Linyi City Research Articles

FOXN4 Inhibits Breast Cancer Progression By Direct Activation Of P53.

BackgroundFork head domain-containing gene family (Fox) transcription factors, consisting of over 20 members, are involved in the progression of certain types of tumor. However, whether FOXN4 is involved in carcinogenesis and tumor progression is still unclear.PurposeIn this study, we investigated the clinicopathological significance and the underlying mechanism of FOXN4 in breast cancer.Methods and resultsWe examined the lower expression of FOXN4 in breast cancer tissues and cancer cell lines. The expression of FOXN4 is negatively correlated with tumor size and lymph node metastasis. Using CCK-8 assay, colony formation assay, wound healing assay, and Transwell assay, we revealed that FOXN4 notably decreased breast cancer cell proliferation, epithelial-mesenchymal transition and invasion in vitro. In addition, quantitative chromatin immunoprecipitation and luciferase assays determined that FOXN4 was able to directly bind with the promoter of P53. RT-qPCR and Western blotting analysis showed that FOXN4 could directly activate P53 expression. Functionally, P53 knockdown rescued the tumor inhibition effects of FOXN4 in breast cancer cells.ConclusionThe present study provides new insights into the role of FOXN4 in breast cancer progression and suggests FOXN4 might represent a potential therapeutic target in breast cancer by modulating P53.

Analysis of 31 Cases of Female Sjogren’s Syndrome Patients with Changes in Muscle Mass

Objective: To observe and analyze the changes in muscle mass in patients with Sjogren’s syndrome and sarcopenia. Methods: From October 2016 to December 2018, the muscle mass of 31 female patients with Sjogren’s syndrome who underwent DXA testing in Linyi City People’s Hospital was tested, and the changes in muscle mass of patients with Sjogren’s syndrome were investigated. Results: The incidence of decreased skeletal muscle mass in patients with Sjogren’s syndrome was lower. The upper and lower limbs of patients with decreased skeletal muscle mass were significantly lower than those with normal skeletal muscle mass (P

Distribution and Potential Ecological Risk of Heavy Metals in Water, Sediments, and Aquatic Macrophytes: A Case Study of the Junction of Four Rivers in Linyi City, China.

The Yi River, the second longest river in Shandong Province, China, flows through Linyi City and is fed by three tributary rivers, Beng River, Liuqing River, and Su River in the northeastern part of the city. In this study, we determined the concentrations of five heavy metals (Cr, Ni, Cu, Zn, and Pb) in water, sediment, and aquatic macrophyte samples collected from the junction of the four rivers and evaluated the potential ecological risk of heavy metal pollution. Most of the heavy metals in water were in low concentrations with the water quality index (WQI) below 1, suggesting low metal pollution. The sediments showed low heavy metal concentrations, suggesting a low ecological risk based on the potential ecological risk index (RI) and the geo-accumulation index (Igeo). The aquatic plant species Potamogeton crispus accumulated considerable amounts of heavy metals, which were closely related to the metal concentrations of the sediment. The plant species Salvinia natans also showed an excellent metal accumulation capability. Based on our results, the junction of the four rivers is only slightly polluted in terms of heavy metals, and the plant species P. crispus is a suitable bioindicator for sediment heavy metal pollution.

Study on risk assessment method of Karst collapse—Taking the Karst collapse in Linyi urban areas as an example

Karst collapse is one of main important geological disasters in Linyi city of Shandong Province. In this article, risk assessment of present and forecast situation of karst collapse have been done by the method of fuzzy comprehensive evaluation based on level analysis at the first time. The hazardous assessment, the vulnerability and the expected loss have been assessed, and then the risk assessment map of karst collapse at present is obtained and prevention and control work of karst collapse is expected to develop. It puts up availability exploration on prevention of the same geohazards, and provides a reference pattern.

Study on the Characteristics of Atmospheric Dust Environment in Xicheng District of Linyi City

This paper analyses the atmospheric dust in Linyi City about the content and the form distribution of heavy metals. The main research focuses on the eight kinds of heavy metal elements, including As, Cd, Cr, Cu, Hg, Mn, Pb, Zn. The research results show that the annual atmospheric dust deposition in the heavy industrial zone reaches the highest amount at 88.50 g/m2. In the Park district, the figure of the year is 28.27 g/m2; compared with the soil background values, the heavy metal content, Hg, Cr, Pb, As, Cd, increased obviously. In addition, the content of Zn is beyond the soil background values of 18 times. And in the industrial zone the content of Zn has the top amount of 3545.55 mg/kg. The enrichment factor of Cu, Cd element is 50~70. The atmospheric dust deposition of Mn is similar to soil background value. Moreover, the source of Mn is mainly from the natural particulate matter of soil.

