Changes In Local Density Research Articles

Investigations on the Corrosion Behavior of a 20 Cell PEMFC Automotive Short Stack Caused By Air/Air Start-Ups at Different Operating Conditions Utilizing a Segmented Current Mapping Board

The Polymer Electrolyte Membrane Fuel Cell (PEMFC) emerges as one of the key technologies for the future of energy and mobility landscapes by offering a clean, efficient, and sustainable power generation. To ensure the commercial viability of PEMFCs, the components, particularly the Membrane Electrode Assembly (MEA), and its operation must be designed to minimize the impact of degradation processes over their entire lifetime and to maximize durability.It is known that the oxidation or corrosion of the cathode catalyst support material resulting from the so-called reverse current decay mechanism caused by gas atmosphere changes when starting up from an inactive state (air/air situation) or shutting down from the active state (H2/air situation) is one of the most significant degradation processes. The Carbon Oxidation Reaction (COR) can lead to a detachment of the supported catalyst particles from the rest of the electrical network or to a delamination from the ionic network and therefore ultimately result in a reduction of the Effective Catalyst Surface Area (ECSA) and in increasing mechanical instability up to the collapse of the catalyst layer [1].In previous work, different approaches have been taken to simulate this degradation mechanism using accelerated stress tests, usually at half-cell or sub-scale level, with active areas <50 cm² [2][3]. The aim of this work is to investigate the effect of Air/Air Start-Ups (AASUs) on a higher integration level using a 20 cell short stack with a single full-size automotive cell active area of >200 cm². AASUs were executed after different air soak durations and under different operating conditions with focus on relative humidity, coolant inlet temperature, hydrogen concentration and inflow rate to vary the gas front residence time within the active area. The short stack is equipped with a Cell Voltage Monitoring (CVM) of each individual cell and a high-resolution segmented Current Mapping Board (CMB) next to the anode Interface Plate (IFP) to record local and internal current density changes, particularly during the passage of the gas atmosphere front, as exemplified and illustrated in Figure 1.After the fundamental investigation of the impact of different operating parameters, a specific parameter set was chosen to assess the degradative effects on an identical stack in a continuous AASU sequence operation until failure. Throughout the stress testing, the cell performances including the local current distribution as well as the ohmic resistance of the stack by Electrochemical Impedance Spectroscopy (EIS) were monitored. Furthermore, morphological investigations using Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS) were performed after disassembly of the stack on different cells in the stack and at different positions within the active area. The formation of degradation gradients within the active cell area and along the stack, induced by AASU stress testing, is demonstrated through changes in local current densities measured with the CMB, accompanied by a loss of overall cell performance and supported by in-depth morphological investigations.

Optimization of graded and partial metamaterial treatments for enhanced broadband sound insulation in partition panels

Resonant metamaterials can achieve unprecedented vibroacoustic attenuation in lightweight partition panels through small resonators attached on a subwavelength scale. Conventional metamaterial treatments are effective only in a narrow band and typically cover the entire panel surface, posing important challenges for industrialization due to manufacturing and cost constraints. To address these issues, in this study we propose graded and partial metamaterial treatments, which are selectively distributed where they are the most effective, avoiding unnecessary coverage, and include a spatially varying resonance frequency for broadband effectiveness. The related design challenges are tackled by developing a numerical methodology that simultaneously optimizes the distribution and the grading of the treatment. The optimization objective is to maximize the broadband diffuse sound transmission loss (STL) of the metamaterial panel, while constraining the maximum fraction of treated area. Leveraging effective medium modelling, the approach efficiently incorporates local changes in the effective mass density of the metamaterial panel to represent partial treatments. Different design cases are considered for different target bands and panel dimensions. Results demonstrate that graded partial metamaterial treatments can achieve broadband improvements with a limited treated area, effectively suppressing the STL dips due to the modes of the host panel and to coincidence effects.

