Lipid Peroxidation In Patients Research Articles

Adverse plasma fatty acid composition in patients with femoral neck fracture1

Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64-86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-α and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-α and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered.

144 Increased lipid peroxidation in patients with skin lesions associated with human papillomavirus infection

144 Increased lipid peroxidation in patients with skin lesions associated with human papillomavirus infection

Iron Homstatin as a Marker on the Oxidative Stress in Patients for Diabetes Mellitus Type 2

The study included measurement of the level of glucose, iron, ferritin, transferrin‚ Total iron binding capacity, Ceruloplasmin Ferroxidase activity, peroxidase activity and lipid peroxidation in the serum of people with type 2 diabetes mellitus (T2DM). The study included (90) blood samples and divided into three groups (I‚ II‚ III) each of them (30) samples‚ (I) control group, (II, III) Type 2 diabetes patients with complications and without of complications, respectively. The results showed a significant increase in the level of glucose, iron, ferritin and lipid peroxidation in patients with type 2 diabetes with and without complications respectively compare with control group. While a decrease was observed efficacy of peroxidase and ferroxidase in patients Compare with control group as well as decreased transferrin and total iron binding capacity.

Investigation of Malondialdehyde (MDA), Homocysteine (Hcy) and C- reactive protein (CRP) in sera of patients with Angina Pectoris

Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD Oxidative stress and free radicals are known to have important roles in the development ofAngina Pectoris. Oxidative stress is present in cardiovascular diseases (CVDs), and hyperhomocysteinemia, an independent risk factor for these diseases, may play a role in inducing production of oxygen free radicals. The aim of this study was to determine a possible relationship between blood serum Hcy levels and lipid peroxidation in patients suffering from Angina Pectoris (AP).To evaluate the possible role of homocysteine (Hcy) in inducing oxidative stress in Angina Pectoris(AP), plasma homocysteine( Hcy), plasma malondialdehyde (MDA) and C reactive protein (CRP) were measured in 60 unstable Angina Pectoris patients, we tested 30 healthy volunteers. Hcy was measured by an enzymatic colorimetric method and MDA, an index of lipid peroxidation, by spectrophotometer. Serum Hcy levels were significantly higher in angina pectories (AP) patients than the controls (23.2±8.0 vs 10.76 ± 2.55 micromol/L; P

Increased lipid peroxidation and erythrocyte glutathione peroxidase activity of patients with type 2 diabetes mellitus: Implications for obesity and central obesity

AimBoth diabetes and obesity are a proxidant state by increased generation of reactive oxygen species. Obesity and central obesity is common among most of patient with type 2 diabetes. We aimed to assess the effect of obesity on GPx and SOD activity and lipid peroxidation of patients with type 2 diabetes mellitus, prediabetes and normoglycaemic healthy controls. MethodsHundred and forty seven type 2 diabetic patients (T2D), forty seven prediabetics (PDM) and hundred and six normoglycaemic controls (NGC) were recruited. T2D, PDM and NGC individuals were further clustered on the presence of obesity and central obesity. Erythrocyte GPx and SOD were determined using enzymatic reagent kits. Lipid peroxidation marker, malondialdehyde (MDA) was measured using thiobarbituric acid reactive substances (TBARS) assay. ResultsT2D had higher GPx activity and plasma MDA compared to PDM and NGC. PDM showed higher SOD activity than T2D and NGC. Obese and centrally obese T2D had higher GPx activity and plasma MDA with markedly reduced SOD activity. ConclusionObesity and central obesity has further triggered the oxidative stress in T2D as indicated by higher plasma MDA and lower SOD activity. However, rise of GPx activity in parallel to the MDA among obese and centrally obese T2D suggest the induction of “reductive stress”.

Цитогенетические изменения и перекисное окисление липидов у больных гастроэзофагеальной рефлюксной болезнью в сочетании с метаболическим синдромом

Цитогенетические изменения и перекисное окисление липидов у больных гастроэзофагеальной рефлюксной болезнью в сочетании с метаболическим синдромом

Correlation of lipid peroxidation and ATP enzyme on erythrocyte membrane with fetal distress in the uterus in patients with intrahepatic cholestasis of pregnancy.

