Aiming at the problem that the loss distribution balance control effect of high-power photovoltaic grid-connected inverter is poor due to the complex loss factors, this paper proposes a loss distribution analysis and balance intelligent control method for high-power photovoltaic grid-connected inverter. The topology structure of high-power photovoltaic grid-connected inverter is constructed and the overall control scheme is designed. The loss of inductance, resonant frequency, harmonic attenuation, and damping resistance in the circuit of PV grid-connected inverter is analyzed, respectively. On this basis, a two-stage loss control model of high-power PV grid-connected inverter is constructed, and the generalized linear decision rule is adopted to schedule PV power supply and fluctuating load. A two-stage loss control model for high-power photovoltaic grid-connected inverter was established and the optimal loss control value was obtained. Experimental results show that the proposed method can accurately suppress voltage and current losses of grid-connected photovoltaic inverters and has strong resonance resistance and robustness.