low biotoxicity, and enhanced luminescence intensity and lifetime, the developed nanoprobe was competent in monitoring the subtle fluctuation of ·OH concentration both in vitro and in vivo.

Controlling Crystallization of All-Inorganic Perovskite Films for Ultralow-Threshold Amplification Spontaneous Emission.

All-inorganic lead halide perovskites have gained considerable interest owing to their potential applications in an array of high-performance optoelectronic devices. However, producing highly luminescent, nearly pinhole-free, all-inorganic perovskite films through a simple solution process remains challenging. Here, we provide a detailed investigation of the crystallization control of inorganic perovskite films fabricated by a one-step spin-coating process. Our results reveal that the coating temperature in the fabrication process is of paramount importance in influencing perovskite crystallization and that lowering the coating temperature and fine stoichiometry modification of the precursors favor the suppression of trap states in CsPbBr3 perovskite films. A broad range of experimental characterizations help us identify that nonsynergistic assembly of solutes, resulting from poor diffusion capability of inorganic salts, is the dominant cause for the inhomogeneous element distribution, low luminescence yield, and poor surface coverage of the resulting films. Importantly, we find that polyethylene glycol can also be used for tailoring the crystallization process, which enables the attainment of high-quality CsPbBr3 films with a maximum luminescence yield of ∼30%. Finally, we demonstrate that amplification spontaneous emission with an ultralow threshold can be readily accomplished by using the developed film as an emissive component. Our findings provide deep insights into the crystallization control of CsPbBr3 perovskite films and establish a systematic route to high-quality all-inorganic perovskite films, paving the way for widespread optoelectronic applications.

Preparation and upconversion emission enhancement of SiO_2 coated YbPO_4: Er^3+ inverse opals with Ag nanoparticles

The rare earth ions doped up-converting inverse opals exhibited application potential in the fields of biosensors and optic–electronic devices. However, there are two major factors which have limited their applications. One is the parity forbidden characters of 4f-f transitions of rare earth ions. Another factor is their low upconversion luminescence efficiency caused by the surface defects. In the present work, the SiO2 shell was coated on the skeleton surface of YbPO4:Er3+ inverse opals to protect the luminescent ions, and about a 10-fold enhancement of upconversion luminescence was obtained. Additionally, the localized surface plasmon resonance from Ag nanoparticles was used to enhance the upconversion luminescence of SiO2 coated YbPO4:Er3+ inverse opals. The green and red upconversion luminescence of inverse opal was enhanced selectively. Finally, the green and red upconversion luminescence are enhanced by about 50 and 30 folds by coupling effect of SiO2 coating and Ag nanoparticles, respectively. The selective enhancement mechanism of upconversion luminescence was investigated.

Enhancing Upconversion Fluorescence with a Natural Bio-microlens.

Upconversion fluorescence has triggered extensive efforts in the past decade because of its superior physicochemical features and great potential in biomedical and biophotonic studies. However, practical applications of upconversion fluorescence are often hindered by its relatively low luminescence efficiency (<1%). Here, we employ a living yeast or human cell as a natural bio-microlens to enhance the upconversion fluorescence. The natural bio-microlens, which was stably trapped on a fiber probe, could concentrate the excitation light into a subwavelength region so that the upconversion fluorescence of core-shell NaYF4:Yb3+/Tm3+ nanoparticles was enhanced by 2 orders of magnitude. As a benefit of the fluorescence enhancement, single-cell imaging and real-time detection of the labeled pathogenic bacteria, such as Escherichia coli and Staphylococcus aureus, were successfully achieved in the dark fields. This biocompatible, sensitive, and miniature approach could provide a promising powerful tool for biological imaging, biophotonic sensing, and single-cell analysis.

Ca-α-SiAlON:Eu Phosphors: Oxidation States, Energy Transfer, and Emission Enhancement by Incorporation-Aimed Surface Engineering.

Ca-α-SiAlON:Eu is one of the most promising phosphors exhibiting potential applications in high power LEDs owing to its excellent thermal stability and relatively high luminescence efficiency comparable to YAG:Ce commercial phosphors. The oxidation states of Eu ions in Ca-α-SiAlON:Eu are still questionable, and furthermore it exhibits lower luminescence intensity than commercial yellow phosphors. Therefore, in the present work, the valences of Eu ions in Ca-α-SiAlON have been examined, from which a mixture of divalence and trivalence is observed. Further improvement in emission intensity involves finding a way to increase the incorporation of larger Eu ions into the Ca-α-SiAlON. Here, we observed preferred doping of Eu around phosphor grain surface and then propose a surface engineering strategy involving HF pickling of glassy surface layer, formation of Eu-rich precursors, and finally post-annealing, aiming to increase surface incorporation of Eu ions. The surface engineered samples exhibit great enhancement in emission intensity with a maximum increment by 80%.

Modulated single band red upconversion luminescence from Ho3+ doped nanoparticles with two-wavelength excitation

Single band red upconversion luminescence has the potential applications from science to engineering, however, suffered from low luminescence efficiency. Single band enhanced red upconversion luminescence from NaYF4: Ho nanoparticles has been realized with the modulation of two-wavelength excitation and the administration of cross relaxation between 5F4, 5S2 → 5F5 and 5I7 → 5I6 of Ho3+. Compared to the sum intensities with single-wavelength excitation at 975 nm and 1150 nm, the upconversion intensity for red and green luminescence is enhanced by the factors of 13.04 and 0.46 respectively with two-wavelength excitation. The red/green ratio of upconversion luminescence intensity is modulated from 15.46 to 115.03 by controlling the interionic distance and cross relaxation between Ho3+ ions. The microscopy mechanism of single band enhanced red upconversion luminescence with two-wavelength excitation at 1150 nm and 975 nm is ascribed to the ground state absorption of 1150 nm and excited state absorption of 975 nm, which was explored by power depended upconversion luminescence intensities, excitation spectra, and absorption spectrum. Besides, single band red upconversion luminescence from NaYF4: 10%Ho nanoparticles with the two-wavelength excitation shows the comparable intensity with that from NaYF4: 20%Yb, 2%Ho nanoparticles excited by 975 nm. Our results might provide a new method for the single band red upconversion luminescence with the applications in biology and three-dimensional displays.