This paper aims to investigate the correlation of lipid peroxide in erythrocytes and ATP (Adenosine Triphosphate) enzyme activity of erythrocyte membrane with fetal distress in patients with intrahepatic cholestasis of pregnancy (ICP). Forty-three patients with ICP treated at Jining No. 1 People's Hospital were enrolled as a study group, and another forty healthy parturient women in the same period were enrolled as a control group, to extract their elbow venous blood and fetal umbilical cord blood. Thiobarbituric acid (TBA) was used to detect superoxide dismutase (SOD) activity of erythrocytes, malondialdehyde (MDA) activity in plasma, Na+-K+-ATP enzyme activity and Ca2+-Mg2+-ATP enzyme activity of erythrocytes, which were compared between the study and control groups. The correlation of MDA, Na+-K+-ATP enzyme and Ca2+-Mg2+-ATP enzyme activities with fetal distress in the study group was analyzed, and the correlation of MDA with Na+-K+-ATP enzyme activity was investigated. SOD and MDA activities of erythrocytes in maternal blood of the study group were significantly higher than those in the control group (p<0.05, p<0.001, respectively), but MDA activity in umbilical cord blood of the study group was markedly higher than that in the control group (p<0.001). Na+-K+-ATP enzyme and Ca2+-Mg2+-ATP enzyme activities of maternal and fetal erythrocytes of the study group were remarkably lower than those of the control group (p<0.001). MDA in the fetal distress group was significantly higher than that in the no fetal distress group in the study group (p<0.001). Na+-K+-ATP enzyme activity was negatively correlated with MDA concentration in maternal and fetal erythrocytes of patients with ICP (both p<0.001). Lipid peroxidation in patients with ICP will affect ATP enzyme activity of erythrocyte membrane, and the down-regulation of ATP enzyme activity in umbilical cord blood of patients with ICP may cause fetal distress in the uterus.

The Effects of Probiotic Supplements on Blood Markers of Endotoxin and Lipid Peroxidation in Patients Undergoing Gastric Bypass Surgery; a Randomized, Double-Blind, Placebo-Controlled, Clinical Trial with 13Months Follow-Up.

The effect of probiotic supplements among subjects undergoing bariatric surgery indicates conflicting results. Moreover, whether these effects remain after ceasing the treatment remained to be elucidated. This study was conducted to assess the effect of probiotic supplements on blood markers of endotoxin (lipopolysaccharides-binding protein: LBP), inflammation and lipid peroxidation (malondialdehyde: MDA) in patients with morbid obesity undergoing the one-anastomosis gastric bypass (OAGB). This study is a placebo-controlled, double-blind, and randomized clinical trial and 9months of additional follow-up. Forty-six morbid obese patients undergoing OAGB were randomized to 4months of probiotic or placebo supplements. Anthropometric indices and blood concentration of LBP, inflammatory markers, MDA, vitamin D3, and B12 were measured at 0, 4, and 13months of study. Probiotic supplements could improve serum LBP (P = 0.039), TNF-α (P = 0.005), vitamin B12 (P = 0.03), vitamin D3 (P = 0.001), and weight loss (P = 0.01) at month 4 in comparison to placebo; however, only serum MDA concentrations decreased significantly in the probiotic group compared with those in the placebo group (P = 0.013) at the end of follow-up period. It was observed that 4months probiotic supplementation compared with placebo prohibited an elevation in the LBP levels and improved serum TNF-α and 25-OH vitamin D3 concentrations and weight loss in patients undergoing the OAGB surgery. However, these effects did not persist 9months after the cessation of the treatment. Further investigations are required to find how long supplementation and which dosage of it can benefit body status for the long-term. This study has been registered at Clinicaltrial.gov with registration number NCT02708589 .