Dynamic changes of gravity field before the Luding MS6.8 earthquake and its crustal material migration characteristics

On September 5, 2022, an earthquake of magnitude MS6.8 occurred in Luding County, Sichuan Province. This earthquake occurred at the key part of the southeast-clockwise extrusion of material on the eastern margin of the Qinghai Plateau, the Y-shaped confluence of the Xianshuihe, Longmenshan and Anninghe fault zones. In this study, the three-dimensional dynamic crustal density changes in the earthquake area are obtained by the typical gravity change data from 2019 to 2022 before the earthquake and gravity inversion by growing bodies. The results indicate that gravity changes presented an obvious four-quadrant and gradient belt distribution in the Luding area before the earthquake. The three-dimensional density horizontal slices show that small density changes occurred at the epicenter in the mid-to-upper crust between 2019.9–2020.9 and 2019.9–2021.9. At the same time, the surrounding areas exhibited a positive and negative quadrant distribution. These observations indicate that the source region was likely in a stable locked state, with locking-in shear forces oriented in the NW and NE directions. From 2021.9 to 2022.8, the epicentral region showed negative density changes, indicating that the source region was in the expansion stage, approaching a near-seismic state. The three-dimensional density vertical slices reveal a southeastward migration of positive and negative densities near the epicenter and on the western of the Xianshuihe Fault Zone, indicating that the material is flowing out to the southeast. The observed local negative density changes at the epicenter along the Longmenshan Fault Zone are likely associated with the NE-oriented extensional stress shown by the seismic source mechanism. The above results can provide a basis for interpreting pre-earthquake gravity and density changes, thereby contributing to the advancement of earthquake precursor theory.

2313: Changes in local bone density after pelvic radiotherapy in patients with pelvic malignancies

2313: Changes in local bone density after pelvic radiotherapy in patients with pelvic malignancies

Male-female spatio-temporal differences of age-related bone changes show faster bone deterioration in older women at femoral regions associated with incident hip fracture.

A better understanding of how age-related bone loss affects the fracture-prone regions of the proximal femur could lead to more informed fracture-prevention strategies. Therefore, the aim of this work was to assess the spatio-temporal distribution of bone deterioration in older men and women with aging. A subset of 305 men (74.87 ± 4.76years; mean ± SD) and 371 age-matched women (74.84 ± 4.71years) with no history of fracture was randomly selected from the Age, Gene/Environment Susceptibility-Reykjavik study. Quantitative computed tomography (QCT) scans of the left proximal femur obtained at baseline and at 5.2 ± 0.4years follow-up were processed to assess local changes in volumetric bone mineral density (vBMD), cortical bone thickness (Ct.Th), and internal bone structure using voxel-based morphometry (VBM), surface-based statistical parametric mapping (surf-SPM), and tensor-based morphometry (TBM). Local parametric changes within each sex and sex differences in these changes were statistically assessed using linear mixed effects models allowing for baseline and time-varying covariates, yielding Student's t-test and p-value statistical maps of the proximal femur. The statistical maps indicated regions with significant parametric changes in each sex and with significant different parametric changes between older men and older women with aging. Older women manifested significantly larger losses in vBMD, (Ct.Th), and structure than older men, and they did so in regions where deficiency in these parameters has been associated with incident hip fracture. Using longitudinal QCT scans of the proximal femur and Computational Anatomy, we provided new insights into the higher fracture rates of the proximal femur in older women compared with men of similar age providing new information on the pathophysiology of osteoporosis.

Investigation of current density and temperature distribution characteristics under transient conditions based on a 108 cm2 segmented proton exchange membrane fuel cell

Visualizing the electrochemical and temperature distribution characteristics inside proton exchange membrane fuel cell (PEMFC) should greatly contribute to the product development and performance optimization. In the study, a customized 27-segment 108 cm2 fuel cell was fabricated based on the printed circuit board methodology to achieve the local current density and local voltage measurement. In addition, 27 thermocouples were embedded in the segmented cathode graphite gas flow plate for local temperature measurement. Detailed information of fuel cell core components, multi-channel data acquisition system, external temperature control system, and uncertainty analysis was presented. According to the test results of 4000 s current rising conditions and 2400 s current decreasing conditions, the measurement deviation of total current between data acquisition system and TOYO test station is 2.4%–3.2%. Meanwhile, the deviation of output voltage ranges from 0.1% to 2.6%. To quantify the degree of distribution non-uniformity, the range and standard deviation of local parameter values as well as contour map are demonstrated. The non-uniformity of local current density and local temperature becomes more significant under higher operating current conditions. Furthermore, the degree of parameter non-uniformity is more noticeable under current rising conditions compared with current decreasing conditions. The transient increase of operating current leads to the sudden overshoot phenomena of local current range, and the change of local current density among all segments is instantaneously finished. However, the range of current demonstrates relatively smooth transition trends when reactant flow rate rises. Higher temperature area appears in the middle of membrane electrode assembly, especially in the position with higher local current density. The parameter distribution and transition characteristics could provide helpful guidance for fuel cell optimization and diagnosis.

