Preservation Of Life Research Articles

A Coupling System for Prediction of Physiological Parameters in an Immersed Condition

This study’s major aim is to use a coupling system to predict the physiological parameters of a person wearing a life preserver in an immersion condition. The coupling system is made up of a thermal manikin that can simulate the human body’s thermoregulatory response in an immersion environment, coupled to a multi-segment human thermal model. By comparing the results with those of the subjects, the coupled system’s predictions were shown to be accurate. The core temperature, skin temperature, and heat flow density of ten healthy men were all continuously measured while they wore life preservers and were exposed to the same temperature of air and water. The coupling system demonstrated accurate predictions of heat production and core temperature compared to real measures, with RMSD of 18.91 W and 0.12 °C, respectively. The majority of the predicted values for mean skin temperature were within SD of the measured values, and the paired sample t-test with a significance level of 0.05 showed good agreement with a maximum temperature difference of 1 °C. Also, the coupling system predicted results and the measured results showed some good accuracy for predicting local skin temperatures.

Human health risk assessment due to mercury use in gold mining areas in the Ecuadorian Andean region

Mining activity drives economic development and has established itself as one of the main industrial spheres globally. However, illegal, and artisanal gold mining, which uses mercury (Hg), is a major source of global pollution. Hg is highly toxic and persistent in the environment, affecting human health and the ecosystem. The objective of this research is to; (a) analyze Hg concentrations in surface waters of nine provinces of the Andean region of Ecuador and compare them with the maximum permissible limits of Ecuadorian regulations, and (b) evaluate the health risk of people exposed to waters with high Hg content through residential and recreational scenarios. In this study, 147 water samples from rivers and streams were analyzed. The results revealed worrying levels of Hg, especially in the provinces of Azuay and Loja where Hg values of up to 0.0913 mg/L and 0.0387 mg/L, respectively, were detected. In addition, it was found that 45% of the samples did not meet the water quality criteria for the preservation of aquatic life, which represents a severe risk to the ecosystem. The probabilistic risk analysis yielded values that exceeded the acceptable exposure limit for adults and children in residential settings in Azuay and Loja, while in the recreational scenario the safe exposure limit was exceeded for both receptors only in the province of Azuay. The elevated presence of Hg in the provinces, mainly in Azuay and Loja, possibly related to illegal gold mining activity, represents a threat to water quality and aquatic life in the Andean region of Ecuador. Children are especially vulnerable, and effective regulation is required to ensure the safety of the population. This study provides valuable information for decision makers regarding the risk associated with Hg exposure in areas of mining activity in the Ecuadorian Andean region. In addition, it can contribute to the development of policies and strategies to control contamination in mining environments and protect human and environmental health in the region.

S1502 Normothermic Machine Preservation: The New Standard for Liver Preservation?

S1502 Normothermic Machine Preservation: The New Standard for Liver Preservation?

사회경제 발전의 새 패러다임

This article presents the realization of the value of human respect as a new paradigm for social and economic development. Economic growth plays an important role in laying the material foundation for human survival and prosperity, but it does not guarantee enjoyment and happiness to members of society in proportion. Under the growth maximization paradigm the human nature could be suppressed by treating humans as one of the factors of production. Growth maximization can make the society unequal and unfair. And also it even causes wars that destroy human life itself.
 The value realization paradigm respects human life rather than material wealth. Individuals pursue maximization of pleasure(Joy max) and a good life through realization of basic values such as respect for life, freedom, trust, and environmental preservation. We aim to become a culturally powerful society beyond a wealthy nation. Using White's cultural development equation which states ‘cultural progress is a function of energy and technology’, we show the newly defined social and economic development culture as CV=E1×T1, where E1 and T1 are energy and technology realizing the value of human respect. The energy E1 used to be increased when status equality, economic growth, checks and balances system, and rule of law were achieved. These variables were achieved by the introduction of social technologies consisting of institutions, organizations, leadership, etc.
 Currently, we need proper social technologies for resolving issues such as income disparity, dichotomous thinking and sharp social conflict. For economic development without income polarization, grassroots innovation must occur. A reform for equal opportunities in education is needed. And a sophisticated system of checks and balances should be strengthened to prevent power dictatorship and economic monopoly.