Spatial Differentiation of Land Reclamation in Shandong Province since the 21st Century

Cultivated land refers to the land on which crops are grown, which are the basic resources and conditions for human survival. This paper uses the data of Shandong Statistical Yearbook (2001-2018) to study the spatial and temporal distribution pattern of cultivated land resources in Shandong Province by using GIS technology. The results show that the area of cultivated land between 2000 and 2016 is generally increasing, which is divided into attenuation and recovery. After adjusting the three stages, the cultivated land area has a downward trend after 2012, which is worthy of attention. From the perspective of the characteristics of the cultivated land resources, the cultivated land resources of the province are characterized by the lack of more than the east and the east, and the growth of the land reclamation rate is expanding to the east. From the perspective of the overall distribution of cultivated land resources, the average annual growth rate of cultivated land area in Shandong Province during the period from 2000 to 2016 was 0.89%, the average annual growth rate in Luzhongnan area was slightly faster at 1.07%, and the highest rate of land reclamation in northwestern Shandong was 60.96%, the most extensive cultivated area is Linyi City, the largest land reclamation rate is Liaocheng, the land reclamation rate is 67.50%, and about 2/3 of the land is cultivated land.

Study on the Distribution of Heavy Metals in Atmospheric Dustfall in the Area around Linyi University

This paper analyses the atmospheric dust in Linyi City about the content and the form distribution of heavy metals. The main research focuses on the eight kinds of heavy metal elements, including As, Cd, Cr, Cu, Hg, Mn, Pb, Zn. The research results show that the formation distribution of heavy metal element is differ, the morphology of Mn and Cu detection rate of 100%, with five kinds of form exist; Cu, Zn, Mn, Pb, Cd in the exchangeable ions and carbonate combined states accounted for 20% of the proportion of high proportion. Cr, Cd, heavy metal forms with exchangeable ions state, carbonate state, iron, manganese oxide combination state, which accounts for 80% to 95% of the total, unstable state 20% has some impact on the environment and the human body.

Medical and housing needs of older part-time migrant workers and the role of government: the Linyi model in China

ABSTRACTThe political, social and academic attention on migrant workers in China has been focused on the full-time worker while those who seek part-time work are rarely studied. We explore the effect of part-time day-labour employment of older migrants in an odd-job market in Linyi City. The medical, housing needs and available services for them are analysed. The Linyi government pioneered a program providing comprehensive services to part-time migrant workers, allowing this study to explore the strengths and weakness of the model. Building the appropriate social service industry competencies demands a joint effort from the government, community, organizations, researchers and enterprises.

Source Apportionment and Pollution Characteristics of PM2.5 During the Two Heavy Pollution Episodes in the Winter of 2016 in a Typical Logistics City

To characterize the chemical composition of PM2.5 and the formation of pollution during a heavy pollution episode in the winter in a typical logistics city, PM2.5 samples were collected from December 2016 to January 2017 at six sampling sites, and the water-soluble ions, elements, and carbon components were determined. The results showed that the average concentration of PM2.5 was (145.2±87.8) μg·m-3 during the whole sampling period, of which 82% of daily average concentrations were above class Ⅱ of the national standards. The average concentrations of PM2.5 during the two heavy pollution episodes were (187.3±79.8) and (205.3±92.0) μg·m-3, which were 5.4 and 5.9 times, respectively, as high as class Ⅱ of the national standard. The results of the chemical composition of the PM2.5 showed that secondary water-soluble inorganic ions (SO42-, NO3-, and NH4+) were the main components of PM2.5 in winter (51.2% of PM2.5 mass concentration), followed by organic matter (OM, 23.8%), and mineral dust (12.7%). Combined with the change trend and accumulation rate of chemical components during the pollution episode, we discovered that the increasing of SNA and OM led to PM2.5 pollution in the first episode, while the growth of SNA caused the second pollution episode. This was further verified by the synchronous change of SOR, NOR, and the OC/EC ratio. PMF analysis indicated that mixed sources of secondary particulate matter and biomass combustion (50.0%), coal combustion (16.8%), vehicles (12.9%), fugitive dust (10.0%), industry (5.3%) and soil dust (5.0%), were the main sources of PM2.5 of Linyi city in the winter. Compared with the average concentration over the whole sampling period, the contribution of secondary particles during the two pollution episodes was significantly increased. This indicates that the formation and accumulation of secondary particulate matter under static and humid meteorological conditions were the main influencing factors during the heavy pollution episodes.