Effects of galaxy environment on merger fraction

Aims. In this work we examine how environment influences the merger fraction, from the low density field environment to higher density groups and clusters. We also study how the properties of a group or cluster, as well as the position of a galaxy in the group or cluster, influences the merger fraction. Methods. We identified galaxy groups and clusters in the North Ecliptic Pole using a friends-of-friends algorithm and the local density. Once identified, we determined the central galaxies, group radii, velocity dispersions, and group masses of these groups and clusters. Merging systems were identified with a neural network as well as visually. With these identifications and properties of groups and clusters and merging galaxy identifications, we examined how the merger fraction changes as the local density changes for all galaxies as well as how the merger fraction changes as the properties of the groups or clusters change. Results. We find that the merger fraction increases as local density increases and decreases as the velocity dispersion increases, as is often found in the literature. A decrease in merger fraction as the group mass increases is also found. We also find that groups with larger radii have higher merger fractions. The number of galaxies in a group does not influence the merger fraction. Conclusions. The decrease in merger fraction as group mass increases is a result of the link between group mass and velocity dispersion. Hence, this decrease in merger fraction with increasing mass is a result of the decrease of merger fraction with velocity dispersion. The increasing relation between group radii and merger fraction may be a result of larger groups having smaller velocity dispersion at a larger distance from the centre or larger groups hosting smaller, infalling groups with more mergers. However, we do not find evidence of smaller groups having higher merger fractions.

A comparative radiographic study of bone density changes around titanium implants in the posterior mandible, preoperative, and postoperative

Background: Implant success and the state of the surrounding bone require multiple measures, especially in humans, and this study aimed to identify the development of the state of the latter by means of radiographic examination performed during the period of osseointegration as well as investigate the changes in bone density that occur after implant installation and 2 months after functional loading. Implant success rates are affected by bone density at the implant site. Therefore, understanding changes in bone density after dental implant placement is essential, as it correlates with subsequent implant success. Materials and methods: Digital radiographs of 28 implants were taken and evaluated at four intervals: preoperatively, 1 and 3 months postoperatively, and 2 months following placement of the permanent prosthesis. Gray values were measured in different areas around the implants through analyzing X-ray images and measuring bone density around the implants using EzDent – 2D software. The aim of this study was to investigate changes in bone density around implants in three regions: apex, neck, and body, as well as to record average density values during the observation period by measuring digital image gray levels (the gray values of the digital radiographs). This was conducted to determine local bone densities in dental implant recipient sites and to study changes in local bone densities at different intervals, preoperatively and postoperatively and after placement of the prosthesis. Results: A decrease was observed in gray values proportional to reference values 1-month after implant insertion, but these increased at 3 months after insertion and continued to rise 2 months after placement of the prosthesis in the apical, body, and neck regions of the implant. Conclusion: Sensor-tuned radiography can be used as an effective method to support clinical follow-ups as well as measure changes in bone densities around implants in critical cases.

Machine-Learning driven STM images prediction of doped/defective graphene: Towards optimized tools for 2D nanomaterials characterization

Scanning tunneling microscopy (STM) is a key characterization technique that allows for visualization of specific features at nanostructures, given its ability to reveal changes in local charge densities in doping or defective sites. Besides the experimental acquisition of STM data from real samples, there is the theoretical route, which allows for STM images simulation from ab-initio calculations on defined nanostructures. This work presents an alternative route for theoretical STM image prediction by means of Machine Learning (ML) methods, based on the training of deep convolutional neural networks using simulated STM data. The ML-based STM predictions for defective, B- and N-doped graphene quantum dots are compared to ab-initio STM simulations, in terms of accuracy of structural rearrangements, charge density localizations, and computational resources requirements. The results demonstrate that STM images predicted by ML-methods are accurate at doping sites, whereas they show good similarity to simulations of large structural vacancies. This work represents a novel alternative for the use of ML methods in image-based characterization routines of doped/defective graphene, and potentially, for other 2-dimensional nanomaterials.

Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium.

Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, cells can intercalate along their own apicobasal axes, adopting a shape named 'scutoid' that allows energy minimization in the tissue. Although several geometric and biophysical factors have been associated with this 3D reorganisation, the dynamic changes underlying scutoid formation in 3D epithelial packing remain poorly understood. Here, we use live imaging of the sea star embryo coupled with deep learning-based segmentation to dissect the relative contributions of cell density, tissue compaction and cell proliferation on epithelial architecture. We find that tissue compaction, which naturally occurs in the embryo, is necessary for the appearance of scutoids. Physical compression experiments identify cell density as the factor promoting scutoid formation at a global level. Finally, the comparison of the developing embryo with computational models indicates that the increase in the proportion of scutoids is directly associated with cell divisions. Our results suggest that apico-basal intercalations appearing immediately after mitosis may help accommodate the new cells within the tissue. We propose that proliferation in a compact epithelium induces 3D cell rearrangements during development.

Autocrine VEGF drives neural stem cell proximity to the adult hippocampus vascular niche.

The vasculature is a key component of adult brain neural stem cell (NSC) niches. In the adult mammalian hippocampus, NSCs reside in close contact with a dense capillary network. How this niche is maintained is unclear. We recently found that adult hippocampal NSCs express VEGF, a soluble factor with chemoattractive properties for vascular endothelia. Here, we show that global and NSC-specific VEGF loss led to dissociation of NSCs and their intermediate progenitor daughter cells from local vasculature. Surprisingly, though, we found no changes in local vascular density. Instead, we found that NSC-derived VEGF supports maintenance of gene expression programs in NSCs and their progeny related to cell migration and adhesion. In vitro assays revealed that blockade of VEGF receptor 2 impaired NSC motility and adhesion. Our findings suggest that NSCs maintain their own proximity to vasculature via self-stimulated VEGF signaling that supports their motility towards and/or adhesion to local blood vessels.

Optical Analysis of Ignition Sparks and Inflammation Using Background-Oriented Schlieren Technique

To determine the timing of inflammation in gas and gasoline combustion engines, the point of 10% mass fraction conversion of fuel (MFB10) is commonly used. The MFB10 can be determined from the heating curve, which in turn is calculated from the in-cylinder pressure curve. However, the cylinder pressure is an indirect parameter with regard to inflammation, as it is the result of the combustion that follows the inflammation. An attempt is made to derive a new, direct parameter of inflammation based on optical measurements in order to detect inflammation more rapidly and accurately. The background-oriented Schlieren technique (BOS) in combination with high-magnification optics and a high-speed camera is used to detect local density changes coming from the particle wave around the ignition kernel of a hydrogen combustion inside a combustion chamber. Via BOS and regular high-magnification high-speed imaging, the influence of ignition coil dwell time and in-cylinder pressure on the spark phases and the inflammation itself are evaluated. As a potential direct parameter for inflammation, the size of the particle wave resulting from the expanding ignition kernel is evaluated. It was found that a higher coil energy supports a faster propagation of the particle wave at ambient pressure. At higher pressures, general combustion effects override the effect of the influence of the coil energy on the propagation speed of the particle wave. In addition, the presence of successful inflammation was found to influence the spark phases. A directly measurable parameter for ignition could be found at a basic level, which will serve as a starting point for further detailed investigations.

The Correlation between the Bone Morphotype and Density and Root Apical Resorption of the Anterior Teeth Due to Orthodontic Forces

The potential side effects of modern orthodontic treatment and its unfavorable impact on dentition and hard tissues have been extensively discussed in professional literature for decades. The presence of uncontrolled forces can result in pulp necrosis, radicular reabsorption, and/or loss of alveolar bone. Dehiscence and fenestration are more commonly found in anterior than posterior teeth, where only the periodontal ligament and the mucosa protect the dental root.&#x0D; Most studies investigating the effect of periodontal phenotype over gingival recession in orthodontic patients have primarily focused on examining the soft tissues. However, due to the vulnerability of thin alveolar bone, the previous evaluation of orthodontic candidate patients may also include the analysis of hard tissues. Bone density plays an important role in facilitating orthodontic tooth movement, such that reductions in bone density can significantly increase movement velocity. These types of localized density changes can affect the rate of orthodontic tooth movement and may also influence the risk of unwanted outcomes, such as the occurrence of dental external apical root resorption.&#x0D; According to the literature, the links of root resorption with the bone morphotype and the density are relevant in clinical dentistry but have not been studied in detail. However, the existing data is not yet conclusive.

