Abstract

The surgical management of breast cancer tumors depends not only on knowing the right histological type of tumor, but also on identifying the grade of axillary node invasion and the presence of metastases. Unfortunately, due to a lack of general understanding of how these tumors actually spread and their path towards axillary lymph nodes, there is a tendency of over or undertreating patients in the surgical environment. Even though we now have the Sentinel Ganglion method to help us, we haven�t decided on a universally accepted algorithm in the management of this disease. Many studies are still needed in order to fully clarify the most appropriate surgical management for each type of tumor and the level of axillary node dissection. Multiple factors should be taken into account when managing the case of a patient suffering from breast cancer and faced with the need of an axillary lymph node dissection (ALND). We have tried to identify some of these factors based on the experience of our clinic and available literature. The factors identified are the positive SLN (Sentinel Lymphatic Node) aspect, the differentiation between micro and macrometastases, the use of the S classification of SLN and microanatomic location of SLN metastases and the microanatomic location (MAL) of the tumor deposit in the sentinel ganglion.

Highlights

  • Along with the size of the tumor, the status of the axillary lymph nodes is a basic element in the staging and prognosis of breast cancer

  • Our retrospective study aims to analyze the accuracy of full axillary lymph node dissection (ALND) (Axillary Lymph Node Dissection) indication in early breast cancer patients in order to avoid the two extremes: under and over surgical treatment of the axilla

  • We have used the following acronyms and definitions: SLN (Sentinel lymphatic node); SLN positive (SLN invaded by tumor cells); ALND (Axillary Lymph Node Dissection); complete ALND - excision of lymph nodes stations I, II and III; partially ALND - excision only of I, II stations; positive ALND; negative ALND; microanatomic location (MAL)

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Summary

Analysis of a series of cases and literature review

DANIEL ION1,2, ALEXANDRA BOLOCAN1,2*, BOGDAN SOCEA2,3, OCTAVIAN ANDRONIC1,2, GEORGIANA RADU2, DAN NICOLAE PADURARU1,2 1University Emergency Hospital Bucharest, 3rd General Surgery Clinic, 169 Splaiul Independentei, 050098, Bucharest, Romania 2Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Str., 020021, Bucharest, Romania 3Sf. Many studies are still needed in order to fully clarify the most appropriate surgical management for each type of tumor and the level of axillary node dissection. Multiple factors should be taken into account when managing the case of a patient suffering from breast cancer and faced with the need of an axillary lymph node dissection (ALND). The simple equation Positive Sentinel Ganglion = Complete ALND has been discussed by numerous studies with multiple adjustments and nuances to center the surgical indication as accurately as possible without ever reaching a universally accepted algorithm [1,2,3]. Our retrospective study aims to analyze the accuracy of full ALND (Axillary Lymph Node Dissection) indication in early breast cancer patients in order to avoid the two extremes: under and over surgical treatment of the axilla

Experimental part Materials and methods
Results and discussions
DISEASE AND THE PRESENCE OF INVASION
Conclusions

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