Lipid Profile In Hypertensive Patients Research Articles

A Study of the Relationship between Serum Magnesium Levels and Lipid Profile in Hypertensive patients on Diuretics

Hypertension (HTN) is a chronic universal health problem. It is considered an important changeable risk factor for morbidity and mortality. Diuretics are among the first-line medications for HTN treatment. Both thiazide-type diuretics and loop diuretics promote urinary loss of electrolytes such as magnesium. Magnesium has been studied for its important involvement in many physiological processes and biochemical pathways. It plays a significant role in regulating the activity of enzymes required in lipids and lipoproteins metabolism like HMG-CoA Reductase, lipoprotein lipase (LPL), and lecithin cholesterol acyl transferase (LCAT). It is well documented that dyslipidemia is a general threat to health and should be determined early to manage cardiovascular disease (CVD) and prevent its complications. The goal of the current study was to investigate the association between serum magnesium levels and lipid profile components in hypertensive patients on long-term diuretics therapy. The study was conducted on 50 adult hypertensive patients and 25 matched healthy subjects at Tishreen University Hospital (TUH) of Lattakia City in Syria. The study showed a statistically significant decrease in serum magnesium concentrations in the patients group (1.87±0.16mg/dl) versus the controls (2.40±0.41mg/dl) (P<0.05). A significant negative correlation between magnesium and triglycerides, total cholesterol, LDL cholesterol was identified, while a significant positive correlation with HDL cholesterol was found. In conclusion, this study has showed that hypomagnesemia is related to increased levels of TC, LDL-c, TG and decreased levels of HDL-c, therefore, an increased risk of dyslipidemia in hypertensive patients on diuretics.

DIABETES INDUCED LIPID PANEL PARTICULARITIES IN HYPERTENSIVE PATIENTS: A PILOT NMR SPECTROSCOPY STUDY

Objective: Cardiovascular diseases are the leading cause of death globally, despite significant advances in diagnosis and treatment. Among the multiple already well-known cardiovascular risk factors, hypertension, diabetes mellitus type II and dyslipidaemia are the most frequent and show the best correlations with the risk of further developing a major cardiovascular event. The main objective consists in identifying the potential particularities that diabetes could have on the lipid profile in hypertensive patients, while also discovering bio-markers with a higher potential accuracy of predicting further major cardiovascular events, using NMR spectroscopy. Design and method: We have selected a group of 30 hypertensive patients and a control group of 17 otherwise healthy individuals in order to assess the influence of diabetes on the lipid panel in hypertensive patients. A blood sample of 6 mL was collected before and after meals and 5 types of NMR spectroscopy experiments were performed for each sample. Results: It was noted that the fasten triglycerides levels, VLDL and IDL particle number, apolipoprotein A1, A2, B100 levels, as well as the ratio apolipoprotein B100/apolipoprotein A1 are all potentially useful markers that could be successfully used to differentiate between the strictly hypertensive patients and the ones that associate type II diabetes mellitus. The study also confirmed once more our previous reports that the fasting status upon sampling has little influence on the lipid panel final values. Conclusions: We have evaluated the lipid panel differences induced by diabetes mellitus type II in hypertensive patients and we have compared the results with an otherwise healthy control group. We have identified the NMR spectroscopy markers that could be able to spot subtle differences in the lipid profiles of the two study groups (two hypertensive groups, one consisting in strictly hypertensive patients, the other one including hypertensive patients with already known type II diabetes mellitus), even when LDL levels have been lowered to normal levels due to statin treatment. We have once more concluded that the patient's fasting status has no influence on the final analysis.