Abstract A043: Building a mammary-specific microenvironment for investigating sex hormones in microvessels and tumors

Abstract The mammary gland is highly vascularized and is exposed to alterations in sex hormones, including estrogen (E2) and progesterone (P4), which also play a role in breast cancer development and progression. Yet, our understanding of hormonal changes on the microvasculature in mammary tissue is limited to studies in rodents and simple 2D cultures. Advances in organ-on-chip technology now allow for models of 3D human microvessels to be generated. However, most microvascular models lack tissue-specific cell types, limiting their physiologic relevance. Thus, we first aimed to generate a tissue-specific breast microvasculature, and next used this model to study the impact of sex hormones. Our final goal is to generate a combined vascularized model of luminal A tumor on-chip. In our recently archived work (doi: 10.1101/2023.04.21.537664), we achieved the first in vitro perfusable breast-specific microvessels. Optimal conditions were achieved to co-culture human mammary vascular endothelial cells HMVEC and mammary fibroblasts on-chip. Through image-based quantification, microvessel morphology, not barrier function, was shown to be strongly influenced by the abundance of fibroblasts, which were critical to achieve lumenized (patent) vessels. Attaining perfusable microvessels allowed the study of discreet phases of the menstrual cycle (period, follicular, ovular, and luteal). The most striking results were observed with high concentrations of E2 (mimic of ovulation phase), which presented with increased vascular growth, and in contrast with high concentrations of P4 (mimic of luteal phase) that resulted in vascular rarefaction (pruning). Effects from combined E2 and P4 were dose-dependent, as demonstrated by significant branching and remodeling in the follicular phase. Hormonal effects were also tissue-specific, as shown by HUVEC-derived microvessels with significantly different morphologic phenotypes in comparison to HMVEC. Interestingly, fibroblasts expressed significantly high levels of receptors for both hormones and likely are major contributors to the hormone-responsiveness of microvessels. With mammary vessels now established, model tumors, spheroids, were generated from luminal-like breast cancer cells. Namely, MCF-7 and T47D, were treated by the same E2 and P4 conditions as in the microvessels. For both tumor spheroids, phase-dependent responses were observed, with high E2 resulting in the most significant growth. Ongoing work has shown the capacity to incorporate these tumor spheroids into our microvascular model, which results in varied local changes in vascular density. Future work involves investigating the role of hormones in the combined tumor-microvascular model. This complex humanized model will be useful in highlighting potential cancer treatment timelines (relevant to female menstrual cycle) and may be used to uncover novel therapeutic targets for luminal A breast cancers. Citation Format: Carmen Moccia, Marta Cherubini, Guido Frigieri, Kristina Haase. Building a mammary-specific microenvironment for investigating sex hormones in microvessels and tumors [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Breast Cancer Research; 2023 Oct 19-22; San Diego, California. Philadelphia (PA): AACR; Cancer Res 2024;84(3 Suppl_1):Abstract nr A043.

Quantification of membrane geometry and protein sorting on cell membrane protrusions using fluorescence microscopy.

Plasma membranes are flexible and can exhibit numerous shapes below the optical diffraction limit. The shape of cell periphery can either induce or be a product of local protein density changes, encoding numerous cellular functions. However, quantifying membrane curvature and the ensuing sorting of proteins in live cells remains technically demanding. Here, we demonstrate the use of simple widefield fluorescence microscopy to study the geometrical properties (i.e., radius, length, and number) of thin membrane protrusions. Importantly, the quantification of protrusion radius establishes a platform for studying the curvature preferences of membrane proteins.

Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility

Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment that induce deformations and remodeling of the fiber network. By measuring these deformations, the traction forces can be reconstructed if the mechanical properties of the matrix and the force-free matrix configuration are known. These requirements limit the applicability of traction force reconstruction in practice. In this study, we test whether force-induced matrix remodeling can instead be used as a proxy for cellular traction forces. We measure the traction forces of hepatic stellate cells and different glioblastoma cell lines and quantify matrix remodeling by measuring the fiber orientation and fiber density around these cells. In agreement with simulated fiber networks, we demonstrate that changes in local fiber orientation and density are directly related to cell forces. By resolving Rho-kinase (ROCK) inhibitor-induced changes of traction forces, fiber alignment, and fiber density in hepatic stellate cells, we show that the method is suitable for drug screening assays. We conclude that differences in local fiber orientation and density, which are easily measurable, can be used as a qualitative proxy for changes in traction forces. The method is available as an open-source Python package with a graphical user interface.

