Lifestyle Factors Research Articles

Mendelian randomization identifies causal effects of major depressive disorder on accelerated aging

BackgroundEvidence links major depressive disorder (MDD) with aging, but it's unclear if MDD accelerates aging and what factors mediate this transition. MethodsTwo-sample Mendelian randomization (MR) analyses were applied to estimate the causal association between MDD and frailty index (FI), telomere length (TL), and appendicular lean mass (ALM) from available genome-wide association studies in populations of European ancestry. Furthermore, we conducted mediation MR analyses to assess the mediating effects of 31 lifestyle factors or diseases on the causal relationship between MDD and aging. ResultsMDD was significantly causally associated with increased FI (βIVW = 0.23, 95 % CI = 0.18 to 0.28, p = 1.20 × 10−17), shorter TL (βIVW = −0.04, 95 % CI = −0.07 to −0.01, p = 0.01), and decreased ALM (βIVW = −0.07, 95 % CI = −0.11 to −0.03, p = 3.54 × 10−4). The mediation analysis through two-step MR revealed smoking initiation (9.09 %), hypertension (6.67 %) and heart failure (5.36 %) mediated the causal effect of MDD on FI. Additionally, alcohol use disorders and alcohol dependence on the causal relationship between MDD and TL were found to be 17.52 % and 17.13 % respectively. LimitationsConfounding, statistical power, and Euro-centric focus limit generalization. ConclusionOverall, individuals with MDD may be at a higher risk of experiencing premature aging, and this risk is partially influenced by the pathways involving smoking, alcohol use, and cardiovascular health. It underscores the importance of early intervention and comprehensive health management in individuals with MDD to promote healthy aging and overall well-being.

Mechanoresponsive ETS1 causes endothelial dysfunction and arterialization in varicose veins via NOTCH4/DLL4 signaling

Varicose veins are the most common venous disorder in humans and are characterized by hemodynamic instability due to valvular insufficiency and orthostatic lifestyle factors. It is unclear how changes in biomechanical signals cause aberrant remodeling of the vein wall. Our previous studies suggest that Notch signaling is implicated in varicose vein arterialization. In the arterial system, mechanoresponsive ETS1 is a transcriptional activator of the endothelial Notch, but its involvement in sensing disrupted venous flow and varicose vein formation has not been investigated. Here, we use human varicose veins and cultured human venous endothelial cells to show that disturbed venous shear stress activates ETS1-NOTCH4/DLL4 signaling. Notch components were highly expressed in the neointima, whereas ETS1 was upregulated in all histological layers of varicose veins. In vitro microfluidic flow-based studies demonstrate that even minute changes in venous flow patterns enhance ETS1-NOTCH4/DLL4 signaling. Uniform venous shear stress, albeit an inherently low-flow system, does not induce ETS1 and Notch proteins. ETS1 activation under altered flow was mediated primarily by MEK1/2 and, to a lesser extent, by MEK5 but was independent of p38MAP kinase. Endothelial cell-specific ETS1 knockdown prevented disturbed flow-induced NOTCH4/DLL4 expression. TK216, an inhibitor of ETS-family, inhibited the acquisition of arterial molecular identity and loss of endothelial integrity in cells exposed to the ensuing altered shear stress. We conclude that ETS1 senses blood flow disturbances and may promote venous remodeling by inducing endothelial dysfunction. Targeting ETS1 rather than downstream Notch proteins could be an effective and safe strategy to develop varicose vein therapies.

Association of healthy lifestyle factors with the risk of hypertension, dyslipidemia, and their comorbidity in Korea: results from the Korea National Health and Nutrition Examination Survey 2019-2021.