Comparative Study of Lipid Profile between Hypertensive Patient and Normotensive Individuals in Northern Region of Bangladesh

Background: Hypertension and dyslipidemia are well-established and partially overlapping risk factors for cardiovascular disease. Hypertension affects nearly 26% of the adult population worldwide and is an important independent predictor of cardiovascular disease, cerebrovascular accidents and death. The prevalence of cardiovascular diseases and Hypertension is rapidly increasing in developing countries. Hypertension has been reported to be responsible for 57% of all stroke deaths and 24% of all cardiovascular deaths in East Asians. Objective: To compare the lipid profile of hypertensive patients with normotensive individuals and socio-demographic and dyslipidemia patterns in hypertensive and normotensive individuals. Methodology: A total of 167 hypertensive patients. This is a descriptive cross-sectional study. An equal number of normotensive individuals were selected at Hypertension & Research Center, Rangpur and the Department of Medicine, Rangpur medical college hospital, Rangpur, from February 2013 to November 2013. Consecutive purposive sampling method and fasting lipid profile was done. Informed written consent was taken from the patient and the normotensive individual. Results: In this study, we studied a total of 334 patients; among them, 167 were hypertensive, and an equal number of normotensive individuals. The age range for hypertensive patients was 20-89 years, whereas for normotensive patients was 20-80. The mean age of the study population was 47.58 (SD±12.027) for the hypertensive group and 40.29 (SD±15.493) for the normotensive group. Males were dominant in both hypertensive (57.5% Vs 42.5%) and normotensive individuals (66.5% Vs 33.5%). The hypertensive population lived more in urban areas (55.6% vs 53.29%). Conclusion: Sub-categorized serum lipid profile as this study shows exceptionally high total cholesterol, high triglycerides and borderline LDL-cholesterol levels are positively associated with Hypertension. Higher lipids levels may be attributed to physical inactivity and stress. So timely lipid profile assessment is necessary in all hypertensive cases, especially in northern Bangladesh, to stop further aggravation and risks of coronary artery diseases.

Apelin and lipid profile in hypertensive patients a correlation data

High blood pressure is directly related to the rise in non-HDL-c harmful fats in the body, as it narrows the arteries and thus increases blood pressure. However, blood pressure decreases significantly with high UHDL-c, so it is considered good fat. Volunteers have divided into two groups the control group included healthy people and the patients’ group involved hypertension. Lipid profile and Apelin were measured for both groups, and apelin was measured using an ELISA kit. As a result, apelin was decreased significantly in hypertension patients’. Also, lipid parameters like TG, LDL-c, and non-HDL-c were elevated. Apelin level in the control group was higher than in the patients’ group, which was a good indicator of normal blood pressure. A low level of apelin in the patients’ group was a bad sign for hypertension, a decrease in apelin concentration in connection with an increase in non-HDL-c levels. So, this maybe increases the risk of hypertension and dyslipidaemia.

Lipid profile of patients with arterial hypertension who underwent COVID-19: possibilities of drug therapy/ LEADER

Aim. To study the dynamics of the lipid profile of hypertensive patients with dyslipidemia who underwent COVID-19.Material and methods. Hypertensive patients with dyslipidemia who underwent COVID-19 [n=126; 58 men and 68 women; median age 60 (56.0; 65.5) years] examined. Patients were included into two groups: group 1 (n=64) received a single pill combination of lisinopril + amlodipine + rosuvastatin; 2 groups (n=62) continued the previous drug treatment. Clinical, demographic, office blood pressure (BP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol, triglycerides, C-reactive protein (CRP) levels were assessed in all patients in 3 visits within 24 weeks.Results. The groups did not differ in prior antihypertensive therapy (except for more frequent use of angiotensin II receptor blockers in group 2, p<0.05), lipid profile and blood pressure parameters at study entry. A decrease in systolic (by 9.5%) and diastolic blood pressure (by 12.1%) after 24 weeks was found in group 1 compared with 4.29% and 5.56%, respectively, in group 2 (p<0.05). A decrease in the level of total cholesterol by 14.5% and LDL-c by 31.4% after 24 weeks was found in group 1 compared with 11.2% and 9.7%, respectively, in group 2 (p<0.05). The level of CRP during the observation period decreased by 53.7% in group 1 versus 43.4% in patients of group 2 (p<0.05).Conclusion. The single pill combination of lisinopril/amlodipine/rosuvastatin in hypertensive patients with dyslipidemia who underwent COVID-19 led to an improvement in lipid profile and blood pressure control.