Integrated methodology for determining provenance of detrital quartz using optical petrographic microscopy and cathodoluminescence (CL) properties

The provenance of detrital quartz is a useful predictor in frontier basin sandstone reservoirs of the availability of coarse-grained quartz grains of plutonic or high grade metamorphic origin. The standard approach is to use scanning electron microscope (SEM) panchromatic cathodoluminescence (CL) imagery and observations from an optical petrographic microscope. We describe a work flow, modified from previous literature proposals, to determine quartz provenance in detrital grains using optical petrographic microscopy and CL properties from both a hot-cathode cathodoluminescence microscope attachment (HCMA) and panchromatic SEM-CL. HCMA analysis permits better discrimination of different types of metamorphic quartz. This method is applied to a Middle Jurassic to Lower Cretaceous section in the Bandol-1 wildcat well, located in the Laurentian sub-basin south of Newfoundland. Two types of high-grade metamorphic quartz are distinguished, one with low luminescence as described in previous literature and one with medium blue CL colour and a moderate colour shift that is also known from granulite in the hinterland. Three phases of detrital supply are identified, suggesting progressive unroofing of higher grade metamorphic sources through the middle Jurassic and major input of plutonic quartz in the early Cretaceous.

Identifying extreme pluvials in the last millennia using optical dating of single grains of quartz from shorelines on Australia’s largest lake

The filling of Kati Thanda-Lake Eyre (KT-LE), Australia’s ‘inland sea’ has captured scientific and cultural interest for over a century and a half. However, despite the presence of multiple shorelines around the modern playa at or near the modern maximum lake-filling levels, no quantitative estimates of major late-Holocene filling events have ever been documented. We develop a preliminary chronological data set using single-grain optically stimulated luminescence (OSL) on lake shoreline samples in order to determine the timing of large lake-filling events (equivalent to 1974 Common Era (CE) as Australia’s wettest year on record) for KT-LE, Australia’s largest lake basin. Despite quartz grains with very low natural dose luminescence (Ln) signal, we derive palaeodoses from geologically recent deposits (decades to centuries) using standard rejection criteria and highlight no signs of partial bleaching but occasional bioturbation in modern deposits. Major modern filling episodes, such as the1974 and 1949/1950 filling events, are successfully captured in the geochronological record, as are two major lake-filling episodes in 1854 ± 21 CE years and 1598–1654 CE. Two additional periods of potential lake-filling events have been identified at 1.2 ± 0.09 and 1.9 ± 0.14 ka, but stratigraphic control on these events is less robust. These chronostratigraphic records, while discontinuous, provide important hydrological evidence for extreme pluvial events akin to 1974 or 1949/1950, and the approach holds promise for identifying climate extremes and landscape response over the late Holocene.

Synthesis and optical characterization of In3+-stabilized γ-Bi2O3 sillenite semiconductor with cation deficiency

Bi3+-containing semiconductors usually show rich optical and electronic properties due to the hybridization between 6s and 6p electronic components together with the lone pair in Bi3+ ions. In this work, an In3+-stabilized γ-Bi2O3 sillenite structure, Bi24InO37.5 (Bi12In0.5O18.75), was prepared through the facile sol-gel method. The samples developed into ball-like nanoparticles with size of 200–300nm. The Rietveld structure refinement was performed. Bi24InO37.5 belongs to cubic sillenite-structure of metastable cubic γ-Bi2O3 (space group I23), a well-known group of non-centrosymmetric crystal. The morphological characteristics were tested by SEM, TEM, EDS and Brunauer–Emmett–Teller (BET) measurements. The optical absorption, band gap energy and electronic structures were discussed. In contrast to the reference Bi2O3, Bi24InO37.5 shows a narrower band energy of 2.48eV. Meanwhile, it has a self-activated emission with a low luminescence quenching.

Highly Stable and Regenerative Metal-Organic Framework Designed by Multiwalled Divider Installation Strategy for Detection of Co(II) Ions and Organic Aromatics in Water.

MOF-based sensors capable of effectively and stably detecting toxic species in water have attracted huge attention in terms of improving environmental monitoring levels and water quality. Combining the flexibility of structure and modifying of pore surface, a multiwalled divider installation (MWDI) strategy is proposed and used for property enhancement. We herein report three metal-organic frameworks (MOFs) 1-3 based on a C3 symmetry organic phosphonic ligand with topology increased from 3,6-connected to 3,8-connected. Among them, MOFs 1 and 2 with remaining binding sites and large pores display lower luminescence response to Co2+ than does the applying standard. Guided by the MWDI strategy, 3 with high rigid framework and triple molecular installer divided rhombic pore was achieved under top-down topological analysis as anticipated, which endows high sensitivity and rapid response to Co2+, contributed by the synergy from free activated sites and appropriate pore and molecular dividing effect. Particularly, the high stability of 3 in boiling solvent and acid/base solutions has been evidenced and explained by structural robustness and kinetic inertness. Moreover, 3 shows excellent detection ability toward trinitrophenol (TNP) over other aromatic analytes in water, attributing to the predomination of energy transfers. Of note is that the used framework can be in situ regenerated into a fresh one. That provides a promising strategy to prepare effective and economic luminescent sensors in a predictable way for property modification.