While many coastal areas are affected by coastal squeeze, quantitative estimations of this phenomenon are still limited. Ambiguity concerning the degree of coastal squeeze, combined with a lack of knowledge on its interaction with human activities may lead to inadequate and unsuccessful management responses. The objective of the present research was to quantify the degree of coastal squeeze on the highly urbanized coast of Mazatlan, Mexico, and to investigate the relationship between the development of tourism and coastal squeeze from various time perspectives. The Drivers, Exchanges, States of the environment, Consequences, and Responses (DESCR) framework was applied to identify the chronic, negative consequences of dense tourism in the area, together with the assessment of coastal squeeze. A Tourism Load Capacity (TLC) estimation was made and correlated with the DESCR results, showing that coastal squeeze is inversely correlated with tourism load in Mazatlan. The medium-intensity coastal squeeze currently experienced in Mazatlan requires interventions to avoid severe degradation of the ecosystem on which the local tourism industry relies, for which immediate, long-term, and administrative recommendations are given.