Lower Energy Expenditure Research Articles

PENYULUHAN BAHAYA SEDENTARY LIFESTYLE PADA MAHASISWA FAKULTAS ILMU KESEHATAN UNIVERSITAS KADIRI

A Sedentary lifestyle is a low energy expenditure, which expends calories 1.5 METs or less. It most likely leads to various metabolic diseases, such as Diabetic Mellitus. Some factors influencing a sedentary lifestyle are knowledge, attitudes, gender, convenience, transportation, technological advances, COVID-19 outbreaks, and consequences. A sedentary behavior becomes a typical lifestyle among teenagers, including students. Therefore, counseling about a sedentary lifestyle and its effects is very much needed among students. This counseling aims to increase knowledge about the sedentary lifestyle and its dangers so that students can avoid it and increase physical activity. The implementation method in this counseling consists of 3 stages, these stages are preparation, implementation and evaluation. Sixty-five nursing students attended this counseling activity; most participants (70%) were female. The result shows that some respondents did not know about the sedentary lifestyle and its dangers. After counseling, almost all respondents knew about the sedentary lifestyle and its risks. Moreover, they were committed to reducing sedentary behavior and increasing physical activity. Based on the results, it can be concluded that counseling may increase students’ commitment to physical activity and sports. Keywords: physical activity, Sedentary lifestyle

Modelling metabolic performance in paediatric obstructive sleep disordered breathing: A case-control study.

Paediatric obstructive sleep disordered breathing (OSDB) has a considerable impact on cardiovascular physiology, but the consequences on children's basal metabolism and response to exercise are far from being known. The objective was to propose model estimations for paediatric OSDB metabolism at rest and during exercise. A retrospective case-control analysis of data from children submitted to otorhinolaryngology surgery was performed. The heart rate (HR) was measured, while oxygen consumption (VO2) and energy expenditure (EE) at rest and during exercise were obtained using predictive equations. The results for the patients with OSDB were compared with controls. A total of 1256 children were included. A total of 449 (35.7%) had OSDB. The patients with OSDB showed a significantly higher resting heart rate (94.55 ± 15.061 bpm in OSDB vs. 92.41 ± 15.332 bpm in no-OSDB, p = 0.041). The children with OSDB showed a higher VO2 at rest (13.49 ± 6.02 mL min-1kg-1 in OSDB vs. 11.55 ± 6.83 mL min-1kg-1 in no-OSDB, p = 0.004) and a higher EE at rest (67.5 ± 30.10 cal min-1kg-1 in OSDB vs. 57.8 + 34.15 cal min-1kg-1 in no-OSDB, p = 0.004). At maximal exercise, patients with OSDB showed a lower VO2max (33.25 ± 5.82 mL min-1kg-1 in OSDB vs. 34.28 ± 6.71 in no-OSDB, p = 0.008) and a lower EE (166.3 ± 29.11 cal min-1kg-1 in OSDB vs. 171.4 ± 33.53 cal min-1kg-1 in no-OSDB, p = 0.008). The VO2/EE increment with exercise (Δ VO2 and Δ EE) was lower in OSDB for all exercise intensities (p = 0.009). This model unveils the effect of paediatric OSDB on resting and exercise metabolism. Our findings support the higher basal metabolic rates, poorer fitness performance, and cardiovascular impairment found in children with OSDB.

Hubungan Sedentary Lifestyle dengan Status Gizi Remaja pada Masa Pandemi Covid-19 di SMPN 14 Jember

More nutritional status occurs because of an imbalance between energy intake and energy expenditure. High energy intake is the result of excessive food consumption, while low energy expenditure is the result of a lack of physical activity. The sedentary lifestyle has increased during the Covid-19 Pandemic. Sedentary lifestyle triggers the risk of overweight and obesity in adolescents. This research uses an analytic observational design with a cross-sectional approach which aims to determine the relationship between sedentary lifestyle and nutritional status of adolescents. Respondents in this study were adolescents aged 13-15 years. The number of samples was 70 respondents used purposive sampling technique. The instrument used was the Adolescent Sedentary Activity Questionnaire (ASAQ) and measurement of nutritional status using standard anthropometric z-score tables to assess nutritional status in children aged 5-18 years. This study obtained the results of the Spearman rank test, obtained a p-value of 0.000 (<0.05) and a correlation coefficient of 0.470, which means that there is a significant and unidirectional relationship with moderate strength between the sedentary lifestyle and the nutritional status of adolescents. It can be concluded that with increasing sedentary lifestyle, nutritional status will also increase. Sedentary lifestyle is a factor associated with overweight status because low physical activity causes fat accumulation due to not burning calories.