A Study on the Lipid Profile of Hypertensive Patients

Background: Dyslipidaemia and hypertension are the commonest risk factors for coronary artery disease (CAD). To study the lipid profile in hypertensive patients.
 Methods: The present study was carried out on a total of 100 hypertensive patients attending our Hospital and 100 age and sex matched healthy controls. Twelve hour fasting lipid analysis was done for Serum triglycerides (TG), total cholesterol(TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL).
 Results: The Mean serum total cholesterol values were highly significant in hypertensive subjects (235.36±32.36mg/dL) as compared to the healthy control subjects (152.36±12.01mg/dL). The mean serum TG level was 110.36±16.12 mg/dl in healthy control subjects, and 215.23±35.36 mg/dl in hypertensive patients. This difference was highly significant. The mean values for HDL was 27.23±6.02 mg/dL for hypertensive subjects whereas 43.21±5.36 mg/dl for healthy control subjects, respectively. The Mean serum LDL values were highly significant in hypertensive subjects (154.36±31.26 mg/dL) as compared to the healthy control subjects (95.36±16.02mg/dL).
 Conclusion: All the lipid profile like cholesterol, LDL, TG and HDL were derange in the hypertensive than those in the healthy controls.
 Keywords: Hypertension ,Lipid profile, HDL ,TG , LDL.

Gender Difference in Lipid Profile in Hypertensive Patients’ Hospital-Based Study

Background and objectives: Hypertension and dyslipidemia are the integral components of metabolic syndrome. It has emerged as cause of substantial mortality in both genders. The objective of the study was to find out the prevalence of dyslipidemia in both gender and difference in pattern of lipid profile in hypertensive patients. Methods: This was an observational study conducted in 2018 to 2019 at Sir Syed university Hospital Karachi Pakistan. Sample size of 250 diagnosed cases of hypertension (comprising equal number of males and females) were collected. The lipid values were interpreted in normal or high-risk category by applying NCEP ATPIII criterion. Fasting sample were collected for sugar and lipid profile. Anthropometric, demographic and biochemical data was tabulated. Categorical variables were displayed as mean ± standard deviation and percentage respectively, compared with chi-square test. Student 't' test was use to assess the difference for the lipid profile at 5% significance level. The prevalence of dyslipidemia was estimated for men and women, and pattern in lipid profile were compared. The factors associated with dyslipidemia in both genders were calculated by multiple logistic regression expressed as odd Ratio with 95% confidence interval (C.I). To evaluate the effect of age on dyslipidemia we made four age groups 25-65 years and lipid pattern was compared. Results: Dyslipidemia was found 63% of hypertensive group, 72% women were dyslipidemia than 54% men and pattern of lipid in males showed low LDL and high cholesterol and in females’ high triglycerides and low HDL. The Predictors of dyslipidemia in female were old age, BMI kg/m2 high blood pressure level, depression and lack of physical activity and in men smoking intake of fried, salty food, smoking and obesity with increasing age. Females have more triglycerides total cholesterol and low HDL compared to men. Conclusion: Dyslipidemia was more found in women with hypertension but as the age increasing more women have dyslipidemia. while treating hypertensive patient’s lipid lowering management gender heterogeneity should be considered.

The Role of Integrated Approach to Yoga Therapy-Based Yoga Module in Improving Cardiovascular Functions and Lipid Profile in Hypertensive Patients: A Randomized Controlled Trial.

Hypertension is a growing public health problem and its optimal management is imperative. Integration of lifestyle modification and yoga with antihypertensive drugs leads to its successful management. Yoga has been shown to modulate blood pressure (BP) and lipid metabolism in individuals with hypertension. The current study is a preliminary effort to ascertain the underlying mechanisms behind it. Hundred patients were screened, among which 65 who met the inclusion criteria were recruited. After baseline assessments, they were randomly allocated (1:1) to an intervention group (IG) who practiced integrated approach to yoga therapy (IAYT)-based yoga module for 6 days a week, for 3 months and a control group (CG) who received no intervention. BP, heart rate variability, and lipid profile were assessed before and after the intervention. Data acquired from 60 cases were analyzed by post-hoc analysis for multiple comparisons between the mean values. At the end of 3 months, within-group comparison showed significant changes (P < 0.05) in IG in all variables except triglycerides, high-density lipoprotein (HDL), and very low-density lipoprotein (LDL) while similar changes were not present in the control group. Significant differences were seen between the groups in the TC (P = 0.005), HDL (P = 0.047), non-HDL (P = 0.013), LDL (P < 0.001), LDL/HDL Ratio (P = 0.031), CHOL/HDL Ratio (P = 0.043), DBP (P < 0.001), SBP (P < 0.001), and all indices of HRV (P < 0.001). These findings suggest that IAYT-based yoga module was effective in improving cardiovascular performance and lipid metabolism, thereby mitigating coronary artery disease risk.