Analisis Hukum Bunga Kredit Usaha Rakyat (KUR) pada Kantor Cabang Pembantu (KCP) BRI Unit Kamal Bangkalan Ditinjau dari Perspektif Maqashid Syariah


 Kredit Usaha Rakyat (KUR) is a debt scheme with a low interest rate provided to small and medium enterprises (MSMEs) that require additional capital and credit for business development. Bank BRI Kamal Unit, as one of the KUR distributors, has successfully implemented this program with a value of 5.5 billion rupiah in 2022. However, from a sharia perspective and based on the opinions of scholars, whether the KUR program with an interest component that is forbidden in Islam can be said to be usury or can be said to be halal if someone is forced to do so, remains to be seen. So the purpose of this research aims to analyze the law of KUR interest through the views of scholars who state that it is haram, halal, or even syubhat in terms of the maqashid sharia perspective. This type of research is descriptive qualitative, where attention is paid to current issues during the research. Through descriptive qualitative research, researchers try to describe events and events in focus without special treatment. The last stage in data analysis is drawing conclusions and verification. As a result, it is known that the view of scholars who allow KUR loans is more in line with Maqasid Sharia, namely the preservation of life (hifz al-nafs) and property (hifz al-mal), compared to its prohibition, both of which are placed at the Dharuriyyat level or at least Hajiyyat.
 Keywords: Interest, KUR, Riba, Maqashid Syariah

Normothermic Ex Vivo Liver Machine Perfusion in Mouse.

This protocol presents an optimized erythrocytes-free NEVLP system using mouse livers. Ex vivo preservation of mouse livers was achieved by employing modified cannulas and techniques adapted from conventional commercial ex vivo perfusion equipment. The system was utilized to evaluate the preservation outcomes following 12 h of perfusion. C57BL/6J mice served as liver donors, and the livers were explanted by cannulating the portal vein (PV) and bile duct (BD), and subsequently flushing the organ with warm (37 °C) heparinized saline. Then, the explanted livers were transferred to the perfusion chamber and subjected to normothermic oxygenated machine perfusion (NEVLP). Inlet and outlet perfusate samples were collected at 3 h intervals for perfusate analysis. Upon completion of the perfusion, liver samples were obtained for histological analysis, with morphological integrity assessed using modified Suzuki-Score through Hematoxylin-Eosin (HE) staining. The optimization experiments yielded the following findings: (1) mice weighing over 30 g were deemed more suitable for the experiment due to the larger size of their bile duct (BD). (2) a 2 Fr (outer diameter = 0.66 mm) polyurethane cannula was better suited for cannulating the portal vein (PV) when compared to a polypropylene cannula. This was attributed to the polyurethane material's enhanced grip, resulting in reduced catheter slippage during the transfer from the body to the organ chamber. (3) for cannulation of the bile duct (BD), a 1 Fr (outer diameter = 0.33 mm) polyurethane cannula was found to be more effective compared to the polypropylene UT - 03 (outer diameter = 0.30 mm) cannula. With this optimized protocol, mouse livers were successfully preserved for a duration of 12 h without significant impact on the histological structure. Hematoxylin-Eosin (HE) staining revealed a well-preserved morphological architecture of the liver, characterized by predominantly viable hepatocytes with clearly visible nuclei and mild dilation of hepatic sinusoids.

Biogenic signatures in the Cryogenian Brusque Metamorphic Complex, Brazil: Geochronological and paleoclimatological implications

The Cryogenian was a period of drastic environmental changes across the entire planet, with glacial erosion limiting the preservation of life forms in most of the geological record. Therefore, to explore more of the biogenic evidence and its implications for this period, here we investigate some metavolcano-sedimentary sequences from the Brusque Metamorphic Complex in Brazil, that record a mid-latitude basin so far unexplored from a paleontological point of view. On the one hand, field discoveries reveal the occurrence of Conophyton-type stromatolites preserved in dolomitic marbles that are isotopically incompatible with cap carbonates. On the other hand, 13C-depleted graphitic schists interspersed in these marbles indicate an accumulation from exceptional volumes of organic matter. Raman spectroscopy and transmission electron microscopy also highlight disordered structures, heterogeneous morphologies, and structures similar to ultra-small microorganisms in this graphite, in compatibility with a biogenic origin. Combined with geochronological data, these records reflect formation during the late Cryogenian greenhouse, between the Sturtian and Marinoan Snowball Earth glaciations. From this, we suggest deposition under conditions of warmer and brighter waters without ice cover, favoring the growth of some stromatolitic barriers. Sturtian nutrient-rich meltwater pulses may also have led to exceptional phytoplankton blooms followed by mass mortality, promoting the exceptional deposition of organic-rich horizons during the transition window to a Precambrian algae-dominated world.