Increasing Public Knowledge About Sedentary Activities Through Counseling at SMPIT Zain Al-Muttaqin, Palembang, Indonesia

Background: Sedentary activities are activities that require very low energy expenditure, such as sitting or lying down while watching television, playing electronic games, and reading which can have negative health effects. This study aimed to describe the comparison of participants' knowledge before and after counseling about sedentary activities.
 Methods: An experimental study with one group pre-test and post-test design was conducted on 22 students of SMPIT Zain Al-Muttaqin Palembang. Data were analyzed using the Wilcoxon test.
 Results: There were 63.6% of participants' knowledge was in the poor category before counseling, and after counseling, the participant's knowledge increased by 59.1% in the good category. From the Wilcoxon test analysis, the result is the value of Sig. (2-tailed) of 0.000 < 0.05.
 Conclusion: Student knowledge is increased about activities sedentary after counseling, and there is a significant difference in the results of sedentary lifestyle counseling based on data pre-test and post-test (P<0,05).

Analysis of Walking Economy after Sleeve Gastrectomy in Patients with Severe Obesity.

Obesity is associated with a higher energy cost of walking which affects activities of daily living. Bariatric surgery with sleeve gastrectomy (SG) has beneficial effects on weight loss and comorbidities. The aim of this study was to analyze the impact of SG on walking economy in subjects with severe obesity. This observational cohort study included all patients with morbid obesity who were considered suitable candidates for SG between June 2017 and June 2019. Each patient underwent an incremental cardiopulmonary exercise test on a treadmill (modified Bruce protocol) one month before and six months after SG. Data on the energy cost of walking were recorded during three protocol stages (stage 0-slow flat walking: speed 2.7 km/h, slope 0%; stage ½-slow uphill walking: speed 2.7 km/h, slope 5%; stage 1-fast uphill walking: speed 4.0 km/h, slope 8%). 139 patients with morbid obesity (78% women; age 44.1 ± 10.7 years; BMI 42.5 ± 4.7 kg/m2) were included in the study. At six months post-SG, patients presented with a significantly decreased body weight (-30.5 ± 17.2 kg; p < 0.05), leading to an average BMI of 31.6 ± 4.2 kg/m2. The net energy cost of walking (measured in J/m and J/kg/m) of the subjects was lower compared to pre-SG at all three protocol stages. This improvement was also confirmed when the subjects were grouped by gender and obesity classes. After a significant weight loss induced by SG, regardless of the severity of obesity and gender, patients exhibited a lower energy expenditure and an improved walking economy. These changes make it easier to perform daily routines and may facilitate an increase in physical activity.

Formation of silver halos by Sphingomonas paucimobilis MX8 and its bioleaching of silver from computer keyboard printed circuit boards.

Silver (Ag) is currently obtained from primary and secondary sources through hydrometallurgical and pyrometallurgical processes. However, these processes consume high amounts of energy and are environmentally unfriendly. The search for bacteria tolerant with a high leaching capacity for to Ag is therefore a necessary requirement as part of the development of bioleaching technologies with reduced impact on the environment and lower energy expenditure. In this sense, the objective of this research was to evaluate the tolerance of Sphingomonas paucimobilis MX8 to Ag added to nutrient agar, and to determine whether this tolerance could favor the bioleaching of Ag present on the printed circuit boards (PCBs) of computer keyboards. The bacteria Sphingomonas paucimobilis MX8 was cultured in Petri dishes with nutrient agar and four different concentrations of AgNO3 (200, 400, 600, and 800mg L-1) at 28°C for 10days. For the bioleaching experiment, the bacteria were grown in a mineral medium with computer keyboard PCBs for 30days at room temperature (17 to 22°C) and centrifugation at 150rpm. The results indicate that Sphingomonas paucimobilis MX8 is tolerant to Ag and forms a silvery halo around its growth in the presence of this metal. Furthermore, Sphingomonas paucimobilis MX8 was able to bioleach 12% of the Ag found in computer keyboard PCBs. The results obtained could help generate more environmentally friendly silver bioleaching processes in which the silver bioleaching capacity of this bacterium is increased.

