Abstract

This study aimed to examine the effects of hesperidin supplement on the glycemic parameters, oxidative DNA damage, and lipid peroxidation in patients with type 2 diabetes. Sixty-four patients were randomly allocated to receive 500mg/day hesperidin or placebo capsules for 6weeks. Data on glycemic parameters, total antioxidant capacity (TAC), 8-hydroxydeoxyguanosine (8-OHDG), and malondialdehyde (MDA) were collected at the baseline and at the end of the study. In hesperidin group, TAC increased (0.74±0.16 vs. 0.82±0.18), while serum froctoseamin (5.79±5.86 vs. 5.01±4.95; p=0.001), 8-OHDG (14.32±6.4 vs. 11.00±7.0; p=0.000), and MDA (5.78±1.76 vs. 4.60±0.75; p=0.000) decreased in comparison with the baseline values. There was a significant difference in percent change of TAC (13.35±19.21 vs. 3.13±10.02; p=0.043), froctoseamin (-10.10±16.84 vs. 4.27±34.646), 8-OHDG (-25.11±28.23 vs. 8.69±35.41; p=0.000), and MDA (-16.46±18.04 vs. -1.82±22.63; p=0.007) between hesperidin and control groups following intervention in adjusted models. These results suggest that hesperidin may improve TAC and alleviate serum froctoseamin, 8-OHDG, and MDA levels in type 2 diabetes. Copyright © 2017 John Wiley & Sons, Ltd.

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