Evaluation of Serum Lipid Profile in Hypertensive Patients at Mirpur Khas, Sindh, Pakistan

Aim: To assess the lipid profile of hypertensive patients. Study Design: Evaluation-based study. Place and duration of study: Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas, Sindh, Pakistan for a period of one year from 1stJuly 2020 to 30thJune 2021. Methodology: Three hundred and fifty-three hypertensive patients were enrolled in the study based on Rao-soft formula. Only those hypertensive patients who had confirmed diagnosis of hypertension were enrolled. The patients were requested for fasting to take the blood sample. Results: 64.87% were males and 35.1% were females. 39.6% patients were above 60 years old and highest range values for systolic blood pressure 201-220mmHg. The majority of the patients 26.34% showed 91-100 mm Hg. The 11.05% of the patients were prescribed with the Atenolol, 7.08% of patients were prescribed with another beta blocker medication Propranolol. The majority of patients were prescribed with Rosuvastatin as antilipidemic drugs however the least majority i.e. 11.61 were prescribed with Simvastatin.The 16.9% patients showed HDL40mg/dL, higher LDL&lt;100mg/dL, total glycerides&lt;150mg/dL, total cholesterol&lt;200mg/dL HDL30-39mg/dL, LDL100-150mg/dL, total glycerides150-200 mg/dL, total cholesterol200-250mg/dL among 31.73% of the patients. The 28.9% of the patients showed the pattern HDL20-29mg/dL. Conclusion: The dyslipidemia associated with the hypertension and hypertensive patients. The irregular values and alteration of in the serum cholesterol and total cholesterol levels of lipid profile proves the association of lipid profile with the elevated systolic blood pressure levels. The total cholesterol, LDL and HDL can be controlled with an appropriate controlling of high blood pressures, thus preventing the cardiovascular diseases and cardiovascular diseases. Key words: Lipid, Hypertension, Assess

A study of lipid profile abnormalities among patients with hypertension attending tertiary care teaching hospital

Background: High blood pressure has been associated with elevated atherogenic blood lipid fractions. A better understanding of the relation between blood pressure and blood lipids may provide insight into the mechanisms where by hypertension is associated with increased risk of coronary heart disease.Methods: The serum lipid profiles of 100 hypertensive patients was studied and compared with those of healthy controls. The serum lipid profiles (TC, TGL.HDL, VLDL, LDL, TC/ HDL, LDL/HDL ratios) were studied with respect to various clinical profiles like age, sex, type, incidence etc. Study group consisted of patients with hypertension as identified by history, clinical examination, and other relevant examinations. Results: Serum TC, TGL, VLDL, LDL, TC/ HDL, LDL/HDL were significantly elevated in hypertensive group as compared to healthy controls. Serum HDL was low in patients with hypertension as was compared with controls, which was statistically significant. The LDL was raised in obese compared to non-obese patients, which is statistically very significant. TC/ HDL and LDL /HDL were also raised in obese patients which is statistically significant. TC is raised in CVA group, which is statistically highly significant. LDL is raised in CVA group, which is statistically very significant. TC/ HDL and LDL/HDL are raised in CVA group compared to non-CVA group, which is statistically very significant. TC is raised in IHD group, which is statistically significant. LDL is raised in IHD group, which is statistically very significant. LDL/HDL is raised in men, which is statically significant.Conclusion: There is significant alteration of lipid profile in hypertensive patients as compared to controls. Total cholesterol, LDL cholesterol, triglycerides, VLDL, TC/HDL and LDL/HDL ratios are significantly elevated in patients with hypertension. HDL is significantly reduced in hypertensive patients. Hyperlipidemia is seen in majority of cases of hypertension with Type IIa pattern being the most frequent. Mean TC, LDL, TC/HDL, LDL/HDL were higher in obese. Mean TC, LDL, TC/HDL and LDL/HDL ratios are raised in CVA group. Mean TC and LDL are raised in IHD group.

