BACKGROUND: Amyloidosis is a group of diseases caused by extracellular accumulation of insoluble fibers referred to as amyloid fibers in tissues and organs. Amyloid fibers have a secondary beta-sheet structure which makes them resistant to proteolysis. In histological examination, amyloid deposits stain with Congo red and show apple-green birefringence in polarized light. Amyloid deposits disturb the function of organs and cause clinical symptoms. Their formation or accumulation within the system may be acquired or inherited. Due to the location of amyloid deposits, one may distinguish systemic and localized amyloidosis with the formation of tumors (usually composed of immunoglobulin light chains). CASE REPORTS: Five cases of amyloidosis in the head and neck region are presented in this paper. Locations of the amyloid deposits were as follows: larynx, nasopharynx, sublingual and submandibular gland and the tongue. The initial clinical presentation correlated with the location of amyloid tumour in our patients. Two patients had a history of local recurrence of the disease. Surgical resection and histopathological examination were performed. Sections stained with Congo red confirmed the diagnosis of amyloidosis. Three patients had potential conditions that predisposed them to amyloidosis, including previous radiotherapy, chronic inflammation due to hepatitis C virus infection and graft versus host disease. CONCLUSION: Amyloidosis should be considered as a possible cause of pathological symptoms in the head and neck region. The diagnosis requires a histopathological examination. The systemic form of the disease must be ruled out in all patients with head and neck amyloidosis. In localized amyloidosis, surgical resection of lesions is the procedure of choice; however, maintenance of organ's functionality should be taken into account.
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