We investigated the association of individual healthy lifestyle factors (HLFs) and their combined healthy lifestyle score (HLS) with hypertension and/or dyslipidemia. We analyzed data from 10,693 adults aged ≥19 from the 2019 to 2021 Korea National Health and Nutrition Examination Survey. HLS was evaluated based on smoking status, alcohol consumption, body mass index (BMI), diet, and physical activity. Using logistic regression models, we estimated odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the associations of HLFs and HLS with hypertension, dyslipidemia, and their comorbidity. The prevalence of hypertension alone, dyslipidemia alone, and their comorbidity was 8.69%, 24.6%, and 15.0%, respectively. Multivariable models showed an inverse association of hypertension (OR, 0.37; 95% CI; 0.30-0.46) and dyslipidemia (OR, 0.36; 95% CI, 0.32-0.41) with healthy BMI. Hypertension was inversely associated with healthy alcohol consumption (OR, 0.46; 95% CI, 0.35-0.61) and diet (OR, 0.79; 95% CI, 0.63-0.99), whereas dyslipidemia was inversely associated with non-smoking (OR, 0.51; 95% CI, 0.43-0.60). Physical activity was inversely associated with their comorbidity (OR, 0.69; 95% CI, 0.56-0.85). Adherence to HLS was associated with significantly lower odds of hypertension (81%), dyslipidemia (66%), and their conditions (89%) (all ptrend<0.001). Stratified analyses consistently showed inverse associations between HLS and hypertension and/or dyslipidemia independently of demographic factors (pinteractions>0.05). HLFs were associated with lower risk for hypertension and/or dyslipidemia. Obesity may contribute significantly to the risk of these conditions, while relevant HLFs for individual chronic diseases may vary significantly.

The association between sleep duration and cardiometabolic risk among children and adolescents in the United States (US): A NHANES study.

This work aims to assess the association of sleep duration with cardiometabolic risk (adiposity, blood pressure, lipids, albuminuria and A1C) and to investigate lifestyle factors (physical activity, light exposure, caffeine consumption and sugar consumption) associated with sleep duration in children. A nationally representative sample of 3907 children ages 6-17 years enrolled in NHANES from 2011 to 2014 was included in this cross-sectional study. Sleep duration was defined as the daily average time spent sleeping over 7days as measured by a physical activity monitor (PAM). Participants without valid sleep data for ≥95% of the study were excluded. Regression models were adjusted for age, sex, race, body mass index (BMI) Z score, physical activity and light exposure. In adjusted regression models, longer sleep duration was associated with lower systolic blood pressure index (β = -3.63*10-5, 95% CI -6.99*10-5, -2.78*10-6, p = 0.035) and BMI Z score (β = -0.001, 95% CI -0.001, 0.000, p = 0.002). In logistic regression models, longer sleep duration was associated with lower odds of obesity (OR = 0.998, 95% CI 0.997, 0.999, p < 0.001) and overweight status (OR = 0.998, 95% CI 0.997, 0.999, p = 0.004). Greater light exposure (β = 6.64*10-5, 95% CI 3.50*10-5, 9.69*10-5, p < 0.001) and physical activity (β = 0.005, 95% CI 0.004, 0.006, p < 0.001) were associated with longer sleep. Longer sleep duration was associated with lower blood pressure and adiposity measures in children. Improving sleep quality by increasing physical activity and light exposure in childhood may decrease the lifetime risk of cardiometabolic disease.

Korea Nurses' Health Study and the health of reproductive-aged women: a cohort profile.

The Korea Nurses' Health Study (KNHS) is an ongoing, large-scale, prospective cohort study of female nurses, focusing on the effects of occupational, environmental, and lifestyle factors on the health of women. The first KNHS survey was performed in 2013-2014 (n=20,613). As of December 2023, 11 follow-up surveys have been conducted. Participants who were pregnant were asked to participate in the early pregnancy survey (n=2,179) and postpartum survey after giving birth (n=2,790). The main variables included sociodemographic, work-related, lifestyle, physical, mental, and women's health factors. Blood, urine, and toenail samples were collected from a participant subgroup of the first survey (n=1,983). The subgroups of the second survey completed a food frequency questionnaire in 2019 (n=300) and 2021 (n=871). In 2020, a subgroup of the first survey answered a coronavirus disease 2019 (COVID-19)-related survey (n=975). To examine various health-related factors in young adults, new participants were added to the KNHS cohort in the 11th (n=1,000) and 12th (n=1,002) surveys. The KNHS cohort will help identify health and illness determinants in Korean women. Data can be accessed at https://coda.nih.go.kr/frt/index.do.