An observational study to assess the lipid profile of hypertensive patients in Southern Odisha

Background: Rated among the most common disease worldwide, Hypertension is fast becoming a cause of significant morbidity and mortality. Owing to its widespread it has become one of the most common risk factors of serious disease including cardiovascular diseases (CVD) along with other illness like renal malfunctioning, myocardial infraction and even leads to loss of vision. There are various other biomarkers of the hypertensive patients that help in realizing the real threat of the cardiovascular diseases among those who are suffering from hypertension. The discrepancies in the different lipid profile biomarkers like total cholesterol (TC), low-density lipoproteins (LDL), serum levels of triglycerides (TG) pose a great risk for the development of CVDs. Aim: To assess the lipid profile of the hypertensive patients in Southern Odisha. Materials and Methods: It was n observational study undertaken at MKCG Medical CollegeBerhampur, Ganjam (Odisha). One hundred fifty patients were included in the study belonging to both the genders. The duration of the study was from June 2019 to November 2019. The patients were divided into two groups, group 1 with 70 patients who were non-hypertensive and 80 patients in group 2 who were hypertensive. CHOD-PAP was the method used to measure the serum total cholesterol. The GPO-Triender method was used to assess the triglycerides. Results: Sixty per cent of the patients in the non-hypertensive group were males, and 70% of the patients in the hypertensive groups were males. The SBP for the non-hypertensive patients was 1204.12 while the DBP was 80.13.21. On the other hand, the SBP for the hypertensive group was 1699.10, and the SBP was 96.125.06. The mean total cholesterol for the non-hypertensive group was 164.253.99, mean Triglycerides was 129.9 8.3, mean HDL was 47.26 5.54, mean LDL was 93.76 12.06, and mean VLDL was 26.98 2.67. On the flip side, the mean total cholesterol for the hypertensive group was 168.9 6.27

The Role of Vitamin D Supplementation in the Treatment of Primary Hypertension: A Double-Blinded Randomized Placebo-Controlled Clinical Trial

Background: Hypertension is one of the most serious global concerns since it has affected over 1.2 billion people. Objectives: The present study aimed to determine the effect of vitamin D supplementation on blood pressure, fasting blood sugar, and lipid profile in hypertensive patients with vitamin D deficiency. Methods: In this double-blinded randomized placebo-controlled clinical trial study, 116 hypertensive patients (intervention and placebo groups, 58 each) with vitamin D deficiency (&lt; 30 ng/mL with ECL) for 14 weeks, started from the beginning of autumn 2019 in Seyed-al-Shohada Educational Hospital in Urmia City. Fifty-five patients (49%) were male with the mean vitamin D 15.89 ± 5.09 ng/mL and 57 females with 17.29 ± 6.31 ng/mL. In a stratified blocked randomization scheme, the patients were randomly allocated into similar sized intervention and control groups based on body mass index (BMI), then the randomization with four block size was performed in each of strata by random allocation software. The intervention group received six doses of 50,000 IU vitamin D supplements for 6 weeks, then two supplements for two following months (one capsule per month). Blood pressure (24/h blood pressure measured by an ambulatory blood pressure monitoring device), vitamin D, FBS, and lipid profile (HDL, LDL, CL, and TG) were all measured at baseline and end of the study. Physical activity (measured by short IPAQ questionnaire), sun exposure using a questionnaire, dietary intake of vitamin D using three 24-hour recalls during the intervention, and anthropometric indices were measured at baseline, middle, and end of the study. Fifty-six patients in each group completed the study. The study was approved by the Ethics Committee of the Urmia University of Medical Sciences (ethics code: IR.UMSU.REC.1398.192). Results: The office blood pressure, 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP), nighttime SBP and DBP were significantly reduced in the intervention group compared to the control group, whereas the reduction of daytime SBP and DBP was not statistically significant. Vitamin D supplementation significantly decreased serum triglyceride, cholesterol, and LDL levels. Conclusions: Vitamin D supplementation had positive effects on blood pressure, triglyceride, cholesterol, and LDL levels in patients with low serum vitamin D.