DYSLIPIDEMIA CHANGES EXERCISE ENERGY EXPENDITURE IN MICE TRANSGENIC FOR HUMAN APOCIII

Hypertriglyceridemia is a predisposing factor for several metabolic diseases in the worldtoday. Their cause is multifactorial, several factors are directly linked to the modification ofplasma lipid metabolism, among them are genetics and exercise. The genic overexpression ofapoCIII makes the animal hypertriglyceridemic and high levels of blood cholesterol, enablingfurther studies to be done on its metabolic profile. This study investigates how apoCIIIoverexpression and exercise modify the metabolism of genetically modified mice, especiallytheir energy expenditure. We used 15-month-old male C57Bl/6 mice, subdivided into 4groups: 2 NTG groups (non-transgenic mice that were submitted to training and theircontrols) and 2 CIII groups (transgenic Mice with basal triglyceridemia above 300mg/dL thatwere submitted to training and their controls). The exercised groups underwent for 8 weeks amoderate intensity training for 40 minutes 3 times a week. All animals were submitted to astress test to evaluate performance and energy expenditure. The trained animals had higherenergy expenditure during all stages of the test (p&amp;lt;0.01) and the area under curve of the EEshowed that the trained animals had higher caloric consumption (p&amp;lt;0.001), while the animalCIII sed had a much higher energy expenditure than its control NTG sed (p&amp;lt;0.001). Weconclude that dyslipidemia makes the CIII animal less fit for exercise, and trained animalshave lower energy expenditure independent of dyslipidemia and produced more work.

Unraveling the mystery of isocaloric endurance training - Influence of exercise modality, biological sex, and physical fitness

BackgroundA sedentary lifestyle with low energy expenditure (EE) is associated with chronic diseases and mortality. Barriers such as “lack of time” or “lack of motivation” are common reasons why physical exercise is neglected in the general population. To optimize EE in the time available, time-efficient but also enjoyable types of exercise are required. We therefore used an isocaloric approach to systematically investigate the effects of six different endurance exercise modalities on metabolic, mechanical, cardiorespiratory, and subjective variables in relation to biological sex and physical fitness. MethodsOut of 104, 92 healthy participants (21 recreationally trained and 18 trained females, 25 recreationally trained and 28 trained males) were subjected to physiological exercise testing to determine the exercise intensities for six exercise modalities, i.e., three different high-intensity interval training (HIIT) protocols (5 × 4 min, 15 × 1 min, 30 × 30 sec intervals), threshold (THR), speed endurance production (SEP), and low-intensity continuous endurance training (LIT). One of three HIIT sessions served as the reference for the subsequent isocaloric exercise modalities which were completed in randomized order. Metabolic and mechanical variables, i.e., EE during exercise, time to isocaloric EE (Tiso), relative and absolute fat contribution, post-exercise oxygen consumption (EPOC), mechanical energy, as well as cardiorespiratory and subjective variables, i.e., heart rate, oxygen uptake response, rating of perceived exertion, and enjoyment were assessed. Data were analyzed using a 6 × 2 × 2 repeated-measures ANOVA. ResultsAll three versions of HIIT and THR achieved the same EE during exercise for the same training duration. We found that LIT had a 1.6-fold (p < 0.001) and SEP a 1.3-fold (p < 0.001) longer Tiso compared to HIIT with no effects of biological sex (p = 0.42, pη2 = 0.01) or physical fitness (p = 0.09, pη2 = 0.04). There was a main effect of exercise modality on EPOC (p < 0.001, pη2 = 0.76) with highest values for HIIT 30 × 30 (p = 0.032) and lowest for LIT (p < 0.001). The highest relative and absolute amounts of fatty acids were measured during LIT (p < 0.001), and the lowest values were obtained during HIIT modalities. HIIT 30 × 30 was the most enjoyable version of HIIT (p = 0.007), while THR was the least enjoyable exercise modality (p = 0.008). ConclusionHIIT modalities are time-saving and enjoyable, regardless of sex and physical fitness. The results illustrate the relationship between exercise modality and metabolic, physiological, and subjective responses, and are thus of great interest to healthy individuals seeking time-saving and enjoyable exercise options.

