INTRODUCTION: A small bowel transit study (SBT) evaluates the accumulation of radiolabeled meal in the terminal ileum (TI) and/or colon 6 hours after ingestion. Anatomic information is limited, often requiring that patients return for confirmatory imaging the next day. Given this inconvenience, a high nutrient liquid meal (Boost) can be given to promote passage of the radiolabeled meal into the colon to enhance visualization; however, the utility of this method is unclear. The primary aim of this study was to quantitatively determine if the administration of Boost at 6 hours facilitates visualization of the TI in equivocal cases, producing a definitive study result. METHODS: This retrospective study included 117 patients undergoing SBT studies from 2/2017 to 9/2019. Two board-certified nuclear medicine radiologists independently evaluated all images (pre-Boost and post-Boost) as equivocal or definitive (i.e. normal or abnormal motility). Mutually agreed upon equivocal pre-Boost cases were included in post-Boost analysis. Post-Boost images were obtained 20 minutes after Boost administration. Any discordance was adjudicated by a third reader. The Pearson-Clopper exact method was used to calculate binomial confidence intervals for proportions. The Fisher exact test was employed to test associations between two categorical variables. RESULTS: Of the included patients (71.8% female, median age 42.0 years) that underwent SBT studies, 37 of 117 were equivocal cases pre-Boost (31.6%, 95% CI = 23.3%–40.9%) compared to 12 of 117 (10.3%, 95% CI = 5.4%–17.2%) equivocal cases post-Boost. One case was excluded in subsequent analysis after adjudicator determination. Of the remaining 36 equivocal cases who received Boost, 25 (69.4%, 95% CI = 51.9%–83.7%) had a definitive result after Boost, while 11 (30.6%, 95% CI = 16.4%–48.1%) remained equivocal. IBS, gastroparesis, and non-early satiety cases appear to remain equivocal even after having received Boost (% equivocal: 100% vs. 24.2%, 43.5% vs. 7.7%, 41.7% vs. 8.3% compared to their counterpart; P = 0.023, 0.031, 0.059, respectively). CONCLUSION: The number of equivocal SBT cases was significantly decreased after administration of Boost at 6 hours, with a majority of cases converting to a definitive result. This suggests that some patients can complete the study without the need for repeat imaging. Boost seemed to be less effective for IBS, gastroparesis, and non-early satiety cases. Future studies exploring the cost-efficiency of using Boost should be considered.