An exploration aboutthe Solar Energy Utilization and the Enclosure SystemRenovation for Rural Residential Buildings in Cold Areas of Northern China——Taking the rural residential renovation design in Zhujialin Village, Linyi as an example

Rural areas in the cold regions of northern China generally suffer from excessive energy consumption, poor thermal comfort, and low thermal efficiency of heating equipment. In order to improve the comfort of ruralresidential buildings, renovation design has become an indispensable part of the current beautiful rural construction.This paper comprehensively analyzes the current situation of rural residential buildings in cold regionsbytaking the transformation ofa farmhouse in Zhujialin of Linyi City as an example. Moreover, the methods of energy-saving renovation of rural houses are explored from two aspects of solar energy utilization and enclosing system renovation. The research provides a feasible reference for energy-saving renovation of other rural areas in the cold regions of northern China.

The Construction of the System about Distribution in Linyi City Based on the Modern Logistics

In the background of the service industry transformation and upgrading about the new retail, new model, new technology and new logistics, big data, cloud computing and Internet of things are widely used. it's important to improve the urban distribution system using the means and mode of modern logistics. This study selected the city distribution system as the research object, to build the distribution system of city, According to the new technology and new model of logistics, the paper puts forward the framework, construction path and configuration of the distribution system.

Epidemiology Characteristics of Human Coxsackievirus A16 and Enterovirus 71 Circulating in Linyi, China, from 2009 to 2017.

In China, a rapid expansion of hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004, and HFMD has become an important issue in China. There are more than 20 types of enterovirus causing HFMD, of which coxsackievirus A16 (CA16) and enterovirus 71 (EV71) are the most common. This study aimed to analyze the epidemiological characteristics of HFMD caused by EV71 and CA16 in Linyi, Shandong province, China, from 2009 to 2017. The stool specimens and throat samples of 5,324 patients with HFMD were obtained for nucleic acid detection of enterovirus. A total of 4,040 HFMD cases were caused by viral pathogens. Of these, 1,706 cases were positive for EV71 and 1,266 were positive for CA16. These 2 virus strains appeared alternately in Linyi city. The incidence of EV71-positive and CA16-positive cases was highest in children aged 0-5 years, with male patients being predominant. This outbreak of HMFD caused by EV71 and CA16 mainly occurred between April and July and appeared alternately between the years 2011 and 2017. These results demonstrated that the epidemiological analysis of EV71 and CA16 can provide a scientific basis for the prevention and treatment of the disease.

A new index for mapping the ‘blue steel tile’ roof dominated industrial zone from Landsat imagery

ABSTRACTIndustrialization is criticized for posing environmental concerns despite its contribution to local economic growth and modern urbanization. Accurately mapping industrial zones is a necessity for the strategic planning of modern industrialization. Unfortunately, industrial zones mapping by remotely sensed imagery over large areas remains methodologically challenging, as the spectral and texture features of industrial zones resemble those of other man-made surfaces. To fill the gap, this paper presents the first attempt at industrial zones mapping through identifying the ‘blue steel tile’-roofed buildings (BSTBs). Specifically, we develop a BSTB index (BSTBI) for extracting the BSTBs in Landsat images. The new index combines the BSTB feature of ‘V-shaped valley’ over visible-near infrared reflection (NIR) span and the most separable band of Landsat sensors (shortwave infrared-2 band). Through the experiments conducted in Linyi city, China, the new index is demonstrated a good performance in detecting BSTBs with an overall accuracy larger than 85% and Kappa coefficient over 0.75 under the support of atmospherically corrected Landsat data.

Effects of postoperative diet intervention on nutritive indexes and functional recovery in patients with frontal lobe glioma

Objective To investigate the effects of postoperative diet intervention on nutritive indexes and functional recovery in patients with frontal lobe glioma. Methods A total of 72 patients with frontal lobe glioma treated in Chinese Medicine Hospital in Linyi City from March 2015 to March 2017 were selected and divided into control group and experimental group according to temporal sequence with 36 cases in each group. The patients in the control group was given routine nursing, while the patients in the experimental group received diet intervention on the basis of the control group. Patients' body mass index (BMI) , total protein, transferrin, prealbumin, hemoglobin, functional recovery of the two groups were compared before intervention and 3 months after intervention. Results There was no statistical difference in the nutritional indexes before the intervention (P>0.05) . The nutritional index levels of both groups increased after the intervention (P<0.05) . The total protein, transferrin, prealbumin, hemoglobin, red-cell count and BMI of the experimental group after intervention were higher, compared with the control group (P<0.05) . The rehabilitation status of the experimental group was significantly better than that of the control group (P<0.05) . Conclusions Dietary intervention is more conducive to improve the nutritional level of patients with frontal lobe gliomas and the rehabilitation of patients' physical function, and has a wide range of clinical applications. Key words: Glioma; Neurosurgical procedures; Hemoglobin; Body mass index; Dietary intervention; Functional rehabilitation