Non-alcoholic fatty liver disease among patients undergoing ultra-sonography abdomen and its associated factors in a tertiary care hospital, Kakinada

Background: Non-alcoholic fatty liver disease (NAFLD) presents a growing global health concern, characterized by the accumulation of hepatic lipids in the absence of significant alcohol consumption. Its prevalence has surged worldwide, including in India, where it has reached alarming levels. Despite its silent progression, NAFLD can lead to severe complications, including liver cirrhosis and hepatocellular carcinoma. Objectives of the study to assess prevalence and its associated factors, which are essential for effective management and prevention strategies. Methods: An observational, analytical cross-sectional study was conducted in a tertiary care hospital in Kakinada, Andhra Pradesh, from June to July 2022. Among 100 subjects, chosen through the simple random sampling. Ethical approval was granted before conducting study. Data on demographics, lifestyle risk factors, anthropometry, and ultrasound findings were collected using a pretested and validated case record form. Statistical analysis was carried out using SPSS software, employing appropriate tests to explore associations between NAFLD and various variables. Results: Among 100 participants, the prevalence of NAFLD was found to be 41%. Significant associations were observed between NAFLD and variables such as BMI (p=0.034), waist-hip ratio (p=0.002), and history of diabetes mellitus (p=0.000). Lifestyle factors, including increased cooking oil consumption, were identified as significant risk factors. Conclusions: The study highlights the high prevalence of NAFLD among subjects undergoing ultrasound abdomen in Kakinada. Significant associations were observed with BMI, waist-hip ratio, and diabetes mellitus history. Promoting healthy behaviours is crucial for NAFLD prevention and management.

PREVALENCE AND RISK FACTORS OF GASTROESOPHAGEAL REFLUX DISEASE (GERD) IN MEDICAL COLLEGE STUDENTS

Gastro-esophageal reflux disease (GERD) is a common gastrointestinal disorder characterized by the reflux of stomach contents into the esophagus, leading to heartburn, regurgitation, and chest pain. Objectives: The study's main aim is to find the prevalence and risk factors of gastroesophageal reflux disease in medical college students. Methods: This cross-sectional study was conducted at Allama Iqbal Medical College Lahore from October 2023 to March 2024. Data were collected from 550 medical college students from 1st year, 2nd, 3rd, 4th and 5th year. Data were collected through an online survey, including demographic data, GERD symptoms, dietary habits and lifestyle factors, and stress levels. GERD symptoms were reported, which include all data related to heartburn, chest pain and dysphagia. Results: Data were collected from 550 participants. The mean age of the participants (with GERD) was 24.0 ± 3.0 years, and without GERD, 23.0 ± 2.5 years. There were 65% female and 35 % male in the GERD group and 55% female and 45% male in the without GERD group. Students with GERD exhibited significantly higher prevalence rates of certain lifestyle factors compared to those without GERD. Specifically, students with GERD reported higher rates of consumption of spicy/acidic foods (50% vs. 35%), high intake of caffeine/carbonated beverages (60% vs. 40%), irregular meal patterns (40% vs. 20%), large meals before bedtime (30% vs. 15%), and sedentary lifestyle behaviors (70% vs. 40%). These differences were statistically significant, as indicated by the p-values &lt;0.05 for consumption of spicy/acidic foods and large meals before bedtime, &lt;0.01 for high intake of caffeine/carbonated beverages and irregular meal patterns, and &lt;0.001 for sedentary lifestyle behaviours. Conclusion: It is concluded that gastroesophageal reflux disease (GERD) presents a significant health concern among medical college students, with a notable prevalence of symptoms reported in this population.

Nutritional Status, Dietary Intake, and Nutrition-Related Interventions Among Older Adults With Type 1 Diabetes: A Systematic Review and Call for More Evidence Toward Clinical Guidelines.