Functional activity of neutrophils and local manifestations of oxidative stress in the mucous membrane of the nasal cavity in the early postoperative period

The purpose of the study was to study the factors of antimicrobial, antioxidant defense, variability of nasal secretion lipid peroxidation in patients with curvature of the nasal septum in the early postoperative period. METHODS: microbiological, immunological (assessment of the activity and intensity of phagocytosis, nitrous tetrazolium reduction test) biochemical (study of content diene conjugates, ketodienes, conjugated trines and Schiff bases in the lipid extract of neutrophilic granulocytes), statistical. RESULTS: The dynamics of the content, functional and biochemical activity of neutrophilic granulocytes in nasal washings in individuals who underwent rhinosurgical intervention testifies to the presence of qualitative and quantitative changes in neutrophilic granulocytes of the nasal secretion, recorded in reactions of oxygen-dependent metabolism, free radical oxidation and antioxidant protection.

The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy.

To evaluate the level of lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy (ESWL). Isoprostane concentration (8-isoPGF2α) was measured in urine, and thiobarbituric acid reactive substance production in serum and erythrocytes. In addition, the concentrations of selected compounds (uric acid, glucose and creatinine) were measured in serum. The patients (before and after ESWL) demonstrated significantly higher levels of two different biomarkers of lipid peroxidation compared with the control group. A correlation was identified between increased amounts of uric acid and biomarkers of lipid peroxidation in patients with nephrolithiasis, both before and after ESWL. Uric acid may be associated with lipid peroxidation in patients with nephrolithiasis.

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The objective of the study was to evaluate cytokine concentration and profile of lipid peroxidation in synovial fluid of patients with osteoarthritis and concomitant defects of articular surfaces. Material and methods Synovial fluid samples were taken from 102 patients with osteoarthritis of the knee joint. Patients with rheumatoid arthritis, osteoarthritis of a post-traumatic etiology, and somatic diseases that could affect results of the study were excluded from the study. Thirty control samples originated from deceased donors of both genders. Synovial fluid was extracted in compliance with Ministry of Health Order No. 694 dtd July 21, 1978, p. 2.24 Guidelines of forensic medical examination in the USSR. Results Findings of laboratory studies showed statistically significant differences in synovial fluid cytokine levels depending on absence or presence of defects on the tibial condyles. Biochemical tests revealed greater changes in lipid peroxidation in patients with articular defects. Total level of lipid peroxidation products resulting in the formation of conjugated dienes (CD), malondialdehyde (MDA) was shown to increase in both groups of patients being significantly higher in patients with defects on articular surfaces. Primary (conjugated dienes) and secondary (malondialdehyde) lipid peroxidation products accumulated in the synovial fluid of the patients with the levels being significantly increased in both groups with no changes in the CD/MDA ratio. Patients with defects on articular surfaces demonstrated increased formation of primary products, and non-defect group showed greater formation of secondary products. Antioxidant enzyme, catalase, appeared to me more active in patients of Group I. Conclusion The findings can be used to evaluate defects on articular surface and identify strategies of medication therapy.

Melatonin Improves Lipid Profile and Ameliorates Lipid Peroxidation in Patients with Chronic Kidney Disease.

Dyslipidemia and oxidative modifications of lipid are frequently associated in patients with chronic kidney diseases (CKD) and considered the most important risk factors for cardiovascular events. Melatonin is a well-known potent antioxidant and has beneficial effect on lipid metabolism. the study was designed to evaluate if Melatonin could improve lipid profile and ameliorates lipid peroxidation. This single blind placebo controlled clinical study carried out on 41 patients with CKD who were randomized into two groups, control groups (n=20) those who received placebo cap and melatonin group those who received 5mg melatonin (n=21). Lipid profile [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C)] and parameters of lipid peroxidation [oxidized LDL (oxLDL) and malondialdehyde (MDA) were measured before and after 12 weeks of the treatment. After 12 weeks of treatment, melatonin significantly increased HDL-C and decreased LDL-C compared to the initial value. The elevation in HDL-C and reduction in LDL-C were significantly different from that in placebo group. Also, both oxLDL and MDA levels significantly lowered by melatonin compared to the baseline and to the placebo group. Collectively, the results of our study showed that melatonin has advantageous effect on lipid profile and inhibit lipid peroxidation in patients with CKD.