Study on Urban Fire Station Planning based on Fire Risk Assessment and GIS Technology

Abstract This paper focuses on the planning of fire station in Lanshan District, Linyi City, Shandong Province. It mainly aims at the deficiency of the fire protection planning in Lanshan district and the new problems brought by the rapid development of the city. The fire risk of city buildings in Lanshan District was identified and evaluated. On the basis of fire risk assessment, GIS technology was introduced to solve the problem of site selection of those new fire stations and layout of old fire stations. The research results suggest that 4 new fire stations should be added, which are close to the great fire risk places. Meanwhile, the new fire stations are also required to be close to the main roads of the city as far as possible. The paper provides some scientific basis and suggestion for the layout optimization of fire stations in Linyi City by the comprehensive utilization of various methods.

温泉旅游发展研究：探索及启示——以临沂市为例

温泉旅游发展研究：探索及启示——以临沂市为例

城市黑臭水体治理技术的思考——以山东省临沂市李公河西支为例

城市黑臭水体治理技术的思考——以山东省临沂市李公河西支为例

Strategies of Preschool Teachers' Professional Growth in Underdeveloped Region in the East China- A Case Study of Linyi City, Shandong Province

Strategies of Preschool Teachers' Professional Growth in Underdeveloped Region in the East China- A Case Study of Linyi City, Shandong Province

Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy

Purpose: To study and compare the analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol, and fentanyl-propofol combinations in colonoscopy.Methods: One hundred and thirty-four patients who received painless colonoscopy in Eastern Medical District of Linyi People's Hospital, Linyi City, Shandong Province, China, from June 2013 to December 2016 were randomly divided into two groups. Patients in the observation group (aged 42 - 65 years) received dezocine-propofol combination as anesthesia, while those in the control group (aged 41 - 67 years) were anesthetized with fentanyl-propofol. Serum levels of pain and inflammatory mediators, as well as contents of immune response molecules were determined prior to, during and after colonoscopy using either enzyme-linked immunosorbent assay (ELISA) or electro-chemiluminescence kits.Results: There were no statistically significant differences in the serum levels of 5-hydroxytryptophan (5-HTP), 5-hydroxy indole acetic acid (5-HIAA), substance P (SP), prostaglandin E2 (PGE2), C-reactive protein (CRP), heat shock protein 70 (HSP70), Interleukin-1 β(IL-1β), adrenocorticotropic hormone (ACTH), Cortisol (Cor), Inositol (Ins), c-peptide (C-P), immunoglobulin G (IgG) and immunoglobulin A (IgA), complement 3 (C3) and complement 4 (C4) before and during colonoscopy between the two groups of patients. However, after the examination, serum levels of 5-HTP, 5-HIAA, SP, PGE2, CRP, HSP70, IL-1 beta, ACTH, Cor, Ins and C-P in the observation group were significantly lower than those in control group (p &lt; 0.05), while IgG, IgA, C3 and C4 contents were significantly higher than those of the control group (p &lt; 0.05).Conclusion: These results suggest that the analgesic effect of dezocine-propofol combination after colonoscopy examination is superior to that of fentanyl-propofol combination, due to its effectiveness in inhibiting inflammatory reactions and improving immune response.Keywords: Colonoscopy, Dezocine, Propofol Fentanyl, Pain mediators, Analgesic, Inflammatory reaction, Immune response

Study on the Development of e-commerce and Modern Logistics in Linyi City, China

The New Technological Revolution, which is chiefly characterized by the rapid development of information technology, is rapidly expanding. The "Internet +" wave is now sweeping all aspects of social and economic activities, and the in-depth development of e-commerce provides a rare opportunity for new third-party logistics, as well as proposing even higher requirements on logistics services. In such an environment featured by rapid development of e-commerce, however, logistics in Linyi City, China, is facing a series of realistic problems such as large amount of scattered operators, single-function services which lack differentiation, out-dated mode of collection on delivery, increasingly serious air pollution, etc,. Given the current situation, the logistics companies and trading enterprises should join hands to form an alliance, to strengthen horizontal communication and take the road of joint development. Besides, the government should play its role in constructing a public logistics trading platform, and promote logistics transportation means to transfer to green and environmental ones.