There is an emerging population of older adults (≥65 years) living with type 1 diabetes. Optimizing health through nutrition during this life stage is challenged by multiple and ongoing changes in diabetes management, comorbidities, and lifestyle factors. There is a need to understand nutritional status, dietary intake, and nutrition-related interventions that may maximize well-being throughout the life span in type 1 diabetes, in addition to nutrition recommendations from clinical guidelines and consensus reports. Three reviewers used Cochrane guidelines to screen original research (January 1993-2023) and guidelines (2012-2023) in two databases (MEDLINE and CENTRAL) to characterize nutrition evidence in this population. We found limited original research explicitly focused on nutrition and diet in adults ≥65 years of age with type 1 diabetes (six experimental studies, five observational studies) and meta-analyses/reviews (one scoping review), since in the majority of analyses individuals ≥65 years of age were combined with those age ≥18 years, with diverse diabetes durations, and also individuals with type 1 and type 2 diabetes were combined. Further, existing clinical guidelines (n = 10) lacked specificity and evidence to guide clinical practice and self-management behaviors in this population. From a scientific perspective, little is known about nutrition and diet among older adults with type 1 diabetes, including baseline nutrition status, dietary intake and eating behaviors, and the impact of nutrition interventions on key clinical and patient-oriented outcomes. This likely reflects the population's recent emergence and unique considerations. Addressing these gaps is foundational to developing evidence-based nutrition practices and guidelines for older adults living with type 1 diabetes.

EVALUATING MACHINE LEARNING MODELS FOR PREDICTING SLEEP DISORDERS IN A LIFESTYLE AND HEALTH DATA CONTEXT

EVALUATING MACHINE LEARNING MODELS FOR PREDICTING SLEEP DISORDERS IN A LIFESTYLE AND HEALTH DATA CONTEXT

Efektivitas Peraturan Daerah Kota Jambi Nomor 2 Tahun 2014 dalam Pemberantasan Pelacuran dan Perbuatan Asusila di Wilayah Kota Jambi

The occurrence of criminal acts of prostitution and immoral acts in the city of Jambi is currently widespread. This can also be proven by the existence of cases of prostitution at OYO accommodation located in the city of Jambi. Even though there is Jambi City Regional Regulation Number 2 of 2014 on the Eradication of Prostitution and Immoral Acts, in reality there is still prostitution in the city of Jambi even though the local area has been closed. The aim of this research is to understand and analyze the factors that influence people to commit prostitution and immoral acts in Jambi City, obstacles in implementing the effectiveness of Jambi City Regional Regulation Number 2 of 2014 in Eradicating Prostitution and Immoral Acts in the Jambi City area and efforts to overcome obstacles in reducing the number of prostitution and immoral acts in the Jambi city area. The research method is an empirical juridical research type with a legal sociology approach and uses data sources, namely primary legal materials and secondary legal materials. The sampling technique was purposeful sampling and data collection techniques were carried out using interviews and document studies and data analysis was carried out using qualitative analysis. The results of his research are that the factors that influence people to commit prostitution and immoral acts in Jambi City are economic and lifestyle factors, a profitable prostitution business, teenagers having broken home family backgrounds and joining the wrong social groups, the existence of hotels and nightclubs or club. The obstacle in carrying out the effectiveness of Jambi City Regional Regulation Number 2 of 2014 in Eradicating Prostitution and Immoral Acts in the Jambi city area is that criminal sanctions are categorized as light and not as a coercive tool to ensnare perpetrators of prostitution, there is no special authority for the police to carry out criminal sanctions in the Regional Regulation. , there was a leak of information during the raid, the condition of the Youth and Women's Social Home in Talang Bakung was still worrying as it could become a rehabilitation place for prostitutes, there was resistance from the community around the prostitution localization to close the prostitution localization, there was foreign culture coming in such as promiscuity. An effort to overcome obstacles in reducing the number of prostitution and immoral acts in the Jambi city area is that the Jambi City Government closes down the localization of prostitution in the city of Jambi, then carries out socialization of Regional Regulation Number 2 of 2014 to the people of Jambi city, the Jambi city government and the Jambi City Civil Service Police Unit. coordinating with the TNI and Polri in carrying out raids as well as the role of the community or parents in supervising their children when using cellphones.

Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences.