Effect of Ginkgo biloba on lipid profile in hypertensive patients on Valsartan monotherapy

Aim: The study was conducted to evaluate the effects of Ginkgo biloba as an add on therapy to Valsartan monotherapy in hypertensive patients on lipid profile. Patients and methods: The study was done in private clinics in Mosul City, during a period of sixth months from 15 October 2017 to 15 April 2018. The total number of patients enrolled in the study was 50 hypertensive patients using Valsartan monotherapy of both sexes. The patients were administered Ginkgo biloba 80 mg twice daily and followed for 2 months duration. Their lipid profile was determined at baseline level and after 2 months from administration of Ginkgo biloba. Results: Treatment with Ginkgo biloba showed a significant reduction in serum total cholesterol and triglycerides, while LDL, VLDL, HDL, and AI showed no significant changes. Conclusion: This study revealed that Ginkgo biloba could be regarded as a natural and relatively safe drug in reducing total cholesterol and triglycerides in hypertensive patients. .

Assessment of lipid profile among hypertensive patients attending to a rural teaching hospital, Sangareddy

Background: Hypertension has become one of the major health problems and a most common risk factor for cardiovascular disease. Objectives: The present study was aimed to assess the lipid profile in hypertensive patients and find out its relation between lipid profile and hypertension. Materials and Methods: The present study was carried out at MNR Medical College & Hospital situated in Sangareddy, part of Medak District, Telangana state. A total of 160 study subjects were selected from the medicine ward of MNR hospital during the period from January 2015 to December 2015. Results: A significantly higher levels of total cholesterol, triglycerides, low-density lipoprotein, and very low-density lipoprotein were estimated in hypertensive subjects when compared with normotensive (< 0.001). The mean HDL of cases was significantly lower than that of controls (p < 0.001). Conclusion: The present study concludes that dyslipidemia is associated with hypertension. Because of increased blood pressure can create disturbances in lipoprotein metabolism. This can be preventing by taking healthy diet, proper medical treatment and life style change. Finally regular assessment of lipid profile among hypertensive patients can prevent cardio vascular diseases.

Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients

Background: Cilnidipine is a novel and unique 1,4-dydropyridine derivative calcium antagonist that exerts potent inhibitory actions not only on L-type but also on N-type voltage dependent calcium channels. Blockade of the neural N-type calcium channel inhibits the secretion of norepinephrine from peripheral neural terminals and depresses sympathetic nervous system activity.Objective and methods: The purpose of this study was to assess the effect of Cilnidipine and Amlodipine on blood pressure (BP) levels. We did BP monitoring before and after once-daily use of Cilnidipine and Amlodipine in 100 hypertensive patients.Results: Both drugs significantly reduced systolic BP (SBP) and diastolic BP (DBP). However, the reductions in pulse rate (PR) were significantly greater in the Cilnidipine group than the Amlodipine group. N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment.Conclusion: There was significant reduction in proteinuria with Clindipine as compared to Amlodipine. However, there were no significant change in total cholesterol level in diabetes and non-diabetics in both the group.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.460-465

Comparative Study on Lipid Profile of Hypertensive Patients and Non-hypertensive Individuals in Bikaner, Rajasthan, India