Melatonin Improves Lipid Profile and Ameliorates Lipid Peroxidation in Patients with Chronic Kidney Disease.

Dyslipidemia and oxidative modifications of lipid are frequently associated in patients with chronic kidney diseases (CKD) and considered the most important risk factors for cardiovascular events. Melatonin is a well known potent antioxidant and has beneficial effect on lipid metabolism. the study was designed to evaluate if Melatonin could improve lipid profile and ameliorates lipid peroxidation. This single blind placebo controlled clinical study carried out on 41 patients with CKD who were randomized into two groups, control groups (n=20) those who received placebo cap and melatonin group those who received 5mg melatonin (n=21). Lipid profile [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C)] and parameters of lipid peroxidation [oxidized LDL (oxLDL) and malondialdehyde (MDA) were measured before and after 12 weeks of the treatment. After 12 weeks of treatment, melatonin significantly increased HDL-C and decreased LDL-C compared to the initial value. The elevation in HDL-C and reduction in LDL-C were significantly different from that in placebo group. Also both oxLDL and MDA levels significantly lowered by melatonin compared to the baseline and to the placebo group. Collectively, the results of our study showed that melatonin has advantageous effect on lipid profile and inhibit lipid peroxidation in patients with CKD.

Alterations in oxidative stress markers and its correlation with clinical findings in schizophrenic patients consuming perphenazine, clozapine and risperidone

Background and ObjectiveToday, the role of oxidative stress in development of schizophrenia has gained attention. Also, some atypical antipsychotic agents showed antioxidant properties. Therefore, in this study, we evaluated the level of oxidative stress parameters between patients treated with perphenazine, clozapine and risperidone and their relationship with schizophrenia symptoms’ severity. Materials and MethodsThis was a descriptive study on 100 patients with chronic schizophrenia. Patient selection was done based on the DSM-IV-TR criteria for at least 3 months regular use of clozapine or risperidone or perphenazine and a minimum period of 2 years of schizophrenia. Ten ml of patient’s blood samples were used to assess serum levels of glutathione (GSH), protein carbonyl, lipid peroxidation (LPO), superoxide dismutase (SOD) and Ferric Reducing Ability of Plasma (FRAP). Also, the severity of symptoms was assessed with the positive and negative syndrome scale (PANSS scale). P-values of less than 0.05 were considered significant. ResultsThe results showed a significant difference between clozapine and risperidone with perphenazine in all subscales of PANSS. Also, there was a positive correlation between MDA and PANSS all subscales in risperidone and perphenazine groups and a negative correlation between MDA and PANSS in all subscales in the clozapine group. Serum level of GSH and negative symptoms in patients receiving clozapine showed a negative correlation. The results also represented that clozapine significantly increased SOD levels in comparison to perphenazine and risperidone and reduced LPO in comparison to perphenazine and risperidone, While the protein carbonyl level did not show a significant difference between three groups (p-value = 0.8). ConclusionThis study showed that clozapine, as an atypical antipsychotic agent, has significant antioxidant effects compared to risperidone and perphenazine. Especially, it increased SOD and GSH levels and reduced LPO in patients with schizophrenia. Therefore, clozapine’s antioxidant effect may be contributive to improving negative symptoms of schizophrenic patients.

Deranged Antioxidant Status and Oxidative Stress in Patients with Cervical Cancer Receiving Radiotherapy

Cervical cancer is the seventh overall, but the second most common cancer in women worldwide. It is the second most common cancer in women of all ages in Ethiopia. Radiotherapy is one of the treatment strategies, but its effect on production of oxygen free radicals that leads to oxidative stress requires proper attention and investigation. In this study oxidative stress in 43 patients with cervical carcinoma before and in the course of radiotherapy was assessed versus 20 normal subjects. Sera were collected at 4 time points from patients, i.e., before radiotherapy, and after 2, 4, and 8 weeks of radiotherapy, but only once from normal controls. Reduced total antioxidant capacity (TAC) was observed in patients than normal subjects before and after radiotherapy. Significantly elevated total peroxide concentration (TPC) was seen in the course of radiotherapy. TPC values at the end of radiotherapy were significantly higher compared to before and after radiotherapy. Oxidative stress index in patients was significantly elevated compared to controls during and at the end of therapy. Levels of lipid peroxides in patients were markedly elevated compared to controls. Our findings showed that cervical cancer induces increased production of oxygen free radicals and radiotherapy has a synergetic effect on the production of oxygen free radicals leading to oxidative stress.