The Oxidative Balance Score (OBS) is commonly used to assess oxidative stress and provides a comprehensive evaluation of dietary and lifestyle-related exposures. However, there is limited research on the association between OBS and colorectal cancer (CRC), its subsites, and complications. The objective of this study was to assess the relationship between OBS and the risk of CRC, its subsites, and common complications in a large prospective cohort study. We included data from 175,808 participants in the UK Biobank data sample repository from 2006 to 2010. We evaluated OBS using a scoring system based on 22 dietary and lifestyle factors. Multiple adjustments, including multivariate Cox proportional hazard regression, gender stratification, subgroup analysis, and sensitivity analysis, were performed to fully explore the relationship between OBS and CRC, its subsites, and complications. The mediation analysis was conducted to investigate whether serum albumin, uric acid, and neutrophil levels mediate the relationship between OBS and CRC. After adjusting for potential confounding factors, a significant negative correlation was found between OBS and the risk of CRC and its subsites (proximal colon cancer, distal colon cancer, and rectal cancer). This correlation was particularly pronounced in male CRC patients. Serum albumin, uric acid, and neutrophil count, which are biomarkers, were found to have a significant mediating effect between OBS and CRC. Our study suggests that higher exposure to antioxidants assessed through OBS (diet and lifestyle rich in antioxidants) may decrease the occurrence of CRC and its subsites.

Development of a Holistic Nursing Model Based on Transcultural Nursing to Improve the Quality of Life of Patients with Type-2 Diabetes Mellitus

Introduction: The management of Type 2 diabetes mellitus (T2DM) primarily emphasizes physical care, yet the quality of life (QoL) remains suboptimal. Often, the management of diabetes neglects psychological, socio-cultural, and spiritual aspects, which are essential components of transcultural nursing. Developing a holistic nursing model rooted in transcultural nursing is imperative to enhance QoL in individuals with T2DM.Purpose: This study aimed to develop a nursing model based on transcultural nursing to enhance the QoL of individuals with T2DM.Methods: In this study, an explanatory research design with a cross-sectional approach was employed. A sample of 145 individuals diagnosed with T2DM was recruited using a simple random sampling technique. A self-developed questionnaire was utilized, incorporating factors from Dossey's holistic nursing model, Leininger's transcultural nursing model, and a Quality of Life (QoL) questionnaire. The study's variables included respondent characteristics, technological factors, religious and life philosophy factors, social and kinship factors, cultural and lifestyle factors, biological factors, psychological factors, holistic nursing based on transcultural nursing, and QoL. Inferential statistics, specifically Smart PLS-Structural Equation Modeling (SEM), were employed for data analysis.Results: The findings revealed that the holistic nursing model based on transcultural nursing in individuals with T2DM was directly influenced by several factors. Specifically, respondent characteristics (t=3.313, p=0.001), religious and life philosophy (t=2.836, p=0.005), social and kinship (t=2.579, p=0.010), cultural and lifestyle (t=2.833, p=0.005), biological (t=2.718, p=0.007), and psychological (t=2.497, p=0.013) factors showed significant influence. However, the technological factor was not significant (t=0.802, p=0.423). Furthermore, there was a direct influence of holistic nursing based on transcultural nursing on the quality of life (t=9.124, p=0.000).Conclusion: The holistic nursing model based on transcultural nursing encompasses six variables: respondent characteristics, religious and life philosophy, social and kinship, cultural and lifestyle, biological, and psychological factors. This model directly impacts and proves useful in enhancing the quality of life of individuals with T2DM.

Inflammation in recurrent miscarriage - a comprehensive perspective from uterine microenvironment and immune cell imbalance to therapeutic strategies.

Recurrent miscarriage, poses a significant challenge for many couples globally, the causes of which are not fully understood. Recent studies have shown the intricate link between uterine inflammation and recurrent miscarriages. While inflammation is essential during early pregnancy stages, especially in embryo implantation, an imbalance can lead to miscarriage. Key inflammatory mediators and an imbalance in immune cells can significantly alter and contribute to recurrent miscarriages. Lifestyle factors like smoking and obesity exacerbate inflammatory responses, increasing miscarriage risks. Understanding the interaction between the uterine environment, immune cell imbalances, and recurrent miscarriages is essential for devising effective treatments. This paper presents the latest data on inflammation's role in recurrent miscarriage, emphasizing the significance of diagnosing chronic endometritis and immune imbalances, offering practical recommendations for treatment and diagnosis.

