Protective effect of salidroside on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis

Abstract

Objective To explore the protective effect of salidroside on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis. Methods 98 patients with acute cerebral infarction who were consistent with intravenous thrombolysis after screening were enrolled in the study.They were equally divided into the control group and the treatment group by sealed envelop method in one to one ratio.The control group received urokinase intravenous thrombolytic therapy on the basis of dehydration, anticoagulation, brain rehabilitation, regulating blood pressure, blood glucose and other conventional treatment.Based on the treatment in the control group, the treatment group was treated with Hongjingtian injection for 10 days.The serum malondialdehyde(MDA), superoxide dismutase(SOD), plasma endothelin-1(ET-1) and high sensitive C-reactive protein(hs-CRP), neurological deficit score(NIHSS), Barthel index and clinical effect in the two groups were observed. Results There were no significant differences in levels of MDA, SOD, ET-1, hs-CRP, NIHSS and Barthel index between the two groups before treatment (t=0.30, 0.26, 0.41, 004, 0.57, 0.33, all P>0.05). After treatment, there were statistically significant differences between the control group and the treatment group in levels of MDA, SOD, ET-1, hs-CRP, NIHSS score and Barthel index[(7.54±1.14)nmol/mL vs.(6.04±1.21)nmol/mL, (92.42±15.28)U/mL vs.(108.54±19.24)U/mL, (64.5±7.4)pg/mL vs.(41.4±8.1)pg/mL, (3.84±1.04)μmol/L vs.(2.54±0.84)μmol/L, (16.5±5.4)points vs.(11.2±3.1)points, (62.1±12.4) vs.(71.4±10.4)](t=6.31, 4.59, 14.74, 6.81, 5.96, 4.02, all P<0.01). The total effective rate of the treatment group was 91.84%, which of the control group was 63.39%, the difference was statistically significant(χ2=8.83, P<0.05). Conclusion Salidroside can relieve lipid peroxidation in patients with acute cerebral infarction, promote decomposition of oxyradical, reduce inflammatory reactions, improve neurological function and quality of life.The curative effect is significant.It has protective effect on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis. Key words: Salidroside; Acute cerebral infarction; Urokinase; Intravenous thrombolysis; Early reperfusion