Investigating the effects of thermoneutral housing on skeletal and cardiac muscle function in D2 mdx mice

Since its discovery, the mdx mouse has been the foundation for research on Duchenne muscular dystrophy (DMD) and its potential therapies. Although, nearly all studies using mdx mice as an experimental model have been conducted under “standard” lab conditions using room (22C) instead of thermoneutral (TN, 30C) temperature housing. Room temperature (RT) is a mild cold stress to mice, causing metabolic adaptations that can confound experimental results, limiting their interpretation and translation to humans. This study investigated the effects of housing temperature on whole-body metabolism and skeletal and cardiac muscle function in the mdx mouse. To this end, 20 D2 mdx mice (age 5 weeks, n = 10 per group) were housed at RT and TN for 10 weeks. Metabolic cage analysis demonstrated that TN housed mdx mice displayed significantly decreased VO2 consumption and reduced food intake that was likely due to lowered daily energy expenditure. TN housed mice also had significantly lower respiratory exchange ratio values, indicative of increased fat metabolism. However, there were no differences in body mass or composition (i.e., % lean and fat mass). Treadmill-to-fatigue experiments revealed no differences in exercise performance. Furthermore, ex vivo muscle contractility analysis displayed no differences in extensor digitorum longus or soleus specific force generation between TN and RT housed mice. Analysis of cardiac structure/function demonstrated that TN housed mdx mice exhibited a reduction in cardiac output, which we attributed to diastolic dysfunction. While ejection fraction and fractional shortening were not different among the two groups, TN housing led to a significant reduction in end diastolic volume (EDV) and left ventricle internal diameter (diastole, LVID;d), as well as increased relative wall thickness (diastole, RWT;d) compared to RT housed mice. Though isovolumic relaxation time was prolonged in TN-housed mice, this did not reach statistical significance. Taken together, our results demonstrate that TN housing had minimal effects on skeletal muscle contractility, but did lead to signs of diastolic dysfunction in young mdx mice. Future studies will examine the effects of TN housing in aged mdx mice, when systolic dysfunction occurs, as well as any influence of TN housing on the efficacy of potential muscle wasting therapeutics. Overall, our results support the growing literature that highlights the importance of selecting the appropriate housing temperature when studying metabolism or muscle wasting conditions in mice. NSERC This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Different Explosive Strength and Physiological Demands Between Male and Female Basketball Teams

Background. The several types of running in the team sports such as basketball, soccer and rugby, vary according to physical characteristics and sports. In particular, in the basketball the running is characterized by continuous acceleration and deceleration phases, which entails greater energy expenditure. This study aimed to assess the strength decrease of the lower limbs and energy expenditure at different running conditions (n=4) with/without the ball during Linear running and Shuttle run (180°) in two groups (male: n=15; female: n=15). Materials and methods. Experimental approach required the following tests/devices: Squat Jump to assess the strength of the lower limbs before/after each test, and a portable Metabolimeter was used to assess the metabolic parameters. The T-test was used for independent samples and Two-way repeated measures ANOVA was used to assess the significant differences for each variable between each running conditions. Results. Initial hypothesis has been confirmed, showing a significantly different strength decrease in different running conditions (Linear Running and Shuttle run with and without ball) and between the two teams considered (male and female). In addition, different energy expenditure between the two groups increases even more during the running with the ball compared to running without the ball. Conclusions. The results of this study could be useful for coaches to optimize training with different training load related to gender and to the running conditions (with and without the ball), but also to optimize the work load of young players in relation to the abilities, skills and experiences of players.

Distance doesn't matter: migration strategy in a seabird has no effect on survival or reproduction.

Migrating animals show remarkable diversity in migration strategies, even between individuals from the same population. Migrating longer distances is usually expected to be costlier in terms of time, energy expenditure and risks with potential repercussions for subsequent stages within the annual cycle. Such costs are expected to be balanced by increased survival, for example due to higher quality wintering areas or lower energy expenditure at lower latitudes. We compared reproductive parameters and apparent survival of lesser black-backed gulls (Larus fuscus) breeding in The Netherlands, whose winter range extends from the UK to West Africa, resulting in one-way migration distances that differ by more than 4500 km. Individuals migrating furthest arrived later in the colony than shorter distance migrants, but still laid in synchrony with the colony and consequently had a shorter pre-laying period. This shorter pre-laying period affected neither egg volumes nor hatching success. We found no relationship between migration distance and apparent survival probability, corresponding with previous research showing that annual energy expenditure and distance travelled throughout the year is similar across migration strategies. Combined, our results indicate an equal fitness payoff across migration strategies, suggesting there is no strong selective pressure acting on migration strategy within this population.

Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism.

The trend of fasting until noon (omission or delayed breakfast) is increasingly prevalent in modern society. This eating pattern triggers discordance between endogenous circadian clock rhythms and the feeding/fasting cycle and is associated with an increased incidence of obesity and T2D. Although the underlying mechanism of this association is not well understood, growing evidence suggests that fasting until noon, also known as an "extended postabsorptive state", has the potential to cause a deleterious effect on clock gene expression and to disrupt regulation of body weight, postprandial and overall glycemia, skeletal muscle protein synthesis, and appetite, and may also lead to lower energy expenditure. This manuscript overviews the clock gene-controlled glucose metabolism during the active and resting phases and the consequences of postponing until noon the transition from postabsorptive to fed state on glucose metabolism, weight control, and energy expenditure. Finally, we will discuss the metabolic advantages of shifting more energy, carbohydrates (CH), and proteins to the early hours of the day.

Environmental Forcing of Upper-Tropospheric Cold Low on Tropical Cyclone Intensity and Structural Change

Abstract The interaction between Typhoon Nepartak (2016) and the upper-tropospheric cold low (UTCL) is simulated to better understand the impact of UTCL on the structural and intensity change of tropical cyclones (TCs). An experiment without UTCL is also performed to highlight the quantitative impacts of UTCL. Furthermore, idealized sensitivity experiments are carried out to further investigate the specific TC–UTCL configurations leading to different interactions. It is shown that a TC interacting with the UTCL is associated with a more axisymmetric inner-core structure and an earlier rapid intensification. Three plausible mechanisms related to the causality between a UTCL and the intensity change of TC are addressed. First, the lower energy expenditure on outflow expansion leads to higher net heat energy and intensification rate. Second, the external eddy forcing reinforces the secondary circulation and promotes further TC development. Ultimately, the shear-induced downward and radial ventilation of the low-entropy air is unexpectedly reduced despite the presence of UTCL, leading to stronger inner-core convections in the upshear quadrants. In general, the TC–UTCL interaction process of Nepartak is favorable for TC intensification owing to the additional positive effect and the reduced negative effect. In addition, results from sensitivity experiments indicate that the most favorable interaction would occur when the UTCL is located to the north or northwest of the TC at a stable and proper distance of about one Rossby radius of deformation of the UTCL.

Resting and total energy expenditure of patients with long-chain fatty acid oxidation disorders (LC-FAODs).

The basis of medical nutrition therapy for patients with LC-FAODs is to provide adequate energy to maintain anabolism and prevent catabolism. In practice, energy needs are estimated based on formulas derived from normal populations but it is unknown if energy expenditure among patients with LC-FAODs is similar to the normal population. We measured resting energy expenditure (REE), total energy expenditure (TEE) and body composition in 31 subjects with LC-FAODs ranging in age from 7 to 64 years. Measured REE was lower than estimated REE by various prediction equations and measured TEE was lower than estimated TEE. It is possible that the lower energy expenditure based on prediction formulas from the normal population is due to differences in body composition; we compared body composition to normal data from the 2017-18 National Health and Nutrition Examination Survey (NHANES). Fat free mass and fat mass was similar between subjects with an LC-FAOD and NHANES normal data suggesting no difference in body composition. We then compared measured REE and TEE to normal published data from the Dietary Reference Intakes (DRI). Measured REE and TEE were significantly lower among subjects with LC-FAODs compared to normal published energy expenditure data. Our results suggests patients with a LC-FAOD exhibit a lower REE and therefore actually have a slightly lower TEE than estimated. Current prediction equations may overestimate energy expenditure of patients with a LC-FAOD.

Sustainable use of reclaimed asphalt pavement (RAP) in pavement applications-a review.