The Evaluation of Physiopathological and Immunological Exercise Effects During Pandemic and Pathogenicity on Coronavirus COVID-19 (with Considerations and Instructions of Doing Related Physical Activity)

Context: The 2019 coronavirus disease (COVID-19), also commonly known as the coronavirus, is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is associated with several challenges, including an increased sedentary lifestyle, obesity, and elevated inflammatory factors and related diseases. Evidence Acquisition: In conducting this research, we utilized the latest articles from prestigious domestic and foreign journals indexed in databases such as PubMed, Google Scholar, and ScienceDirect. Results: There are various hypotheses regarding the intensity of exercise and its impact on infection rates. Moderate-intensity exercise is believed to enhance immune function and reduce mortality, whereas high-intensity and stressful exercise may have the opposite effect. When exposed to infection, high-intensity exercise can suppress the immune system, whereas moderate-intensity exercise may reduce inflammation. Conclusions: Therefore, given that exercise affects the strength and anti-inflammatory mechanisms of the immune system, it plays a crucial role in reducing complications for patients. Consequently, it can be concluded that exercise strengthens the immune system, reduces inflammation, and creates favorable physiological and immunological conditions to aid athletes in overcoming the virus.

Highly conserved bifidobacteria in the human gut: Bifidobacterium longum subsp. longum as a potential modulator of elderly innate immunity.

Aging is a physiological and immunological process involving the deterioration of human health, characterised by the progressive alteration of organs and their functions. The speed and extent of such decline are dependent on lifestyle, environment, and genetic factors. Moreover, with advancing age, humans become progressively more fragile and prone to acute and chronic diseases. Although the intestinal microbiota is predisposed to perturbations that accompany aging and frailty, it is generally accepted that the gut microbiota engages in multiple interactions that affect host health throughout the host life span. In the current study, an exhaustive in silico investigation of gut-associated bifidobacteria in healthy individuals from birth to old age revealed that Bifidobacterium longum subsp. longum is the most prevalent member, especially during infancy and in centenarians. Moreover, B. longum subsp. longum genome reconstruction and strain tracing among human gut microbiomes allowed the identification of prototypes of this taxon in the human gut microbiota of healthy elderly individuals. Such analyses guided culturomics attempts to isolate B. longum subsp. longum strains that matched the genomic content of B. longum subsp. longum prototypes from healthy elderly individuals. The molecular effects of selected B. longum subsp. longum strains on the human host were further investigated using in vitro microbe-host interactions, revealing differences in the host immune system transcriptome, with a reduction in gene expression of inflammation-related cytokines. These intriguing findings support the potential anti-aging effects of elderly associated prototypes of B. longum subsp. longum.

Bridging gaps in awareness of cancer associated lifestyle factors in adolescents and young adults: an interventional study in Chandigarh

Bridging gaps in awareness of cancer associated lifestyle factors in adolescents and young adults: an interventional study in Chandigarh

Significance of Ayurvedic Cosmetology in Contemporary Context: A Critical Review

Introduction: The human skin, the body’s largest organ, serves vital functions in physical protection and health reflection. However, modern lifestyle factors often compromise skin health, leading individuals to rely on cosmetic products that may exacerbate damage. Materials and Methods: Ayurveda, an ancient Indian medicinal system, offers holistic approaches to skin care and beauty maintenance, emphasizing internal and external well-being. Ayurvedic texts detail various herbal formulations and practices for skin care, including external applications like Lepa and internal remedies such as Vayasthapan Mahakashaya and Varnya Mahakashaya. Results: Ayurveda addresses a broad spectrum of dermatological concerns, including skin and hair care, fairness, stretch mark elimination, foot care, hair coloring, removal, acne treatment, scar reduction, and dandruff management. These treatments are known for their safety, affordability, and high efficacy. Discussion: This review explores Ayurvedic principles and practices relevant to contemporary dermatological challenges, highlighting its effectiveness in skin care and beauty maintenance. Conclusion: Ayurveda presents promising solutions for modern skin care dilemmas, offering safe, affordable, and effective alternatives to conventional cosmetic products.

Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study.