Cardiovascular diseases are the highest cause of death in the industrialized world, and many of these deaths may be work related. Hypertension is the most common of the cardio-vascular diseases which is the leading cause of morbidity and mortality in the industrial world. Stress, tension, smoking, liquors, insufficient rest, metabolic disorders, excessive consumption of tea or coffee, emotional disturbance etc. are also associated with high blood pressure. Several previous studies showed the relation between hyperlipidemia and hypertension. An excessive daily intake of saturated fats, cholesterol, and other sources of calories and subsequent disturbance of lipid profile leading to hypertriglyceridemia and hypercholesterolemia are associated with obesity and, consequently, hypertension. The present study was designed to compare the serum triglyceride, cholesterol, High Density Lipo-protein (HDL) and Low Density Lipo-protein (LDL levels in hypertensive and non-hypertensive individuals. While the relation between hyperlipidemia and hypertension is clearly shown, there are only a few studies which have compared the lipid profiles of hypertensive and non-hypertensive cases. The aim and objectives of the present case-control study were to find out the relationship between serum lipids levels of the hypertensive patients with controls in Bikaner, Rajasthan, India. This study was conducted in the Department of Physiology, Sardar Patel Medical College, Bikaner and Department of General Medicine, Kothari Medical and Research Institute, Bikaner. Patients were selected randomly from the city, and the selected subjects were divided into two groups each comprising of 50 patients. Group I: untreated hypertension and served as study group; Group II: normotensive persons having normal Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (BP) and served as a control group. Patients included in both the groups were assessed for lipid profile. Overall, it could be concluded that the serum lipid profile of recently diagnosed untreated hypertensive patient was deranged specially in a middle age group (the study group) as compared to healthy subjects. Based on the results obtained from the present study, it could be further envisaged that serum cholesterol; triglyceride levels are positively correlated with hypertensive patients whereas HDL-cholesterol has no significant changes with hypertension.

Effect of Amlodipine Alone and in Combination with Enalapril on Lipid Profile in Hypertensive Patients with Chronic Kidney Disease (Gaza Strip)

Hypertension with dyslipidemia is becoming a common morbidity and hyperlipidemia is considered as an independent risk factor in development of cardiovascular diseases [1]. To evaluate the effects of Amlodipine (Calcium channel blocker) alone and in combination with Enalapril (Angiotensin Converting Enzyme inhibitor) on serum lipid profile in hypertensive patients with Chronic Kidney Disease (CKD), fifty hypertensive patients with CKD were divided equally into Amlodipine (5-10mg/day) treated group and Amlodipine/Enalapril combination (5-10mg/day, 10-20mg/day) treated group. Serum lipid profile were determined before and after 2, 4 and 6 months of treatment in both groups. A significant decrease in the levels of serum lipid profile in the hypertensive patients with CKD resulted with Amlodipine therapy alone and in combination with Enalapril. In both treated groups, the used drugs significantly improved Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C) and Low Density Lipoprotein Cholesterol (LDL-C) levels of the patients. The effect on these parameters being more pronounced in the group treated with the combination drug, when compared to that of Amlodipine treatment alone. The results indicated that both, Amlodipine monotherapy as well as Amlodipine/Enalapril combination affect the lipid profile. The observed overall higher protective effect of the combination as compared to that of Amlodipine monotherapy may improve the cardiovascular changes caused by hypertensive nephropathy.

Evaluation of Role of Serum Lipoprotein and Lipid Profile in Essential Hypertension Patients in a Tertiary Care Hospital

Introduction: Hypertension is a leading cause of mortality and morbidity worldwide. It doubles the risk of cardiovascular diseases. Elevated serum lipoprotein (a) are associated with an increasing risk of cardiovascular disease in hypertensive patients. Aims and Objectives: To determine levels of serum lipoprotein (a) and lipid profile in hypertensive patients and to correlate the serum lipoprotein (a) levels with lipid parameters. Material and Methods: Lipid profile and serum lipoprotein (a) were estimated in 68 hypertensive patients and compared with 63 age and sex matched healthy controls. Serum lipoprotein (a) was estimated by immunoturbidometric assay and lipid profile by standard biochemical methods. Result: Serum lipoprotein (a) was found to be significantly increased (p<0.001) in hypertensive patients (36.52 ± 9.34 mg/dl) as compared to healthy individuals (17.96 ± 8.42 mg/dl). Total cholesterol, LDL, triglycerides were significantly increased (p<0.001) and HDL was significantly decreased (p<0.001) in cases compared to controls. The correlation study between serum lipoprotein (a) and lipid profile in hypertensive cases showed, that only LDLc had a significant positive correlation with lipoprotein (a). Conclusion: Elevated lipoprotein (a) in hypertensive patients can be a independent risk factor for development of cardiovascular disease.