The purpose of this review is to examine the innovative usage ofReclaimed Asphalt Pavement (RAP) in flexible pavement applications. RAP is elucidated as isolated pavement earthly materials consisting of asphalt and aggregates. When the existing/old asphalt is removed for reconstruction, and resurfacing, these materials are generated. Now, it is highly required to classify the available RAP for further essential use in road construction. RAP addresses the issues regarding the diminishing of Virgin Aggregate (VA) sources, storage of material and disposal of RAP material nearby the site. The utilization of RAP includes social benefits like depletion of manufacturing waste, conservation of non-renewable natural stockpiles and low energy expenditure. The reviewed literature reveals that RAP has been utilized mainly for base and sub-base materials on the roads. To summarize, 100% replacement of VA by RAP possessed lesser strength and little resistance to creep and long-lasting deformations. Hence, RAP can be appended with natural aggregate or blended with cement or other admixtures like Fly ash (FA) or confined with geocell. It also accelerates the strength and stiffness of the base and sub-base of pavement as it degrades the failure like rutting and fatigue cracking of pavement due to dynamic loads.

Enhancing aircraft control surface effectiveness by co-flow jet flap at low energy expenditure

This paper conducts Improved Delayed Detached Eddy Simulation (IDDES) to compare applying co-flow jet (CFJ) active flow control on the flap and on the front main part of an aircraft control surface. Trade studies with varying CFJ momentum coefficients (Cμ) and flap deflection angles (δ) indicate that using CFJ on the flap is much more effective and efficient than applying CFJ on the front main part of the control surface. It is attributed to the feature that CFJ is more advantageous to work in severe adverse pressure gradient (APG). With a small Cμ of 0.025, the configuration with CFJ on the flap achieves a 46.1% increase of lift coefficient (CL) with an 80.8% lower power consumption compared with the one using CFJ on the front part. Moreover, the control surface with CFJ on the flap can attach the flow very well at a very high deflection angle of 70∘ and achieves a CL of 2.5 times larger than that of the baseline control surface.

Characterization of vulnerable communities in terms of the benefits and burdens of the energy transition in Pacific Northwest cities

Energy transition to renewable sources has occurred along with the development of various clean energy policies aimed at decarbonization and electrification. However, the transition can inadvertently lead to social inequity resulting in increasing burdens on vulnerable communities. Although many studies have tried to define and identify vulnerable communities, there has been no study specifically aimed at characterizing vulnerable communities in terms of the benefits and burdens of such energy transition. In response, the objective of this study is to characterize vulnerable communities by examining rooftop solar adoption and energy expenditure using spatial and mixed-effect models. Rooftop solar adoption operationalizes energy resilience and benefits, and energy expenditure operationalizes energy dependence and burdens of the transition. The study also investigates the link between rooftop solar adoption and energy expenditure by considering city-level variability in three Pacific Northwest cities. The results show that Bellevue has 50.4% less rooftop solar adoption than Portland, while Portland has 16.1% or $223 more energy expenditure than Seattle. On average, an increase in annual energy expenditure of $431 is associated with 29% increase in rooftop solar adoption, specifically Bellevue, Seattle, and Portland by 21.4%, 39.1%, and 26.2%, respectively, but not vice versa. Furthermore, the group of communities more vulnerable in housing attributes has 15.2% less rooftop solar adoption than the group of more vulnerable communities in socioeconomic attributes. In addition, the city centers, commercial areas, or mid-rise and high-rise zones are found to have lower rooftop solar adoption and energy expenditure than other areas. The results suggest that policymakers should consider between-city variability when identifying vulnerable communities. Policies should also be tailored to local communities based on their attributes as communities with similar attributes tend to cluster together. Furthermore, policymakers should focus more on housing and built environment attributes to promote resilient communities.

Home range variability and philopatry in Cinereous vultures (Aegypius monachus) breeding in Iberia