Global Water Dances in Viçosa/MG: dance and environmental activism

This research aimed to analyze the impacts of the actions of an extension project in dance whose proposal was to participate in the international event Global Water Dances 2021 – involving participants in the planning process, rehearsals, production, and presentation –, to raise awareness and sensitize about the importance of water for the preservation of life. Dance was approached in this context as an articulator of the body-environment relationship and in its political character, in the sense of enabling the opening to new social configurations. Based on the analysis of the impacts of the project's actions, dance was recognized as an epistemology that enabled awareness and social mobilization, as well as the construction of a sense of community.

Awareness of Sustainable Development Goals: Perception of Head Teachers of Secondary School

The member states of the United Nations agreed on the Sustainable Development Goals (SDGs) in 2015. These goals were established to address issues such as poverty, hunger, health, education, gender equality, clean water, sanitation, clean energy, economic development, infrastructure, inequalities, sustainability, responsible production, climate change mitigation, and the preservation of life on land. The agreement was reached unanimously by the member states of the United Nations. By the year 2030, the mission is to make it possible for every person on the planet to live in peace and prosperity. Regarding the Sustainable Development Goals (SDGs), the awareness of head teachers in secondary schools was investigated in a study. According to the findings, a sizeable percentage of secondary school head teachers know the Sustainable Development Goals (SDGs), however there was no discernible variation in levels of awareness based on geography, gender, or district. According to the study's findings, head teachers should consider participating in community engagement activities centered on Sustainable Development Goals (SDG), such as awareness campaigns, workshops, and events involving the participation of local NGOs and the government.

Dolphin Conservation in Pengelana Laut Short Story: Greg Garrard's Ecocriticism Study

The short story "Pengelana Laut" by Linda Christanty focuses on the theme of preserving dolphins. Therefore, this study aims to investigate the environmental phenomena and the importance of environmental education in the story. This qualitative design presents descriptive data using the Grag Garrard ecocritical approach. The primary data source is the short story "Pengelana Laut," published in Kompas newspaper and ruangsastra.com, containing words, phrases, and sentences related to marine ecological phenomena, collected using the literature study techniques. The data obtained were analyzed using interactive interpretive models involving data condensation, data display, and conclusion drawing/verifying. The NVivo software program was used to code the data. The result showed that the short story contains various environmental phenomena, such as pollution, wilderness, apocalypse, dwelling, animals, and earth, with a focus on the exploitation of dolphins by humans. In conclusion, environmental education is crucial for dolphin conservation, hence it is imperative to incorporate such material in literacy skills for students to cultivate a sense of concern for and environmental preservation of marine life.

Medicinskaya sluzhba zheleznyh dorog v gody Velikoj Otechestvennoj vojny

Based on statistical data, the analysis of the dynamics of the development of the medical network of the Transport Medical and Sanitary Administration of the People's Commissariat of Railways during the Great Patriotic War was carried out. Summary data on the scale of patient care in outpatient and inpatient medical institutions of the People's Commissariat of Railways are presented. The relatively high-quality level of departmental healthcare of railways is indicated. Sanitary and anti-epidemic activities on the railway are highlighted. The conclusion is made about the significant contribution of railway healthcare to the preservation of life and health of the population.

Theoretical and methodological aspects of developing the methods of schoolchildren’s eco-oriented life activity in the study of cultural landscape