Age is the most important risk factor for cancer, but aging rates are heterogeneous across individuals. We explored a new measure of aging-Phenotypic Age (PhenoAge)-in the risk prediction of site-specific and overall cancer. Using Cox regression models, we examined the association of Phenotypic Age Acceleration (PhenoAgeAccel) with cancer incidence by genetic risk group among 374,463 participants from the UK Biobank. We generated PhenoAge using chronological age and nine biomarkers, PhenoAgeAccel after subtracting the effect of chronological age by regression residual, and an incidence-weighted overall cancer polygenic risk score (CPRS) based on 20 cancer site-specific polygenic risk scores (PRSs). Compared with biologically younger participants, those older had a significantly higher risk of overall cancer, with hazard ratios (HRs) of 1.22 (95% confidence interval, 1.18-1.27) in men, and 1.26 (1.22-1.31) in women, respectively. A joint effect of genetic risk and PhenoAgeAccel was observed on overall cancer risk, with HRs of 2.29 (2.10-2.51) for men and 1.94 (1.78-2.11) for women with high genetic risk and older PhenoAge compared with those with low genetic risk and younger PhenoAge. PhenoAgeAccel was negatively associated with the number of healthy lifestyle factors (Beta = -1.01 in men, p<0.001; Beta = -0.98 in women, p<0.001). Within and across genetic risk groups, older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle. This work was supported by the National Natural Science Foundation of China (82230110, 82125033, 82388102 to GJ; 82273714 to MZ); and the Excellent Youth Foundation of Jiangsu Province (BK20220100 to MZ).

Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study

Background:Age is the most important risk factor for cancer, but aging rates are heterogeneous across individuals. We explored a new measure of aging-Phenotypic Age (PhenoAge)-in the risk prediction of site-specific and overall cancer.Methods:Using Cox regression models, we examined the association of Phenotypic Age Acceleration (PhenoAgeAccel) with cancer incidence by genetic risk group among 374,463 participants from the UK Biobank. We generated PhenoAge using chronological age and nine biomarkers, PhenoAgeAccel after subtracting the effect of chronological age by regression residual, and an incidence-weighted overall cancer polygenic risk score (CPRS) based on 20 cancer site-specific polygenic risk scores (PRSs).Results:Compared with biologically younger participants, those older had a significantly higher risk of overall cancer, with hazard ratios (HRs) of 1.22 (95% confidence interval, 1.18–1.27) in men, and 1.26 (1.22–1.31) in women, respectively. A joint effect of genetic risk and PhenoAgeAccel was observed on overall cancer risk, with HRs of 2.29 (2.10–2.51) for men and 1.94 (1.78–2.11) for women with high genetic risk and older PhenoAge compared with those with low genetic risk and younger PhenoAge. PhenoAgeAccel was negatively associated with the number of healthy lifestyle factors (Beta = –1.01 in men, p&lt;0.001; Beta = –0.98 in women, p&lt;0.001).Conclusions:Within and across genetic risk groups, older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle.Funding:This work was supported by the National Natural Science Foundation of China (82230110, 82125033, 82388102 to GJ; 82273714 to MZ); and the Excellent Youth Foundation of Jiangsu Province (BK20220100 to MZ).

SOCIOLOGICAL PERSPECTIVES ON OSTEOARTHRITIS MANAGEMENT: INSIGHTS AND CHALLENGES

This study examines how medical sociology intersects with osteoarthritis management, with both the perspectives of individuals affected by the condition and the healthcare system, drawing insights from theoretical frameworks and empirical evidence. Two main themes were addressed: gender disparities and the living experience with osteoarthritis. It was found that the female gender is more susceptible to developing knee osteoarthritis due to lifestyle factors and other environmental influences. Additionally, women tend to report pain earlier compared to men, leading to a higher likelihood of seeking medical attention for symptoms. Regarding the experience of living with this condition, important themes such as the refusal to give up, pragmatism in treatment, staying in charge and the care from others were presented, being essential for managing this condition. Additionally, it was discovered that better communication between doctor and patient, the exchange of specific, relevant and sufficient information, contributes to a positive experience during a medical consultation and forms the foundation of a trustworthy relationship between the individual and the healthcare system. Overall, this research shows that managing osteoarthritis is complex and requires personalized healthcare approaches. Keywords: osteoarthritis, medical sociology, gender disparities, living experience, management.