Intensity of lipid peroxidation in patients with cold injury

Intensity of lipid peroxidation in patients with cold injury

Comparison of the effects of flaxseed oil and sunflower seed oil consumption on serum glucose, lipid profile, blood pressure, and lipid peroxidation in patients with metabolic syndrome

Metabolic syndrome (MetSyn) increases the risk of type II diabetes and morbidity and mortality due to cardiovascular diseases. Flaxseed oil (FO), as a functional food, is one of the major vegetal sources of essential omega-3 fatty acids. This study aimed to compare the effects of consumption of FO and sunflower seed oil (SO) on lipid peroxidation and other symptoms of MetSyn. This randomized controlled interventional trial was conducted on 60 volunteers aged 30 to 60years who were diagnosed with MetSyn in Shiraz, Iran. The participants who fulfilled the inclusion criteria were randomly assigned to SO (n=30, receiving 25mL/d SO) and FO (n=30, receiving 25ml/d FO) groups using block randomization. The diets were identical for all the participants. Blood pressure (BP), serum lipid, fasting blood sugar, and malondialdehyde were measured at baseline and at the end of week7. The results showed no significant difference between the 2 groups regarding blood lipid levels and fasting blood sugar at the end of the study. However, significant reductions in total cholesterol, low-density lipoprotein cholesterol (5.6% in FO and 10.8% in SO), and triglyceride levels were seen within each group after treatment with FO and SO (P<.05). Nonetheless, between-group changes were significant (<0.05) for systolic BP (mean [±standard deviation {SD}] changes were -14.0±22.41 in the FO group [P=.004] and 0.92±8.70 in the SO group [P=.594]) and diastolic BP (mean [±SD] changes were -4.26±7.44 in the FO group [P=.007] and 1.30±6.91 in the SO group [P=.344]), but marginally significant (P=.053) for malondialdehyde level (mean [±SD] changes were -1.29±1.48 in the FO group [P<.001] and -0.52±1.34 in the SO group [P=.52]). A significant decrease in weight was also found in both groups. However, waist circumference decreased significantly only in the FO group at the end of the study (P<.05). Our results indicated that dietary FO could be effective in amelioration of some symptoms of MetSyn and decrease BP and lipid peroxidation.

Evaluation of hemostasis parameters and the role of the oxidative damage to plasma proteins in the modulation of hemostasis in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy.

PurposeExtracorporeal shock wave lithotripsy (ESWL) is a commonly-used method in urology, which may modulate hemostasis and may induce lipid peroxidation in patients with nephrolithiasis. However, previous studies only examine changes occurring in patients 30–240 min after ESWL. The main aim of the present study was to determine whether oxidative stress may modulate the hemostatic activity of plasma in patients with nephrolithiasis before ESWL and the day after treatment ESWL. This will be performed by measuring selected parameters of hemostasis in these patients, both before ESWL and the following day, and assessing the level of oxidative damage to plasma proteins in these patients by measuring two biomarkers.MethodsTwelve patients with nephrolithiasis and 10 healthy participants were included. The following parameters of hemostasis were measured: the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of plasma, the level of fibrinogen, the level of D-dimer and blood platelet count. In addition, two selected biomarkers of oxidative stress were measured: protein carbonylation level and the number of protein thiol groups.ResultsNo difference was observed between patients with nephrolithiasis before and after ESWL and healthy controls with regard to PT, TT or APTT. Fibrinogen concentration and blood platelet count were lower in the nephrolithiasis patients in the period after ESWL than before ESWL. The nephrolithiasis patients demonstrated elevated D-dimer concentration after ESWL. However, although oxidative damage was observed in the plasma proteins in the nephrolithiasis patients, this was not influenced by ESWL.ConclusionOxidative stress may induce changes of hemostasis in patients with nephrolithiasis, both before and after ESWL. In addition, changes of hemostasis parameters such as fibrinogen, blood platelet count and D-dimer level can be observed in these patients, especially after ESWL, and this may suggest that ESWL modulates hemostasis. By having a better understanding of the influence of ESWL on hemostasis, this could lead to modifying patient care for those patients at increased risk of bleeding.

Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

This study aimed to examine the effects of hesperidin supplement on the glycemic parameters, oxidative DNA damage, and lipid peroxidation in patients with type 2 diabetes. Sixty-four patients were randomly allocated to receive 500mg/day hesperidin or placebo capsules for 6weeks. Data on glycemic parameters, total antioxidant capacity (TAC), 8-hydroxydeoxyguanosine (8-OHDG), and malondialdehyde (MDA) were collected at the baseline and at the end of the study. In hesperidin group, TAC increased (0.74±0.16 vs. 0.82±0.18), while serum froctoseamin (5.79±5.86 vs. 5.01±4.95; p=0.001), 8-OHDG (14.32±6.4 vs. 11.00±7.0; p=0.000), and MDA (5.78±1.76 vs. 4.60±0.75; p=0.000) decreased in comparison with the baseline values. There was a significant difference in percent change of TAC (13.35±19.21 vs. 3.13±10.02; p=0.043), froctoseamin (-10.10±16.84 vs. 4.27±34.646), 8-OHDG (-25.11±28.23 vs. 8.69±35.41; p=0.000), and MDA (-16.46±18.04 vs. -1.82±22.63; p=0.007) between hesperidin and control groups following intervention in adjusted models. These results suggest that hesperidin may improve TAC and alleviate serum froctoseamin, 8-OHDG, and MDA levels in type 2 diabetes. Copyright © 2017 John Wiley & Sons, Ltd.

Protective effect of salidroside on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis

Objective To explore the protective effect of salidroside on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis. Methods 98 patients with acute cerebral infarction who were consistent with intravenous thrombolysis after screening were enrolled in the study.They were equally divided into the control group and the treatment group by sealed envelop method in one to one ratio.The control group received urokinase intravenous thrombolytic therapy on the basis of dehydration, anticoagulation, brain rehabilitation, regulating blood pressure, blood glucose and other conventional treatment.Based on the treatment in the control group, the treatment group was treated with Hongjingtian injection for 10 days.The serum malondialdehyde(MDA), superoxide dismutase(SOD), plasma endothelin-1(ET-1) and high sensitive C-reactive protein(hs-CRP), neurological deficit score(NIHSS), Barthel index and clinical effect in the two groups were observed. Results There were no significant differences in levels of MDA, SOD, ET-1, hs-CRP, NIHSS and Barthel index between the two groups before treatment (t=0.30, 0.26, 0.41, 004, 0.57, 0.33, all P>0.05). After treatment, there were statistically significant differences between the control group and the treatment group in levels of MDA, SOD, ET-1, hs-CRP, NIHSS score and Barthel index[(7.54±1.14)nmol/mL vs.(6.04±1.21)nmol/mL, (92.42±15.28)U/mL vs.(108.54±19.24)U/mL, (64.5±7.4)pg/mL vs.(41.4±8.1)pg/mL, (3.84±1.04)μmol/L vs.(2.54±0.84)μmol/L, (16.5±5.4)points vs.(11.2±3.1)points, (62.1±12.4) vs.(71.4±10.4)](t=6.31, 4.59, 14.74, 6.81, 5.96, 4.02, all P<0.01). The total effective rate of the treatment group was 91.84%, which of the control group was 63.39%, the difference was statistically significant(χ2=8.83, P<0.05). Conclusion Salidroside can relieve lipid peroxidation in patients with acute cerebral infarction, promote decomposition of oxyradical, reduce inflammatory reactions, improve neurological function and quality of life.The curative effect is significant.It has protective effect on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis. Key words: Salidroside; Acute cerebral infarction; Urokinase; Intravenous thrombolysis; Early reperfusion