Introduction. In the conditions of environmental crisis, ecologically oriented life activity in the cultural landscape is considered as a guarantor of ecological safety and sustainable development of territories. In this context, one of the priority tasks of anticipatory education is the formation of a new type of interaction between man and nature, that implies the awareness of the managerial role and man’s responsibility for preservation of life on the Earth. In this regard, the development of a theoretical justification and methodological tools for the development of ecologically oriented life activity methods in cultural landscape is one of the constructive ways to solve the problem. The aim of the study is theoretical substantiation, development and experimental confirmation of efficiency of ecologically oriented life activity methods developed on the basis of culturally oriented integral situations. Materials and methods. The study involved 70 members of children’s environmental associations aged 12-15 years old. The main survey methods were as follows: analysis of scientific and methodological literature; modelling a system of integral culturally oriented situations; pedagogical experiment based on the original diagnostic methodology including a number of criteria, indicators and diagnostic assignments. Results. The authors developed relevant theoretical and methodological foundations including popular worldview ideas and approaches: cultural-ecological, axiological, environmental landscaping, personalpragmatic, integral-situational – which formed the scientific and theoretical basis for designing a pedagogical technology for the formation of environmentally-oriented life activity methods with the use of integral culturally-oriented situations. The authors present an original method for assessing the maturity level of schoolchildren’s ecologically oriented life activity practices in cultural landscape. The use of this methodology in the activity of children’s environmental associations made it possible to conclude that ¾ of the pupils of experimental groups studying with the use of culturally oriented integral situations have formed due methods of ecologically oriented life activity. Conclusion. The experimental research carried out according to the original methodology have made it possible to confirm the efficiency of theoretical and methodological foundations for the development of ecologically oriented life activity of schoolchildren in cultural landscape.

Ethyl Pyruvate; from Liver Preservation Solutions University of Wisconsin (UW) Increases the Effectiveness of the Solution

The most important factor affecting the success rate of liver transplants is the preservation of the normal histologic and biochemical properties of the cells in the tissue taken. The study aimed to identify the possible increase in efficacy of ethyl pyruvate, which has a hepatoprotective effect, on the University of Wisconsin (UW) solution. Rats were randomly selected and divided into 4 groups. After a laparotomy, the small intestines were removed from the abdomen and the portal pedicle was identified. Arterial and venous circulation of the liver was interrupted. After the portal vein was cannulated (and the distal of the portal pedicle was ligated, the liver was perfused with a solution. Perfusion solution was selected as Ringer Lactate in Group 1. In group 2, UW solution was chosen as the perfusion solution. In Group 3, the perfusion solution was chosen as the UW solution, but ethyl pyruvate at a dose of 40 mg/kg was administered intraperitoneally to the experimental animals 30 minutes before hepatectomy. In Group 4, as a perfusion solution, a UW solution with 40 mg/kg dose of ethyl pyruvate added to it was used. With TUNEL and Caspase-3 staining, a significant decrease was found in the apoptosis rates of Groups 2, 3, and 4 at the 12th hour post hepatectomy when compared with Group 1. When the morphometric liver sinusoid/parenchyma ratios and vena centralis diameters of the groups were examined, it was found that all preservation solutions containing the UW solution were more protective than the RL solution. Ethyl pyruvate is regarded as a promising agent that can increase the effect of the UW solution on organ preservation solutions. Because this study is the first in literature to apply ethyl pyruvate in preservation solutions, additional studies with larger series and different doses are needed.

VOLODYMYR VERNADSKYI’S CONCEPT OF EDUCATION

The article analyzes the essence of such terms as: "concept", "education", "higher education", "scientific outlook", "noosphere", "noosphere pedagogy", "planetary thinking" in the context of the views of Volodymyr Vernadskyi. The main aspects of the pedagogical activity of V. Vernadskyi, his ideas regarding the composition of higher education and its role in the existence of society, the preservation of life on Earth are disclosed. The ideas of V. Vernadskyi regarding the higher school as a system in which the formation of a scientific worldview and thought, as determining in the life of mankind, assimilation of universal human culture, takes place; V. Vernadskyi’s concepts of formation of worldview values of young people, as well as the substantiation of a holistic picture of the world, the interdependence of man, nature and society are analyzed in the article; also, author has reviewed the opinion regarding higher education as the main tool and a powerful factor in the spiritual development of humanity and the achievement of the noospheric stage of social development and an important factor in preserving the national identity of Ukraine. Moreover, new scientific approaches to the organization of education, the leading role of universities in the implementation of its strategic tasks, the maximum use of the potential of higher education are substantiated.
 The essence of the concept and the main directions of noosphere pedagogy, the principles of construction and its role in national education, in the creation of a world community without war, and the preservation of the planet Earth are characterized. The importance of science in the implementation of the noosphere concept, which involves the fulfillment of a number of natural, socio-economic and political conditions, the formation of a new biosocial existence of humanity, is reflected. It is emphasized that science becomes the main spiritual tool of the noosphere if it is fixed in the state structure as an important social, artistic, and material phenomenon, that the strengthening of the importance of science in the state inevitably leads to the democratization of all spheres of the state system.

Recent Development on Sensing Strategies for Small Molecules Detections.