A note on the response of elastic bodies whose material moduli depend on the density and the mechanical pressure

In this note we study the response of an inhomogeneous body, whose material moduli depend on the density and the mechanical pressure, that is described by an implicit constitutive relation between the Cauchy stress and the right Cauchy–Green tensor. Such a constitutive relation is relevant to the study of the deformation of porous elastic solids as the porous structure varies and the local density changes. The boundary value problems of a plate of such a material subject to uniaxial and bi-axial extension and compression are considered. We find that regions that are more porous, and thus of lower macroscopic density, have the propensity to fail than regions of higher density, in the sense the load carrying capacity decreases, when other measures such as the stress are comparable.

Development of Sports Tourism Resources Based on Spatial Analysis Perspective

Abstract This paper examines the reality of sports tourism resources by effectively integrating the universal symbiosis and spatial hierarchy of sports tourism resources. Spatial analysis is utilized to view each element of the near-neighboring related element environment to find the spatial distribution probability density value of the random distribution within the sports tourism resources. The overall data distribution can be inferred from the limited samples, and calculations are performed to recognize localized density changes in the distribution of point-like samples. The highest mean value of sports resources density is 0.827, the highest comprehensive value of tourism resources evaluation is 0.82 points, and the maximum value of tourism competitiveness is 0.389. The spatial analysis perspective greatly improves the sports tourism industry’s comprehensive strength and the economy’s sustainable development is realized.

The effect of scattering instability induced by high intensity seed on backward Raman amplification

Backward Raman amplification (BRA) in plasma has become one of the most promising techniques for further promoting light intensity. In this work, BRA in plasma is simulated using one-dimensional particle-in-cell code with different seed intensity, showing that higher seed intensity (in the range of 2×1011–2×1015 W/cm2) will increase energy conversion efficiency with pump pulse of fixed intensity (2×1014 W/cm2), which is pre-depleted by spontaneous Raman scattering. We find that the scattering instability of amplified seed pulse is enhanced and the plasma wave fluctuation level is promoted with seed intensity at 2×1016 W/cm2 because the local plasma density changes in the pump scattering depletion region. In the simulations, we also found that the enhanced Raman scattering and secondary Raman scattering of amplified seed pulse causes a rapid energy consumption and earlier saturation of the amplification, which significantly affects the temporal shape of the amplified seed pulse to form a double peak shape. In addition, we explore the evolution of the energy and the pulse duration of the double peaks in detail and reveal the law of pulse energy growth with different pulse durations in a Raman amplifier.

Iterative approaches for regional Moho determination using on-orbit gravity gradients: A case study in Qinghai-Tibet Plateau and its near zone

Summary Moho determination is an important issue in studying the Earth’s interior structure. In accordance with the isostasy-compensation hypothesis in geodesy, it is possible to recover regional or global Moho by employing gravimetric data. The non-linear property is one of the main difficulties in solving the inverse problem of isostasy. To effectively address this issue, we propose an improved iterative inversion method that combines three-dimensional integration and linear regularization to achieve an approximate non-linear solution. To estimate the contributions of different components in the gravity-gradient tensor from the Gravity field and steady-state Ocean Circulation Explorer (GOCE), other than the vertical component, we additionally develop two joint inversion scenarios that utilize diagonal horizontal components and all five non-vertical components. The validating experiments are implemented in Qinghai-Tibet Plateau and its near zone. Simulations and applications illustrate that horizontal responses of Moho undulation are also significant. Yet the off-diagonal components provide minimal contributions, adding only 0.25 km of bias to the joint inversion results. Truncation effects serve as the primary source of systematic errors, resulting in ∼1 km error in vertical inversion results and ∼2.3 km error in joint inversion results. Then, the gravimetric Moho results are compared with CRUST1.0, and they show a generally strong correlation. Differences are obvious at the northern and eastern margins of the plateau. It is maybe due to the local changes in crust-mantle density contrasts. Upwelling of asthenospheric materials and fluid flow in the middle-lower crust are the two main factors. Based on high-precision satellite gravimetry, our study could provide new insights into the tectonic structure of Qinghai-Tibet Plateau.