Large scavengers are strongly dependent on environmental conditions and carrion distribution and abundance, so season and breeding-related factors may influence the spatial ecology of species such as the Cinereous Vulture (Aegypius monachus), the largest European raptor. Iberia holds one of the biggest populations worldwide, but some aspects of the spatial ecology of the species in this region remain unknown. In this study, 17 adult Cinereous Vultures were GPS-tracked in order to study their spatial ecology during the adult phase. The average monthly home ranges (95% Kernel Density Estimation, KDE) and core areas (50% KDE) were 6543 ​± ​19,935 ​km2 and 1174 ​± ​4004 ​km2, respectively. The average monthly home range fidelity ranged between 50 and 73%. Differences in movement-related variables between the seasonal periods (incubation, chick-rearing and non-breeding) were found. During the chick-rearing period, the monthly accumulated distance was higher than during the other periods: 3316 ​± ​1108 (chick-rearing) vs. 1621 ​± ​622 (incubation) vs. 1726 ​± ​1159 ​km per month (non-breeding). Additionally, large home range sizes were more frequent during the chick-rearing period. There are two likely causes for these seasonal differences. Firstly, chick-rearing entails a higher energetic expenditure by the parental individuals in foraging activities, so larger movements and foraging areas are expected during this period. Secondly, the flight is favoured during spring and summer due to environmental conditions. Matching chick-rearing and warm months is a great evolutionary advantage for soaring-gliding raptors, as it allows them to cover larger areas with low energy expenditure. Furthermore, six individuals tagged as nestlings highlight the philopatric behaviour of the species: vultures settle their breeding areas 54 ​± ​51 ​km from their natal nest (range ​= ​9–138 ​km).

Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms.

Microbiota dysbiosis and metabolic syndrome, consequences of a non-adequate diet, generate a feedback pathogenic state implicated in Alzheimer's disease development. The lower production of short chain fatty acids (SCFAs) under dysbiosis status leads to lipid homeostasis deregulation and decreases Angptl4 release and AMPK activation in the adipose tissue, promoting higher lipid storage (adipocyte hypertrophy) and cholesterol levels. Also, low SCFA generation reduces GPR41 and GPR43 receptor activation at the adipose tissue (increasing leptin release and leptin receptor resistance) and intestinal levels, reducing the release of GLP-1 and YPP. Therefore, lower satiety sensation and energy expenditure occur, promoting a weight gaining environment mediated by higher food intake and lipid storage, developing dyslipemia. In this context, higher glucose levels, together with higher free fatty acids in the bloodstream, promote glycolipotoxicity, provoking a reduction in insulin released, insulin receptor resistance, advanced glycation products (AGEs) and type 2 diabetes. Intestinal dysbiosis and low SCFAs reduce bacterial biodiversity, increasing lipopolysaccharide (LPS)-producing bacteria and intestinal barrier permeability. Higher amounts of LPS pass to the bloodstream (endotoxemia), causing a low-grade chronic inflammatory state characterized by higher levels of leptin, IL-1β, IL-6 and TNF-α, together with a reduced release of adiponectin and IL-10. At the brain and neuronal levels, the generated insulin resistance, low-grade chronic inflammation, leptin resistance, AGE production and LPS increase directly impact the secretase enzymes and tau hyperphosphorylation, creating an enabling environment for β-amyloid senile plaque and tau tangled formations and, as a consequence, Alzheimer's initiation, development and maintenance.

Consumer wearable device-based measures of physical activity and energy expenditure in community-dwelling older adults with different levels of frailty: A STROBE compliant study.

Physical activity is important for positive health outcomes, and wearable activity devices are useful for tracking physical activity patterns and energy expenditure. This study investigated differences in, and correlations of, duration of physical activity according to activity intensity and energy expenditure among community-dwelling older adults with different levels of frailty. This cross-sectional study enrolled 88 adults older than 65 years from communities between June 2019 and January 2020. The participants were divided into non-frail, pre-frail, and frail groups according to the frailty criteria. Outcomes included the frailty score, duration of physical activity according to the intensity of activity (sedentary, light, fairly active, fairly to very active, and very active), and energy expenditure measured by a consumer wearable device. The duration of physical activity according to the intensity of activity and energy expenditure were compared among non-frail, pre-frail, and frail groups. In addition, linear correlation analysis was used to identify significant associations of objectively measured physical activity and energy expenditure with frailty. Non-frail older adults showed significantly longer daily duration of light to very active physical activity and increased energy expenditure compared to the frail group (P < .05). Additionally, non-frail older adults engaged in significantly more light and fairly to very active physical activity, and showed increased energy expenditure, compared to the pre-frail group (P < .05). The non-frail group showed a significantly lower duration of sedentary behavior compared to the pre-frail group. Correlation analysis showed that frailty was significantly associated with decreased light to very active physical activity and energy expenditure, as well as increased sedentary behavior (P < .05). This study provides evidence of differences in objectively measured physical activity and energy expenditure between frail and non-frail older adults, and reveals an association of frailty with physical activity and energy expenditure. Daily physical activity that exceeds low-intensity, low-energy expenditure activity should be encouraged among older adults with frailty.