Sensors play a critical role in the detection and monitoring of various substances present in our environment, providing us with valuable information about the world around us. Within the field of sensor development, one area that holds particular importance is the detection of small molecules. Small molecules encompass a wide range of organic or inorganic compounds with low molecular weight, typically below 900 Daltons including gases, volatile organic compounds, solvents, pesticides, drugs, biomarkers, toxins, and pollutants. The accurate and efficient detection of these small molecules has attracted significant interest from the scientific community due to its relevance in diverse fields such as environmental pollutants monitoring, medical diagnostics, industrial optimization, healthcare remedies, food safety, ecosystems, and aquatic and terrestrial life preservation. To meet the demand for precise and efficient monitoring of small molecules, this summary aims to provide an overview of recent advancements in sensing and quantification strategies for various organic small molecules including Hydrazine, Glucose, Morpholine, Ethanol amine, Nitrosamine, Oxygen, Nitro-aromatics, Phospholipids, Carbohydrates, Antibiotics, Pesticides, Drugs, Adenosine Triphosphate, Aromatic Amine, Glutathione, Hydrogen Peroxide, Acetone, Methyl Parathion, and Thiophenol. The focus is on understanding the receptor sensing mechanism, along with the electrical, optical, and electrochemical response. Additionally, the variations in UV-visible spectral properties of the ligands upon treatment with the receptor, fluorescence and absorption titration analysis for limit of detection (LOD) determination, and bioimaging analysis are discussed wherever applicable. It is anticipated that the information gathered from this literature survey will be helpful for the perusal of innovation regarding sensing strategies.

Mesenchymal Stem Cell Utilization for In Vitro Donor Liver Machine Perfusion Preservation: Current Status and Future Directions.

Liver transplantation is the only effective treatment for end-stage liver disease. Currently, the shortage of high-quality donors has led to the exploration of the use of marginal organs. However, several factors limit the in vitro long-term preservation and long-distance transport of livers, which can also lead to ischemia-reperfusion injuries, resulting in poor prognosis. Therefore, an efficient and convenient strategy to improve this situation is urgently required. Normothermic machine perfusion (NMP) is expected to improve the liver environment in vitro and provide better evaluation indices for organ repair mechanisms. Mesenchymal stem cells (MSCs) can repair damaged hepatocytes or exert their protective effects via paracrine mechanisms, such as the release of extracellular vesicles (EVs). We hypothesized that combining the regenerative ability of MSCs and the significant advantages of NMP may improve the quality and utilization rate of organs, especially marginal organs. In this study, we review different strategies for liver preservation in vitro, as well as their strengths and weaknesses. We also introduce MSCs, derived EVs, and MSCs applications in liver preservation in vitro. Finally, we discuss the current challenges and future trends of MSCs applications for in vitro liver preservation. We envision novel bioreactor designs that employ 3D cell culturing and offer the possibility to reconstruct MSCs microenvironments to promote cell growth and biofunction expression. Large-scale MSCs production can be combined with normothermic machine perfusion to enhance in vitro liver preservation, thereby promoting donor organ function to benefit recipients in need of liver transplantation.

Upfront Normothermic Machine Perfusion for a Liver Graft with Severe Macrovesicular Steatosis: A Proof-of-Concept Case

Graft steatosis has been associated with inferior outcomes after liver transplantation. Given the rising prevalence of obesity and fatty liver disease, strategies allowing safe and successful utilization of fatty liver grafts are needed. Liver preservation by normothermic machine perfusion (NMP) allows reducing ischemia-reperfusion injury, extending preservation time and assessing graft viability prior to implantation into the recipient. NMP can be initiated at the donor hospital using a transportable device (referred to as upfront NMP or normothermic machine preservation) or after a period of cold ischemia (known as back-to-base). In this report, we present the case of a graft from an HCV-positive DBD donor with 70% macrovesicular steatosis, which was successfully preserved and transplanted using upfront NMP. This approach was key to minimize initial injury to the graft and allowed assessing its viability before transplantation, while improving transplant logistics. Upfront NMP represents a promising approach to enhance the transplantation of fatty liver grafts.

