Evaluation of Role of Serum Lipoprotein and Lipid Profile in Essential Hypertension Patients in a Tertiary Care Hospital

Abstract

Introduction: Hypertension is a leading cause of mortality and morbidity worldwide. It doubles the risk of cardiovascular diseases. Elevated serum lipoprotein (a) are associated with an increasing risk of cardiovascular disease in hypertensive patients. Aims and Objectives: To determine levels of serum lipoprotein (a) and lipid profile in hypertensive patients and to correlate the serum lipoprotein (a) levels with lipid parameters. Material and Methods: Lipid profile and serum lipoprotein (a) were estimated in 68 hypertensive patients and compared with 63 age and sex matched healthy controls. Serum lipoprotein (a) was estimated by immunoturbidometric assay and lipid profile by standard biochemical methods. Result: Serum lipoprotein (a) was found to be significantly increased (p<0.001) in hypertensive patients (36.52 ± 9.34 mg/dl) as compared to healthy individuals (17.96 ± 8.42 mg/dl). Total cholesterol, LDL, triglycerides were significantly increased (p<0.001) and HDL was significantly decreased (p<0.001) in cases compared to controls. The correlation study between serum lipoprotein (a) and lipid profile in hypertensive cases showed, that only LDLc had a significant positive correlation with lipoprotein (a). Conclusion: Elevated lipoprotein (a) in hypertensive patients can be a independent risk factor for development of cardiovascular disease.