Evaluation of the Lipid Profile of Hypertensive Patients Compared to Non- Hypertensive Individuals

Introduction: This study was designed to compare the lipid profiles of hypertensive and non-hypertensive cases. Materials and Methods:In this case-control study, we assessed 200 hypertensive patients alongside 200 healthy individuals who were referred to our cardiology clinics from 2007 to 2008, in Mashhad, Iran. Blood pressure and serum lipids profile including total cholesterol, triglyceride, High-density lipoprotein (HDL) and low-density lipoprotein (LDL) were evaluated in both the case and control group. Results: Total cholesterol and the mean of serum LDL level were significantly higher in the hypertensive patients compared to non-hypertensive cases (P=0.001), while the mean of serum triglyceride levels was higher in the case group compared to the control group (P= 0.001). Conclusion: We concluded that only the serum triglyceride levels were significantly different between the hypertensive and non-hypertensive individuals.

Пилотное исследование влияния резвератрола по сравнению с розувастатином и их комбинации на липидный спектр у больных с гипертонической болезнью

Цель: оценить влияние резвератрола по сравнению с розувастатином и их комбинации на липидный спектр у больных с гипертонической болезнью и дислипидемией.Материал и методы. В исследовании приняли участие 73 пациента, которые были распределены на две группы: I группа (n = 38) в начале исследования получала розувастатин в дозе 20 мг/сут в течение месяца, затем к терапии добавляли резвератрол в дозе 50 мг/сут еще месяц; II группа (n = 35) в начале исследования получала резвератрол в дозе 50 мг/сут один месяц, затем к терапии добавляли розувастатин в дозе 20 мг/сут. В начале и через 2 месяца исследования оценивали данные лабораторных исследований: уровень ОХС, ХС ЛПВП, ХС ЛПНП, ТГ; измеряли офисное артериальное давление (АД), частоту сердечных сокращений, проводили суточное мониторирование АД.Результаты. В конце наблюдения мы отметили общее снижение уровня ОХС в первой группе на 28,8 %, степень снижения (Δ) составила –1,7 ммоль/л, во второй группе уровень ОХС снизился на 32,4 %, (Δ = –2,2 ммоль/л). Пациенты, которые принимали в группах резвератрол, независимо от стадии лечения показывали лучшее снижение уровня ОХС. Снижение уровня ОХС наблюдалось как в первой, так и во второй группе, причем добавление второго препарата потенцировало холестеринснижающий эффект лечения. К концу периода наблюдения мы отметили достоверное снижение уровня ХС ЛПНП у пациентов обеих групп (p = 0,005/0,005): в первой группе на 27 % (Δ = –1 ммоль/л) против 25 % (Δ = –0,9 ммоль/л) во второй группе, различия недостоверны. Снижение уровня ХС ЛПНП было наиболее выражено у пациентов первой группы. Наиболее благоприятный эффект на уровень ХС ЛПВП мы отметили во второй группе: уровень ХС ЛПВП увеличился на 35,7 % (Δ = +0,5 ммоль/л) у этих пациентов, однако этот эффект был достигнут в результате значимого их увеличения после второго месяца лечения при дополнительном приеме розувастатина. Как в первой, так и во второй группе мы отметили достоверно значимое снижение ТГ, однако более выраженное снижение было в первой группе после добавления резвератрола к терапии. Следует отметить, что при меньшей степени снижения уровня ТГ (Δ –0,4/–0,2 ммоль/л в группах) и при меньшем количестве пациентов с ТГ выше 1,7 ммоль/л во второй группе мы отмечаем наибольшее уменьшение количества пациентов и степени снижения ТГ в процентном отношении. Мы выделили подгруппы пациентов Т (резвератрол), у которых уровень ТГ был выше 1,7 ммоль/л. В конце периода наблюдения уровень ТГ снизился до 1,6 ± 0,1 ммоль/л, степень снижения — –1,2 ммоль/л, в процентном отношении — 42,9 %, а количество пациентов уменьшилось до 3 человек.Выводы. Терапия резвератролом в сочетании с розувастатином приводила к нормализации липидного спектра крови у больных ГБ с дислипидемией. Резвератрол потенцировал холестеринснижающий эффект статина. Резвератрол достоверно снижал уровень триглицеридов в крови, особенно при исходно повышенном их уровне. Терапия резвератролом была безопасной, хорошо переносилась, побочные реакции не были зафиксированы у пациентов на протяжении всего периода наблюдения.