Effectiveness of machine perfusion in liver transplantation: A meta-analysis of randomized controlled trials

BackgroundIn contemporary transplantation research, the utilization of machine perfusion to facilitate the perfusion, preservation, evaluation, and repair of donor livers has garnered considerable attention.In an effort to comprehensively assess the clinical outcomes of liver transplantation procedures incorporating machine perfusion, a meta-analysis of published randomized controlled trials (RCTs) was undertaken. MethodsThe relevant literature was obtained from PubMed, EMBASE, Web of Science, and other databases up until December 2022. Subsequently, the authors extracted the requisite data, conducted a meta-analysis, and arrived at a conclusion based on the findings derived from the analysis. ResultsA total of seven high-quality prospective RCTs, comprising 917 patients, were included in the analysis. Machine perfusion demonstrated significant superiority over cold storage in reducing the incidence of major postoperative complications (RR 0.55, 95% CI 0.42 to 0.73; p < 0.0001) and early allograft dysfunction (RR 0.52, 95% CI 0.41 to 0.67; p < 0.00001). Notably, postoperative aspartate aminotransferase peak, bilirubin levels, and post-reperfusion lactate were also found to decrease. However, no statistically significant differences were observed for other outcomes. Hypothermic oxygenation machine perfusion demonstrated a lower frequency of re-transplantation (RR 0.29, 95% CI 0.10 to 0.86; p = 0.03), rejection (RR 0.55, 95% CI 0.32 to 0.95; p = 0.03), and resulted in shorter hospital stays (Std, MD -0.30, 95% CI -0.52 to -0.07; p = 0.009). ConclusionsThe application of machine perfusion can yield significant improvements in the outcomes of liver transplantation.

24-hour normothermic machine perfusion of discarded human liver grafts: Case series single-center study

BackgroundThe persistent shortage of liver allografts contributes to significant waitlist mortality. Normothermic machine perfusion (NMP) has the potential to extend viability and allow liver function evaluation in discarded organs. The main aim of the study was to evaluate the possibility for extended preservation and the potential recovery of non-usable human livers utilizing NMP. Methods6 high-risk human liver grafts that were discarded after national allocation underwent normothermic liver preservation for an extended period of 24 h. Transmedics Organ Care System™ liver perfusion device was used to preserve a donor liver in a functioning, near physiologic state. Parameters of biochemical and synthetic liver function were collected periodically and subsequently analyzed. Liver parenchyma and bile duct biopsies were obtained pre- and 24 h post-NMP. Results4/6 (67%) grafts were DCDs with a median age of 54 (IQR: 42–61) years and median CIT of 262 (IQR: 209–1024) minutes. 5/6 (83%) livers produced a median of 75 ml of bile (Range 55–100) after 24 h of NMP. Lactate dropped to normal levels (<2 mmol/L) for all livers after around 4 h on NMP. The overall cellular architecture, lobular steatosis and necrosis grades were preserved after extended NMP. Biopsies showed improvement of liver parenchyma architecture with reduced inflammation for 2/6 (33%) at the end of the perfusion. ConclusionProlonged NMP for discarded liver grafts can be safely maintained on NMP and may identify certain grafts that are suitable for transplantation. Further studies utilizing NMP with subsequent transplantation would validate this strategy, as well as existing viability markers.

How to program autonomous vehicle (AV) crash algorithms: an Islamic ethical perspective

PurposeFully autonomous self-driving cars not only hold the potential for significant economic and environmental advantages but also introduce complex ethical dilemmas. One of the highly debated issues, known as the “trolley problems,” revolves around determining the appropriate actions for a self-driving car when faced with an unavoidable crash. Currently, the discourse on autonomous vehicle (AV) crash algorithms is primarily shaped by Western ethical traditions, resulting in a Eurocentric bias due to the dominant economic and political influence of the West. However, considering that AV technology will be deployed across diverse cultural and religious contexts, this paper aims to contribute to the discourse by providing an Islamic perspective on programming the response of AVs in the event of an imminent crash.Design/methodology/approachThis study proposes a novel methodology based on the Islamic concept of maṣlaḥa for the normative assessment of ethical decisions related to AV programming.FindingsDrawing upon the works of classic Islamic jurists, this study highlights two distinct normative visions within Islamic traditions (akin to deontology and consequentialism) concerning the preservation of human lives in the context of AVs. This study explores the shared and divergent elements between Islamic and Western ethical approaches proposed for AVs.Originality/valueThis pioneering work examines AV crash algorithms from an Islamic perspective, filling a void in the global ethical discourse. This work will also serve an important role to bridge the gap between the theoretical Islamic ethical principles and their practical application in the realm of AVs.